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基于CiteSpace的我国“互联网+护理服务”研究热点与趋势分析

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全科护理 2024年第4期22卷 619-624页

作者：彭静谭江红夏咪刘志宏李金秀吉首大学医学院 416000 中南大学湘雅医学院附属株洲医院 412007

目的:深度剖析我国“互联网+护理服务”领域的研究趋势与前沿热点,为国内该领域的进一步发展提供参考。方法:通过CiteSpace 5.7R5软件对中国知网(CNKI)数据库中2013年1月1日—2023年8月30日的“互联网+护理服务”相关文献进行发文量、... 详细信息

目的:深度剖析我国“互联网+护理服务”领域的研究趋势与前沿热点,为国内该领域的进一步发展提供参考。方法:通过CiteSpace 5.7R5软件对中国知网(CNKI)数据库中2013年1月1日—2023年8月30日的“互联网+护理服务”相关文献进行发文量、作者、研究机构和关键词可视化分析。结果:共纳入有效文献2 355篇,高频关键词包括护士、生活质量、智慧养老、健康教育等。结论:近10年我国“互联网+护理服务”的研究数量总体处于上升趋势,但仍存在合作欠缺、管理制度不完善、试点经验辐射范围有限等问题,未来可进一步加强合作,完善相关法律制度和可复制模式的创新应用,为“互联网+护理服务”的进一步发展提供参考。

关键词：互联网+护理服务 CiteSpace软件可视化分析

Synthesis of indole-allene compounds

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Synthesis of indole-allene compounds

罗沙司他对维持性腹膜透析患者贫血指标及心功能的影响

河南省化学会2016年学术年会

作者： xia mi Huai-xia Yang College of Pharmacy Henan University of Chinese Medicine

Indoles derivatives have received much attention as building blocks for the synthesis of many natural products and other biological active compounds. Allene is a class of unsaturated compound with cumulated double bonds. Recently, allenes have been widely used in organic synthesis as important precursors including the S N2 substitution, migration process, 1,4-addition, transition metal-catalyzed reaction, ring opening reaction and photocyclization. In view of these, we envisaged that indole-allene compounds might be utilized to allow cyclization reaction to provide indole-fused polycycles. Herein, we will describe the synthesis of indole-allenes to further explore the properties of this compound.

关键词： indole allene indole-allene compound synthesis

来源： cnki会议评论

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世界临床药物 2024年第2期45卷 147-152页

作者：朱爱民徐晓宏陈秋香米侠张策张驰南京鼓楼医院集团宿迁医院/徐州医科大学附属宿迁医院肾内科江苏宿迁223800

目的探讨罗沙司他对维持性腹膜透析(maintenance peritoneal dialysis,MPD)患者贫血指标及心功能的影响。方法选取2019年1月至2022年12月于我院腹膜透析中心规律随访至少3个月的接受MPD的肾性贫血患者90例,分为对照组及观察组,每组45例... 详细信息

目的探讨罗沙司他对维持性腹膜透析(maintenance peritoneal dialysis,MPD)患者贫血指标及心功能的影响。方法选取2019年1月至2022年12月于我院腹膜透析中心规律随访至少3个月的接受MPD的肾性贫血患者90例,分为对照组及观察组,每组45例。对照组皮下注射促红细胞生成素,观察组口服罗沙司他胶囊,均连续治疗16周。收集并比较两组治疗前后贫血指标[红细胞(red blood cell,RBC)、血红蛋白(hemoglobin,Hb)、血细胞比容(hematocrit,Hct)]、铁代谢指标[转铁蛋白(transferrin,TRF)、总铁结合力(total iron binding capacity,TIBC)、血清铁、血清铁蛋白(serum ferritin,SF)、铁调素(Hepcidin,Hepc)]及心功能指标[脑钠肽(brain natriuretic peptide,BNP)、左心室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end systolic diameter,LVESD)]。结果治疗后,两组RBC、Hb及Hct较治疗前明显改善(P0.05)。结论罗沙司他可明显改善MPD患者贫血状态,且对心功能有一定改善作用。

关键词：罗沙司他维持性腹膜透析贫血心功能

NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer

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Oncology Research 2024年第2期32卷 283-296页

作者： xiaNGDONG SUN HUIJUAN WEN FAZHAN LI IHTISHAM BUKHARI FEIFEI REN xia XUE PENGYUAN ZHENG YANG mi Henan Key Laboratory for Helicobacter Pylori&microbiota and GI Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and senescence.However,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly understood.We constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor prognosis.Some immune checkpoint genes were upregulated in the high-risk group.In addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk group.Notably,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk scores.Furthermore,the treatment of NMN showed increased proliferation of AGS and MKN45 cells.In addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN treatment.We conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients.

关键词： NAD+ LncRNAs Cancer Cell infiltration Prognosis Tumor microenvironment

An Efficient Palladium（Ⅱ） Catalyst for Oxidative Heck-type Reaction under Base and Ligand-free Conditions

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An Efficient Palladium（Ⅱ） Catalyst for Oxidative Heck-typ...

第十七届全国金属有机化学学术讨论会

作者： xia mi Mengmeng Huang Yangjie Wu College of Chemistry and Molecular Engineering Henan Key Laboratory of Chemical Biology and Organic ChemistryKey Laboratory of Applied Chemistry of Henan UniversitiesZhengzhou University

＜正＞Since the discovery of the mizoroki–Heck reaction in early 1970s[1],it has become a powerful tool for synthesis of the substituted alkenes and has received numerous modifications.Owing to the comparative stability of arylboronic acids,relatively nontoxic and easily accessible,the oxidative Heck reactions between arylboronic acids and various alkenes have been one of the most popular studies in this field for stereoselective alkene

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湘西地区老年人多维健康现状及影响因素分析

职业与健康 2024年第3期40卷 348-351,357页

作者：夏咪谭江红李金秀李星星孙靖涵陈正英吉首大学医学院湖南吉首416000 中南大学湘雅医学院附属株洲医院护理部湖南株洲412000

目的了解湘西地区老年人多维健康现状及影响因素,为政府制定相关政策提供依据。方法2022年1—3月采取多阶段分层抽样法,在湘西地区抽取符合纳排标准的540名老年人,采用中国老年健康功能多维评定量表评价其多维健康状况。结果老年人多维... 详细信息

目的了解湘西地区老年人多维健康现状及影响因素,为政府制定相关政策提供依据。方法2022年1—3月采取多阶段分层抽样法,在湘西地区抽取符合纳排标准的540名老年人,采用中国老年健康功能多维评定量表评价其多维健康状况。结果老年人多维健康总均分为(72.98±12.22)分,6个维度得分由高到低分别为日常生活能力[(23.47±3.16)分]、社会关系资源[(18.50±3.37)分]、精神健康[(18.23±3.16)分]、身体健康[(18.22±3.40)分]、经济资源[(17.97±3.49)分]与认知能力[(13.43±2.09)分]。多元逐步回归分析结果提示,有无慢性病、文化程度、目前居住地及婚姻状况是老年人多维健康的主要影响因素(均P<0.05)。结论湘西地区老年人多维健康水平有待提高,患有慢性病、文化程度不高、目前居住地为城乡接合部、未婚为老年人多维健康的危险因素。建议加强对女性、离异、文化程度较低、住在城乡接合部、靠政府或他人救助、有慢性病、无子女老年人的家庭及社会保障支持。

关键词：湘西地区老年人多维健康

JA-mediated MYC2/LOX/AOS feedback loop regulates osmotic stress response in tea plant

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Horticultural Plant Journal 2024年第3期10卷 931-946页

作者： Junyan Zhu Hongrong Chen Lu Liu xiaobo xia xiaomei Yan xiaozeng mi Shengrui Liu Chaoling Wei State Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Tea Processing of ministry of Agriculture/Anhui Provincial Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefeiAnhui 230036China

Osmotic stress caused by low-temperature,drought and salinity was a prevalent abiotic stress in plant that severely inhibited plant development and agricultural yield,particularly in tea plant.Jasmonic acid(JA)is an important phytohormone involving in plant stress.However,underlying molecular mechanisms of JA modulated osmotic stress response remains unclear.In this study,high concentration of mannitol induced JA accumulation and increase of peroxidase activity in tea plant.Integrated transcriptome mined a JA signaling master,MYC2 transcription factor is shown as a hub regulator that induced by mannitol,expression of which positively correlated with JA biosynthetic genes(LOX and AOS)and peroxidase genes(PER).CsMYC2 was determined as a nuclei-localized transcription activator,furthermore,ProteinDNA interaction analysis indicated that CsMYC2 was positive regulator that activated the transcription of CsLOX7,CsAOS2,CsPER1 and CsPER3via bound with their promoters,respectively.Suppression of CsMYC2 expression resulted in a reduced JA content and peroxidase activity and osmotic stress tolerance of tea plant.Overexpression of CsMYC2 in Arabidopsis improved JA content,peroxidase activity and plants tolerance against mannitol stress.Together,we proposed a positive feedback loop mediated by CsMYC2,CsLOX7 and CsAOS2 which constituted to increase the tolerance of osmotic stress through fine-tuning the accumulation of JA levels and increase of POD activity in tea plant.

关键词： Camellia sinensis Jasmonic acid(JA) MYC2 transcription factor Lipoxygenase(LOX) Osmotic stress Peroxidase(POD) Reactive oxygen species(ROS)

Preparation and electrocatalytic property of Au-Pt/SnO_2/GC composite electrode

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Rare Metals 2009年第4期28卷 350-354页

作者： YU Zhihui XIE Jia BAI Jie TIAN mi xia Dingguo College of Environmental and Energy Engineering Beijing University of Technology Beijing 100124 China

Au-Pt/SnO2/GC composite electrode was prepared by self-assembling Au-Pt nanoparticles on SnO2 film, which was deposited on actived glassy carbon （GC）. Atomic force microscopy （AFM） and scanning electron microscopy （SEM） images revealed that dense and uniform Au-Pt particles with 25-nm diameter were dispersed on SnO2 film. X-ray photoelectron spectroscopy （XPS） results proved that there was an interaction between Au-Pt nanoparticles and SnO2 support. Electrochemical experiments showed that Au-Pt/SnOz/GC composite electrode had a good electrocatalytic activity to the oxidation of methanol

关键词： . electrochemistry composite electrode self-assembling Au-Pt SnO2 methanol oxidation

Simultaneous Optimality of LSE and ANOVA Estimate in General mixed Models

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Acta Mathematica Sinica,English Series 2008年第10期24卷 1637-1650页

作者： mi xia WU Song Gui WANG Kai Fun YU College of Applied Sciences Beijing University of Technology Beijing 100022 P. R. China Division of Epidemiology Statistics and Prevention Research National Institute of Child Health and Human DevelopmentNIHJDHHS 6100 Executive Boulevard RockviUe MD 20852 USA Division of Epidemiology Statistics and Prevention Research National Institute of Child Health and Human DevelopmentNIH/DHHS 6100 Executive Boulevard Rockville MD 20852 USA

Problems of the simultaneous optimal estimates and the optimal tests in general mixed models are considered. A necessary and sufficient condition is presented for the least squares estimate of the fixed effects and the analysis of variance （Hendreson III＇s） estimate of variance components being uniformly minimum variance unbiased estimates simultaneously. This result can be applied to the problems of finding uniformly optimal unbiased tests and uniformly most accurate unbiased confidential interval on parameters of interest, and for finding equivalences of several common estimates of variance components.

关键词： Linear mixed model Least squares estimate Analysis of variance estimate minimum variance unbiased estimate Uniformly most powerful unbiased test