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Chinese Chemical Letters 2011年第2期22卷 167-170页

作者： xia ping ma zhi ming li quan rui wang Department of Chemistry Fudan University Shanghai 200433 China Received 14 May 2010

The thermal Claisen rearrangement of O-allyl substituted isotetronic acids 1 was successfully carried out within a glass microreactor operated with temperature at 150℃and a flow rate of 1 mL/*** strategy provides an efficient alternative way toβ-allyl substituted isotetronic acid derivatives 2 in high yields with much accelerated reaction speed.

关键词： Microreactor Claisen rearrangement O-Allyl substituted isotetronic acids β-Allyl substituted isotetronic acids

An effective synthesis of β-aryl substituted isotetronic acids via Suzuki coupling

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Chinese Chemical Letters 2008年第11期19卷 1309-1311页

作者： Huan Sheng Chen xia ping ma zhi ming li quan rui wang Feng Gang Tao Department of Chemistry Fudan University Shanghai 200433 China

Isotetronic acids are of great agricultural and pharmacological relevance and occur in a number of natural products. A convenient synthetic pathway to β-aryl substituted isotetronic acid derivatives was developed via Suzuki cross-coupling of the corresponding β-bromo substituted isotetronic acid derivatives with arylboronic acids under palladium acetate catalysis. Good to excellent yields have been achieved

关键词： lsotetronic acids Palladium Suzuki coupling Arylboronic acids

Temporal trends and rural-urban disparities in cerebrovascular risk factors,in-hospital management and outcomes in ischaemic strokes in China from 2005 to 2015:a nationwide serial cross-sectional survey

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Stroke & Vascular Neurology 2023年第1期8卷 34-50页

作者： Chun-Juan wang Hong-Qiu Gu Xin-Miao Zhang Yong Jiang Hao li Janet Prvu Bettger xia Meng Ke-Hui Dong Run-Qi wangqin Xin Yang Meng wang Chelsea liu li-ping liu Bei-Sha Tang Guo-Zhong li Yu-ming Xu zhi-Yi He Yi Yang Winnie Yip Gregg C Fonarow Lee H Schwamm Ying xian Xing-quan Zhao Yi-Long wang Yongjun wang Zixiao li China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeiingChina Center of Stroke Beijing Institute for Brain DisordersBeijngChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Duke Clinical Research Institute Duke UniversityDurhamNorth CarolinaUSA Department of Neurology Duke Univeristy Medical CenterDurhamNorth CarolinaUSA Department of Epidemiology Harvard T H Chan School of Public HealthBostonMassachusettsUSA Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Neurology The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Key Laboratory of Cerebrovascular Disease Prevention and Treatment National Health Commission(Province and Ministry Co-constructed)ZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Neurology The First Hospital of Jilin UniversityChangchunJilinChina Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMAUSA Ahmanson-UCLA Cardiomyopathy Center Ronald Reagan-UCLA Medical CenterLos AngelesCAUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Neurology The University of Texas Southwestern Medical CenterDallasTexasUSA Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Inst

Background Stroke is the leading cause of mortality in China,with limited evidence of in-hospital burden obtained from nationwide *** aimed to monitor and track the temporal trends and rural-urban disparities in cerebrovascular risk factors,management and outcomes from 2005 to *** We used a two-stage random sampling survey to create a nationally representative sample of patients admitted for ischaemic stroke in 2005,2010 and *** sampled participating hospitals with an economic-geographical region-stratified random-sampling approach first and then obtained patients with a systematic sampling *** weighed our survey data to estimate the national-level results and assess changes from 2005 to *** We analysed 28277 ischaemic stroke admissions from 189 participating *** 2005 to 2015,the estimated national hospital admission rate for ischaemic stroke per 100000 people increased(from 75.9 to 402.7,Ptrendlipidaemia and current smoking,*** composite score of diagnostic tests for stroke aetiology assessment(from 0.22 to 0.36,Ptrendma)(from 15.2%(95%CI 13.7%to 16.7%)to 8.6%(8.1%to 9.0%);adjusted Ptrend=0.046),and decreases in in-hospital mortality(0.7%in 2015 vs 1.8%in 2005;adjusted OR(aOR)0.52;95%CI 0.32 to 0.85)and the composite outcome of in-hospital mortality or DAma(8.4%in 2015 vs 13.9%in 2005;aOR 0.65;95%CI 0.47 to 0.89)were *** between rural and urban hospitals narrowed;however,disparities persisted in in-hospital management(brain MRI:rural-urban difference from−14.4%to−11.2%;cerebrovascular assessment:from−20.3%to−16.7%;clopidogrel:from−2.1%to−10.3%;anticoagulant for atrial fibrillation:from−10.9%to−8.2%)and in-hospital outcomes(DAma:from 2.7%to 5.0%;composite outcome

关键词： admitted nationwide survey

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-Dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng li Feng liu Yu-Guo Zhao Jin-ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing wang Ke-Ning Wu Feng-Rong Zhang ming-Kui Zhang Zhou Shi Wan-Zhu ma Gang Xin zhi-ping Qi Qing-rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen Yun-Zhong Dong Chun-Lan Han ling li li-ming liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng wang Tian-Wei wang xiang-Hua Wei Hong-Qi Wu xia Zhao Qing Zhou Gan-lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su zhi-Hai Peng Ren Lang Tao Jiang Qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-Sheng ma Qi-Gen li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan wang Zi-Qiang li Mu-Jian Teng Jun-Jie li Wen-Tao Jiang Jian-Hua li quan-Bao Zhang Ning-Qi Zhu Zheng-Xin wang Kang He Qiang xia Shao-Hua Song zhi-Ren Fu Wei Qiu Guo-Yue Lv rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao xiang-Qun Cui Guo-ping li Yao-quan Chu Jian-Rong Shi Gang wang Jian-Nan Zhang Zhong-rui Bai xiao-Yan Chen Feng-Fei wang Yan-Xin Guo Jian-Jun Chen Bing Du xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han Song Yue Wu Yan-xia Zhang Xin-lin Zhou Fang Zuo Peng Du lin He Wen Hou Yi-Qiao Dong Jian li Guang-Wei li Shuang li Jing Song Yuan Tian Meng-Xin wang Yong-Hui Hou zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua li Qi li Yin-Dun mao Zheng-Hong Tang Qing-Sheng Tao liang-ping Tu Da-Qing wang Dan wang Jian-ping wang Lei wang Shou-Guan wang Shu-Qing wang Ya-Nan wang You wang Yue-Fei wang ming-zhi Wei xiang-xiang Xue xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang Jing Zhang li-ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi xiang-Qun Cui Yao-quan Chu Guo-ping li Zhong-rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu zhi-Ying Huo Lei Jia Fang-Hua Jiang xiang Jiang zhi-Bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu zhi-Gang liu Wen-zhi Lu Yu Luo Yin-Dun mao Heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-ping wang Jun-xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng Wei ming-zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-xia Zhang Zheng-Chao Zhang ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder:a randomized controlled trial

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Chinese Medical Journal 2020年第1期133卷 61-67页

作者： Hong-Xing wang Kun wang Wen-rui Zhang Wen-Feng Zhao xiao-Tong Yang li wang mao Peng zhi-Chao Sun Qing Xue Yu Jia Ning li Kai Dong Qian Zhang Shu-Qin Zhan Bao-quan Min Chun-Qiu Fan Ai-Hong Zhou Hai-Qing Song Lu Yin Tian-Mei Si Jing Huang Jie Lu Hai-xia Leng Wei-Jun Ding Yuan liu Tian-Yi Yan Yu-ping wang Departm ent of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Neuromodulation Beijing 100053China Center of Epilepsy Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100053China Department of Neurology Beijing Puren HospitalBeijing 100062China Medical Research&Biometrics Centre National Centre for Cardiovascular DiseasesBeijing 102300China Peking University Sixth Hospital Beijing 100083China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China School of life Science Beijing Institute of TechnologyBeijing 100081China

Background:Transcranial alternating current stimulation(tACS)offers a new approach for adult patients with major depressive disorder(MDD).The study is to evaluate the efficacy and safety of tACS treating ***:This is an 8-week,double-blind,randomized,placebo-controlled ***-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min,77.5-Hz,15-ma sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks(week 4),following a 4-week observation period(week 8).The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale(HDRS-17)score≤7 at week *** outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17,the proportion of participants having improvement in the clinical global impression-improvement,the change in HDRS-17 score(range,0-52,with higher scores indicating more depression)over the study,and variations of brain imaging and neurocognition from baseline to week *** will be assessed by vital signs at weeks 4 and 8,and adverse events will be collected during the entire ***:The tACS applied in this trial may have treatment effects on MDD with minimal side *** registration:Chinese Clinical Trial Registry,ChiCTR1800016479;http://***/***?proj=22048.

关键词： major depressive disorder Transcranial alternating current stimulation Treatment Trial

云南北中亚热带植烟区土壤养分的空间分布特征与肥力质量评价

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西南农业学报 2024年第9期37卷 2077-2085页

作者：钱颖颖马翔夏建军王萝萍刘馨芮彤张志明闫辉李枝武倪明王炽云南中烟工业有限责任公司原料中心昆明650201 云南省农业科学院农业环境资源研究所昆明650205 马龙红壤坡耕地保育与水土流失云南省野外科学观测研究站昆明650205

【目的】云南北中亚热带气候区烤烟与其它作物种植区域交错重叠。明确该气候区植烟土壤的肥力空间变异特征,为该区作物养分管理和土壤肥力调控提供技术支持。【方法】以2019年云南北中亚热带2548个植烟土壤样品为研究对象,采用模糊数学... 详细信息

【目的】云南北中亚热带气候区烤烟与其它作物种植区域交错重叠。明确该气候区植烟土壤的肥力空间变异特征,为该区作物养分管理和土壤肥力调控提供技术支持。【方法】以2019年云南北中亚热带2548个植烟土壤样品为研究对象,采用模糊数学模型隶属函数法对土壤肥力质量进行综合评价,运用主成分分析法确定各指标的权重和造成肥力差异的主控因子,并通过GIS空间插值确定土壤肥力质量指数的空间分布特征。【结果】云南北中亚热带植烟区土壤肥力质量指数平均值为0.65,处于较高肥力水平。土壤SOM、TN、AP和AK的变异系数分别为46.84%、48.69%、75.64%和52.34%,均属于中等变异强度,且含量较为丰富。土壤AP是影响土壤肥力差异的主要限制因子。云南北中亚热带植烟区土壤肥力质量指数呈中部高,东部或西部部分区域低的分布格局,局部地区有零星分布。【结论】云南北中亚热带植烟区土壤较适宜烟草生长。平衡施肥时应注意控制氮肥,增施有机肥和磷钾肥,有效平衡并协调土壤养分,提高植烟区土壤肥力和烟叶品质。

关键词：北中亚热带植烟区土壤土壤养分土壤肥力质量评价

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奈达铂联合替加氟治疗晚期食管癌

中华肿瘤杂志 2008年第12期30卷 937-939页

作者：樊青霞王瑞路平赵永福路太英韩建伟王俊生罗素霞路守平王贵吉耿丽张明智马智勇宋敏吴欣爱陈小兵焦智敏王瑞林郑州大学第一附属医院肿瘤科 450052 河南省新乡医学院第一附属医院肿瘤科河南省林州市人民医院肿瘤科河南省安阳市肿瘤医院肿瘤科河南省肿瘤医院内科河南省邓州市人民医院肿瘤科河南省滑县人民医院肿瘤科

目的评价奈达铂（NDP）联合替加氟（FT-207）治疗晚期食管癌的疗效和毒副反应。方法65例晚期食管癌患者中，初次化疗患者27例，术后接受辅助化疗38例。NDP20mg／m^2，静脉滴注2h，第1—5天；FT-207500mg／m^2，静脉滴注8h，第1～5天；21... 详细信息

目的评价奈达铂（NDP）联合替加氟（FT-207）治疗晚期食管癌的疗效和毒副反应。方法65例晚期食管癌患者中，初次化疗患者27例，术后接受辅助化疗38例。NDP20mg／m^2，静脉滴注2h，第1—5天；FT-207500mg／m^2，静脉滴注8h，第1～5天；21d为1个周期。结果65例患者共完成193个化疗周期，其中可评价疗效的患者63例。27例初次化疗的患者中，CR6例，PR16例，有效率为81．5％；36例复治的患者中，CR6例，PR10例，有效率为44．4％。所有患者的中位疾病进展时间（TTP）为5．6个月，中位生存时间为9．3个月，1年生存率为24．9％。临床毒副反应为恶心、呕吐，患者均能耐受。63例可评价毒副反应的患者中，有2例（3．2％）出现Ⅲ～Ⅳ度中性粒细胞降低。结论NDP联合FT-207对晚期食管癌疗效肯定，毒副反应轻，可作为治疗晚期食管癌的主要治疗方案。

关键词：食管肿瘤奈达铂替加氟化疗