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Improving acceptor efficacy rather than energy transfer efficiency:Dominant contribution of monomers of acceptors modified on upconversion nanoparticles

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Journal of Rare Earths 2022年第5期40卷 702-708,I0001页

作者： Jie Ren Yadan Ding Hancheng Zhu Zhipeng Li xia hong Huiying Zhao hong Zhang Key Laboratory of UV-Emitting Materials and Technology(Northeast Normal University) Ministry of EducationChangchun 130024China Department of Basic Medicine Gerontology Department of First Bethune HospitalUniversity of JilinChangchun 130021China Van’t Hoff Institute for Molecular Sciences University of AmsterdamScience Park 9041098XHAmsterdamthe Netherlands

Upconversion nanosensitizers have been widely considered to have important applications in the treatment of major diseases such as tumors and the utilization of solar *** of the efforts so far have been focused on improving the efficiency of energy transfer(ET)between upconversion nanoparticles(UCNPs)and the anchored sensitizers with premise that high ET efficiency will lead to high acceptor *** premise is,however,proved by our current work to be invalid for commonly used *** between adjacent sensitizing molecules was found to be critical which undermines the amount of excited monomer sensitizers and thus fades the *** NaYF_(4):Yb^(3+),Er^(3+)UCNPs and rose bengal(RB)photosensitizer molecules were used as the model energy donors and acceptors,*** to monotonous increase of the ET efficiency from UCNPs to RB species with increasing RB loading,acceptor efficacy characterized by the reactive oxygen species,as well as the RB fluorescence,exhibits bizarre dependence on the RB *** underlying mechanism was well studied by the steady-state and time-resolved spectroscopy of a series of *** aggregates are believed to be responsible for the severe deviation between the ET efficiency and acceptor *** conclusion was validated by in vitro test where the photodynamic therapy with the most monomer RB in UCNPs-RB nanosensitizers kills 35.8%more cells than that with the highest RB *** understanding sheds light on construction of new ET based nanosystems for broad applications,such as medicine,solar energy utilization and optical storage.

关键词： Upconversion nanoparticle Energy transfer Monomer Aggregate Reactive oxygen species Rare earths

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Type 2 Diabetes Meilitus Easily Develops into Alzheimer’s Disease via Hyperglycemia and Insulin Resistance

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Current Medical Science 2021年第6期41卷 1165-1171页

作者： Ting LI hong-xia CAO Dan KE Department of Pathophysiology School of Basic Medicine and the Collaborative Innovation Center for Brain ScienceKey Laboratory of Ministry of Education of China and Hubei Province for Neurological DisordersTongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

With the acceleration of population aging,the incidence of type 2 diabetes mellitus(T2DM)and Alzheimer’s disease(AD)is progressively increasing due to the age-relatedness of these two *** association between T2DM and AD-like dementia is receiving much attention,and T2DM is reported to be a significant risk factor for *** aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD.

关键词： type 2 diabetes mellitus Alzheimer’s disease hyperglycemia insulin resistance cognition

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Establishment of Real-Time TaqMan-Fluorescence Quantitative RT-PCR Assay for Detection and Quantification of Porcine Lipoprotein Lipase mRNA

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Agricultural Sciences in China 2009年第10期8卷 1256-1262页

作者： LIAN hong-xia LU De-xun GAO Min College of Animal Science and Veterinary Medicine Henan Agricultural University Zhengzhou 450002 P.R. China Institute of Animal Nutrition Inner Mongolian Academy of Agricultural and Animal Sciences Huhhot 010031 P.R. China

Porcine lipoprotein lipase （LPL） cDNA was cloned as the standard for real-time quantifying LPL mRNA and the TaqMan-fluorescence quantitative PCR assay for detection was established. The total RNA extracted from Longissimus dorsi of porcine was reverse-transcribed to cDNA. LPL cDNA was ligated with pGM-T vector and transformed into Escherichia coli TOP10. Plasmid DNA extracted from positive clones was verified by PCR amplification and sequenced. LPL was amplified by real-time fluorescence quantitative PCR from the plasmid DNA. The concentration of DNA template purified was detected by analyzing absorbance in 260 nm and then the combined plasmid was diluted to series as standard for fluorescence quantitative PCR （FQ-PCR）. The method of LPL mRNA real-time PCR was well established, which detected as low as 103 with the linear range 10^3 to 10^10 copies. The standard curves showed high correlations （R2 = 0.9871）. A series of standards for real-time PCR analysis have been constructed successfially, and real-time TaqMan-fluorescence quantitative RT-PCR is reliable to quantitatively evaluate FQ-PCR mRNA in L. dorsi of porcine.

关键词： porcine lipoprotein lipase FQ-PCR TaqMan fluorogenic probe

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Synthesis and Crystal Structure of 2-Benzylamino-6-methyl-3-cyano-8- phenyl-5H-bispyrazolo[3,4-d,3',2'-b]pyrimidine

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Chinese Journal of Structural Chemistry 2005年第8期24卷 962-964页

作者： YANG Li-Min LI hong-xia LIU Zhao-Jie Key Laboratory of Pesticide & Chemical Biology of Education Ministry College of Chemistry Central China Normal University Wuhan 430079 China

The title compound 2-benzylamino-6-methyl-3-cyano-8-phenyl-5H-bispyrazolo[3,4-d,3＇,2＇-b]pyrimidine crystallizes in orthorhombic, space group Pbca with a = 17.945（7）, b =10.862（4）, c = 19.481（7） A°, β = 90°, Z = 8, V = 1151.8（4） A°^3, Mr = 379.43, Dx = 1.327 g/cm^3,μ（MoKa） = 0.084 mm^-1, F（000） = 1584, the final R = 0.0513 and wR = 0.1128 for 2608 observed reflections （I 〉 2σ（I））. X-ray analysis reveals that the tricyclic portion of the molecule is effectively planar. In addition, there exist three intermolecular hydrogen bonds.

关键词： crystal structure bispyrazolo[3,4-d 3',2'-b]pyrimidine synthesis

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A comparative investigation of NdSrCu_(1-x) Co_x O_(4-δ) and Sm_(1.8) Ce_(0.2) Cu_(1-x) Co_x O_(4-δ) (x:0–0.4) for NO decomposition

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Journal of Environmental Sciences 2010年第3期22卷 448-453页

作者： Jiguang Deng Lei Zhang Yunsheng xia hongxing Dai hong He Laboratory of Catalysis Chemistry and Nanoscience Department of Chemistry and Chemical Engineering College of Environmental and Energy EngineeringBeijing Unversity of Technology Beijing 100124 China.

A series of single-phase T-structured NdSrCu 1-x Co x O 4-δ with oxygen vacancies and T -structured Sm 1.8 Ce 0.2 Cu 1-x Co x O 4-δ （x： 0–0.4） with oxygen excess were prepared using ultrasound-assisted citric acid complexing method, and characterized by means of techniques such as thermogravimetric analysis and NO temperature-programmed desorption （NO-TPD）. The catalytic activities of these materials were evaluated for the decomposition of NO. It was found that the NdSrCu 1-x Co x O 4-δ catalysts were of oxygen vacancies whereas the Sm 1.8 Ce 0.2 Cu 1？x Co x O 4-δ ones possessed excessive oxygen （i.e., over-stoichiometric oxygen）; with a rise in Co doping level, the oxygen vacancy density of NdSrCu 1-x Co x O 4-δ decreased while the over-stoichiometric oxygen amount of Sm 1.8 Ce 0.2 Cu 1-x Co x O 4-δ increased. The NO-TPD results revealed that NO could be activated much easier over the oxygen-deficient perovskite-like oxides than over the oxygen-excessive perovskite-like oxides, with the NdSrCuO 3.702 catalyst showing the best efficiency in activating NO molecules. Under the conditions of 1.0% NO/helium, 2800 hr -1 , and 600–900°C, the catalytic activity of NO decomposition followed the order of NdSrCuO 3.702 〉 NdSrCu 0.8 Co 0.2 O 3.736 〉 NdSrCu 0.6 Co 0.4 O 3.789 〉 Sm 1.8 Ce 0.2 Cu 0.6 Co 0.4 O 4.187 〉 Sm 1.8 Ce 0.2 Cu 0.8 Co 0.2 O 4.104 〉 Sm 1.8 Ce 0.2 CuO 4.045 , in concord with the sequence of decreasing oxygen vacancy or oxygen excess density. Based on the results, we concluded that the higher oxygen vacancy density and the stronger Cu 3＋ /Cu 2＋ redox ability of NdSrCu 1-x Co x O 4-δ account for the easier activation of NO and consequently improve the catalytic activity of NO decomposition over the catalysts.

关键词： perovskite-like oxide catalysts NO decomposition oxygen nonstoichiometry Cu^ 3+ /Cu ^2+ Cu^ 2+ /Cu^ +

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On P≥3-factor Deleted Graphs

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 178-186页

作者： Si-zhong ZHOU Zhi-ren SUN hong-xia LIU School of Science Jiangsu University of Science and TechnologyZhenjiang 212100China School of Mathematical Sciences Nanjing Normal UniversityNanjing 210023China School of Mathematics and Information Sciences Yantai UniversityYantai 264005China

A spanning subgraph F of a graph G is called a path factor of G if each component of F is a path.A P≥k-factor means a path factor with each component having at least k vertices,where k≥2 is an ***,Benhamdine,Li and Wozniak[***,***,***,***,Partitioning vertices of 1-tough graph into paths,***.263(2001)255–261.]obtained a toughness condition for a graph to have a P≥*** introduce the concept of a P≥k-factor deleted graph,that is,if a graph G has a P≥k-factor excluding e for every e∈E(G),then we say that G is a P≥k-factor deleted *** this paper,we show four sufficient conditions for a graph to be a P≥3-factor deleted ***,it is shown that four results are best possible in some sense.

关键词： toughness isolated toughness connectivity P≥3-factor P≥3-factor deleted graph

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Statics,Dynamics and Linear Viscoelasticity from Dissipative Particle Dynamics Simulation of Entangled Linear Polymer Melts

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Chinese Journal of Polymer Science 2023年第9期41卷 1392-1409,I0007页

作者： Fan Wang Lu-Kun Feng Ye-Di Li hong-xia Guo Beijing National Laboratory for Molecular Sciences Joint Laboratory of Polymer Sciences and MaterialsState Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Dissipative particle dynamics(DPD)with bond uncrossability shows a great potential in studying entangled polymers,however relatively little is known of applicability range of entangled DPD model to be use as a model for ideal chains and properly describe the full dynamics of entangled ***,we perform a comprehensive study on structure,dynamics and linear viscoelasticity of a typical DPD entangled model system,semiflexible linear polymer *** polymers obey Flory's ideality hypothesis in chain dimensions,but their local structure exhibits nonideal behavior due to weak correlated hole *** monomer motion and viscoelasticity relaxation reproduce the full pictures as predicted by reptation *** stronger chain length dependent diffusion coefficient and relaxation time as well as dynamic moduli are in close agreement with predictions of modern tube model that accounts for additional relaxation mechanisms besides chain ***,an anomalous sub-diffusive center of mass motion is observed both before and after the intermediate reptation regime and the cross-correlation between chains is not negligible even these polymers obey stress-optical law,indicating limitations of the reptation *** semiflexible linear entangled DPD model can correctly describe statics and dynamics of entangled polymer melts.

关键词： Entangled polymer melts Dynamics Linear viscoelasticity Dissipative particle dynamics

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Value of clinical applications of differential pressure and relative pressure imaging in the left ventricle

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World Journal of Clinical Cases 2023年第17期11卷 3967-3975页

作者： An-Sheng Zheng hong-xia Yu Department of Ultrasound Medicine The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002Henan ProvinceChina

Regional pressure differences between sites within the left ventricular cavity have long been identified,and the potential clinical value of diastolic and systolic intraventricular pressure differences(IVPDs)is of increasing *** study concluded that the IVPD plays an important role in ventricular filling and emptying and is a reliable indicator of ventricular relaxation,elastic recoil,diastolic pumping,and effective left ventricular *** pressure imaging,as a novel and potentially clinically applicable measure of left IVPDs,enables early and more comprehensive identification of the temporal and spatial characteristics of *** the future,as research related to relative pressure imaging continues,this measurement method has the possibility to become more refined and serve as an additional clinical aid that can replace the gold standard cardiac catheterization technique for the diagnosis of diastolic dysfunction.

关键词： Cardiac imaging techniques Echocardiography Ventricular dysfunction Left ventricle Cardiovascular physiological phenomena Hemodynamics Ventricular pressure

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Studies of n-Octanol/water Partition Coefficients (lgK_(ow)) for Organophosphate Compounds by Density Functional Theory

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Chinese Journal of Structural Chemistry 2007年第3期26卷 367-373页

作者： LIU hong-xia WANG Zun-Yao ZHAI Zhi-Cai LIU hong-Yan WANG Lian-Sheng Department of Material and Chemical Engineering Guilin Institute of Technology Guangxi 541004 China School of Biological and Chemical Engineering Jiaxing University Zhejiang 314001 China State Key Laboratory of Pollution Control and Resources Reuse School of the Environment Nanjing University Nanjing 210093 China

Optimized calculation of 35 dialkyl phenyl phosphate compounds （OPs） was carded out at the B3LYP/6-31G^＊ level in Gaussian 98 program. Based on the theoretical linear solvation energy relationship （TLSER） model, the obtained parameters were taken as theoretical descriptors to establish the novel QSPR model for predicting n-octanol/water partition coefficients （lgKow） of OPs. The new model achieved in this work contains three variables, i.e., molecular volume （Vm）, dipole moment of the molecules （μ） and enthalpy （H^0）. For this model, R^2 = 0.9167 and SD = 0.31 at large t values. In addition, the variation inflation factors （VIF） of variables are all close to 1.0, suggesting high accuracy of the predicting model. And the results of cross-validation test （q^2 = 0.8993） and method validation also showed the model of this study exhibited optimum stability and better predictive power than that from semi-empirical method. The model achieved can be used to predict IgKow of congeneric compounds.

关键词： organophosphate compounds (OPs) n-octanol/water partition coefficients (Kow) quantitative structure-property relationship (QSPR) density functional theory (DFT)

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The electrochemical behavior of N-n-undecy1-N＇-（sodium-p- amino-benzenesulfonate） thiourea and its interaction with bovine serum albumin

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Chinese Chemical Letters 2008年第5期19卷 581-584页

作者： hong xia Luo Yang Du Zhi Xin Guo Department of Chemistry Renmin University of China Beijing 100872 China

In pH 5.5 phosphate buffer solution, N-n-undecyl-N＇-（sodium-p-amino-benzenesulfonate） thiourea （UPT） produced a pair of redox peaks on the bare glassy carbon electrode. At the multi-walled carbon nanotube （MWNT） modified electrode, the electrochemical behavior of UPT enhanced greatly. In the presence of bovine serum albumin （BSA）, the peak currents of UPT decreased linearly due to the formation of a super-molecular complex. This method was successfully applied to the determination of BSA in a bovine serum sample.

关键词： N-n-Undecyl-N'-(sodium-p-amino-benzenesulfonate) thiourea Carbon nanotube Electrocatalysis Bovine serum albumin

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