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Suppression of Pulse Interference in Partial Discharge Measurement Based on Phase Correlation and Waveform Characteristics

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Journal of Energy and Power Engineering 2015年第3期9卷 289-295页

作者： Shengyou Gao Qi Wang Junfeng Gui Yunfeng xia jianhua Lin jianhua Huang Xiyang Chen Electrical Engineering Department Tsinghua University Beijing 100084 China

Partial discharge measurement is one of the most effective methods to find insulation defects and early failure of high voltage power equipments. The accuracy is significantly reduced by the interference in the partial discharge on-site detection or on-line monitoring, especially by the pulse interference. This paper studies the phase correlation of some types of typical partial discharge pulses and their characteristics in time domain and frequency domain. By collecting enough partial discharge pulse data, the correlation coefficient can be calculated based on both phase correlation and waveform similarity. The type of pulse will be determined by the scope of the calculated correlation coefficient. The pulses with very strong correlation will be identified as periodic pulse interference. The pulses with very weak correlation will be identified as random pulse interference. Only the pulses whose correlation coefficients fall into a specific range will be identified as partial discharge signals. In laboratory, simulated pulse interference is injected into measurement circuit, and typical partial discharge pulses are sampled by a high-speed acquisition system. The pulse interference can be effectively separated from partial discharge signals by correlation coefficient.

关键词： Correlation coefficient partial discharge phase correlation pulse interference waveform characteristic.

逆向供应链概念性服务模块二层匹配方法及应用

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机械工程学报 2017年第2期53卷 164-174页

作者：王蕾夏绪辉曹建华武汉科技大学冶金矿产资源高效利用与造块湖北省重点实验室武汉430081 武汉科技大学机械自动化学院武汉430081

逆向供应链服务是废弃物资源化处理和综合利用的有效运行管理模式之一。针对逆向供应链服务活动复杂多样、服务资源数量庞大导致其模块化及匹配困难问题,在分析逆向供应链服务过程的基础上,提出逆向供应链概念性服务的概念,并构建一种... 详细信息

逆向供应链服务是废弃物资源化处理和综合利用的有效运行管理模式之一。针对逆向供应链服务活动复杂多样、服务资源数量庞大导致其模块化及匹配困难问题,在分析逆向供应链服务过程的基础上,提出逆向供应链概念性服务的概念,并构建一种逆向供应链概念性服务模块二层匹配框架模型、提出其两层匹配方法,以获取满足客户需求的最优服务活动和服务供应商组合方案。针对功能性服务模块组合经验知识难以定量度量问题,提出基于矢量空间模型的服务活动抽象模块匹配方法;针对服务响应时间、服务成本和服务质量等多目标优化常相互冲突难以同时达到最优的问题,提出基于多目标遗传优化的服务供应商知识模块匹配方法,通过加权组合的Pareto选优,从所获得的无法进行简单比较的Pareto最优解集中得到符合客户需求偏好的最优解,进而指导最终服务供应商优选。以某钢铁企业废钢逆向供应服务为例,验证逆向供应链概念性服务模块匹配方法的可行性、有效性和实用性。

关键词：逆向供应链服务概念性服务模块框架模型服务模块匹配多目标遗传算法

Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4312-4328页

作者： Yanyan Zhang Yun Huang Dianping Yu Mengting Xu Hongmei Hu Qing Zhang Minchen Cai xiangxin Geng Hongwei Zhang jianhua xia Mengmeng Guo Dong Lu Hanchi Xu Linyang Li Xing Zhang Qun Wang Sanhong Liu Weidong Zhang Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Phytochemistry School of PharmacySecond Military Medical UniversityShanghai 200433China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China The Research Center for Traditional Chinese Medicine Shanghai Institute of Infectious Diseases and BiosafetyInstitute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China

Programmed cell death ligand-1(PD-L1)is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1(PD-1)to promote immune escape of tumor *** with antibody therapies,small molecule drugs show better prospects due to their advantages such as higher bioavailability,better tissue penetration,and reduced risk of ***,we found that the small molecule demethylzeylasteral(Dem)can significantly downregulate the expression of PD-L1 in colorectal cancer cells and enhance the killing effect of T cells on tumor ***,Dem binds to the deubiquitinating enzyme USP22 and promotes its degradation,resulting in increased ubiquitination and degradation of PD-L1 through the proteasome *** addition,Dem increased the activity of cytotoxic T cells and reduced the number of myeloid-derived suppressor cells(MDSCs)and regulatory T cells(Tregs)in tumor-infiltrating lymphocytes(TILs),thereby activating the tumor immune microenvironment and inhibiting the growth of subcutaneous MC38 tumors in C57BL/6 ***,we also found that the combination of Dem and CTLA4 antibodies can further improve the efficacy of antitumor *** study reveals the mechanism by which Dem promotes PD-L1 degradation and suggests that the combination of Dem and CTLA4 antibodies may improve the efficacy of immunotherapy.

关键词： Demethylzeylasteral PD-L1 USP22 Deubiquitination Tumor-infiltrating lymphocytes Colorectal cancer Immune checkpoint blockade Antitumor immunity

Effect of Ultrasonic Vibration on Dealloying Corrosion of CuCrAl Alloy in H2SO4 Solutions

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材料科学与工程（中英文A版） 2011年第2X期1卷 253-257页

作者： Zhe Zhang Chaoyi Yan Chunyue Liu Yinfeng xia jianhua Liu Ruijun Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China

Analysis of Disastrous Climate and Its Coping Mechanisms and Measures in the Tobacco-growing Areas of Luzhou

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Meteorological and Environmental Research 2018年第4期9卷 33-35,40页

作者： Jiang Sheng xia Chun xia jianhua Zhang Yonghui Zhao Jinchao Xie Qiang Zhang Yuangai Lei xiao Zhang Mingjin Gu Yong Luzhou City Company of Sichuan Provincial Tobacco Company Luzhou 646000 China

Flue-cured tobacco is one of the main pillar industries for increasing fiscal efficiency and tobacco farmers＇ income in Gulin and Xuyong counties. However, the annual loss caused by natural disasters such as low temperature and rain, rainstorm and flood, high temperature and drought, and hail accounts for about 20%, and they have become one of the important factors restricting the development of tobacco industry in Luzhou. In recent years, a lot of work has been done in disaster prevention and mitigation in the process of flue-cured tobacco production, and cer-tain results have been achieved. However, it still needs further exploration and research in the face of natural disasters that are gradually changing frequently and even develop in a normal way. In this paper, common meteorological disasters in the tobacco-growing areas of Luzhou were ana-lyzed firstly, and then corresponding countermeasures were put forward, which is of great significance to ensure the sustainable and healthy devel-opment of tobacco in Luzhou.

关键词： Flue-cured tobacco Meteorologic disasters Measures

课堂观察视野下的科学探究活动——安徽省高中化学优质课评析及反思

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化学教育 2010年第9期31卷 12-14,20页

作者：夏建华曹淑芳安徽省教育科学研究院合肥230061 安徽师范大学附属中学

制作观察量表，用“课堂观察”的方法对新课程倡导的科学探究活动中学生自主学习的情况进行观察和研究，能够更加客观地评价探究活动的有效性问题，为教师的个人反思提供方向，探寻更加合理的科学探究模式。

关键词：科学探究活动自主学习课堂观察观察量表科学探究模式

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异丙酚对剖宫产子代大鼠肝功能的影响

中华麻醉学杂志 2016年第11期36卷 1326-1328页

作者：姚滢夏建华郭锋解放军第四一一医院麻醉科上海市200081

目的探讨异丙酚对剖宫产子代大鼠肝功能的影响。方法SD大鼠24只，孕龄20 d，体重230～270 g，采用随机数字表法分为4组（n＝6）：对照组（C组）、异丙酚2.0 mg/kg组（P2组）、异丙酚4.0 mg/kg组（P4组）和异丙酚8.0 mg/kg组（P8组）。P... 详细信息

目的探讨异丙酚对剖宫产子代大鼠肝功能的影响。方法SD大鼠24只，孕龄20 d，体重230～270 g，采用随机数字表法分为4组（n＝6）：对照组（C组）、异丙酚2.0 mg/kg组（P2组）、异丙酚4.0 mg/kg组（P4组）和异丙酚8.0 mg/kg组（P8组）。P2组、P4组和P8组静脉注射相应剂量的异丙酚，翻正反射消失30 min时行剖宫产术，C组于相应时点采用脱颈法处死孕鼠，然后立即取出子代大鼠，并给予充分吸氧，迅速处死，经心脏采血样，测定血浆谷丙转氨酶（ALT）和谷草转氨酶（AST）浓度。取肝脏组织，HE染色，显微镜下观察病理学结果。结果与C组比较，P2组、P4组和P8组子代大鼠血浆ALT和AST浓度升高（P〈0.05）；与P2组比较，P4组和P8组子代大鼠血浆ALT和AST浓度升高（P〈0.01）；与P4组比较，P8组子代大鼠血浆ALT和AST浓度升高（P〈0.01）。P2组、P4组和P8组子代大鼠肝组织发生明显病理学损伤，且损伤程度依次加重。结论异丙酚可诱导剖宫产子代大鼠肝损伤，且呈剂量依赖性。

关键词：二异丙酚剖宫产术婴儿,新生肝功能试验

低能Ar^+、Xe^+轰击SiO_2的溅射模型

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北京航空航天大学学报 2017年第9期43卷 1766-1772页

作者：张建华夏勇丁利商圣飞北京航空航天大学宇航学院北京100083

为了得到在低能条件下更为精确的Ar^+和Xe^+轰击SiO_2的溅射模型,对已有化合物溅射模型进行调研分析,总结了3种溅射模型,分别为Pencil模型、Bach模型和Seah模型,并对其不足之处加以分析。在Seah模型基础上,对溅射阈值采用新的计算方法,... 详细信息

为了得到在低能条件下更为精确的Ar^+和Xe^+轰击SiO_2的溅射模型,对已有化合物溅射模型进行调研分析,总结了3种溅射模型,分别为Pencil模型、Bach模型和Seah模型,并对其不足之处加以分析。在Seah模型基础上,对溅射阈值采用新的计算方法,并利用等效原子法改进溅射参数和表面键能的计算方法,形成改进后的新模型。结合已有的关于Ar^+和Xe^+法向轰击SiO_2的实验数据,对4种模型的计算结果进行对比分析。对于Ar^+和Xe^+法向轰击SiO_2,改进后的溅射模型的均方根误差最小,拟合优度最高,均优于其他3种模型。说明在低能状态下,采用改进后的模型可以更为精确地计算Ar^+和Xe^+轰击SiO_2的溅射率。

关键词：氩离子氙离子二氧化硅溅射改进

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关于强化长江河道采砂管理的思考

人民长江 2018年第11期49卷 1-2,13页

作者：马建华夏细禾水利部长江水利委员会湖北武汉430010

在全面归纳长江河道采砂管理现状的基础上,详细介绍了近两年长江河道采砂管理已采取的措施,系统分析了目前长江河道采砂依然存在的问题,进一步提出了强化长江河道采砂管理的工作思路和有关措施,以实现长江河道砂石资源科学、绿色、可持... 详细信息

在全面归纳长江河道采砂管理现状的基础上,详细介绍了近两年长江河道采砂管理已采取的措施,系统分析了目前长江河道采砂依然存在的问题,进一步提出了强化长江河道采砂管理的工作思路和有关措施,以实现长江河道砂石资源科学、绿色、可持续利用,维护长江河势稳定,保障长江防洪、通航、生态安全以及国民经济健康可持续发展。

关键词：河道采砂生态保护长江干流长江经济带