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GSTM1 and XRCC3 Polymorphisms:Effects on Levels of Aflatoxin B1-DNA Adducts

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Chinese Journal of Cancer Research 2009年第3期21卷 177-184页

作者： xi-dai long Yun Ma Zhou-lin Deng Department of Pathology Youjiang Medical College for Nationalities Baise 533000 China Department of Pathology Guangxi Medical University Nanning 530021 China

Objective： Aflatoxin B1 （AFB1）, which can cause the formation of AFB1-DNA adducts, is a known human carcinogen. AFB1-exposure individuals with inherited susceptible carcinogen-metabolizing or repairing genotypes may experience an increased risk of genotoxicity. This study was designed to investigate whether the polymorphisms of two genes, the metabolic gene Glutathione S-transferase M1 （GSTM1） and DNA repair gene x-ray repair cross-complementing group 3 （XRCC3）, can affect the levels of AFB1-DNA adducts in Guangxi Population （n= 966） from an AFB1-exposure area. Methods： AFB1-DNA adducts were measured by ELISA, and GSTM1 and XRCC3 codon 241 genotypes were identified by PCR-RFLP. Results： The GSTM1-null genotype [adjusted odds ratio （OR） = 2.09; 95% confidence interval （CI） = 1.61-2.71] and XRCC3 genotypes with 241 Met alleles [i.e., XRCC3-TM and -MM, adjusted ORs （95% CI） were 1.43 （1.08-1.89） and 2.42 （1.13-5.22）, respectively] were significantly associated with higher levels of AFB1-DNA adducts. Compared with those individuals who did not express any putative risk genotypes as reference （OR = 1）, individuals featuring all of the putative risk genotypes did experience a significantly higher DNA-adduct levels （adjusted ORs were 2.87 for GSTM1-null and XRCC3-TM; 5.83 for GSTM1-null and XRCC3-MM）. Additionally, there was a positive joint effect between XRCC3 genotypes and long-term AFB1 exposure in the formation of AFB1-DNA adducts. Conclusion： These results suggest that individuals with susceptible genotypes GSTM1-null, XRCC3-TM, or XRCC3-MM may experience an increased risk of DNA damage elicited by AFB1 exposure.

关键词： Aflatoxin B1 (AFB1) AFB1-DNA adducts GSTM1 XRCC3 Polymorphism

Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma

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World Journal of Hepatology 2024年第8期16卷 1131-1144页

作者： Qiu-Ju Liang Qin-Qin long Feng-Qin Tian Qun-Ying Su xiao-Ying Zhu xi-dai long Clinicopathological Diagnosis and Research Center The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Tumor Pathology Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education InstitutesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The dysregulation of tissue inhibitor of metalloproteinase-3(TIMP3)was positively correlated with the progression of hepatocellular carcinoma(HCC).However,it is not clear whether TIMP3 expression is associated with the clinico-pathological features and prognosis of aflatoxin B1(AFB1)-related HCC(AHCC).A retrospective study,including 182 patients with AHCC,was conducted to explore the link between TIMP3 expression in cancerous tissues and the clinico-pathological characteristics and prognosis of ***3 expression was detected by immunohistochemistry and its effects on the clinicopathological features and prognosis of AHCC were evaluated by Kaplan-Meier survival analysis and Cox regression survival *** ratio,hazard ratio(HR),median overall survival time(MST),median tumor recurrence-free survival time(MRT),and corresponding 95%confidential interval(CI)was calculated to RESULTS Kaplan-Meier survival analysis showed that compared with high TIMP3 expression,low TIMP3 expression in tumor tissues significantly decreased the MST(36.00 mo vs 18.00 mo)and MRT(32.00 mo vs 16 mo)of patients with *** Cox regression survival analysis further proved that decreased expression of TIMP3 increased the risk of death(HR=2.85,95%CI:2.04-4.00)and tumor recurrence(HR=2.26,95%CI:1.57-3.26).Furthermore,decreased expression of TIMP3 protein in tissues with AHCC was significantly correlated with tumor clinicopatho-logical features,such as tumor size,tumor grade and stage,tumor microvessel density,and tumor blood ***,TIMP3 protein expression was also negatively associated with amount of AFB1-DNA adducts in tumor *** These findings indicate that the dysregulation of TIMP3 expression is related to AHCC biological behaviors and affects tumor outcome,suggesting that TIMP3 may act as a prognostic biomarker for AHCC.

关键词： Tissue inhibitor of metalloproteinase-3 expression Aflatoxin B1 Hepatocellular carcinoma Clinicopathological feature Prognosis

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肝细胞癌糖原代谢重编程的研究进展

世界华人消化杂志 2016年第22期24卷 3391-3397页

作者：卢君夏强龙喜带上海交通大学医学院附属仁济医院肝脏外科上海市200127

肝细胞癌(hepatocellular carcinoma,HCC)是一种高发恶性肿瘤,糖原代谢则是肝脏内重要的代谢过程,其涉及的多种酶和蛋白在HCC发生过程中可发生结构、功能及表达水平的改变实现代谢重编程,进而调控整个糖原代谢网络使其适合HCC生长.本文... 详细信息

肝细胞癌(hepatocellular carcinoma,HCC)是一种高发恶性肿瘤,糖原代谢则是肝脏内重要的代谢过程,其涉及的多种酶和蛋白在HCC发生过程中可发生结构、功能及表达水平的改变实现代谢重编程,进而调控整个糖原代谢网络使其适合HCC生长.本文主要总结葡萄糖转运体、糖原合成酶激酶3β、糖原磷酸化酶等糖原代谢调控因子,近年来在糖原代谢重编程方面的研究进展.

关键词：肝细胞癌糖原代谢重编程葡萄糖转运体糖原合成酶激酶3β 糖原磷酸化酶

月氏(Yuèzhī)乎?月氏(Ròuzhī)乎?——浅论语言的微观变化

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湖南大学学报（社会科学版） 2006年第6期20卷 101-108页

作者：戴希龙湖南大学外国语学院湖南长沙410082

语言变化规律常常呈现出无序—有序—无序这样的变化发展过程。语言的无序状态是绝对的,而有序则是相对的。这种无序与有序状态构成社会语言系统的“内稳态”。无序和有序是社会语言的非规范和规范的语言现象长期磨合,相互依存的变化过... 详细信息

语言变化规律常常呈现出无序—有序—无序这样的变化发展过程。语言的无序状态是绝对的,而有序则是相对的。这种无序与有序状态构成社会语言系统的“内稳态”。无序和有序是社会语言的非规范和规范的语言现象长期磨合,相互依存的变化过程。这个过程时间有长有短,其中还有地域的差别,过程的结果是语言词汇发生了变异,词汇的发音也起了变化。本文试图通过对“大月氏”词汇的微观音变的个案考察,揭示语言在社会生活中的微观变化。

关键词：月氏西域变化

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PLK1在肝细胞癌中的研究进展

世界华人消化杂志 2024年第9期32卷 652-659页

作者：梁秋菊龙勤琴田丰琴龙喜带右江民族医学院附属医院临床病理诊断与研究中心广西壮族自治区百色市533000 右江民族医学院研究生学院广西壮族自治区百色市533000 广西高校肿瘤分子病理学重点实验室广西壮族自治区百色市533000

Polo样激酶1(polo-like kinase 1,PLK1)是一种调节细胞周期的蛋白激酶,研究发现PLK1能介导调控与肝细胞癌(hepatocellular carcainoma,HCC)发生发展相关的信号通路,从而影响肝肿瘤细胞的增殖、迁移和侵袭等生物学行为.因此,PLK1可能是治... 详细信息

Polo样激酶1(polo-like kinase 1,PLK1)是一种调节细胞周期的蛋白激酶,研究发现PLK1能介导调控与肝细胞癌(hepatocellular carcainoma,HCC)发生发展相关的信号通路,从而影响肝肿瘤细胞的增殖、迁移和侵袭等生物学行为.因此,PLK1可能是治疗HCC的一个非常有潜力的靶点,该文就PLK1在HCC发生中的相关信号通路与PLK1抑制剂在治疗HCC方面进行综述.

关键词：肝细胞癌 PLK1 信号通路 PLK1抑制剂

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工频有芯铸铁保温炉炉衬损毁原因分析及改进

铸造 2008年第5期57卷 518-520页

作者：邓少霞代西龙薛群虎皖西学院基础实验中心安徽六安237012 西安建筑科技大学材料学院省部共建西部建筑技术重点实验室培育基地陕西西安710055

对工频有芯铸铁保温炉炉衬的使用条件、损毁原因及存在问题进行了分析。提出了改进炉衬的措施:降低水泥用量,改变颗粒级配,改进浇注料基质,使用活性氧化铝粉和高效减水剂。通过改进,新炉衬使球铁炉和灰铁炉的使用寿命提高1个月以上,通... 详细信息

对工频有芯铸铁保温炉炉衬的使用条件、损毁原因及存在问题进行了分析。提出了改进炉衬的措施:降低水泥用量,改变颗粒级配,改进浇注料基质,使用活性氧化铝粉和高效减水剂。通过改进,新炉衬使球铁炉和灰铁炉的使用寿命提高1个月以上,通铁量提高8%～10%。

关键词：保温炉炉衬使用寿命通铁量

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无芯感应电炉用耐火胶泥的配制及应用

铸造 2006年第5期55卷 528-529页

作者：代西龙王臻白宏光高云琴西安秦翔科技有限责任公司陕西西安710075

研究了耐火胶泥原料组成和颗粒级配,对其施工、养护和烘烤进行了阐述,并在1.5t无芯感应电炉上进行了应用,获得了满意的使用效果。

关键词：耐火胶泥无芯感应电炉

Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu xiaoxi dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao Yu-Jiao Gao xi Wang Li-Hong Guo Su Zheng Wu Yang Yi-Nan dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics