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Inguinal and subinguinal micro-varicocelectomy, the optimal surgical management of varicocele： a meta-analysis

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Asian Journal of Andrology 2015年第1期17卷 74-80,I0008页

作者： Jun Wang Shu-Jie xia zhi-Hong Liu le Tao Ji-Fu Ge Chen-Min Xu Jian-Xin Qiu Department of Urology Shanghai First People's Hospital Medical College of Shanghai Jiao Tong University Shanghai China.

Conventional meta-analyses have shown inconsistent results for the efficacy of various treatments of varicoceles. Therefore, we performed a multiple-treatment meta-analysis to assess the effectiveness and safety of 10 methods of varicocelectomy and embolization/sclerotherapy. We systematically reviewed 35 randomized controlled trials and observational studies, from 1966 to August 5, 2013, which compared any of the following treatments for varococeles： laparoscopic, retroperitoneal, open inguinal and subinguinal varicocelectomy, microsurgical subinguinal and inguinal varicocelectomy, percutaneous venous embolization, Tauber antegrade sclerotherapy, retrograde sclerotherapy and expectant therapy （no treatment）. Inguinal and subinguinal microsurgery, open inguinal, laparoscopic varicocelectomy showed a significant advantage over expectant therapy in terms of pregnancy rates （odds ratio （OR）： 3.48, 2.68, 2.92 and 2.90, respectively）. Compared with retroperitoneal open surgery, inguinal microsurgery showed an improvement of sperm density （mean difference （MD）： 10.60, 95% confidence interval （Cl）： 1.92-19.60） and sperm motility （MD： 9.09, 95% Cl. 4.88-13.30）. Subinguinal and inguinal microsurgery outperformed retroperitoneal open surgery in terms of recurrence （OR： 0.05, 0.06 respectively）. Tauber antegrade sclerotherapy and subinguinal microsurgery were associated with the lowest risk of hydrocele formation. The odds of overall complication, compared with retroperitoneal open varicocelectomy, were lowest for inguinal microsurgery （OR = 0.07, 95% Ch 0.02-0.19）, followed by subinguinal microsurgery （OR = 0.09, 95% CI. 0.02-0.19）. Inguinal and subinguinal micro-varicocelectomy had the highest pregnancy rates, significant increases in sperm parameters, with low odds of complication. These results warrant additional properly conducted randomized controlled clinical studies with larger sample sizes.

关键词： meta-analysis varicocele varicocelectomy

Colorful Cause Geared to Help Develop Tibet

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China's Tibet 1995年第6期6卷 4-9页

作者： zhi xia,YONG le

ＣｏｌｏｒｆｕｌＣａｕｓｅＧｅａｒｅｄｔｏＨｅｌｐＤｅｖｅｌｏｐＴｉｂｅｔＺＨＩＸＩＡ，ＹＯＮＧＬＥＩｎｔｈｅｇｏｌｄｅｎａｕｔｕｍｎｍｏｎｔｈｏｆＡｕｇｕｓｔ，ＬｉＲｕｉｈｕａｎ，ｃｈａｉｒｍａｎｏｆｔｈｅＣｈｉｎ... 详细信息

ＣｏｌｏｒｆｕｌＣａｕｓｅＧｅａｒｅｄｔｏＨｅｌｐＤｅｖｅｌｏｐＴｉｂｅｔＺＨＩＸＩＡ，ＹＯＮＧＬＥＩｎｔｈｅｇｏｌｄｅｎａｕｔｕｍｎｍｏｎｔｈｏｆＡｕｇｕｓｔ，ＬｉＲｕｉｈｕａｎ，ｃｈａｉｒｍａｎｏｆｔｈｅＣｈｉｎｅｓｅＰｅｏｐｌｅ＇ｓＰｏｌｉｔｉ...

关键词： Colorful Cause Geared to Help Develop Tibet

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI zhi-min WANG xia LIU xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(Plevels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(Pleaved-caspase-3,-4 and GRP78 protein expressions(Pled the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

Path signature-based XAI-enabled network time series classification

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Science China(Information Sciences) 2024年第7期67卷 91-106页

作者： le SUN Yueyuan WANG Yongjun REN Feng xia Department of Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science and Technology School of Computing Technologies Royal Melbourne Institute of Technology

Classifying network time series(NTS) is crucial for automating network administration and ensuring cyberspace security. It enables the detection of anomalies, the identification of network attacks,and the monitoring of performance issues, thereby providing valuable support for network protection and optimization. However, modern communication networks pose challenges for NTS classification *** include handling large-scale and complex NTS data, extracting features from intricate datasets, and addressing explainability requirements. These challenges are particularly pronounced for complex 5G networks. Notably, explainability has become crucial for the widespread deployment of network automation for 5G networks and beyond. To tackle these challenges, we propose a path-signature-based NTS classification model called recurrent signature(Recur Sig). This innovative model is designed to overcome the time-consuming feature selection problem by utilizing deep-learning(DL) techniques. Additionally, it provides a solution for addressing the black-box issue associated with DL models in network automation systems(NAS) by incorporating an explainable classification approach. Extensive experimentation on various public datasets demonstrates that Recur Sig outperforms existing models in accuracy and explainability. The results indicate its potential for application in cyberspace security and automated network management, offering an explainable solution for network protection and optimization.

关键词： network time series classification explainable artificial intelligence path signature automated network management recurrent neural network

High-Order Two-Scale Asymptotic Paradigm for the Elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： Wei-zhi Luo Mu He Liang xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation Multi-Echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion ***,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order *** such a context,a compact,fast,and accurate asymptotic paradigm is *** work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be ***,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional *** numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

A modified back analysis method for deep excavation with multi-objective optimization procedure

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1373-1387页

作者： Chenyang Zhao le Chen Pengpeng Ni Wenjun xia Bin Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Guangdong Research Center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai519000China Jiangsu Provincial Transportation Engineering Construction Bureau Nanjing210004China

Real-time prediction of excavation-induced displacement of retaining pile during the deep excavation process is crucial for construction *** paper proposes a modified back analysis method with multi-objective optimization procedure,which enables a real-time prediction of horizontal displacement of retaining pile during *** opposed to the traditional stage-by-stage back analysis,time series monitoring data till the current excavation stage are utilized to form a multi-objective ***,the multi-objective particle swarm optimization (MOPSO) algorithm is applied for parameter *** optimized model parameters are immediately adopted to predict the excavation-induced pile deformation in the continuous construction *** achieve efficient parameter optimization and real-time prediction of system behavior,the back propagation neural network (BPNN) is established to substitute the finite element model,which is further implemented together with MOPSO for automatic *** proposed approach is applied in the Taihu tunnel excavation project,where the effectiveness of the method is demonstrated via the comparisons with the site monitoring *** method is reliable with a prediction accuracy of more than 90%.Moreover,different optimization algorithms,including non-dominated sorting genetic algorithm (NSGA-II),Pareto Envelope-based Selection Algorithm II (PESA-II) and MOPSO,are compared,and their influences on the prediction accuracy at different excavation stages are *** results show that MOPSO has the best performance for high dimensional optimization task.

关键词： Multi-objective optimization Back analysis Surrogate model Multi-objective particle swarm optimization(MOPSO) Deep excavation

Currentless Multiple Switch Open-Circuit Faults Diagnosis for Modular Multilevel Converters with Nearest level Modulation in HVDC Systems

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1642-1653页

作者： zhi Geng Minxiao Han Changjiang xia Longze Kou School of Electrical and Electronic Engineering North China Electric Power University(NCEPU)Beijing 102206China State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconnection Research InstituteBeijing 102209China

Due to the large number of submodules(SMs),and modular multilevel converters(MMCs)in high-voltage applications,they are usually regulated by the nearest level modulation(NLM).Moreover,the large number of SMs causes a challenge for the fault diagnosis strategy(FDS).This paper proposes a currentless FDS for MMC with *** FDS,the voltage sensor is relocated to measure the output voltage of the *** acquire the capacitor voltage and avoid increasing extra sensors,a capacitor voltage calculation method is *** on the measurement of output voltages,the faults can be detected and the number of different-type switch open-circuit faults can be confirmed from the numerous SMs in an arm,which narrows the scope of fault ***,the faulty SMs and faulty switches in these SMs are further located without arm current according to the sorting of capacitor voltages in the voltage balancing *** FDS is independent of the arm current,which can reduce the communication cost in the hierarchical control system of ***,the proposed FDS not only simplifies the identification of switch open-circuit faults by confirming the scope of faults,but also detects and locates multiple different-type faults in an *** effectiveness of the proposed strategy is verified by the simulation results.

关键词： Fault diagnosis high voltage direct current(HVDC) modular multilevel converter(MMC) nearest level modulation(NLM) switch open-circuit fault

Focal mechanics and disaster characteristics of the 2024 M 7.6 Noto Peninsula Earthquake,Japan

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1378-1387页

作者： Guang-qi CHEN Yan-qiang WU Ming-yao xia zhi-yuan LI School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300131China Graduate School of Engineering Kyushu UniversityFukuoka 819-0395Japan The First Monitoring and Application Center China Earthquake AdministrationTianjin 300180China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

On January 1,2024,a devastating M 7.6 earthquake struck the Noto Peninsula,Ishikawa Prefecture,Japan,resulting in significant casualties and property *** information from the first six days after the earthquake,this article analyzes the seismic source characteristics,disaster situation,and emergency response of this *** results show:1)The earthquake rupture was of the thrust type,with aftershock distribution showing a north-east-oriented belt-like feature of 150 km.2)Global Navigation Satellite System(GNSS)and Interferometric synthetic aperture radar(InSAR),observations detected significant westward to north-westward co-seismic displacement near the epicenter,with the maximum horizontal displacement reaching 1.2 m and the vertical uplift displacement reaching 4 m.A two-segment fault inversion model fits the observational data well.3)Near the epicenter,large Peak Ground Velocity(PGV)and Peak Ground Acceleration(PGA)were observed,with the maxima reaching 145 cm/s and 2681 gal,respectively,and the intensity reached the highest level 7 on the Japanese(Japan Meteorological Agency,JMA)intensity standard,which is higher than level 10 of the United States Geological Survey(USGS)Modified Mercalli Intensity(MMI)standard.4)The observation of the very rare multiple strong pulse-like ground motion(PLGM)waveform poses a topic worthy of research in the field of earthquake engineering.5)As of January 7,the earthquake had left 128 deaths and 560 injuries in Ishikawa Prefecture,with 1305 buildings completely or partially destroyed,and had triggered a chain of disasters including tsunamis,fires,slope failures,and road ***,this paper summarizes the emergency rescue,information dissemination,and other disaster response and management measures taken in response to this *** work provides a reference case for carrying out effective responses,and offers lessons for handling similar events in the future.

关键词： Noto Peninsula Earthquake earthquake rupture mechanism earthquake disaster emergency response pulse-like ground motion

Effect of BaO and MgO on structure and properties of aluminate slag with various CaO/Al_(2)0_(3)ratios

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Journal of Iron and Steel Research International 2024年第1期31卷 204-214页

作者： Yu-qi Kong Ting Wu Wen-zhi xia Wen Yang Hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resource Recycling(Ministry of Education) Anhui University of TechnologyMa’anshan243002AnhuiChina

To provide theoretical guidance for performance stability control of low-reactive mold fluxes,the effects of BaO and MgO on the structure and properties of aluminate slag with various CaO/Al_(2)0_(3)(C/A)ratios were investigated using the Fourier transform infrared spectrometer,Raman spectroscope,hemispherical melting point instrument,rotational viscometer and X-ray *** results indicated that with BaO and MgO addition,the structure polymerization was first weakened and then enhanced at C/A of 1.1,and the transition contents corresponded to 8 wt.%BaO and 2 wt.%MgO,respectively,while the structure polymerization decreased continuously at C/A of *** the viscosity change was well consistent with the structure evolution,the polymerization degree played a more prominent role in the slag viscosity than superheat degree when the melting temperature difference was within 40℃.The break temperature decreased initially and then increased with augment of BaO and MgO at C/A of 1.1,while it manifested a decrease trend with BaO addition,and it decreased obviously but then turned to increase with MgO increment at C/A of *** crystallization phase and crystallization ratio kept stable with BaO increment,while the crystallization ratio rose greatly with MgO promoting LiAlO_(2)precipitation at C/A of *** crystal types of all experimental slags were mainly Ca_(12)Al_(14)O_(33)and CaF_(2)at C/A of 1.3,and the precipitation of crystalline phase BaAl2O4 demonstrated a rising trend,while that of Ca_(12)Al_(14)O_(33)gradually declined with BaO augment.

关键词： Aluminate slag Structure MgO BaO Viscosity Property