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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia liu xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Analysis of SE~τ IR~ω S Epidemic Disease Models with Vertical Transmission in Complex Networks

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 63-74页

作者： xia liu De-ju XU Department of Mathematics Capital Normal UniversityBeijing 100048China

When the role of network topology is taken into consideration, one of the objectives is to understand the possible implications of topological structure on epidemic models. As most real networks can be viewed as complex networks, we propose a new delayed SETIRWS epidemic disease model with vertical transmission in complex networks. By using a delayed ODE system, in a small-world （SW） network we prove that, under the condition R0 ≤ 1, the disease-free equilibrium （DFE） is globally stable. When R0 〉 1, the endemic equilibrium is unique and the disease is uniformly persistent. We further obtain the condition of local stability of endemic equilibrium for R0 〉 1. In a scale-free （SF） network we obtain the condition R1 〉 1 under which the system will be of non-zero stationary prevalence.

关键词： SETIRWS SW network SF network DFE

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Risk assessment of water security in Haihe River Basin during drought periods based on D-S evidence theory

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Water Science and Engineering 2014年第2期7卷 119-132页

作者： Qian-jin DONG xia liu State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Hubei Provincial Collaborative Innovation Center for Water Resources Security Wuhan University School of Geography and Planning Sun Yat-sen University

The weights of the drought risk index （DRI）, which linearly combines the reliability, resiliency, and vulnerability, are difficult to obtain due to complexities in water security during drought periods. Therefore, drought entropy was used to determine the weights of the three critical indices. Conventional simulation results regarding the risk load of water security during drought periods were often regarded as precise. However, neither the simulation process nor the DRI gives any consideration to uncertainties in drought events. Therefore, the Dempster-Shafer （D-S） evidence theory and the evidential reasoning algorithm were introduced, and the DRI values were calculated with consideration of uncertainties of the three indices. The drought entropy and evidential reasoning algorithm were used in a case study of the Haihe River Basin to assess water security risks during drought periods. The results of the new DRI values in two scenarios were compared and analyzed. It is shown that the values of the DRI in the D-S evidence algorithm increase slightly from the original results of Zhang et al. （2005）, and the results of risk assessment of water security during drought periods are reasonable according to the situation in the study area. This study can serve as a reference for further practical application and planning in the Haihe River Basin, and other relevant or similar studies.

关键词： risk assessment " water security " drought periods " entropy " D-S evidence theory "evidential reasoning algorithm " Haihe River Basin

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Construction of Solutions and L^1-error Estimates of Viscous Methods for Scalar Conservation Laws with Boundary

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Acta Mathematica Sinica,English Series 2007年第3期23卷 393-410页

作者： Hong xia liu Tao PAN Department of Mathematics Jinan University Guangzhou 510632 P. R. China

This paper is concerned with an initial boundary value problem for strictly convex conservation laws whose weak entropy solution is in the piecewise smooth solution class consisting of finitely many discontinuities. By the structure of the weak entropy solution of the corresponding initial value problem and the boundary entropy condition developed by Bardos-Leroux Nedelec, we give a construction method to the weak entropy solution of the initial boundary value problem. Compared with the initial value problem, the weak entropy solution of the initial boundary value problem includes the following new interaction type： an expansion wave collides with the boundary and the boundary reflects a new shock wave which is tangent to the boundary. According to the structure and some global estimates of the weak entropy solution, we derive the global L^1-error estimate for viscous methods to this initial boundary value problem by using the matching travelling wave solutions method. If the inviscid solution includes the interaction that an expansion wave collides with the boundary and the boundary reflects a new shock wave which is tangent to the boundary, or the inviscid solution includes some shock wave which is tangent to the boundary, then the error of the viscosity solution to the inviscid solution is bounded by O（ε^1/2） in L^1-norm; otherwise, as in the initial value problem, the L^1-error bound is O（ε｜ In ε｜）.

关键词： scalar conservation laws initial boundary value problem global weak entropy solution,error estimate of viscous methods

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Stability and Instability of Schwarzschild-AdS for the Nonlinear Einstein-Klein-Gordon System

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Acta Mathematicae Applicatae Sinica 2022年第4期38卷 778-812页

作者： Feng-xia liu Bo-Ling GUO Institute of Artificial Intelligence Beihang UniversityBeijing 100083China Institute of Applied Physics and Computational Mathematics Beijing 100088China

In this paper,we study the global behavior of solutions to the spherically symmetric(it means that the problem is 2+2 framework)coupled Nonlinear-Einstein-Klein-Gordon(NLEKG)system in the presence of a negative cosmological *** prove the well posedness of the NLEKG system in the Schwarzschild-AdS spacetimes and that the Schwarzschild-AdS spacetimes(the trivial black hole solutions of the EKG system for whichφ=0 identically)are asymptotically *** perturbations of Schwarzschild-AdS initial data again lead to regular black holes,with the metric on the black hole exterior approaching a SchwarzschildAdS *** argument on the black hole exterior,with the redshift effect and weighted Hardy inequalities playing the fundamental role in the *** integrated decay and pointwise decay estimates are obtained.

关键词： nonlinear-Einstein-Klein-Gordon equation schwarzschild-AdS spacetime well-posedness bootstrap

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Identifying the sensitive areas in targeted observation for predicting the Kuroshio large meander path in a regional ocean model

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Acta Oceanologica Sinica 2022年第2期41卷 3-14页

作者： xia liu Qiang Wang Mu Mu School of Mathematics Zhengzhou University of AeronauticsZhengzhou 450046China Key Laboratory of Marine Hazards Forecasting of Ministry of Natural Resources Hohai UniversityNanjing 210098China College of Oceanography Hohai UniversityNanjing 210098China Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China

With the Regional Ocean Modeling System(ROMS),this paper investigates the sensitive areas in targeted observation for predicting the Kuroshio large meander(LM)path using the conditional nonlinear optimal perturbation *** identify the sensitive areas,the optimal initial errors(OIEs)featuring the largest nonlinear evolution in the LM prediction are first calculated;the resulting OIEs are localized mainly in the upper 2500 m over the LM upstream region,and their spatial structure has certain similarities with that of the optimal triggering *** on this spatial structure,the sensitive areas are successfully identified,located southeast of Kyushu in the region(29°–32°N,131°–134°E).A series of sensitivity experiments indicate that both the positions and the spatial structure of initial errors have important effects on the LM prediction,verifying the validity of the sensitive ***,the effect of targeted observation in the sensitive areas is evaluated through observing system simulation *** targeted observation is implemented in the identified sensitive areas,the prediction errors are effectively reduced,and the prediction skill of the LM event is improved *** provides scientific guidance for ocean observations related to enhancing the prediction skill of the LM event.

关键词： Kuroshio large meander targeted observation sensitive areas ROMS

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Discussions on Orthogonal Factorizations in Digraphs

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 417-425页

作者： Si-zhong ZHOU Hong-xia liu School of Science Jiangsu University of Science and TechnologyZhenjiang 212100China School of Mathematics and Information Sciences Yantai UniversityYantai 264005China

Let m,t,r and k_(i)(1≤i≤m)be positive integers with k_(i)≥(t+3)r/2,and G be a digraph with vertex set V(G)and arc set E(G).Let H_(1),H_(2),…,H_(t) be t vertex-disjoint subdigraphs of G with mr *** this article,it is verified that every[0,k_(1)+k_(2)+…+k_(m)-(m-1)r]-digraph G has a[0,k_(i)]_(1)^(m)-factorization r-orthogonal to every H_(i) for 1≤i≤t.

关键词： network digraph factor factorization orthogonal factorization

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Transition and fracture shift behavior in LCF test of dissimilar welded joint at elevated temperature

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Journal of Materials Science & Technology 2018年第4期34卷 720-731页

作者： Xiongfei Wang ChendongShao xia liu Fenggui Lu Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghaiJiao Tong UniversityShanghai 200240China Shanghai Turbine Plant of Shanghai Electric Power Generation Equipment Co.Ltd. Shanghai 200240China

This work focused on the low-cycle fatigue （LCF） behavior of modified 9Cr/CrMoV dissimilar welded joint at elevated temperature. Narrow gap submerged arc welding （NG-SAW） process via multi-pass and multi-layer techniques was employed to fabricate the welded joint. LCF tests at different strain amplitude range from 0.22% to 0.75% were performed at strain ratio R = -1. The two-slope behavior based on fracture location shift was presented both on the cyclic stress-strain （CSS） curve and Manson-Coffin （M-C） curve, which could be applied to predict the fatigue life more precisely especially at relatively low strain amplitude. The results indicated that the joint failed in CrMoV-base metal （BM） at relatively low strain amplitude below 0.4% while failure shifted to CrMoV-over tempered zone （OTZ） at higher strain amplitude above 0.4%. Fatigue failure occurred in CrMoV-BM at low strain amplitude could be attributed to temperature softening effect in CrMoV-BM combined with cyclic strengthening in CrMoV- OTZ. While CrMoV-OTZ with a comparable number of grain boundaries and much lower hardness than that of CrMoV-BM was deemed to be the weakest zone across the welded joint at higher strain amplitude. EBSD investigations also revealed that CrMoV-BM experienced more fatigue damage at relatively low strain amplitude, while CrMoV-OTZ accumulated more plastic strain at higher strain amplitude.

关键词： Low-cycle fatigue 9Cr/CrMoV dissimilar welded joint Elevated temperature Fracture transition EBSD analysis

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Three-dimensional spin–orbit coupled Fermi gases:Fulde–Ferrell pairing, Majorana fermions, Weyl fermions,and gapless topological superfluidity

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Chinese Physics B 2015年第5期24卷 44-55页

作者： xia-Ji liu Hui Hu Han Pu Center for Quantum and Optical Science Swinburne University of Technology Department of Physics and Astronomy and Rice Quantum Institute Rice University Center for Cold Atom Physics Chinese Academy of Sciences

We theoretically investigate a three-dimensional Fermi gas with Rashba spin-orbit coupling in the presence of both out-of-plane and in-plane Zeeman fields. We show that, driven by a sufficiently large Zeeman field, either out-of-plane or in-plane, the superfluid phase of this system exhibits a number of interesting features, including inhomogeneous Fulde- Ferrell pairing, gapped or gapless topological order, and exotic quasi-particle excitations known as Weyl fermions that have linear energy dispersions in momentum space （i.e., massless Dirac fermions）. The topological superfluid phase can have either four or two topologically protected Weyl nodes. We present the phase diagrams at both zero and finite temperatures and discuss the possibility of their observation in an atomic Fermi gas with synthetic spin-orbit coupling. In this context, topological superfluid phase with an imperfect Rashba spin-orbit coupling is also studied.

关键词： Fulde-Ferrell superfluid topological superfluid spin-orbit coupling

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Ozonated graphene oxides as high efficient sorbents for Sr(Ⅱ) and U(Ⅵ) removal from aqueous solutions

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Science China Chemistry 2016年第7期59卷 869-877页

作者： xia liu xiangxue Wang Jiaxing Li xiangkeWang School of Chemistry and Environment North China Electric Power University Beijing 102206 China Key Laboratory of Novel Thin Film Solar Cells Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China School for Radiological and Interdisciplinary Sciences (RAD-X) Soochow University Suzhou 215123 China NAAM Research Group Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia

Ozone was used to oxidize graphene oxides （GO） to generate ozonated graphene oxides （OGO） with higher oxygen-containing functional groups. The as-prepared OGO was characterized by Fourier transformed infrared spectroscopy （FTIR）, scanning electron microscopy （SEM） and X-ray photoelectron spectroscopy （XPS）. Based on the results of potentiometric acid-base ti- trations, the total carboxylic acid concentration on OGO surface was calculated to be 3.92 retool/g, which was much higher than that on GO surface. The results of adsorption experiments indicated that the adsorption capacities of OGO for Sr（II） and U（VI） removal were improved significantly after ozonization.

关键词： ozone graphene oxide adsorption Sr(II) U(VI)

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