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Cyanidin-3-glucoside protects the photooxidative damage of retinal pigment epithelium cells by regulating sphingolipid signaling and inhibiting MAPK pathway

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Food Science and Human Wellness 2024年第2期13卷 621-632页

作者： Tingting Liu Wentao Qi Wenting Peng Jianan Zhang Yong wang School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Academy of National Food and Strategic Reserves Administration Beijing 100037China Department of Chemistry University of North Carolina at Chapel HillChapel HillNC 27599USA

Cyanidin-3-glucoside(C3G)is the most common anthocyanin in dark grains and berries and is a food functional factor to improve visual ***,the mechanisms of C3G on blue light-induced retinal pigment epithelial(RPE)cell photooxidative damage needs further *** investigated the effects of C3G on blue light-irradiated A2E-containing RPE cells and explored whether sphingolipid,mitogen-activated protein kinase(MAPK),and mitochondria-mediated pathways are involved in this *** light irradiation led to mitochondria and lysosome damage in RPE cells,whereas C3G preserved mitochondrial morphology and function and maintained the lysosomal integrity.C3G suppressed the phosphorylation of JNK and p38 MAPK and mitochondria-mediated pathways to inhibit RPE cell *** data showed that C3G protected RPE cells against blue light-induced lipid peroxidation and apoptosis by maintaining sphingolipids balance.C3G significantly inhibited ceramide(Cer d18:0/15:0,Cer d18:0/16:0 and Cer d18:0/18:0)accumulation and elevated galactosylceramide(GalCer d18:1/15:0 and GalCer d18:1/16:0)levels in the irradiated A2E-containing RPE ***,C3G attenuated cell membrane damage by increasing phosphatidylcholine and phosphatidylserine levels.C3G inhibited apoptosis and preserved the structure of mitochondria and lysosome by regulating sphingolipid signaling and suppression of MAPK activation in RPE ***,dietary supplementation of C3G prevents retinal photooxidative damage.

关键词： Cyanidin-3-glucoside Ceramide MAPK pathway Mitochondria-dependent apoptosis Lipidomics analysis

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小胶质细胞在糖尿病视网膜病变视网膜神经血管单元中的作用

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国际眼科杂志 2024年第5期24卷 731-736页

作者：陈志王子佩李红遵义医科大学贵州省遵义市563003 遵义医科大学附属医院眼科、贵州省眼科医院贵州省遵义市563003 国家眼病临床研究中心贵州省分中心、贵州省眼疾病特色重点实验室贵州省遵义市563003

糖尿病视网膜病变(DR)是工作年龄人群主要致盲眼病,血-视网膜屏障破坏是关键环节。近年研究显示,DR不再是单纯微血管病变,而是视网膜胶质细胞与神经退行性变、微血管病变的共同发展结果。DR病程早期视网膜神经血管单元(RNVU)中神经元的... 详细信息

糖尿病视网膜病变(DR)是工作年龄人群主要致盲眼病,血-视网膜屏障破坏是关键环节。近年研究显示,DR不再是单纯微血管病变,而是视网膜胶质细胞与神经退行性变、微血管病变的共同发展结果。DR病程早期视网膜神经血管单元(RNVU)中神经元的损伤可能早于血管内皮的变化,胶质细胞的激活加重血管屏障功能障碍。视网膜小胶质细胞是常驻视网膜的局部免疫细胞,参与长期高糖诱导的慢性炎症反应、高糖诱导其分泌多种炎症因子,破坏血-视网膜屏障结构、增加神经元凋亡、改变Müller细胞胶质化等,影响视网膜局部稳态平衡。RNVU作为一个单元结构研究,近年来受到越来越多的关注,本文将针对小胶质细胞在RNVU中的作用机制、研究进展进行综述。

关键词：小胶质细胞视网膜神经血管单元糖尿病视网膜病变炎症综述

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ATSSC:An Attack Tolerant System in Serverless Computing

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China Communications 2024年第6期21卷 192-205页

作者： Zhang Shuai Guo Yunfei Hu hongchao Liu Wenyan wang Yawen Information Engineering University Zhengzhou 450002China

Serverless computing is a promising paradigm in cloud computing that greatly simplifies cloud *** serverless computing,developers only provide function code to serverless platform,and these functions are invoked by its driven ***,security threats in serverless computing such as vulnerability-based security threats have become the pain point hindering its wide *** ideas in proactive defense such as redundancy,diversity and dynamic provide promising approaches to protect against ***,these security technologies are mostly applied to serverless platform based on“stacked”mode,as they are designed independent with serverless *** lack of security consideration in the initial design makes it especially challenging to achieve the all life cycle protection for serverless application with limited *** this paper,we present ATSSC,a proactive defense enabled attack tolerant serverless *** integrates the characteristic of redundancy,diversity and dynamic into serverless seamless to achieve high-level security and ***,ATSSC constructs multiple diverse function replicas to process the driven events and performs cross-validation to verify the *** order to create diverse function replicas,both software diversity and environment diversity are ***,a dynamic function refresh strategy is proposed to keep the clean state of serverless *** implement ATSSC based on Kubernetes and *** and experimental results demonstrate that ATSSC can effectively protect serverless computing against cyberattacks with acceptable costs.

关键词： active defense attack tolerant cloud computing security serverless computing

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Unstable evolution of railway slope under the rainfall-vibration joint action

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Journal of Mountain Science 2024年第4期21卷 1419-1431页

作者： DONG Haoyu wang Jiading ZHANG Dengfei LI Lin XU Yuanjun State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China

Understanding the unstable evolution of railway slopes is the premise for preventing slope failure and ensuring the safe operation of ***,as two major factors affecting the stability of railway slopes,few scholars have explored the unstable evolution of railway slopes under the joint action of *** on the model test of sandy soil slope,the unstable evolution process of slope under locomotive vibration,rainfall,and rainfall-vibration joint action conditions was simulated in this *** comparing and analyzing the variation trends of soil pressure and water content of slope under these conditions,the change laws of pore pressure under the influence of vibration and rainfall were *** main control factors affecting the stability of slope structure under the joint action conditions were further *** with the slope failure phenomena under these three conditions,the causes of slope instability resulting from each leading factor were ***,according to the above conclusions,the unstable evolution of the slope under the rainfall-vibration joint action was *** test results show that the unstable evolution process of sandy soil slope,under the rainfall-vibration joint action,can be divided into:rainfall erosion cracking,vibration promotion penetrating,and slope instability sliding three *** the process of slope unstable evolution,rainfall and vibration play the roles of inducing and promoting slide *** addition,the deep cracks,which are the premise for the formation of the sliding surface,and the violent irregular fluctuation of soil pressure,which reflects the near penetration of the sliding surface,constitute the instability characteristics of the railway slope *** paper reveals the unstable evolution of sandy soil slopes under the joint action of rainfall-vibration,hoping to provide the theoretical basis for the early warning and prevention technology of railway slopes.

关键词： Rainfall vibration joint action Small scale model tests Unstable evolution process Unstable characteristics Inducing sliding and promoting sliding

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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 557-567页

作者： Sheng ZENG Shaoqiang xiNG Yifei ZHANG Haifeng wang Qian LIU Department of Urology Tianjin First Central HospitalTianjin 300192China Department of Urology First Central Clinical CollegeTianjin Medical UniversityTianjin 300192China

Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery,radiotherapy,and chemotherapy,with some promising *** aims to kill tumor cells by mobilizing or stimulating cytotoxic immune ***,the clinical applications of tumor immunotherapies are limited owing to a lack of adequate delivery pathways and high ***,nanomaterials and genetic engineering have shown great potential in overcoming these limitations by protecting the delivery of antigens,activating targeted T cells,modulating the immunosuppressive tumor microenvironment,and improving the treatment *** Calmette-Gué;rin(BCG)is a live attenuated Mycobacterium bovis vaccine used to prevent tuberculosis,which was first reported to have antitumor activity in *** therapy can activate the immune system by inducing various cytokines and chemokines,and its specific immune and inflammatory responses exert antitumor *** was first used during the 1970s as an intravesical treatment agent for bladder cancer,which effectively improved immune antitumor activity and prevented tumor *** recently,nano-BCG and genetically engineered BCG have been proposed as treatment alternatives for bladder cancer due to their ability to induce stronger and more stable immune *** this study,we outline the development of nano-BCG and genetically engineered BCG for bladder cancer immunotherapy and review their potential and associated challenges.

关键词： Bladder cancer Bacillus Calmette-Gué rin vaccine Nanocarrier Genetic engineering Immunotherapy

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Engineered stem cells by emerging biomedical stratagems

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Science Bulletin 2024年第2期69卷 248-279页

作者： Jinglin wang xiaoxuan Zhang Hanxu Chen Haozhen Ren Min Zhou Yuanjin Zhao Department of Vascular Surgery.Nanjing Drum Tower Hospital Affliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Division of Hepatobiliary Surgery and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518038China

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable *** the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical *** the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are *** optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell *** review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future *** begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical ***,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

关键词： Stem cells Genetic modification Biomaterials Microfluidics Organ-on-a-chip Bioprinting

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Genesis and Accumulation of Paleo-Oil Reservoir in Dabei Area,Kuqa Depression,Northwest China:Implications for Tight-Gas Accumulation

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Journal of Earth Science 2024年第2期35卷 655-665页

作者： Fujie Jiang xiao Chen Pengwei wang xinghe Shao Haijun Yang State Energy Center for Shale Oil Research and Development Beijing102206China National Key Laboratory of Oil and Gas Resources and Engineering Beijing102249China College of Geosciences China University of PetroleumBeijing102249China CNOOC International Ltd. Beijing100027China Research Institute of Petroleum Exploration&Production SINOPECBeijing100083China Research Institute of Petroleum Exploration and Development Tarim OilfieldPetroChinaKorla841000China

Paleo-oil reservoir is of great importance to understand hydrocarbon enrichment mechanism and hydrocarbon exploration potential,but is yet poorly investigated in Kuqa *** occurrence of the paleo-oil reservoir in Dabei area was proved by quantitative grain fluorescence(QGF)and fluid inclusion *** history of the paleo-oil reservoir was reconstructed through:(1)oil-source correlation;(2)time coupling of source rock maturation,porosity evolution and migration *** impact of paleo-oil reservoir on tight-gas accumulation was consequently *** suggest that considerable oil was accumulated in the K_(1)bs reservoir with paleo oil-water contact in Dabei 2 Well and Dabei 201 Well at 5800 and 6040 m,*** oil was primarily sourced from Triassic source rocks with Jurassic source rocks of secondary importance,which was at oil generation window(0.7%–1.1%Ro)during 9–6 and 7.5–5 Ma,*** occurrence of K_(1)bs tight reservoir(porosityximately from 8 to 3.5 ***,the tight oil accumulation was formed during 8–5 *** paleo-oil reservoir in Dabei 1 gas field was destroyed by the evaporation fractionation in later stage.

关键词： Paleo-oil reservoir Dabei area Kuqa Depression Northwest China petroleum geology

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Progressive fragmentation of granular assemblies within rockslides: Insights from discrete-continuous numerical modeling

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Journal of Mountain Science 2024年第4期21卷 1174-1189页

作者： JIANG Hui ZHOU Yuande wang Jinting DU xiuli HUANG Hailong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China. Key Laboratory of the Hydrosphere Sciences of the Ministry of Water Resources Tsinghua UniversityBeijing 100084China China Three Gorges Construction Management Co. Ltd.Chengdu 610000China

Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during *** present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in *** rock granular assemblies are released along an inclined plane and flow onto a horizontal *** numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle *** evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is *** general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass *** process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing *** simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the *** propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock *** findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.

关键词： Rock fragmentation Rockslide Numerical modelling Discrete-continuous modelling Runout Cohesive zone model

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Formulation of international standards of Chinese medicine technology:clinical practice guide of Chinese medicine for cough

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Journal of Traditional Chinese Medicine 2024年第2期44卷 396-402页

作者： FANG Hanyu hong Zheng LI Deming ZHANG hongchun SHI Yihang LI xiaojuan SUN Zengtao CHEN Wei ZHANG Chuchu ZU Yaqi Beijing University of Chinese medicine Beijing 100029China Department of Traditional Chinese Medicine for Pulmonary Diseases Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029 National Center for Respiratory Medicine Beijing 100029China Department of Traditional Chinese Medicine for Pulmonary Diseases Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250China Center for Evidence-based Medicine Beijing University of Chinese MedicineBeijing 100029China Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To formulate the first clinical practice guideline for the treatment of cough using Chinese medicine based on the grading of recommendations assessment,development,and evaluation(GRADE)systematic approach,including clinical evidence,evaluation of ancient literature,and expert ***:In the process of development,the regulation of"evidence-based,consensus-assisted,and empirical"was followed,and a comprehensive systematic approach of recommendation assessment,GRADE,evidence-based evaluation,expert consensus,and the Delphi method was *** the process of guideline development,evidence-based evaluation of ancient literature was included for the first time,and clinical evidence was fully integrated with clinical expert ***:The clinical practice guidelines for the treatment of cough with Chinese herbal medicine were developed after a comprehensive consideration of evidence-based evaluation and expert *** guideline recommendations focused on recommending herbal compound decoctions and Chinese patent medicines for cough in different *** on the GRADE systematic approach,we conducted an evidence-based evaluation of the recommended Chinese patent medicines one by one;meanwhile,the expert consensus method was used to unify the recommendations of ***:Based on clinical evidence,ancient literature evaluation,and expert consensus,a clinical practice guideline for Traditional Chinese Medicine(TCM)in the treatment of cough was developed,providing the first current clinical practice guideline for domestic and foreign TCM and Western medicine practitioners,especially respiratory professionals at home and abroad.

关键词： Medicine Chinese Traditional clinical practice cough practice guide international standard

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Multi-Period Resilient Model for VSC-Based AC-DC HDS Considering Public-Safety Power Shutoff to Mitigate Wildfires

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 821-833页

作者： Zekai wang Tao Ding xiaosheng Zhang Chenggang Mu Pengwei Du Fangxing Li School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049China Electric Reliability Council of Texas AustinTX76574 USA Department of Electrical Engineering and Computer Science The University of TennesseeKnoxville(UTK)TN37996USA

This paper proposes a voltage source converter (VSC) -based AC-DC hybrid distribution system (HDS) resilient model to mitigate power outages caused by wildfires. Before a wildfire happens, the public-safety power shutoff (PSPS) strategy is applied to actively cut some vulnerable lines which may easily cause wildfires, and reinforce some lines that are connected to critical loads. To mitigate load shedding caused by active line disconnection in the PSPS strategy, network reconfiguration is applied before the wildfire occurrence. During the restoration period, repair crews (RCs) repair faulted lines, and network reconfiguration is also taken into consideration in the recovery strategy to pick up critical loads. Since there exists possible errors in the wildfire prediction, several different scenarios of wildfire occurrence have been taken into consideration, leading to the proposition of a stochastic multi-period resilient model for the VSC-based AC-DC HDS. To accelerate the computational performance, a progressive hedging algorithm has been applied to solve the stochastic model which can be written as a mixed-integer linear program. The proposed model is verified on a 106-bus AC-DC HDS under wildfire conditions, and the result shows the proposed model not only can improve the system resilience but also accelerate computational speed.

关键词： AC-DC hybrid distribution system restoration network reconfiguration progressive hedging public safety power shutoffs strategy resilience

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