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Myotis bat STING attenuates aging-related inflammation in female mice

Zoological Research 2024年第5期45卷 961-971页

作者： xi Wang Jing-kun Jia Qi Wang Jing-Wen Gong Ang Li Jia Su Peng zhou Wuhan Institute of Virology Chinese Academy of SciencesWuhanHubei 430071China Guangzhou National Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China University of Chinese Academy of Sciences Beijing 100000China State Key Laboratory of Respiratory Disease First Affiliated Hospital of Guangzhou Medical SchoolGuangzhouGuangdong 510005China

Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 ***,the mechanisms underlying these distinctive traits remain incompletely *** our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced *** substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse *** monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging *** transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in *** results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent *** the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.

关键词： Bat STING Longevity Aging-related inflammation Virus reservoir host

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A chromosome-level genome assembly for Chinese plum‘Wushancuili'reveals the molecular basis of its fruit color and susceptibility to rain-cracking

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Horticultural Plant Journal 2024年第3期10卷 672-688页

作者： kun zhou Jingwen Wang Lin Pan Fang xiang Yi zhou Wei xiong Ming Zeng Donald Grierson Wenbin Kong Lingyu Hu Wanpeng xi College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqing 400715China Department of Pomology Chongqing Agricultural Technology Extension StationChongqing 401420China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughborough LE125RDUK Wuxi Economical Crop Technology Extension Station Chongqing 405800China

Chinese plum(Prunus salicina Lindl.)originates from China and makes a large contribution to the global production of *** ***‘Wushancuili'has a green coloration and high fruit quality and is economically important in eliminating poverty and protecting ecology in the Yangtze River Three Gorges ***,rain-induced cracking(rain-cracking,literally skin cracking caused by rain)is a limitation to‘Wushancuili'fruit production and causes severe *** study reported a high-quality‘Wushancuili'genome assembly consisting of a 302.17-Mb sequence with eight pseudo-chromosomes and a contig N50 of 23.59 Mb through the combination of Illumina sequencing,Pacific Biosciences HiFiⅢsequencing,and high-throughput chromosome conformation capture technology.A total of 25109 protein-coding genes are predicted and 54.17%of the genome is composed of repetitive sequences.‘Wushancuili'underwent a remarkable orthoselection during *** identification revealed that loss-of-function in four core MYB10 genes results in the anthocyanin deficiency and absence of red color,revealing the green coloration due to the residual high chlorophyll in fruit ***,the occurrence of cracking is assumed to be closely associated with cell wall modification and frequently rain-induced pathogen enrichment through transcriptomic *** loss of MYB10 genes might render fruit more susceptible to pathogen-mediated cracking by weakening the epidermal strength and reactive oxygen species(ROS)*** findings provided fundamental knowledge regarding fruit coloration and rain-cracking and will facilitate genetic improvement and cultivation management in Chinese plums.

关键词： Chinese plum Fruit coloration Fruit epidermis Genome MYB10 Rain-cracking

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Generalized Inverses and Units in a Unitary Ring

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1000-1014页

作者： Yu kun zhou Jian Long CHEN School of Mathematics Southeast UniversityNanjing 210096P.R.China

Let R be a unitary ring and a,b∈R with ab=*** find the 2/3 property of Drazin invertibility:if any two of a,b and a+b are Drazin invertible,then so is the third ***,we combine the 2/3 property of Drazin invertibility to characterize the existence of generalized inverses by means of *** applications,the need for two invertible morphisms used by You and Chen to characterize the group invertibility of a sum of morphisms is reduced to that for one invertible morphism,and the existence and expression of the inverse along a product of two regular elements are obtained,which generalizes the main result of Mary and Patricio(2016)about the group inverse of a product.

关键词： Leftπ-regular element stronglyπ-regular element group inverse Drazin inverse inverse along an element

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Noninvasive Diagnostic Technique for Nonalcoholic Fatty Liver Disease Based on Features of Tongue Images

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Chinese Journal of Integrative Medicine 2024年第3期30卷 203-212页

作者： WANG Rong-rui CHEN Jia-liang DUAN Shao-jie LU Ying-xi CHEN Ping zhou Yuan-chen YAO Shu-kun Graduate School of Beijing University of Chinese Medicine Beijing100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing100029China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Nanjing Linkwah Micro-electronics Institute Beijing100191China Institute of Microelectronics Tsinghua UniversityBeijing100084China Peking University China-Japan Friendship School of Clinical Medicine Beijing100029China

Objective:To investigate a new noninvasive diagnostic model for nonalcoholic fatty liver disease(NAFLD) based on features of tongue ***:Healthy controls and volunteers confirmed to have NAFLD by liver ultrasound were recruited from China-Japan Friendship Hospital between September 2018 and May 2019,then the anthropometric indexes and sampled tongue images were *** tongue images were labeled by features,based on a brief protocol,without knowing any other clinical data,after a series of corrections and data *** algorithm was trained on images using labels and several anthropometric indexes for inputs,utilizing machine learning ***,a logistic regression algorithm and a decision tree model were constructed as 2 diagnostic models for ***:A total of 720 subjects were enrolled in this study,including 432 patients with NAFLD and 288 healthy *** them,482 were randomly allocated into the training set and 238 into the validation *** diagnostic model based on logistic regression exhibited excellent performance:in validation set,it achieved an accuracy of 86.98%,sensitivity of 91.43%,and specificity of 80.61%;with an area under the curve(AUC) of 0.93 [95% confidence interval(CI) 0.68–0.98].The decision tree model achieved an accuracy of 81.09%,sensitivity of 91.43%,and specificity of 66.33%;with an AUC of 0.89(95% CI 0.66–0.92) in validation ***:The features of tongue images were associated with *** the 2 diagnostic models,which would be convenient,noninvasive,lightweight,rapid,and inexpensive technical references for early screening,can accurately distinguish NAFLD and are worth further study.

关键词： nonalcoholic fatty liver disease noninvasive diagnosis tongue image tongue diagnosis Chinese medicine machine learning

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Energy harvesting technology for AC overhead insulated transmission line based on electric field induction

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High Voltage 2024年第4期9卷 816-825页

作者： Le zhou Hongwei Liu kun Zuo Kuo Shang School of Electrical and Electronic Engineering North China Electric Power UniversityBeijingChina Electric Power Company of Sichuan Province Tianfu Power Supply Company ChengduSichuanChina Changde Power Supply Branch State Grid Hunan Electric Power Company LimitedChangdeHunanChina

To solve the problem of the energy harvesting(EEH)effect of the condition monitoring devices power supply on the transmission line is not *** authors designed three kinds of EEH schemes based on AC electric field induction,which can effectively improve the output power of load power *** EEH principle of each scheme was analysed in detail,and the influence factors such as the shape of outer energy harvester,capacitance compensation and impedance matching characteristics were ***,the experiment showed that 140.9 mW of power was obtained in direct-mode field EEH when the line voltage level was 10 *** high-potential field EEH mode obtained 4.1 mW of *** harvesting effect of the inner energy harvester with the same potential as the aluminium wire was obviously better,and 30.7 mW of power was ***,based on the third mode,when the load resistance was 2200Ω,the rectifier received 23.7 mW DC *** experimental results are in agreement with the theoretical analysis,which verifies the effectiveness of the electric field induction power supply technology.

关键词： field harvesting mode

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Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 29-40页

作者： xi Li Zhongyang Zhang Hua Shi Feifan zhou Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan University Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

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Quasi-shadowing for Z^(d)-actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： Juan PAN xian kun REN Yun Hua zhou School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorphism is non-uniformly partially hyperbolic if it preserves an ergodic measure with at least one zero Lyapunov *** prove that a C^(1)-smooth Z^(d)-action has the quasishadowing property if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly partially hyperbolic ergodic measure

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Macro-microscopic dynamic characteristics of the ballast bed induced by the variation of moisture content

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Particuology 2024年第7期90卷 118-127页

作者： Shuchen Wang Longlong Fu Yongjia Qiu Haonan xi Shunhua zhou Key Laboratory of Road and Traffic Engineering of the Ministry of Education Tongji UniversityShanghai 201804China Shanghai Key Laboratory of Rail Infrastructure Durability and System Safety Tongji UniversityShanghai 201804China

Due to the excellent drainage performance of the ballast,existing studies mainly focus on the dynamic response of ballast under field capacity or *** has rarely been paid to dynamic changes in moisture content and potential *** this article,we firstly conduct a model test to determine the variation of ballast moisture content under artificial *** that,a full-scale model test with cyclic loading is carried out to study the effect of moisture content variation on the macro-microscopic response of the ballast bed,where several wireless particle sensors are installed to obtain ballast motion characteristics at strategic *** results show that the moisture content increases gradually and stabilizes at a flat peak under rainfall,despite the excellent drainage performance of ballast *** halting rainfall,the moisture content drops back to field capacity,which indicates dynamic flowing surface water on ballast particles under *** flowing surface water brings changes to the original dynamic equilibrium of ballast bed:macroscopically,the deformation rate of stabilized ballast bed increases significantly,reaching a local peak under field capacity;microscopically,the x-and z-angular accelerations of the ballast show positive correlation with rainfall *** multiscale responses indicate that field capacity is a critical moisture content.

关键词： Railway ballast Flowing surface water Wireless particle sensor Multidimensional motion Full-scale model test

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An open access dataset for strong-motion data(PGA,PGV,and Site V_(S30))of 2023 M6.2 Jishishan,Gansu,China earthquake

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Earthquake Science 2024年第6期37卷 584-587页

作者： Jian zhou Li Li Nan xi kun Chen xin Tian Chao Wang Jifeng Tian Institute of Geophysics China Earthquake AdministrationBeijing 100081China China Earthquake Network Center Beijing 100045China

*** On December 18,2023,a M6.2 earthquake struck central China with epicenter at Jishishan,Gansu(35.70°N,102.79°E).In the USGS Latest Earthquake platform,the event was identified as M_(W)5.9,35.743°N,102.827°E,labeled 37 km WNW of Linxia Chengguanzhen,*** study presents an open-access dataset comprising PGA and PGV records of the main-shock from 202accelerometers and 539 Micro-Electro-Mechanical System(MEMS)sensors within two arcdegrees of the epicenter.

关键词： China. earthquake epicenter

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Influence of in situ formed spinel in bonding phase on mechanical properties and air permeability of magnesia-chrome porous purging materials

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Journal of Iron and Steel Research International 2024年第6期31卷 1459-1472页

作者： Yi An Hao Liu zhou-fu Wang Yan Ma xi-tang Wang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Magnesia-chrome porous purging plugs are crucial functional components to remove inclusions and stabilize the flow field during iron and steel ***,practical applications of magnesia-chrome porous purging materials are stil hampered by the poor scouring resistance to molten steel and unstable air permeability owing to their low mechanical properties and uncontrollable pore ***,the particle-packing type magnesiachrome porous purging materials reinforced by in situ formed spinel were prepared using fused magnesia-chrome particles and Al powders as major raw *** results show that in situ formed spinel solid solutions in bonding phase led to the decreased median pore size and increased pore surface fractal dimension from the reactions between Al powders and magnesia-chrome particles and along with high-temperature sintering,bonding between magnesia-chrome particles and the resultant mechanical properties of materials were greatly ***,the results of air permeability tests and polynomial ftting indicated that the formation of spinel solid solutions was the main contributing factor for controllable air permeability,and pressure drop of porous purging materials was positively correlated with surface fractal dimension of ***,the as-prepared porous purging materials added with 6 wt.%Al powders obtained the maximum cold crushing strength(54.2 MPa)and hot modulus of rupture(12.9 MPa)with median pore size of 24.06μm and ftting non-Darcian permeability coefficient of 0.97×10^(-6)m.

关键词： Magnesia Chrome porous purging material Metallic Al-Spinel Mechanical strength Air permeability

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