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Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis

World Journal of Gastroenterology 2010年第24期16卷 2994-3001页

作者： xia, xian-ming Wang, Fang-Yu Wang, Zhen-Kai Wan, Hai-Jun Xu, Wen-An Lu, Heng Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM: To investigate the effect of emodin on expression of claudin4, claudin5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. METHODS: Experimental pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Emodin was injected via the external jugular vein 3 h after induction of acute pancreatitis. Rats from sham operation group and acute pancreatitis group were injected with normal saline (an equivalent volume as emodin) at the same time point. Samples of lung and serum were obtained 6 h after drug administration. Pulmonary morphology was examined with HE staining. Pulmonary edema was estimated by measuring water content in lung tissue samples. Tumor necrosis factorα (TNFα) and interleukin6 (IL6) level were measured by enzymelinked immunospecific assay. Serum amylase and pulmonary myeloperoxidase (MPO) activity were detected by spectrophotometry. Alveolar epithelial barrier was assessed by pulmonary dye extravasation. Expression of claudin4, claudin5 and occludin in lung tissue samples was examined by immunohistology, quantitative realtime reverse transcription polymerase chain reaction and Western blotting analysis, ***: Pancreatitis-associated lung injury was char-acterized by pulmonary edema, leukocyte infiltration, alveolar collapse, and elevated serum amylase level. The pulmonary damage, pulmonary pathological scores, serum amylase and MPO activity, TNF-α and IL-6 levels, and wet/dry ratio were decreased in rats after treatment with emodin. Immunostaining of claudin-4, claudin-5 and occludin was detected in lung tissue samples from rats in sham operation group, which was distributed in alveolar epithelium, vascular endothelium, and bron-chial epithelium, respectively. The mRNA and protein expression levels of claudin-4, claudin-5 and occludin in lung tissue samples were markedly decreased, the expression level of claudin-4, claudin-

关键词： Acute pancreatitis Emodin Lung injury Claudin Occludin Epithelial barrier

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Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 201-208页

作者： Li, Zong-Fang xia, xian-ming Huang, Chen Zhang, Shu Zhang, Jian Zhang, Ai-Jun Xi An Jiao Tong Univ Sch Med Affiliated Hosp 2 Dept Surg Xian 710004 Peoples R China Xi An Jiao Tong Univ Minist Educ Key Lab Environm & Genes Related Dis Xian 710004 Peoples R China Wannan Med Coll Yijishan Hosp Dept Surg Wuhu 241001 Peoples R China

BACKGROUND: Stromal derived factor-1 (SDF-1) is an efficacious leukocyte chemoattractant, which can attract lymphocytes and mononuclear cells from bloodstream into the site of inflammation. Emodin., an anthraquinone derivative from Radix et Rhizoma Rhei, and baicalein, a flavone from Scutellaria baicalensis Georgi, both have been reported to possess anti-inflammatory activities. The expression pattern of SDF-1 in experimental acute pancreatitis (AP) and the effect of emodin or baicalein on that are not well defined. The present study aimed to investigate the effects of emodin and baicalein on pancreatic myeloperoxidase (MPO) activity (reflecting leukocyte sequestration) and cytokine production, as well as tissue SDF-1 expression in the setting of AP. METHODS: A :rat model of AP was induced by administration (of 5% sodium taurocholate through the biliopancreatic duct. The level of tumor necrosis factor-a (TNF-alpha), interleukin-6 (IL-6) and MPO in the pancreas, and serum amylase were tested by immunohistochemistry, ELISA and chromatometry. The expressions of SDF-1 alpha and SDF-1 beta were detected by real-time PCR, Western blotting, and immunohistochemistry. RESULT: Combination of emodin and baicalein significantly reduced pancreatic TNIP-alpha, IL-6 and MPO, and also inhibited pancreatic SDF-1 expression. CONCLUSIONS: The inhibition of SDF-1 expression by emodin and baicalein might contribute, in part at least, to the amelioration of pancreatic inflammation. The present study also shows benefits of simultaneous treatment of AP.

关键词： acute pancreatitis stromal derived factor-1 myeloperoxidase traditional Chinese medicine

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“学、思、测、用、评”互嵌的《信号与系统》教学设计与实践

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贵州师范学院学报 2024年第8期40卷 60-70页

作者：闫改珍徐朝胜夏显明樊晓宇刘宗飞安徽科技学院电气与电子工程学院安徽蚌埠233000 安徽科技学院管理学院安徽蚌埠233000

从新工科人才需求出发,以专业、课情、学情特点为依据,基于OBE理念对《信号与系统》进行了宏观和微观教学设计。在宏观上,以实现知识传授、能力培养、价值塑造为目标,设计教学目标、教学内容、教学活动与考核反馈等教学环节。在微观上,... 详细信息

从新工科人才需求出发,以专业、课情、学情特点为依据,基于OBE理念对《信号与系统》进行了宏观和微观教学设计。在宏观上,以实现知识传授、能力培养、价值塑造为目标,设计教学目标、教学内容、教学活动与考核反馈等教学环节。在微观上,进行知识点精分,以“问题牵引”为主要手段,“学、思、测、用、评”教学活动相互内嵌,融入工程能力的培养。通过教学实践证明,该教学方法可以为教学活动提供弹性伸缩空间,更加有利于因材施教,提升学习效果。

关键词：产出导向学生中心链式教学课堂对分

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Immobilizing Triphenylamine with Photoredox Inert Sr^(2+)Forming Sr-MOF with Controlled Electron Migration for Photocatalytic Oxidation of Thiols to Disulfides

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Chinese Journal of Chemistry 2024年第10期42卷 1093-1099页

作者： Ying-xia Wang Fang Zheng Dong-xia Song Bao-Yue Niu Lu-Qian Deng xian-ming Zhang Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education) Schoolof Chemistry and Materials ScienceShanxi Normal UniversityTaiyuanShanxi 030006China Key Laboratory of Interface Science and Engineering in Advanced Material(Ministry of Education) College of ChemistryTaiyuan University of TechnologyTaiyuanShanxi 030024China

The photocatalytic oxidative coupling of thiols is one of the most popular methods to synthesize the *** and its derivatives(TPAs)are promising for the above reaction,but suffer from the easy polymerization and difficult *** overcome these obstacles while controlling the photogenerated electrons transfer directly to target substrates,herein,we constructed one TPA-based metal-organic framework(MOF),(Me_(2)NH_(2))[Sr(TCBPA)]·DMA·3H_(2)O(1),by direct self-assembly of tris(4′-carboxybiphenyl)amine(H_(3)TCBPA)and photoredox inert strontium ion(Sr^(2+)).DFT calculations revealed that the valence band maximum(VBM)and the conduction band minimum(CBM)are mainly located on TCBPA^(3-),successfully inhibiting the undesirable electron migration to metal *** results indicated that 1 displays superior performance than homogeneous H_(3)TCBPA,which may result from the abundant π…π and C—H…π interactions between the well-arranged TCBPA^(3-)and the build-in electric field between the anionic framework and the Me_(2)NH^(2+).This work highlights that immobilizing TPAs into MOFs is one promising approach to designing heterogeneous photocatalysts for the synthesis of disulfides by oxidative coupling of thiols.

关键词： Triphenylamine Metal-organic frameworks Strontium Photooxidation Thiols Disulfides

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CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

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World Journal of Gastroenterology 2010年第23期16卷 2873-2880页

作者： xia, xian-ming Wang, Fang-Yu Xu, Wen-An Wang, Zhen-Kai Liu, Jiong Lu, You-Ke Jin, Xin-Xin Lu, Heng Shen, Yun-Zhu Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in ***:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the *** morphology was examined by hematoxylin and eosin *** cytokines were determined by enzyme-linked immunosorbent ***(MPO) activity(indicator of inflammatory infiltration) was observed *** permeability was assessed by mucosal-to-serosal clearance of fluorescein isothiocyanate-conjugated dextran 4000(FD4) in everted gut *** apoptosis of colonic epithelium was assessed by Hoechst-33342 *** further elucidate the role of CXCR4 in colonic inflammation,we also investigated the effect of AMD3100 on migration and cytokine production of isolated peripheral blood mononuclear cells(PBMCs).RESULTS:DSS-induced colitis was characterized by morphologic changes,as well as increased colonic cytokines,inflammatory infiltration,epithelial apoptosis,and intestinal permeability in *** AMD3100-treated mice,epithelial destruction,inflammatory infiltration,and submucosal edema were markedly reduced;colonic tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interferon-γ(IFN-γ) levels,as well as MPO activity were significantly *** intestinal permeability in DSS-treated mice was signif icantly reduced by *** number of apoptotic cells in colitis mice was markedly increased after DSS administration,and decreased when treated with the CXCR4 antagonist *** pre-activated PBMCs,CXCL12 stimulation signif icantly increased the migration of PBMCs,and was inhibited by *** increased TNF-α,IL-6,and IFN-γ from CXCL12-treated PBMCs were also reduced by ***:The CXCR4 antagonist AMD3100 exerts the

关键词： Ulcerative colitis Chemokine stromal cellderived factor-1 receptor Inflammation Apoptosis Intestinal permeability Epithelial barrier

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Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research International 2024年第1期31卷 195-203页

作者： Zhi-gang Que Jin-ming Shi xian-bin Ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

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Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease： a meta-analysis

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Chinese Medical Journal 2013年第16期126卷 3146-3150页

作者： ZHU Hai-di WANG Heng xia xian-ming XU Shu-man LAN Yao Huazhong University of Science and Technology Wuhan Hubei430030 China The Fourth Affiliated Hospital of Anhui Medical University HefeiAnhui 230022 China Social Science and Health Management School Anhui MedicalUniversity Hefei Anhui 230032 China

Background Several randomized controlled trials （RCTs） have compared endoscopic and symptomatic relapses in patients with erosive gastroesophageal reflux disease （GERD）.We have summarized current evidence for rabeprazole 10 or 20 mg once daily for GERD maintenance treatment over 1 or 5 *** MEDLINE,EMBASE,and the Cochrane Central Register of Controlled Trials were searched,through August 2012,for eligible RCTs of adults with erosive *** efficacies of rabeprazole 10 and 20 mg/d were *** The search identified 288 citations,and five RCTs containing 1480 patients were considered *** relapse rates did not differ significantly between patients treated with rabeprazole 10 and 20 mg/d for 1 year （relative risk （RR）=1.29; 95％ confidence interval （CI）：0.97-1.72）,but differed in patients treated for 5 years （RR=1.274; 95％ CI：1.005-1.615）.Endoscopic relapse rates differed significantly between rabeprazole 10 and 20 mg/d for 1 year （RR=1.92;95％ CI：1.21-3.06）,for 5 years （RR=1.667; 95％ CI：1.073-2.589）,and in combined 1-and 5-year maintenance trials （RR=1.785; 95％ CI：1.298-2.456）.Conclusion Rabeprazole 20 mg/d was superior to rabeprazole 10 mg/d in preventing endoscopic relapse of erosive GERD,but that the two dosages were equivalent in symptomatic relief over 1 year.

关键词： gastroesophageal reflux disease proton pump inhibitors rabeprazole relapse endoscopy heartburn

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Communication Resource-Efficient Vehicle Platooning Control With Various Spacing Policies

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 362-376页

作者： xiaohua Ge Qing-Long Han xian-ming Zhang Derui Ding IEEE School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia

Platooning represents one of the key features that connected automated vehicles may possess as it allows multiple automated vehicles to be maneuvered cooperatively with small headways on roads. However, a critical challenge in accomplishing automated vehicle platoons is to deal with the effects of intermittent and sporadic vehicle-to-vehicle data transmissions caused by limited wireless communication resources. This paper addresses the co-design problem of dynamic event-triggered communication scheduling and cooperative adaptive cruise control for a convoy of automated vehicles with diverse spacing policies. The central aim is to achieve automated vehicle platooning under various gap references with desired platoon stability and spacing performance requirements, while simultaneously improving communication efficiency. Toward this aim, a dynamic event-triggered scheduling mechanism is developed such that the intervehicle data transmissions are scheduled dynamically and efficiently over time. Then, a tractable co-design criterion on the existence of both the admissible event-driven cooperative adaptive cruise control law and the desired scheduling mechanism is derived. Finally, comparative simulation results are presented to substantiate the effectiveness and merits of the obtained results.

关键词： Automated vehicles constant time headway spacing constant spacing cooperative adaptive cruise control event-triggered communication vehicle platooning

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Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1547-1556页

作者： Yang Yang xiao-Chuan Duan Shao-Hui Guo xian-ming Zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure

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Al-containing Ge-rich IWV:rapid synthesis via interzeolite transformation and application in Baeyer-Villiger oxidation

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Science China Chemistry 2024年第7期67卷 2282-2291页

作者： Meichen Jiao Chunmin Jia Hao Xu Peng Wu xian-ming Zhang School of Chemistry&Material Science Shanxi Normal UniversityTaiyuan 030006China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China School of Chemistry Taiyuan University of TechnologyTaiyuan 030024China

Ge-containing Lewis acidic zeolites are typically synthesized using a conventional hydrothermal strategy from amorphous silica sources,through a long time-and energy-consuming approach limiting their wide *** study reports a rapid synthesis strategy for a series of IWV aluminogermanosilicate zeolites(T-x-Al)with a wide range of Si/Ge molar ratios(5–15)by interzeolite transformation of dealuminated FAU(DA-FAU).Notably,Ge-rich IWV could be obtained with crystallization time as short as one day by the equimolecular Si/Ge ratio *** effect of synthetic parameters was investigated and the obtained T-x-Al samples were characterized by XRD,SEM,EDS,ICP,^(29)Si and^(27)Al MAS NMR,FTIR,and N_(2)physisorption *** with a previously reported IWV germanosilicate(H-3),T-x-Al displayed a better catalytic activity in Baeyer-Villiger(BV)oxidation,attributed to the presence of the active framework Ge sites with the assistance of the extraframework Al *** cyclic catalysis tests revealed that the presence of framework Al species contributed to the stability of the ***,T-x-Al,with 14-membered ring(MR)supercages,outperformed the typical 12-MR Sn-beta catalyst in the BV oxidation of large ketone-like 2-admantanone,indicating a promising potential application in the macromolecular catalytic process.

关键词： Ge-rich IWV interzeolite transformation Al assistance Baeyer-Villiger oxidation

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