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CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

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Oncology Research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG zeng xi CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN SHAO LIU Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular Engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration

金融科技与银行脆弱性——基于外源性金融科技和内部数字化转型视角

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江西财经大学学报 2024年第3期 23-36页

作者：林曦王仁曾华南理工大学经济与金融学院广东广州510006

在系统性金融风险日益严峻的背景下,分析金融科技与银行脆弱性的关系,审视金融科技能否与商业银行有效融合,这对于推进商业银行数字化转型、防范系统性金融风险具有重要意义。研究运用2012—2020年银行、城市层面数据,基于内外双重视角... 详细信息

在系统性金融风险日益严峻的背景下,分析金融科技与银行脆弱性的关系,审视金融科技能否与商业银行有效融合,这对于推进商业银行数字化转型、防范系统性金融风险具有重要意义。研究运用2012—2020年银行、城市层面数据,基于内外双重视角分析外源性金融科技和银行内部数字化转型对银行脆弱性的影响。研究发现,外源性金融科技和银行内部数字化转型主要通过改善银行存贷款结构和信贷质量显著降低银行脆弱性,其对农村商业银行脆弱性的降低程度明显高于城市商业银行,且外源性金融科技能够通过技术溢出效应促进银行内部数字化转型。进一步研究发现,外源性金融科技能够降低银行系统性风险,但边际作用逐渐减弱。在银行内部数字化转型初期,其对银行系统性风险无显著抑制作用,随着银行内部数字化转型的不断推进,其对银行系统性风险的抑制作用逐渐显现并呈现边际作用增强态势。因此,银行要合理规划金融科技发展战略,抓住数字化转型机遇,引导金融科技良性发展。

关键词：外源性金融科技银行内部数字化转型银行脆弱性银行系统性风险

Molecular Epidemiology and Clinical Characteristics of Hand, Foot and Mouth Disease in North Sichuan Region, China, 2018-2023: A Descriptive Study

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Advances in Microbiology 2024年第6期14卷 317-332页

作者： Zhe Xu Zheng Zhao Linming Fan Manyu Liang Jinglu Chen Jia zeng Ping Shi xi’en Gu Zhengdong Li Department of Pediatrics Guangyuan Central Hospital Guangyuan China Department of Clinical Laboratory Guangyuan Central Hospital Guangyuan China Department of Dermatology Guangyuan Central Hospital Guangyuan China Precision Medical Centre Guangyuan Central Hospital North Sichuan Regional Medical Centre Guangyuan China Department of Pulmonary and Critical Care Medicine Guangyuan Central Hospital Guangyuan China

Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.

关键词： Enterovirus HFMD Epidemiology Clinical Characteristics

基于自感知连梁的剪力墙墙肢转角变形识别及其试验验证

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工程力学 2024年第9期41卷 91-100页

作者：单伽锃潮曦王律己钱江同济大学结构防灾减灾工程系上海200092 上海韧性城市与智能防灾工程技术研究中心上海200092

联肢剪力墙作为高层结构重要的抗侧体系,对建筑的震后功能可持续至关重要。近年来,带可更换构件的剪力墙结构体系被学术界提出,并成功应用于国内外高层建筑项目。需要注意的是,作为结构抗震第一道防线的易损高耗能连梁,其震后的快速诊... 详细信息

联肢剪力墙作为高层结构重要的抗侧体系,对建筑的震后功能可持续至关重要。近年来,带可更换构件的剪力墙结构体系被学术界提出,并成功应用于国内外高层建筑项目。需要注意的是,作为结构抗震第一道防线的易损高耗能连梁,其震后的快速诊断与更换将决定建筑结构性能与功能恢复效率。该文从带可更换连梁联肢剪力墙结构变形机理出发,基于前期提出的自感知可更换连梁,提出了一种剪力墙墙肢转角变形识别方法,实现对墙肢转角及相邻墙肢转角差等状态的识别。通过大比例剪力墙模拟体的动力加载试验,并与多种试验测量技术进行对比,验证了墙肢转角识别方法的准确性与鲁棒性。

关键词：可更换连梁状态识别结构监测自感知剪力墙

Two-dimensional localized modes in nonlinear systems with linear nonlocality and moiré lattices

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Frontiers of physics 2024年第4期19卷 265-273页

作者： xiuye Liu Jianhua zeng Center for Attosecond Science and Technology State Key Laboratory of Transient Optics and PhotonicsXi’an Institute of Optics and Precision Mechanics of Chinese Academy of SciencesXi’an 710119China University of Chinese Academy of Sciences Beijing 100049China Collaborative lnnovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Periodic structures structured as photonic crystals and optical lattices are fascinating for nonlinear waves engineering in the optics and ultracold atoms ***éphotonic and optical lattices—two-dimensional twisted patterns lie somewhere in between perfect periodic structures and aperiodic ones—are a new emerging investigative tool for studying nonlinear localized waves of diverse ***,a theory of two-dimensional spatial localization in nonlinear periodic systems with fractional-order diffraction(linear nonlocality)and moiréoptical lattices is ***,the flat-band feature is well preserved in shallow moiréoptical lattices which,interact with the defocusing nonlinearity of the media,can support fundamental gap solitons,bound states composed of several fundamental solitons,and topological states(gap vortices)with vortex charge s=1 and 2,all populated inside the finite gaps of the linear Bloch-wave *** the linear-stability analysis and direct perturbed simulations,the stability and instability properties of all the localized gap modes are surveyed,highlighting a wide stability region within the first gap and a limited one(to the central part)for the third *** findings enable insightful studies of highly localized gap modes in linear nonlocality(fractional)physical systems with shallow moirépatterns that exhibit extremely flat bands.

关键词： moiréoptical lattices gap solitons and vortices ultracold atoms Gross-Pitaevskii/nonlinear fractional Schrödinger equation nonlinear fractional systems

中国自主的数字贸易知识体系建构——以西方经典理论为参照系的比较

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求是学刊 2024年第4期51卷 22-44页

作者：马述忠胡增玺吴鹏浙江大学中国数字贸易研究院杭州310058 浙江财经大学经济学院杭州310018

数字贸易的迅速发展颠覆了传统国际经济学和国际商务的理论范式,中国学者在数字贸易领域的率先实践为中国自主的数字贸易知识体系的建构提供了历史机遇。文章从中国数字贸易发展事实出发,以西方经典贸易和商务理论为参照,在全面梳理中... 详细信息

数字贸易的迅速发展颠覆了传统国际经济学和国际商务的理论范式,中国学者在数字贸易领域的率先实践为中国自主的数字贸易知识体系的建构提供了历史机遇。文章从中国数字贸易发展事实出发,以西方经典贸易和商务理论为参照,在全面梳理中国学者原创性贡献并适当参考西方有价值的前沿研究基础上提出数字贸易一般性分析框架。具体地,数字技术是数字贸易发展的基础,数字技术、平台、消费者、数据、全球公司和智能制造六大主体及其内在关系构成了基于数字技术创新的数字贸易主分析框架,是数字贸易核心研究领域;以此为基础,形成了以贸易成本、多边贸易、全球生态网络、全要素生产率、劳动力市场和数字贸易规则六大重点研究领域构成的基于消费者偏好的全球贸易平台次分析框架,以及平台生态系统、组织变革、商业模式、供应链管理、数字营销和数字并购六大重点研究领域构成的基于需求驱动的全球公司次分析框架。文章构建的数字贸易分析框架是动态演进的学术范式,有利于推动具有中国特色的数字贸易学科体系、学术体系、话语体系的形成。

关键词：数字贸易自主知识体系国际经济学国际商务

Locally unlocks prodrugs by radiopharmaceutical in tumor for cancer therapy

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Science Bulletin 2024年第17期69卷 2745-2755页

作者： Changlun Wang Mengxin Xu Zihang Zhang Senhai zeng Siyong Shen Zexuan Ding Junyi Chen xi-Yang Cui Zhibo Liu Beijing National Laboratory for Molecular Sciences Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental ScienceKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Peking University-Tsinghua University Center for Life Sciences Peking UniversityBeijing 100871China Changping Laboratory Beijing 102206China Key Laboratory of Carcinogenesis and Translational Research of Ministry of Education Key Laboratory for Research and Evaluation of Radiopharmaceuticals of National Medical Products AdministrationDepartment of Nuclear MedicinePeking University Cancer HospitalBeijing 100142China

Chemotherapy is the first-line treatment for cancer, but its systemic toxicity can be severe. Tumorselective prodrug activation offers promising opportunities to reduce systemic toxicity. Here, we present a strategy for activating prodrugs using radiopharmaceuticals. This strategy enables the targeted release of chemotherapeutic agents due to the high tumor-targeting capability of radiopharmaceuticals. [^(18)F]FDG(2-[^(18)F]-fluoro-2-deoxy-D-glucose), one of the most widely used radiopharmaceuticals in clinics, can trigger Pt(IV) complex for controlled release of axial ligands in tumors, it might be mediated by hydrated electrons generated by water radiolysis resulting from the decay of radionuclide18F. Its application offers the controlled release of fluorogenic probes and prodrugs in living cells and tumor-bearing mice. Of note,an OxaliPt(IV) linker is designed to construct an [^(18)F]FDG-activated antibody-drug conjugate(Pt-ADC).Sequential injection of Pt-ADC and [^(18)F]FDG efficiently releases the toxin in the tumor and remarkably suppresses the tumor growth. Radiotherapy is booming as a perturbing tool for prodrug activation,and we find that [^(18)F]FDG is capable of deprotecting various radiotherapy-removable protecting groups(RPGs). Our results suggest that tumor-selective radiopharmaceutical may function as a trigger, for developing innovative prodrug activation strategies with enhanced tumor selectivity.

关键词： Prodrugactivation Radiopharmaceutical Radiochemistry [^(18)F]FDG Platinum(IV)prodrug

基质辅助激光解吸电离-飞行时间质谱法快速测定米饭和乳制品中蜡样芽孢杆菌呕吐毒素Cereulide

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食品科学 2024年第1期45卷 232-238页

作者：曾羲王宇徐巨才黄穗东王涓徐振林华南农业大学食品学院广东省食品质量安全重点实验室广东广州510642 广州市食品检验所广东广州511400 五邑大学生物科技与大健康学院江门市大健康国际创新研究院广东江门529020

建立基质辅助激光解吸电离-飞行时间质谱(matrix-assisted laser desorption ionization time-of-flight mass spectrometry,MALDI-TOF MS)法分析蜡样芽孢杆菌呕吐毒素Cereulide的快速检测方法。分析了Cereulide标准物质的裂解规律,考察基质种类、点靶方式、基质溶剂和用量、激光强度等对Cereulide的质谱信号强度的影响,并进行方法学验证和实际样品检测。结果表明,选择以α-氰基-4-羟基肉桂酸为基质,均匀分散在50%乙腈-水(含0.1%三氟乙酸)中,采用先点基质再点样品的点样方式,反射线性正离子模式下选择激光强度70%进行食品中MALDI-TOF MS筛查时,可检测到Cereulide的[M+Na]^(+)和[M+K]^(+)目标离子峰,此质谱信号稳定、强度高、响应重复性好。方法学验证结果表明,Cereulide的[M+Na]^(+)和[M+K]^(+)目标离子峰在5~100 ng/mL范围内线性好,相关系数(r)>0.99;方法的检出限分别为3.0 ng/g和5.0 ng/g;对米饭和牛乳样品的加标回收率为73.3%~118.2%,相对标准偏差为0.3%~10.9%(n=6)。本方法分析速度快、准确性高、灵敏度好、抗干扰能力强、无需内标即可实现对米饭和乳制品中Cereulide的批量筛查和检测。

关键词：基质辅助激光解吸-电离飞行时间质谱蜡样芽孢杆菌呕吐毒素 α-氰基-4-羟基肉桂酸

NOSES联合ERAS与常规腹腔镜手术治疗直肠癌的临床疗效对比

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解放军医学杂志 2024年第1期49卷 31-36页

作者：宋枫高峰徐明高健毛增喜解放军联勤保障部队第940医院结直肠肛门外科甘肃兰州730050 解放军联勤保障部队第944医院结直肠肛门外科甘肃酒泉753000

目的比较经自然腔道取标本手术(NOSES)联合快速康复外科(ERAS)与常规腹腔镜手术治疗直肠癌患者的临床疗效。方法选取2019年1月-2021年12月于解放军联勤保障部队第940医院结直肠肛门外科确诊的100例直肠癌患者为研究对象,其中49例行NOSE... 详细信息

目的比较经自然腔道取标本手术(NOSES)联合快速康复外科(ERAS)与常规腹腔镜手术治疗直肠癌患者的临床疗效。方法选取2019年1月-2021年12月于解放军联勤保障部队第940医院结直肠肛门外科确诊的100例直肠癌患者为研究对象,其中49例行NOSES联合ERAS治疗(设为观察组),51例行常规腹腔镜直肠癌根治术治疗(设为对照组)。比较两组术后C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、白细胞计数(WBC)、中性粒细胞百分比(NEUT)、K+浓度,术后肠蠕动恢复时间、首次离床活动时间、首次进流食时间、拔除尿管和引流管时间、住院时间,以及术中出血量、淋巴结检出数目、切缘阳性率、并发症发生率、疼痛评分等临床指标。结果观察组术后CRP、PCT、IL-6水平均明显低于对照组(P0.05)。观察组术后肠蠕动恢复时间、首次离床活动时间、首次进流食时间、拔除尿管及引流管时间、住院时间等均短于对照组,手术时间长于对照组,差异有统计学意义(P0.05)。两组并发症发生率比较差异无统计学意义(4.1%vs.7.8%,P>0.05);观察组术后第1、2、3天的疼痛评分均明显低于对照组(P<0.05)。结论NOSES联合ERAS治疗直肠癌,可缩小手术切口,减轻应激反应及术后疼痛,安全可行,有利于提高疗效,降低并发症发生率,值得推广应用。

关键词：直肠癌经自然腔道取标本手术快速康复外科腹腔镜外科手术