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Prognostic value of number of examined lymph nodes in patients with node-negative gastric cancer

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World Journal of Gastroenterology 2014年第13期20卷 3640-3648页

作者： Xu-Guang Jiao Jing-Yu Deng Ru-Peng Zhang Liang-Liang Wu Li Wang Hong-Gen Liu xi-shan hao Han Liang Key Laboratory of Cancer Prevention and Therapy Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer

AIM: To elucidate the potential impact of examined lymph nodes (eLNs) on long-term survival of node-negative gastric cancer patients after curative surgery.

关键词： Gastric carcinoma Examined lymph nodes Node-negative Prognosis

Change in expression of apoptosis genes after hyperthermia,chemotherapy and radiotherapy in human colon cancer transplanted into nude mice

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World Journal of Gastroenterology 2007年第32期13卷 4365-4371页

作者： Han Liang Hong-Jie Zhan Bao-Gui Wang Yuan Pan xi-shan hao Department of Gastrointestinal Oncological Surgery Tianjin Cancer Hospital Tianjin Medical University Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China

AIM:To investigate the change in expression of p53 ,Bcl-2 ,and Bax genes in human colon cancer cells transplanted into nude mice after hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy and thermochemoradiotherapy. METHODS:Human colon cancer cell line (HT29) was transplanted into the hind limbs of nude mice. Under laboratory simulated conditions of hyperthermia (43℃,60 min),the actual radiation doses and doses of mitomycin C (MMC) were calculated in reference to the clinical radiotherapy for human rectal cancer and chemotherapy prescription for colon cancer. The mice were divided into 6 groups according to the treatment approaches:hyperthermia,chemotherapy,radiotherapy,thermochemotherapy,thermoradiotherapy,and thermochemoradiotherapy. The mice were sacrificed at different time points and the tumor tissue was taken for further procedures. The morphologic changes in membrane,cytoplasm and nuclei of tumor cells of p53,Bcl-2,and Bax after treatment,were observed by immunohistochemistry staining. RESULTS:All of the six treatment modalities down-regulated the expression of p53,Bcl-2 and up-regulated the expression of Bax at different levels. The combined therapy of hyperthermia,with chemotherapy,and/or irradiation showed a greater effect on down-regulating the expression of p53 (0.208 ± 0.009 vs 0.155 ± 0.0115,P < 0.01) and Bcl-2 (0.086 ± 0.010 vs 0.026 ± 0.0170,P < 0.01) and up-regulating Bax expression (0.091 ± 0.0013 vs 0.207 ± 0.027,P < 0.01) compared with any single ***:Hyperthermia enhances the effect of radio-and chemotherapy on tumors by changing the expression of apoptosis genes,such as p53,Bcl-2 and Bax.

关键词： Hyperthermia Apoptosis p53 Bcl-2 Bax Nude mice Colon cancer Cell line

Inhibitory effect of antisense vascular endothelial growth factor RNA on the profile of hepatocellular carcinoma cell line in vitro and in vivo

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World Journal of Gastroenterology 2006年第7期12卷 1140-1143页

作者： Ji-Hui hao Ming Yu Hui-Kai Li Yu-Rong Shi Qiang Li xi-shan hao Department of Abdominal Surgery Tianjin Cancer Hospital Tianjin 300060 China Public Health College Tianjin Medical UniversityTianjin 300070 China

AIM： To evaluate the effect of antisense vascular endothelial growth factor （VEGF） RNA （PCMV-FGEV） transfection on the profile of hepatocellular carcinoma （HCC） SMMC-7721 cells in vitro and in vivo.METHODS： SMMC-7721 cells were transfected with PCMV-FGEV antisense, PCMV-VEGF sense and empty vector plasmid encapsulated by lipofectamine as antisense group, sense group and control group respectively. The positive cell clones were selected with G418. The stable transfection and expression of VEGF in the cells were determined by RT-PCR and immunohistochemistry. Cell proliferation was observed by Mnassay. FACS analysis was used to determine the effect of PCMV-FGEV transfection on cell apoptosis. The growth of transfected cells in vivo was also observed in nude mice.RESULTS： VEGF expression was reduced in SMMC-7721 transfected with PCMV-FGEV, which was confirmed by RT-PCR and immunohistochemistry. No effect of PCMV- FGEV transfection was found on cell proliferation and cell apoptosis of SMMC-7721 in vitro. The growth of cells transfected with PCMV-FGEV was slow in nude mice and accompanied with obvious apoptosis. The latent time of tumors in the antisense group was 25.0 ：l： 1.8 d, which was longer than that in sense and control groups （F= 19.455, P〈 0.01）. The average tumor weight in antisense group （0.96 g±0.28 g） was the smallest among the three groups （F= 21.501, P〈 0.01）.CONCLUSION： The expression of VEGF can be inhibited by antisense PCMV-FGEV. Antisense PCMV-FGEV has no effect on cell proliferation and apoptosis of SMMC-7721 in vitro but can inhibit tumor growth and induce cell apoptosis in vivo.

关键词： Antisense RNA Vascular endothelial growth factor Gene expression Hepatocellular carcinoma Transfection

Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma： Hints to Identify the Normal B-cell Counterpart

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Clinical oncology and cancer researeh 2011年第2期8卷 65-70页

作者： Hui-lai ZHANG Hua-qing WANG xi-shan hao Daniela Capello Sergio B. Cogliatti Francesco Bertoni Franco Cavalli Laboratory of Experimental Oncology Oncology Institute of Southern Switzerland(IOSI) Bellinzona Switzerland Department of Lymphoma Tianjin MedicalUniversity Cancer Hospital and Institute KeyLaboratory of Cancer Prevention andTherapy Tianjin 300060 China Division of Hematology Department ofClinical and Experimental Medicine &Centro Interdisciplinare di Biotecnologieper la Ricerca Medica Applicata "AmedeoAvogadro" University of Eastern PiedmontNovara Italy Department of Pathology State HospitalSt.Gallen Switzerland

Mantle cell lymphoma （MCL） is an aggressive nonHodgkin＇s lymphoma, originating from naive B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain （IgH） genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.

关键词： mantle cell lymphoma immunoglobulin genes somatic hypermutation.

Cancer Biology & Medicine Index in PubMed/SCIE

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Cancer Biology & Medicine 2018年第4期 320-320页

作者： xi-shan hao Chinese Academy of Engineering Cancer Biology & Medicine Tianjin Cancer Institude National Clinical Research Center for Cancer

Dear colleague, Cancer Biology & Medicine(CBM) (ISSN 2095-3941) is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA). Published quarterly, the journal mainly focused on translat...

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Cancer Biology & Medicine

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Cancer Biology & Medicine 2019年第1期 205-205页

作者： xi-shan hao Chinese Academy of Engineering Tianjin Cancer Institute National Clinical Research Center for Cancer

Indexed in PubMed/SCIE IF:4.607Dear colleague,Cancer Biology&Medicine (CBM)(ISSN 2095-3941) is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA). Published quarterly, the journal mainly focuses on translational cancer research, dedicating to narrowing the gap between bench and *** adhering to guidelines of the International Committee of Medical

关键词： Cancer Biology Medicine

Cancer Biology & Medicine

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Cancer Biology & Medicine 2018年第3期 186-186页

作者： xi-shan hao Chinese Academy of Engineering Cancer Biology & Medicine Tianjin Cancer Institute National Clinical Research Center for Cancer

Indexed in PubMed/SCIE IF:4.607 Dear colleague,Cancer Biology&Medicine(CBM)(ISSN 2095-3941)is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA).Published quarterly,the journal mainly focuses on translational cancer research,dedicating to narrowing the gap between bench and bedside.

关键词：

Cancer Biology & Medicine

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Cancer Biology & Medicine 2018年第S1期15卷 4-4页

作者： xi-shan hao Chinese Academy of Engineering Tianjin Cancer Institute National Clinical Research Center for Cance

Indexed in PubMed/SCIE IF:4.607 Dear colleague,Cancer Biology&Medicine(CBM)(ISSN 2095-3941)is a peer-reviewed open-access journal sponsored by the China Anti-Cancer Association(CACA).Published quarterly,the journal mainly focuses on translational cancer research,dedicating to narrowing the gap between bench and bedside.

关键词： Cancer Biology Medicine

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CBM is indexed in SCIE

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Cancer Biology & Medicine 2017年第2期 102-102页

作者： xi-shan hao Chinese Anti-Cancer Association Tianjin Cancer Institute National Clinical Research Center for Cancer Union for International Cancer Control (UICC)

Dear colleague,As the editor-in-chief,I would like to declare the good news that Cancer Biology&Medicine(CBM)has been indexed in Science Citation Index Expanded(SCIE)and will get an impact factor *** the official journal of the Chinese Anti-Cancer Association(CACA)which possesses more than 40,000 members,CBM holds a large audience both in China and *** journal mainly focuses on translational cancer research,dedicating to narrowing

关键词： CBM is indexed in SCIE SCIE