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A Study on the Assessment and Integration of Multi-Source Evapotranspiration Products over the Tibetan Plateau

Advances in Atmospheric Sciences 2024年第3期41卷 435-448页

作者： ming CHENG Lei ZHONG Yaoming MA Han MA Yaoxin CHANG Peizhen LI Meilin CHENG xian WANG Nan GE School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China Jiangsu Collaborative Innovation Center for Climate Change Nanjing 210023China Frontiers Science Center for Planetary Exploration and Emerging Technologies University of Science and Technology of ChinaHefei 230026China Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemResources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan

Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy *** present,a large number of multi source ET products *** to sparse observations,however,great challenges exist in the evaluation and integration of ET products in remote and complex areas such as the Tibetan Plateau(TP).In this paper,the applicability of the multiple collocation(MC)method over the TP is evaluated for the first time,and the uncertainty of multisource ET products(based on reanalysis,remote sensing,and land surface models)is further analyzed,which provides a theoretical basis for ET data *** results show that 1)ET uncertainties quantified via the MC method are lower in RS-based ET products(5.95 vs.7.06 mm month^(-1))than in LSM ET products(10.22 vs.17.97 mm month^(-1))and reanalysis ET estimates(7.27 vs.12.26 mm month-1).2)A multisource evapotranspiration(MET)dataset is generated at a monthly temporal scale with a spatial resolution of 0.25°across the TP during *** has better performance than any individual product.3)Based on the fusion product,the total ET amount over the TP and its patterns of spatiotemporal variability are clearly *** annual total ET over the entire TP is approximately 380.60 ***,an increasing trend of 1.59±0.85 mm yr^(-1)over the TP is shown during *** study provides a basis for future studies on water and energy cycles and water resource management over the TP and surrounding regions.

关键词： evapotranspiration data fusion multiple collocation the Tibetan Plateau

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-xiang Gu xian-xia Yan Hong-Wei Fan ming-ming Zhang Yu Qiao xiao-Die Liu Bao-Juan Li ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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Free radicals trigger the closure of open pores in lignin-derived hard carbons toward improved sodium-storage capacity

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Journal of Energy Chemistry 2024年第7期94卷 551-559页

作者： Wen-Jun Ji Zong-Lin Yi ming-Xin Song xiao-Qian Guo Yi-Lin Wang Yi-Xuan Mao Fang-Yuan Su Jing-Peng Chen xian-xian Wei Li-Jing Xie Cheng-Meng Chen CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030001ShanxiChina

The chemical activation of various precursors is effective for creating additional closed pores in hard carbons for sodium ***,the formation mechanism of closed pores under the influence of pore-forming agents is not well ***,an effective chemical activation followed by a high-temperature self-healing strategy is employed to generate interconnected closed pores in lignin-derived hard carbon(HCs).By systematic experimental design combined with electron paramagnetic res-onance spectroscopy,it can be found that the content of free radicals in the carbon matrix influences the closure of open pores at high *** high activation temperature(>700 C)leads to a low free radical concentration,making it difficult to achieve self-healing of open pores at high *** activation at 700°C,a balance between pore making and self-healing is achieved in the final hard carbon.A large number of free radicals triggers rapid growth and aggregation of carbon microcrys-tals,blocking pre-formed open micropores and creating additional interconnected closed pores in as-obtained hard *** a result,the optimized carbon anode(LK-700-1300)delivers a high reversible capacity of 330.8 mA h g^(-1) at 0.03 A g^(-1),which is an increase of 86 mA h g^(-1) compared to the pristine lignin-derived carbon anode(L-700-1300),and exhibits a good rate performance(202.1 mA h g^(-1) at 1 A g^(-1)).This work provides a universal and effective guidance for tuning closed pores of hard carbons from otherprecursors.

关键词： Hard carbon Chemical activation Free radical Self-healing Closed pores Sodium ion batteries

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Pleural effusion,ascites,colon ulcers and hematochezia:What we can learn from the diagnostic process of a patient with plasma cell myeloma:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5196-5207页

作者： ming-xian Yan Department of Gastroenterology The First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Plasma cell myeloma(PCM)is characterized by hypercalcemia,renal impairment,anemia,and bone *** pleural effusion,ascites,abdominal pain,and bloody stool are common manifestations of lung disease or gastrointestinal disorders,they are rarely observed in patients with *** SUMMARY A 66-year-old woman presented with complaints of recurrent chest tightness,wheezing,and abdominal bloating accompanied by bloody *** tomography revealed pleural effusion and *** effusion tests showed inflammation,but the T-cell spot test and carcinoembryonic antigen were *** showed colonic mucosal edema with ulcer formation and local intestinal lumen *** revealed enlarged atria and reduced left ventricular systolic *** diagnosis remained *** testing revealed elevated blood light chain lambda and urine immunoglobulin *** immunofixation electrophoresis was positive for immunoglobulin G lambda *** cytology of the bone marrow showed a high proportion of plasma cells,accounting for about 4.5%.Histopathological examination of the bone marrow suggested *** cytometry showed abnormal plasma cells with strong expression of CD38,CD138,cLambda,CD28,CD200,and *** in situ hybridization gene testing of the bone marrow suggested 1q21 gene amplification,but cytogenetic testing showed no clonal *** mucosa and bone marrow biopsy tissues were negative for Highman Congo red *** patient was finally diagnosed with *** A diagnosis of PCM should be considered in older patients with pleural effusion,ascites,and multi-organ injury.

关键词： Plasma cell myeloma Pleural effusion Ascites Hematochezia Colon ulcers Bone marrow aspirate Case report

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Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： xian-Shuai Kou Fan-Fan Li Yun Meng Jian-ming Zhao Sheng-Fen Liu Lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus *** prognosis is generally *** case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented *** SUMMARY The patient presented with large HCC complicated by intratumoral *** involved a multidisciplinary approach,providing individualized *** strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody *** months after treatment,the patient achieved complete radiological remission,with significant symptom *** studies showed no lesions or recurrence,and clinical assessments confirmed complete *** report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar *** This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report

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Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

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Journal of Pharmaceutical Analysis 2024年第6期14卷 926-929页

作者： Shiyu Chen Yuxuan Li Yingrui Zhang Hongren Yao Tong Xu Yi Zhang Jin-ming Lin xian-Li Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing100084China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China

Microneurovascular units(mNVUs),comprising neurons,micro-glia,and blood-brain barrier(BBB)endothelial cells,are pivotal to the central nervous system and are associated with cerebral hypoxia and brain *** hypoxia triggers microglial overactivity,causing inflammation,neuronal injury,and disruption of the BBB[1].Salidroside(Sal),a key compound in Tibetan medicine Rhodiola crenulata,mitigates hypoxia-induced metabolic disorders and neuronal damage by preserving mitochondrial function[2].

关键词： injuries preserving Tibetan

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往复挤压对挤压态ZK60镁合金微观组织和力学性能的影响

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塑性工程学报 2017年第3期24卷 78-83页

作者：夏显明谢瑞薛克敏李萍安徽科技学院机械工程学院安徽凤阳233100 合肥工业大学材料科学与工程学院安徽合肥230009

在350℃下,对挤压态ZK60镁合金分别进行1、4、8道次的往复挤压变形(CEC)。利用金相显微镜(OM)、透射电镜(TEM)观察往复挤压前后ZK60镁合金的微观组织,利用X射线衍射仪(XRD)分析变形前后晶面取向变化,在万能拉伸试验机上测试变形前后镁... 详细信息

在350℃下,对挤压态ZK60镁合金分别进行1、4、8道次的往复挤压变形(CEC)。利用金相显微镜(OM)、透射电镜(TEM)观察往复挤压前后ZK60镁合金的微观组织,利用X射线衍射仪(XRD)分析变形前后晶面取向变化,在万能拉伸试验机上测试变形前后镁合金的力学性能,并利用扫描电镜(SEM)观察拉伸断口形貌。往复挤压后的检测结果表明,挤压态ZK60镁合金晶粒显著细化,晶粒尺寸分布较均匀,随着挤压道次增多,晶粒尺寸逐渐减小;1道次变形后组织内产生了大量晶格缺陷,出现了大角度晶界,第二相粒子分布在晶粒内部和晶界上;各晶面衍射峰增强,拉伸断口内存在大量基体撕裂棱和明显的韧窝分布;ZK60镁合金的力学性能变化较大,随着挤压道次增多,伸长率大幅提高,抗拉强度小幅增大,而屈服强度降低。

关键词： ZK60镁合金往复挤压微观组织力学性能

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Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-ming xiao Heng Zheng Ping Yuan Jun-Hui Luo Lin-Lin Shen Jie-Feng Tan xian-You Luo De Li Yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228China

Hard carbon(HC)has emerged as one of the superior anode materials for sodium-ion batteries(SIBs),with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl(decreasing from 5.71 at%to 2.12 at%)and hydroxyl groups(decreasing from 7.73 at%to 6.26 at%).Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na^(+).Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na^(+)*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g^(-1)to an impressive 251.97 m Ah·g^(-1)at a current density of 50 mA·g^(-1).Even at 400 mA·g^(-1),the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·g^(-1).Hence,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Hard carbon Spark plasma sintering Sodiumion batteries Closed pores Oxygen functional groups

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PAHs removal by soil washing with thiacalix[4]arene tetrasulfonate

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Environmental Science and Ecotechnology 2024年第5期21卷 256-267页

作者： Le-Yao Xing Guan-Han Meng Ji-xian Yang ming-Han Xu Yi-ming Xu Hai-xiao Xie Ai-Jie Wang Yi-Lu Sun State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Hangzhou Yanqu Information Technology Co. Ltd.Y2Hangzhou310003China

Remediating soil contaminated with polycyclic aromatic hydrocarbons(PAHs)presents a significant environmental challenge due to their toxic and carcinogenic *** PAHs remediation methodsdchemical,thermal,and bioremediationdalong with conventional soil-washing agents like surfactants and cyclodextrins face challenges of cost,ecological harm,and *** we show an effective and environmentally friendly calixarene derivative for PAHs removal through soil ***[4]arene tetrasulfonate(TCAS)has a unique molecular structure of a sulfonate group and a sulfur atom,which enhances its solubility and facilitates selective binding with *** forms host-guest complexes with PAHs through p-p stacking,OH-p interactions,hydrogen bonding,van der Waals forces,and electrostatic *** interactions enable partial encapsulation of PAH molecules,aiding their desorption from the soil *** results show that a 0.7%solution of TCAS can extract approximately 50%of PAHs from contaminated soil while preserving soil nutrients and minimizing adverse environmental *** research unveils the pioneering application of TCAS in removing PAHs from contaminated soil,marking a transformative advancement in resource-efficient and sustainable soil remediation strategies.

关键词： Calixarenes Soil-washing Host-guest interaction PAHs

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Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

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Cancer Communications 2024年第2期44卷 205-225页

作者： Chen ming-Kun Chen Zi-xian Cai Mao-Ping Chen Hong Chen Zhuang-Fei Zhao Shan-Chao Department of Urology The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China The Third Clinical College Southern Medical UniversityGuangzhouGuangdongP.R.China Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyangHenanP.R.China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Targeted delivery of anti-tumor drugs and overcoming drug resistance in malig-nant tumor cells remain significant clinical ***,there are only few effective methods to address these *** vesicles(EVs),actively secreted by cells,play a crucial role in intercellular information transmis-sion and cargo *** studies have demonstrated that engineered EVs can serve as drug delivery carriers and showed promising application ***,there is an urgent need for further improvements in the isolation and purification of EVs,surface modification techniques,drug assem-bly processes,and precise recognition of tumor cells for targeted drug delivery *** this review,we summarize the applications of engineered EVs in cancer treatment and overcoming drug resistance,and current challenges asso-ciated with engineered EVs are also *** review aims to provide new insights and potential directions for utilizing engineered EVs as targeted delivery systems for anti-tumor drugs and overcoming drug resistance in the near future.

关键词： drug delivery drug resistance extracellular vesicles nanoparticles

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