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Acute and subchronic toxicity as well as evaluation of safety pharmacology of modified pulsatilla granules

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Journal of Integrative Agriculture 2017年第3期16卷 671-678页

作者： JIA Rui-lin SONG Xu GUO Yu-fei yin Zhong-qiong LIU fei XIONG Juan LIU Qiu-yan JIA Ren-yong LI Li-xia ZOU Yuan-feng yin Li-zi HE Chang-liang liang xiao-xia YUE Gui-zhou College of Veterinary Medicine Sichuan Agricultural University Chengdu 611130 P.R. China Jinling Institute of Technology Nanjing 211169 P.R. China College of Science Sichuan Agricultural University Ya'an 625014 P.R.China

The present study investigated acute and subchronic toxicity and safety pharmacology of modified pulsatilla granules（MPG）to provide a basis for a comprehensive understanding of MPG *** results of acute toxicity testing showed that the median lethal dose of MPG was more than 5 000 mg kg^-1,suggesting that MPG was considered as practically *** subchronic toxicity study for 30 days was conducted by daily oral administration at doses of 375,750 and 1 500 mg kg^-1 in Sprague-Dawley *** results of subchronic toxicity study showed that the body weight and relative organ weight were not significantly changed by administration of *** clinical chemistry study showed that MPG could induce kidney and liver *** histopathological,mild lesions in liver and kidney were also observed,suggesting that the liver and kidney might be potential target organs of *** the safety pharmacology study,MPG did not exhibited any side effects to rats in cardiovascular system,respiratory system and central nervous *** results suggested that MPG could be considered safe for veterinary use.

关键词： modified pulsatilla granules acute toxicity subchronic toxicity safety pharmacology

Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-Lin Wang Li-Ming Zhang Kai Zhang Jian Wang Jian-Ping Zhou Wen-feng Peng Fa-liang yin Chao Zhong xia Yan Pi-Yang Liu Hua-Qing Zhang yong-fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice

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The Crop Journal 2023年第1期11卷 108-118页

作者： Xinghai Yang Baoxuan Nong Can Chen Junrui Wang Xiuzhong xia Zongqiong Zhang Yu wei Yu Zeng Rui feng Yanyan Wu Hui Guo Haifeng Yan Yuntao liang Shuhui liang yong Yan Danting Li Guofu deng Guangxi Key Laboratory of Rice Genetics and Breeding Rice Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi University for NationalitiesNanning 530006GuangxiChina Biotechnology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Sugarcane Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Microbiology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina

The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental *** the N use efficiency(NUE)of rice varieties is crucial for sustainable *** we report the cloning and characterization of OsNPF3.1,a gene that controls rice *** amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated ***3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain *** OsNPF3.1 protein is located in the plasma *** OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica ***3.1 can be used as a new target gene for breeding rice varieties with high NUE.

关键词： Rice OsNPF3.1 Functional analysis Evolutionary analysis Natural variation

Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu feng Jin-Xin Hao Zi-Huang Cao Jin-Min Bai Ji Yang Xu Zhou yong-Qiang Yao Jin-liang Hou yong-Heng Zhao Yu Liu Teng-fei Song Li-yong Liu Jia yin Hua-Lin Chen Chong Pei Ali Esamdin Lu Ma Chun-Hai Bai Peng wei Jing Xu Guang-Xin Pu Guo-Jie feng Xuan Zhang liang Ming Abudusaimaitijiang Yisikandee Jian-Rong Shi Jian Li Yuan Tian Zheng Wang xia Wang xiao-Jun Jiang Jian-feng Wang Jian-feng Tian Yan-Jie Xue Jian-Sheng Chen Jing-Yao Hu Zhi-xia Shen Yun-ying Jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between March 2017 and March 2019.

关键词： techniques telescope-site testing

Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1725-1740页

作者： Zhe deng yong-Jie Teng Qing Zhou Zhao-Guang Ouyang Yu-Xing Hu Hong-Ping Long Mei-Jie Hu Si Mei feng-xia Lin Xin-Jun Dai Bo-Yu Zhang Ting feng Xue-fei Tian College of Integrated Chinese and Western Medicine Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Preventive Dentistry Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou Medical UniversityGuangzhou 510132Guangdong ProvinceChina Experiment Center of Medical Innovation The First Hospital of Hunan University of Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Physiology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Cardiology Shenzhen Bao'an Traditional Chinese Medicine Hospital GroupThe Affiliated Hospital of Guangzhou University of Chinese MedicineShenzhen 518133Guangdong ProvinceChina College of Acupuncture and Massage Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is characterized by dysregulation of the immune microenvironment and the development of ***,expression of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)axis,an immune checkpoint,may lead to tumour immune escape,resulting in disease *** latest research shows that tumour immune escape may be caused by the upregulation of PD-L1 mediated by hypoxia-inducible factor-1 alpha(HIF-1α),and simultaneous inhibition of HIF-1αand PD-L1 has the potential to enhance the host’s antitumour ***,inhibition of the PD-1/PD-L1 axis may mitigate tumour *** pills(SYPs)contain immunity-enhancing and antitumour components,making them a potential HCC *** To investigate the efficacy of SYPs for HCC treatment via simultaneous HIF-1α and PD-L1 inhibition and the mechanism *** A subcutaneous xenograft tumour model was first established in BALB/c nude mice by the subcutaneous injection of 1×107 SMMC-7721 *** mice(male,5 weeks old;n=24)were then randomly divided into the following four groups(n=6):Control(0.9%normal saline),SYP(200 mg/kg),SYP+cisplatin(DDP)(200 mg/kg+5 mg/kg DDP weekly via intraperitoneal injection),and DDP(5 mg/kg cisplatin weekly via intraperitoneal injection).The dose of saline or SYPs for the indicated mouse groups was 0.2 mL/d via intragastric *** tumour volumes and body weights of the mice were measured every 2 *** mice were euthanized by cervical dislocation after 14 d of continuous treatment,and the xenograft tissues were excised and *** blot assays were used to measure the protein expression of HIF-1α,PD1,PD-L1,CD4+T cells,and CD8+T cells in HCC tumours from *** reverse transcription polymerase chain reaction was used for real-time quantitative detection of PD-1,PD-L1,and HIF-1α mRNA *** immunofluorescence assay was conducted to examine the expressio

关键词： Shuyu pills Hepatocellular carcinoma Tumour microenvironment Immune escape Chemoresistance

Effect of high-molecular-weight glutenin subunit Dy10 on wheat dough properties and end-use quality

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Journal of Integrative Agriculture 2023年第6期22卷 1609-1617页

作者： WANG Yan GUO Zhen-ru CHEN Qing LI Yang ZHAO Kan WAN yong-fang Malcolm JHAWKESFORD JIANG Yun-feng KONG Li PU Zhi-en deng Mei JIANG Qian-tao LAN Xiu-jin WANG Ji-rui CHEN Guo-yue MA Jian ZHENG You-liang wei Yu-ming QI Peng-fei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Chengdu 611130P.R.China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130P.R.China Rothamsted Research Harpenden AL52JQUK

High-molecular-weight glutenin subunits(HMW-GSs) are the most critical grain storage proteins that determine the unique processing qualities of wheat. Although it is a part of the superior HMW-GS pair(Dx5+Dy10), the contribution of the Dy10 subunit to wheat processing quality remains unclear. In this study, we elucidated the effect of Dy10 on wheat processing quality by generating and analyzing a deletion mutant(with the Dy10-null allele), and by elucidating the changes to wheat flour following the incorporation of purified Dy10. The Dy10-null allele was transcribed normally,but the Dy10 subunit was lacking. These findings implied that the Dy10-null allele reduced the glutenin:gliadin ratio and negatively affected dough strength(i.e., Zeleny sedimentation value, gluten index, and dough development and stability times) and the bread-making quality;however, it positively affected the biscuit-making quality. The incorporation of various amounts of purified Dy10 into wheat flour had a detrimental effect on biscuit-making quality. The results of this study demonstrate that the Dy10 subunit is essential for maintaining wheat dough strength. Furthermore, the Dy10-null allele may be exploited by soft wheat breeding programs.

关键词： HMW-GS nonsense mutation Dy10-null allele end-use quality

Data processing and data products from 2017 to 2019 campaign of astronomical site testing at Ali,Daocheng and Muztagh-ata

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Research in Astronomy and Astrophysics 2020年第6期20卷 109-130页

作者： Zi-Huang Cao Jin-Xin Hao Lu feng Hugh RAJones Jian Li Jing Xu Li-yong Liu Teng-fei Song Jian-feng Wang Hua-Lin Chen Yan-Jie Xue Huang Shen yong-Heng Zhao Zhao-xiang Qi Jian-Rong Shi Yuan Tian Zheng Wang xia Wang Jin-liang Hou Jin-Ming Bai Ji Yang Xu Zhou yong-Qiang Yao Jia yin Ali Esamdin Guang-Xin Pu Peng wei Chun-Hai Bai Guo-Jie feng Lu Ma Xuan Zhang Yu Liu Chong Pei Zhi-xia Shen Yun-ying Jiang Jian-feng Tian xian-Qun Zeng Zhi-Gang Hou Xu Yang Jun-Bo Zhang Shi-Long Liao Dong-wei Fan Yun-fei Xu Jian-Ping Xiong Tai-Sheng Yan Xi Zhang Chang-Hua Li Yi-Han Tao Si-Cheng Yu Zhi-Song Cao Hong-Shuai Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Centre for Astrophysics University of HertfordshireHatfieldUK School of Journalism Communication University of ChinaBeijing 100024China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China Beijing Kaiyang Space Technology Co. LtdBeijing 100085China

Based on previous site testing and satellite cloud data,Ali,Daocheng and Muztagh-ata have been selected as candidate sites for the Large Optical/Infrared Telescope(LOT) in *** present the data collection,processing,management and quality analysis for our site testing based on using similar *** analyze meteorological data,seeing,background light,cloud and precipitable water vapor data from 2017 March 10 to 2019 March *** also investigated the relative usefulness of our all-sky camera data in comparison to that from the meteorological TERRA satellite data based on a night-by-night comparison of the correlation and consistency between *** find a 6% discrepancy arising from a wide range of factors.

关键词： LOT Site-selection-data processing

Extracorporeal Membrane Oxygenation Therapy for Critically Ill Coronavirus Disease 2019 Patients in Wuhan,China:A Retrospective Multicenter Cohort Study

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Current Medical Science 2021年第1期41卷 1-13页

作者： Jing FANG Rui LI Yue CHEN Juan-juan QIN Ming HU Chao-lin HUANG Lin CHENG Yi HE Yi LI Qiang ZHOU Dai-xing ZHOU fei HUANG Fang LEI Bo YANG Jun CHEN Hong-ping deng Yu-feng YUAN Jia-hong xia Song WAN Hong-liang LI xiang wei Division of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationWuhan 430030China NHC Key Laboratory of Organ Transplantation Ministry of HealthWuhan 430030China Key Laboratory of Organ Transplantation Chinese Academy of Medical SciencesWuhan 430030China National Public Health Event Medical Center National Health Commission of the People’s Republic of ChinaWuhan 430030China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Basic Medical School Wuhan UniversityWuhan 430071China Department of Critical Care Medicine Wuhan Pulmonary HospitalWuhan 430030China Wuhan Jinyintan Hospital Wuhan 430023China Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Intensive Critical Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Model Animal of Wuhan University Wuhan 430071China Department of Cardiac Surgery University of MichiganAnn ArborMI 48109USA Department of Vascular Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Division of Cardiothoracic Surgery Department of Surgerythe Chinese University of Hong KongPrince of Wales HospitalHong Kong999077 China

Currently,little in-depth evidence is known about the application of extracorporeal membrane oxygenation(ECMO)therapy in coronavirus disease 2019(COVID-19)*** retrospective multicenter cohort study included patients with COVID-19 at 7 designated hospitals in Wuhan,*** patients were followed up until June 30,*** and multivariate logistic regression analyses were performed to identify the risk factors associated with unsuccessful ECMO *** score matching was used to match patients who received veno-venous ECMO with those who received invasive mechanical ventilation(IMV)-only *** 88 patients receiving ECMO therapy,27 and 61 patients were and were not successfully weaned from ECMO,***,15,15,and 65 patients were further weaned from IMV,discharged from hospital,or died during hospitalization,*** the multivariate logistic regression analysis,a lymphocyte count≤0.5×10^(9)/L and D-dimer concentration>4×the upper limit of normal level at ICU admission,a peak PaCO_(2)>60 mmHg at 24 h before ECMO initiation,and no tracheotomy performed during the ICU stay were independently associated with lower odds of ECMO *** the propensity scorematched analysis,a mixed-effect Cox model detected a lower hazard ratio for 120-day all-cause mortality after ICU admission during hospitalization in the ECMO *** presence of lymphocytopenia,higher D-dimer concentrations at ICU admission and hypercapnia before ECMO initiation could help to identify patients with a poor *** could facilitate weaning from *** relative to IMV-only therapy was associated with improved outcomes in critically ill COVID-19 patients.

关键词： coronavirus disease 2019 extracorporeal membrane oxygenation mechanical ventilation acute respiratory distress syndrome viral pneumonia

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-Dong Song fei Yang Hua-yong Wu Jing Zhang De-Cheng Li feng Liu Yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-Ping Bai Jia-ying Chen Jie Chen yin-Jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun deng-feng Wang Tian-wei Wang xiang-Hua wei Hong-Qi Wu xia Zhao Qing Zhou Gan-Lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification