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Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

World Journal of Gastroenterology 2010年第2期16卷 217-224页

作者： Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld xavier rogiers Department of Hepatobiliary Surgery and Transplant Surgery University Hospital Hamburg-Eppendorf20246 HamburgGermany Department of Medicine University Hospital Hamburg-Eppendorf20246 HamburgGermany Institute of Experimental and Clinical Pharmacology and Toxicology University Hospital Hamburg-Eppendorf20246 HamburgGermany Gent University Hospital and Medical School 9000 GentBelgium

AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow *** progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent ***:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th *** 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the ***,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc *** phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for *** line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells.

关键词： CD133 antigen CD14 antigen c-kit protein Breast cancer resistance protein-1 protein Progenitor cells CXC chemokine receptor 4 Stromal cell-derived factor-1 Liver cirrhosis

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Quality of life after liver transplantation:State of the art

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World Journal of Hepatology 2016年第18期8卷 749-756页

作者： Louis Onghena Wouter Develtere Carine Poppe Anja Geerts Roberto Troisi Aude Vanlander Frederik Berrevoet xavier rogiers Hans Van Vlierberghe xavier Verhelst Department of Hepatology and Gastroenterology Ghent University Hospital Liver Transplantation Service Ghent University Hospital and Medical School

Quality of life(QoL) after deceased donor liver transplantation is increasingly recognized as a major outcome parameter. We reviewed recent publications in this rapidly evolving field in order to summarize recent achievements in the field and to define opportunities and perspectives for research and improvement of patient care. QoL does improve after liver transplantation according to a typical pattern. During the first year, there is a significant improvement in QoL. After one year, the improvement does stabilise and tends to decline slightly. In addition to the physical condition, different psychological parameters(such as depression, anxiety, sexual function) and sociodemographic elements(professional state, sex, marital state) seem to impact QoL. Opportunities for further research are the use of dedicated questionnaires and identification of influencing factors for QoL.

关键词： Epidemiologic factors Liver transplantation Demographic factors Quality of life Mental health Sociol

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