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ANALYSIS OF CRACK-TIP SINGULARITIES FOR AN INTERFACIAL PERMEABLE CRACK IN METAL/PIEZOELECTRIC BIMATERIALS

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Acta Mechanica Solida Sinica 2007年第3期20卷 247-257页

作者： Li Qun Chen Yiheng~* (School of Aerospace,xi’an jiao-Tong University,xi’an 710049,China) School of Aerospace Xi''an Jiao-Tong University Xi''an 710049 China

By modeling metal as a special piezoelectric material with extremely small piezoelec- tricity and extremely large permittivity,we have obtained the analytical solutions for an interfacial permeable crack in metal/piezoelectric bimaterials by means of the generalized Stroh formalism. The analysis shows that the stress fields near a permeable interfacial crack tip are usually with three types of singularities:r;and r;.Further numerical calculation on the oscillatory indexεare given for 28 types of metal/piezoelectric bimaterials combined by seven commercial piezoelectric materials: PZT-4,BaTiO;,PZT-5H,PZT-6B,PZT-7A,P-7 and PZT-PIC 151 and four metals:copper,silver,lead and aluminum,*** explicit expressions of the crack tip energy release rate（ERR）and the crack tip generalized stress intensity factors（GSIF）are *** is found that both the ERR and GSIF are independent of the electric displacement loading,although they seriously depends on the mechanical loadings.

关键词： interfacial permeable crack metal/piezoelectric bimaterials energy release rate intensity factor

Clinical and radiological outcomes of dynamic cervical implant arthroplasty:A 5-year follow-up

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World Journal of Clinical Cases 2021年第16期9卷 3869-3879页

作者： Li Zou xin Rong xi-jiao Liu Hao Liu Department of Pediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Orthopedics West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Dynamic cervical implant(DCI)stabilization has been reported to have satisfactory clinical and radiological results with short-and mid-term follow-up in the treatment of cervical degenerative disc ***,few reports about the clinical and radiological outcome with more than 5-year follow-up *** To investigate the long-term clinical and radiological results of DCI *** A total of 40 patients who received DCI arthroplasty were consecutively reviewed from May 2010 to August *** analogue scale(VAS),neck disability index(NDI)score,Japanese Orthopaedic Association(JOA)score,and SF-36 items were used to assess neural function *** and dynamic radiographs and 3-dimentional computed tomography were used to evaluate the radiological *** The scores of neck/arm VAS,NDI,JOA,and 8-dimensions of SF-36 were significantly improved at the 1-mo follow-up(P0.05),except the ROM of FSU lateral bending(P0.05).At the last follow-up,12(26.1%)segments developed heterotopic *** DCI arthroplasty is a safe and effective non-fusion technique to treat cervical degenerative disc disease in long-term follow-up.

关键词： Dynamic cervical implant Cervical arthroplasty Cervical disc degeneration Clinical outcomes Radiological outcomes Range of motion

The Evaluation of Connection Coefficients on an Interval

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Communications in Nonlinear Science and Numerical Simulation 1998年第4期3卷 252-255页

作者： xiaolin ZHOU and Wu ZHANG(Department of Applied Mathematics, xi’an jiao Tong University, xi’an 710049, China) Department of Applied Mathematics Xi'an Jiaotong University Xi'an 710049 China

A connection coefficient is an interval of products of wavelet basis functions,their derivatives and their translates. It can be used to solve PDEs numerically by the wavelet- Galerkin method. This paper presents an e... 详细信息

关键词： connection coefficients wavelets

Predictive and prognostic value of serum AFP level and its dynamic changes in advanced gastric cancer patients with elevated serum AFP

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World Journal of Gastroenterology 2018年第2期24卷 266-273页

作者： Ya-Kun Wang Lin Shen xi jiao xiao-Tian Zhang Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research Peking University Cancer Hospital and Institute

AIM To investigate predictive and prognostic value of serum alpha-fetoprotein(AFP) level and its dynamic changes in patients with advanced gastric cancer with elevated serum AFP(AFPAGC).METHODS One hundred and five patients with AFPAGC were enrolled in the study, and all of them underwent at least one cycle of systemic chemotherapy at our institute and had serum AFP ≥ 20 ng/m L at diagnosis or recurrence. Clinicopathologic features, serum AFP level at diagnosis and changes during treatment, first-line chemotherapy regimens, efficacy and toxicity, and survival information were collected. A Person's χ~2 or Fisher's exact test was used to measure the differences between variables. Survival prognostic factors were investigated using the Kaplan-Meier method and Cox *** Median serum AFP level was 161.7 ng/m L(range, 22.9-2557110 ng/m L). Objective response rates(ORR) was significantly lower in the AFP ≥ 160 ng/m L group than in the AFP < 160 ng/m L group(30.4% vs 68.3%, P < 0.001). ORR to doublet regimens was significantly lower in the AFP ≥ 160 ng/m L group, whereas ORR to triplet regimens was similar between the two groups. Liver metastasis rate was significantly higher in the AFP ≥ 160 ng/m L group than in the AFP < 160 ng/m L(69.8% vs 50.0%, P < 0.001). Overall survival(OS) in the two cohorts did not show any significant difference(P = 0.712). Dynamic changes of AFP were consistent with response to chemotherapy, and median OS of patients with a serum AFP decline ≥ 50% and those with a serum AFP decline < 50% was 17.5 m and 10.0 m, respectively(P = 0.003). Hepatic(P = 0.005), peritoneal(P < 0.001), non-regional lymph node metastasis(P < 0.001), and portal vein tumor thrombus(PVTT)(P = 0.042) were identified as independent prognostic factors for AFPAGC. CONCLUSION Real-time examination of AFP has great predictive and prognostic value for managing AFPAGC. For those with markedly elevated AFP, triplet regimens may be a better choice.

关键词： Alpha-fetoprotein AFP-producing gastric cancer Predictive factor Prognostic factor Triplet regimen

Discussion　on　the　physics　phenomena　and　the　mechanism　of　forming　weld　joint　in　the　process　of　copper－stainless　steel　friction　welding

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China Welding 1995年第1期4卷 19-27页

作者： Shi Kai(xi’an Petroleum Institute)Wang Shiyan Qiu Fengxiang and xia Wei(xi’an jiao Tong University)

The physics phenomena of copper and stainless steel in the process of forming friction welding joint are recorded and observed by the interrupted test *** test shows that the butt friction welding process of copper and stainless steel bar can be divided into three stages approximately: the adhesion at the beginning friction stage, the friction inside the copper and the plastic ring expansion, and the friction on the bound surface of copper-stainless steel and in stainless steel. During the process,the friction surface was transformed twice.

关键词： copper-stainless steel friction welding interrupted test method

维普期刊数据库

Transonic flow of moist air around an NACA 0012 airfoil with non-equilibrium condensation

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Progress in Natural Science:Materials International 2005年第9期15卷 838-842页

作者： LI Liang**, SUN xiuling, FENG Zhenping and LI Guojun(School of Energy & Power Engineering, xi’an jiao Tong University, xi’an 710049, China) School of Energy & Power Engineering Xi'' an Jiao Tong University Xi'' an 710049 China

The classical condensation model of water vapor is coupled with the Euler equations to calculate transonic flows of moist air with non-equilibrium condensation. By means of this model, numerical computations are implemented to investigate the aerodynamic characteristics of an NACA 0012 airfoil in transonic flows of moist air at various angles of attack and relative humidities, and the results are compared with those in dry air flows. For different angles of attack considered at 50% relative humidity, the lift decreases 30%—40%. The pressure drag increases when the angle of attack is smaller than 1.4° and decreases when higher than 1.4°. At zero angle of attack, with the relative humidity rising from zero to 90%, the pressure drag increases exponentially. At 90% relative humidity, the pressure drag increases 160%, and self-oscillation takes place periodically and alternately over the upper and lower surfaces of the airfoil. The oscillation is caused by the interactions of local supersonic flow and heat release in the condensation process.

关键词： NACA 0012 airfoil moist air non-equilibrium condensation.

Highly Sensitive and Specific Monoclonal Antibody-Based Serological Methods for Rice Ragged Stunt Virus Detection in Rice Plants and Rice Brown Planthopper Vectors

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Journal of Integrative Agriculture 2014年第9期13卷 1943-1951页

作者： LIU Huan SONG xi-jiao NI Yue-qun LU Li-na ZHOU Xue-ping WU Jian-xiang Institute of Biotechnology College of Agriculture & Biotechnology Zhejiang University

Rice ragged stunt virus（RRSV） is a serious rice disease in Asia, causing serious yield losses on rice. The capsid protein（CP） gene of the major outer capsid protein of RRSV was expressed in Escherichia coli BL21（DE3） using the pMAL-C2 X expression vector. The recombinant protein was used as the immunogen to immunize BALB/c mice. A hybridoma cell line 8A12 secreting monoclonal antibody（MAb） against RRSV was obtained by fusing mouse myeloma cells（Sp 2/0） with spleen cells from the immunized BALB/c mice. Western blot analysis showed that the MAb 8A12 can specifically react with RRSV CP. Using the MAb, an antigen-coated-plate enzyme-linked immunosorbent assay（ACP-ELISA）, a dot enzyme-linked immunosorbent assay（dot-ELISA）, and immunocapture-RT-PCR（IC-RT-PCR） assay were developed to detect RRSV. The established ACP-ELISA, dot-blot ELISA and IC-RT-PCR methods could detect RRSV in infected rice tissue crude extracts with dilutions of 1：40 960, 1：1 280 and 1：655 360（w/v, g mL-1）, respectively. The ACP-ELISA and dot-blot ELISA methods could detect RRSV in infected insect vector crude extracts with dilutions of 1：12 800 and 1：1 600（an individual planthopper μL-1）, respectively. The field survey revealed that Rice ragged stunt disease occurs on rice in Hainan, Yunnan, Guangxi, Sichuan, Guizhou, Fujian, Hunan, Jiangxi and Zhejiang in China.

关键词： Rice ragged stunt virus rice brown planthopper monoclonal antibody antigen-coated-plate enzyme-linked immunosorbent assay(ACP-ELISA) dot-blot ELISA immunocapture RT-PCR

维普期刊数据库

Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers

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The Innovation 2020年第2期1卷 17-27页

作者： Zhihao Lu Zhi Peng Chang Liu Zhenghang Wang Yakun Wang xi jiao Jian Li Lin Shen Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteNo.52 FuCheng RoadHai-Dian DistrictBeijing100142China These authors contributed equally

Gastrointestinal(GI)cancers represent a major public health problem *** to the late detection and high heterogeneity of GI cancers,traditional treatments,including surgery,radiotherapy,chemotherapy,and targeted therapy,have shown limited effects,and the overall prognosis of these patients remains ***,immunotherapy,involving programmed cell death-1(PD-1)and its ligand(PD-L1),has shown promising efficacy in several solid cancers and seems to have become a potential treatment option for GI cancers This review focuses on data on the development of immunotherapy-based clinical trials in esophageal cancer,gastric cancer,and colorectal *** predictive biomarkers and combination strategies in clinical trials and translational medicine are also ***,prospects for immunotherapy in the treatment of GI cancers are *** only a small proportion of patients with GI cancers respond to PD-1/PD-L1 blockade,we strongly believe that precision immunotherapy might improve the overall survival of many more GI cancer patients in the future.

关键词： GASTROINTESTINAL CANCER IMMUNE CHECKPOINT BLOCKADE BIOMARKERS PRECISION IMMUNOTHERAPY

Structural and biochemical basis of FLS2-mediated signal activation and transduction in rice

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Plant Communications 2024年第3期5卷 216-231页

作者： Qiaoqiao Zhao Jinlin Bao Huailong Li Wei Hu Yanqiong Kong Yifeng Zhong Qiang Fu Guolyu Xu Fenmei Liu xi jiao Jian Jin Zhenhua Ming State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi Key Laboratory for Sugarcane BiologyGuangxi UniversityNanning 530004P.R.China

The receptor-like kinase FLAGELLIN-SENSITIVE 2(FLS2)functions as a bacterialflagellin receptor local-ized on the cell membrane of *** Arabidopsis,the co-receptor BRI1-ASSOCIATED RECEPTOR KI-NASE 1(BAK1)cooperates with FLS2 to detect theflagellin epitopeflg22,resulting in formation of a signaling complex that triggers plant defense ***,the co-receptor responsible for recog-nizing and signaling theflg22 epitope in rice remains to be determined,and the precise structural mecha-nism underlying FLS2-mediated signal activation and transduction has not been *** study pre-sents the structural characterization of a kinase-dead mutant of the intracellular kinase domain of OsFLS2(OsFLS2-KDD1013A)in complex with ATP or ADP,resolved at resolutions of 1.98 A˚and 2.09 A˚,*** analysis revealed that OsFLS2 can adopt an active conformation in the absence of phosphorylation,although it exhibits only weak basal catalytic activity for ***-quent investigations demonstrated that OsSERK2 effectively phosphorylates OsFLS2,which reciprocally phosphorylates OsSERK2,leading to complete activation of OsSERK2 and rapid phosphorylation of the downstream substrate receptor-like cytoplasmic kinases OsRLCK176 and *** mass spectrometry experiments,we successfully identied critical autophosphorylation sites on OsSERK2,as well as sites transphosphorylated by ***,we demonstrated the interaction between OsSERK2 and OsFLS2,which is enhanced in the presence *** evidence suggests that OsRLCK176 and OsRLCK185 may function downstream of the OsFLS2-mediated signaling *** study reveals the molecular mechanism by which OsFLS2 mediates signal transduction pathways in rice and provides a valuable example for understanding RLK-mediated signaling pathways in plants.

关键词： FLS2 active conformation kinase activation transphosphorylation signal transduction