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Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： xi Quan Jun Zhang Linlin Yin Wei Zuo Yu Tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

Liquid metal biomaterials: translational medicines,challenges and perspectives

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National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu Jincheng Lu Yikuang xi Xuelin Wang Jing Liu Department of Biomedical Engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics

Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3591-3604页

作者： Juan Rong Chenxia Han Yan Huang Yiqin Wang Qi Qiu Manjiangcuo Wang Shisheng Wang Rui Wang Juqin Yang xia Li Chenggong Hu Zhiyao Chen Lihui Deng Wei Huang Qing xi Dan du West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest China Hospital/West China Medical SchoolSichuan UniversityChengdu 610041China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Advanced Mass Spectrometry Center Research Core FacilityFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Proteomics-Metabolomics Platform Research Core FacilityInstitutes for Systems GeneticsWest China HospitalSichuan UniversityChengdu 610093China Biobank West China HospitalSichuan UniversityChengdu 610093China West China School of Nursing Sichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

Acute pancreatitis(AP)is a potentially fatal condition with no targeted treatment *** inhibiting xanthine oxidase(XO)in the treatment of AP has been studied in several experimental models and clinical trials,whether XO is a target of AP and what its the main mechanism of action is remains ***,we aimed to re-evaluate whether XO is a target aggravating AP other than merely generating reactive oxygen species that trigger *** first revealed that XO expression and enzyme activity were significantly elevated in the serum and pancreas of necrotizing AP *** also found that allopurinol and febuxostat,as purine-like and non-purine XO inhibitors,respectively,exhibited protective effects against pancreatic acinar cell death in vitro and pancreatic damage in vivo at different doses and treatment time ***,we observed that conditional Xdh overexpression aggravated pancreatic necrosis and *** mechanism analysis showed that XO inhibition restored the hypoxia-inducible factor 1-alpha(HIF-1α)-regulated lactate dehydrogenase A(LDHA)and NOD-like receptor family pyrin domain containing 3(NLRP3)signaling pathways and reduced the enrichment of^(13)C_(6)-glucose to^(13)C_(3)-***,we observed that clinical circulatory XO activity was significantly elevated in severe cases and correlated with C-reactive protein levels,while pancreatic XO and urate were also increased in severe AP *** results together indicated that proper inhibition of XO might be a promising therapeutic strategy for alleviating pancreatic necrosis and preventing progression of severe AP by downregulating HIF-1α-mediated LDHA and NLRP3 signaling pathways.

关键词： Xanthine oxidase inhibitor Multi-omics HIF-1a Necrotizing acute pancreatitis Lactate Therapeutic target NLRP3 Metabolic flux

Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： DAN GUO xi xiA JIAN YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

3D-QSAR Models of Anti-tumor Activity for Histone Deacetylase Inhibitors Containing Dihydropyridin-2-one

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Chinese Journal of Structural Chemistry 2020年第5期39卷 855-860页

作者：冯惠堵锡华陈艳冯长君 School of Chemistry&Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsu 221018China

A 3D-QSAR study was conducted to analyze the anti-tumor activity(pHs,s=1,6)of dihydropyridin-2-one containing histone deacetylase inhibitor(DHDACi)to histone deacetylase(HDACs,s=1,6)by the comparative molecular field analysis(CoMFA)*** predicting model was established based on the training set of 22 compounds,which was verified by the test set of 6 compounds containing template *** results showed that the contributions of steric and electrostatic fields to pH1 are 37.6%and 62.4%,and those to pH6 are 44.6%and 55.4%,*** coefficients of the cross-validation(Rcv2)and the non cross-validation(R2)are 0.574 and 0.947 for pH1,and 0.488 and 0.884 for pH6,*** models were then used to predict the activities of the compounds for the training and testing *** results indicated that the models had strong stability and good *** on the 3D contour maps,several new potential inhibitors with higher anti-tumor activity were ***,the effectiveness of these potential inhibitors is still needed to be verified by the experimental results.

关键词： dihydropyridin-2-one histone deacetylase inhibitor anti-tumor activity 3D-QSAR comparative molecular field analysis

Surface pollen and modern vegetation in Southern xinjiang,China

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Science China Earth Sciences 2024年第2期67卷 510-530页

作者： Yun ZHANG Lixin CHEN Yaoyao xi Zhaochen KONG xianguo QIAO State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Institute of Botany Chinese Academy of SciencesBeijing100093China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China School of Geosciences and Resources China University of Geosciences(Beijing)Beijing100083China

The study of modern pollen,and vegetation can improve the accuracy of paleoenvironmental reconstruction based on fossil pollen data.A total of 188 pollen surface samples were collected from Southern xinjiang(34°00’–43°00’N,74°00’–94°00’E)in China,with an elevation range of 888–4530 *** pollen and vegetation were studied in the northern region of the Kunlun Mountains and the southern region of the Tianshan *** results showed that the surface pollen assemblages on the southern slope of the Tianshan Mountains(3530–1124 m)were divided into three pollen zones,namely,montane steppe,montane desert steppe,and montane *** zones were dominated by Artemisia,Chenopodiaceae,and Ephedra *** surface pollen assemblages in the eastern Pamir Plateau(4530–1287 m)could be divided into alpine meadow,montane desert steppe,and montane desert zones,which were predominantly characterized by Artemisia,Chenopodiaceae,and Asteraceae ***,the Southern Tarim Basin(3548–888 m)comprised montane desert steppe and montane desert zones,which was dominated by Artemisia and Chenopodiaceae *** geographic distribution of the surface pollen sites obtained using ArcGIS,the R-value,and Pearson correlation analyses indicated that the over-represented Picea and Pinus pollen were of external origin and were transported by wind,water(rivers),and ice(glacier movement).Over-representation of Ephedra and Nitraria pollen was mainly distributed in the montane desert and desert steppe zones,*** from Chenopodiaceae and Artemisia were over-represented and broadly distributed across Southern *** pollen was concentrated in areas with walnut trees,strongly indicating the presence of local parent *** to the Hybrid Singleparticle Lagrangian Integrated Trajectory model,more Pinus pollen was transported to the Pamir region by external airflows during spring and summer,resulting in its higher surface pollen *** elucidating t

关键词： Surface pollen Vegetation Distribution Picea Southern xinjiang

Parameter-Free Shifted Laplacian Reconstruction for Multiple Kernel Clustering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1072-1074页

作者： xi Wu Zhenwen Ren F.Richard Yu the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010China the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010 the Guangxi Key Laboratory of Machine Vision and Intelligent Control Wuzhou UniversityWuzhou 543002 the Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen 518060China

Dear Editor,This letter proposes a parameter-free multiple kernel clustering(MKC)method by using shifted Laplacian *** MKC can effectively cluster nonlinear data,but it faces two main challenges:1)As an unsupervised method,it is up against parameter problems which makes the parameters intractable to tune and is unfeasible in real-life applications;2)Only considers the clustering information,but ignores the interference of noise within Laplacian.

关键词： parameter letter Parameter

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收放式光电复合缆集成检测装置创新设计

制造业自动化 2023年第3期45卷 162-165,187页

作者：金伟清刘笃喜西安明德理工学院智能制造与控制技术学院西安710124 西北工业大学机电学院西安710072

光电复合缆是将光单元复合于低压电力电缆内,同时具有电力传输和光通信传输能力,收放式光电复合缆能在一定的工作负载下进行拖曳、系留及野外应急等收放操作。为了保障收放式光电复合缆工作准确和安全可靠,往往需要测量线缆张力、位移... 详细信息

光电复合缆是将光单元复合于低压电力电缆内,同时具有电力传输和光通信传输能力,收放式光电复合缆能在一定的工作负载下进行拖曳、系留及野外应急等收放操作。为了保障收放式光电复合缆工作准确和安全可靠,往往需要测量线缆张力、位移及速度等过程参数。基于TRIZ理论,进行了一种收放式光电复合缆多功能集成检测装置的创新设计,它是在三滑轮式张力传感器上集成了霍尔式增量型旋转编码器,可同时实现光电复合缆收放张力、位移及速度等的自动在线测量和监测。

关键词：收放式光电复合缆集成检测 TRIZ 创新设计三滑轮式张力传感器霍尔式磁性编码器

CToMP: a cycle-task-oriented memory protection scheme for unmanned systems

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Science China(Information Sciences) 2024年第6期67卷 399-417页

作者： Chengyan MA Ning xi Di LU Yebo FENG Jianfeng MA School of Cyber Engineering Xidian University School of Computer Science and Technology Xidian University Department of Computer and Information Science University of Oregon

Memory corruption attacks(MCAs) refer to malicious behaviors of system intruders that modify the contents of a memory location to disrupt the normal operation of computing systems, causing leakage of sensitive data or perturbations to ongoing processes. Unlike general-purpose systems, unmanned systems cannot deploy complete security protection schemes, due to their limitations in size, cost and *** in unmanned systems are particularly difficult to defend against. Furthermore, MCAs have diverse and unpredictable attack interfaces in unmanned systems, severely impacting digital and physical sectors. In this paper, we first generalize, model and taxonomize MCAs found in unmanned systems currently, laying the foundation for designing a portable and general defense approach. According to different attack mechanisms,we found that MCAs are mainly categorized into two types — return2libc and return2shellcode. To tackle return2libc attacks, we model the erratic operation of unmanned systems with cycles and then propose a cycle-task-oriented memory protection(CToMP) approach to protect control flows from tampering. To defend against return2shellcode attacks, we introduce a secure process stack with a randomized memory address by leveraging the memory pool to prevent Shellcode from being executed. Moreover, we discuss the mechanism by which CTo MP resists the return-oriented programming(ROP) attack, a novel variant of return2libc attacks. Finally, we implement CTo MP on CUAV V5+ with Ardupilot and Crazyflie. The evaluation and security analysis results demonstrate that the proposed approach CTo MP is resilient to various MCAs in unmanned systems with low footprints and system overhead.

关键词： unmanned system memory corruption attack memory protection system security randomized memory address

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