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Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

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Protein & Cell 2024年第2期15卷 121-134页

作者： Hui Sun tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Vaccines for Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China xiang An Biomedicine Laboratory Xiamen 361102China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSchool of MedicineSouthem University of Science and TechnologyShenzhen 518112China The Second Affliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or *** rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus ***,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron ***-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric *** antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant ***,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.

关键词： SARS-CoV-2 broad neutralizing antibody rearrangement synergistic neutralization

Perinatal outcomes of re-recurrent gestational diabetes mellitus and their prognostic factors:A retrospective cohort study in China

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Chinese Medical Journal 2024年第4期137卷 499-501页

作者： xia Xu Yanni Guo tingting Liao Huale Zhang Rumeng Jiang Shuyao Huang Jianying Yan Department of Obstetrics and Gynecology Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian 350001China

To the Editor:Gestational diabetes mellitus(GDM)is a pathologic condition in which glucose intolerance and insulin resistance develop to different degrees during *** with GDM have higher odds of adverse maternal and fetal *** with a history of GDM were at a significantly increased risk for recurrence of GDM in subsequent *** previous and some other studies found an increased incidence of adverse perinatal outcomes in pregnant with recurrent GDM.^([1])So far,women with a prior history of GDM are not recommended to refrain from subsequent pregnancy in light of the limited available *** about those women with a history of recurrent GDM?Should women with recurrent GDM be recommended to avoid further pregnancy?Currently,studies on perinatal outcomes of women with re-recurrent GDM and their prognostic factors are very ***,this retrospective cohort study was performed to explore perinatal outcomes of pregnant woman with re-recurrent GDM and their prognostic factors.

关键词： mellitus pregnancy diabetes

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浙东地区褡裢荷包的造型及制作工艺

丝绸 2017年第3期54卷 59-64页

作者：金晨怡夏婷婷卢杰温州大学美术与设计学院浙江温州325035 江南大学纺织服装学院江苏无锡214122

褡裢荷包在浙东地区使用频繁,具有一定的研究价值。以浙江台州刺绣博物馆中70余件传世褡裢荷包为研究对象,对其造型归类,可发现浙东地区褡裢荷包主要以直角形、圆角形、如意形造型为主,造型过程中善用曲线结构。为更清楚地了解浙东地区... 详细信息

褡裢荷包在浙东地区使用频繁,具有一定的研究价值。以浙江台州刺绣博物馆中70余件传世褡裢荷包为研究对象,对其造型归类,可发现浙东地区褡裢荷包主要以直角形、圆角形、如意形造型为主,造型过程中善用曲线结构。为更清楚地了解浙东地区褡裢荷包的造型结构,文章选取工艺较为复杂的如意形褡裢荷包做复原。此外,将浙东地区褡裢荷包造型与其他类荷包进行对比,了解到浙东地区荷包造型间的联系与区别。从而得出浙东地区褡裢荷包造型结构精巧、工艺精湛,并且丰富的造型凸显出浙东地区善于构思、独具匠心的地域心理特征。

关键词：褡裢造型工艺地域文化浙江东部

Research on the Development of Rural E-commerce in China

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Asian Agricultural Research 2022年第7期14卷 15-18页

作者： Zhiyue XIONG Minghua GU Wei ZHOU Yongxian LIU tingting xia Mengling NONG Xinsheng LI Yimiao LI Jie LIANG Lishan HE College of Agriculture Guangxi UniversityNanning 530004China Guangxi Key Laboratory of Sugarcane Biology Nanning 530004China Guangxi Key Laboratory for Agro-Environment and Agro-Products Safety Nanning 530004China National Demonstration Center for Experimental Plant Science Education Guangxi UniversityNanning 530004China Agricultural Resource and Environment Research Institute Guangxi Academy of Agricultural SciencesNanning 530007China

At present,rural e-commerce is characterized by obvious improvement in market prospect,development scale and development momentum,but there are also some problems,such as farmers’low acceptance of e-commerce,lack of promotion and training of rural e-commerce,and lack of rural e-commerce *** on these problems,the government needs to increase financial support for rural e-commerce,improve the distribution logistics system,and strengthen the training of rural e-commerce personnel to promote the sustainable development of rural e-commerce.

关键词： E-commerce Rural areas Internet

化学教科书中视觉表征的比较研究——以“化学键”内容为例

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化学教学 2021年第10期 25-32页

作者：马文夏婷婷孙影安徽师范大学化学与材料科学学院安徽芜湖241002 安徽省芜湖市中江中学安徽芜湖241005

借鉴Gkitzia等人开发的分析框架,运用内容分析法对中国大陆、中国台湾地区、美国、新加坡等地的主流化学教科书中化学键部分的视觉表征进行分析。从表征的类型(C1)、表面特征的注释(C2)、表征与文本的关联情况(C3)、是否存在合适标题(C4... 详细信息

借鉴Gkitzia等人开发的分析框架,运用内容分析法对中国大陆、中国台湾地区、美国、新加坡等地的主流化学教科书中化学键部分的视觉表征进行分析。从表征的类型(C1)、表面特征的注释(C2)、表征与文本的关联情况(C3)、是否存在合适标题(C4)以及多重表征内各从属表征间连接情况(C5)这五个维度对教科书进行编码统计,获得不同版本化学教科书中视觉表征的信息,以期为后续教科书视觉表征的设计和使用提供参考。

关键词：化学教科书视觉表征三重表征教材比较

大豆食心虫幼虫结茧次数的影响因素及其对低温环境适应性的影响

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植物保护学报 2019年第4期46卷 885-893页

作者：夏婷婷徐伟李旋崔娟史树森吉林农业大学植物保护学院长春130118

为明确大豆食心虫Leguminivora glycinivorella幼虫结茧次数及其相关因子以及结茧次数对其低温环境适应性的影响,通过人工剥茧扰动间隔持续观察法测定大豆食心虫越冬幼虫结茧次数,分析结茧次数与体重、茧重的关系,同时测定不同结茧次数... 详细信息

为明确大豆食心虫Leguminivora glycinivorella幼虫结茧次数及其相关因子以及结茧次数对其低温环境适应性的影响,通过人工剥茧扰动间隔持续观察法测定大豆食心虫越冬幼虫结茧次数,分析结茧次数与体重、茧重的关系,同时测定不同结茧次数虫体的过冷却点、结冰点及虫体海藻糖含量和虫茧蛋白氨基酸组成,并在自然环境条件下检测其越冬存活率。结果显示,大豆食心虫越冬幼虫有很强的结茧能力,其平均结茧次数为9.86次。幼虫体重影响其结茧次数,结茧次数与其体重呈显著负相关(y=14.8231-0.5456x,R^2=0.9223);性别对其结茧次数无显著影响。虫茧蛋白由16种氨基酸组成,各氨基酸组分含量与结茧次数均呈直线负相关。随着结茧次数增加,越冬幼虫过冷却点和冰点值均有所升高,结茧1次的过冷却点平均值为-18.19℃,显著低于结茧3次和5次的过冷却点;越冬幼虫体内海藻糖相对含量随结茧次数增加呈下降趋势;幼虫越冬存活率与结茧次数呈显著负相关,结茧1次、结茧2次和结茧3次的越冬存活率分别为66.05%、36.05%和13.60%,三者之间差异显著。表明大豆食心虫越冬幼虫随着结茧次数的增加其对低温环境适应性显著降低。

关键词：大豆食心虫越冬幼虫结茧次数环境适应性越冬存活率

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： xiaozhong Chen Wei Wang Qingfeng Zou xiaodong Zhu Qin Lin Yi Jiang Yan Sun Liangfang Shen Lin Wang Guorong Zou xiaoyan Lin Shaojun Lin Minying Li Ying Wang Ruilian Xu Rui Ao Rensheng Wang Haifeng Lin Shuang Huang tingting Xu Wenting Li Mengying xia Yu xia Zhongmin Wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

中国迈进创新型国家行列了么--基于六大权威评价指标体系的综合研判

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科技进步与对策 2022年第15期39卷 20-30页

作者：杜斌张可云夏婷婷兰州财经大学经济学院甘肃兰州730020 中国人民大学应用经济学院北京100872 兰州财经大学国际经济与贸易学院甘肃兰州730020

创新型国家建设是化解新时代中国社会主要矛盾的有力抓手,是关乎中国在国际竞争格局中地位的战略举措和迈向现代化科技强国的必然要求。2020年中国迈进创新型国家行列是《国家中长期科学和技术发展规划纲要(2006-2020年)》明确提出的奋... 详细信息

创新型国家建设是化解新时代中国社会主要矛盾的有力抓手,是关乎中国在国际竞争格局中地位的战略举措和迈向现代化科技强国的必然要求。2020年中国迈进创新型国家行列是《国家中长期科学和技术发展规划纲要(2006-2020年)》明确提出的奋斗目标,也是《国家创新驱动发展战略纲要》提出的“三步走”战略之首要一步。以国际公认的六大权威评价指标体系为蓝本,深入研判中国是否符合创新型国家标准,并结合国情及国际横向可比性,构建5大类16项指标体系,通过设定目标值,采用等权重相对衡量法测度中国创新型国家建设水平。研究表明:中国整体进入创新型国家行列,并迈向跨越创新型国家前列的崭新发展阶段,但不平衡性、不充分性、不协调性问题依然突出,中国创新型国家建设任重而道远。

关键词：创新型国家评价指标体系创新驱动

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阿根廷新左派对“第三世界”概念的阐释

外国问题研究 2022年第4期 95-103,126页

作者：夏婷婷上海大学外国语学院上海200444

“第三世界”的概念起源于冷战时期,随后在世界范围内得到广泛的传播和实践。拉丁美洲国家理解和传播这一概念的路径具有自己的特色,阿根廷新左派是其中一个较为典型的案例。20世纪中叶,阿根廷逐渐形成神学左派、庇隆左派、马列左派等... 详细信息

“第三世界”的概念起源于冷战时期,随后在世界范围内得到广泛的传播和实践。拉丁美洲国家理解和传播这一概念的路径具有自己的特色,阿根廷新左派是其中一个较为典型的案例。20世纪中叶,阿根廷逐渐形成神学左派、庇隆左派、马列左派等新左派,他们基于自身的知识结构和政治立场,分别从贫困、文化殖民和依附理论等角度阐释和理解“第三世界”的概念,这体现了“第三世界”概念在阿根廷左翼思想中的变形,这一“变形”的背后折射出阿根廷独特的政治发展进程。

关键词：阿根廷新左派第三世界概念地缘政治