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Hepatocyte cryopreservation:Is it time to change the strategy?

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World Journal of Gastroenterology 2010年第1期16卷 1-14页

作者： xavier Stéphenne Mustapha Najimi Etienne M Sokal Catholic University of Louvain and St Luc Clinics Paediatric Department(HPED)PEDI unitLaboratory of Paediatric Hepatology and Cell Therapy

Liver cell transplantation presents clinical benefit in patients with inborn errors of metabolism as an alternative,or at least as a bridge,to orthotopic liver *** success of such a therapeutic approach remains limited by the quality of the transplanted *** remains the best option for long-term storage of hepatocytes,providing a permanent and sufficient cell ***, isolated adult hepatocytes are poorly resistant to such a process,with a significant alteration both at the morphological and functional ***,the aim of the current review is to discuss the state of the art regarding widely-used hepatocyte cryopreservation protocols,as well as the assays performed to analyse the post-thawing cell quality both in vitro and in vivo. The majority of studies agree upon the poor quality and efficiency of cryopreserved/thawed hepatocytes as compared to freshly isolated *** ice formation or exposure to hyperosmotic solutionsremains the main phenomenon of cryopreservation process,and its effects on cell quality and cell death induction will be *** increased knowledge and understanding of the cryopreservation process will lead to research strategies to improve the viability and the quality of the cell suspensions after *** strategies,such as vitrification,will be discussed with respect to their potential to significantly improve the quality of cell suspensions dedicated to liver cell-based therapies.

关键词： Hepatocyte Cryopreservation Quality Mitochondria Intracellular ice formation

The potential leaching and mobilization of trace elements from FGD-gypsum of a coal-fired power plant under water re-circulation conditions

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Journal of Environmental Sciences 2015年第6期27卷 72-80页

作者： Patricia Córdoba Iria Castro Mercedes Maroto-Valer xavier Querol Centre for Innovation on Carbon Capture and Storage Institute of Mechanical Process and Energy Engineering Heriot-Watt University Institute of Environmental Assessment and Water Research

Experimental and geochemical modelling studies were carried out to identify mineral and solid phases containing major, minor, and trace elements and the mechanism of the retention of these elements in Flue Gas Desulphurisation（FGD）-gypsum samples from a coal-fired power plant under filtered water recirculation to the scrubber and forced oxidation conditions. The role of the p H and related environmental factors on the mobility of Li, Ni, Zn, As, Se, Mo, and U from FGD-gypsums for a comprehensive assessment of element leaching behaviour were also carried out. Results show that the extraction rate of the studied elements generally increases with decreasing the p H value of the FGD-gypsum leachates. The increase of the mobility of elements such as U, Se, and As in the FGD-gypsum entails the modification of their aqueous speciation in the leachates; UO2SO4, H2 Se, and HAs O2 are the aqueous complexes with the highest activities under acidic *** speciation of Zn, Li, and Ni is not affected in spite of p H changes; these elements occur as free cations and associated to SO4 ^2 in the FGD-gypsum leachates. The mobility of Cu and Mo decreases by decreasing the p H of the FGD-gypsum leachates, which might be associated to the precipitation of Cu Se2 and Mo Se2, respectively. Time-of-Flight mass spectrometry of the solid phase combined with geochemical modelling of the aqueous phase has proved useful in understanding the mobility and geochemical behaviour of elements and their partitioning into FGD-gypsum samples.

关键词： Geochemical modelling studies Trace elements Leaching Landfills FGD-gypsum ToF mass spectrometry

Analysis of a Prototypical Multiscale Method Coupling Atomistic and Continuum Mechanics:the Convex Case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： xavier Blanc Claude Le Bris FrédéricLegoll Laboratoire J.L.-Lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CERMICS Ecole Nationale des Ponts et Chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a solid which deforms smoothly in some region, but non smoothly in some other region, many multiscale methods have been recently proposed that aim at coupling an atomistic model （discrete mechanics） with a macroscopic model （continuum mechanics）. We provide here a theoretical basis for such a coupling in a one-dimensional setting, in the case of convex energy.

关键词： Multiscale methods variational problems continuum mechanics discrete mechanics

A European digital accelerometric database:statistical analysis of engineering parameters of small to moderate magnitude events

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Earthquake Engineering and Engineering Vibration 2014年第4期13卷 583-597页

作者： Carlos S.Oliveira Gerard Gassol xavier Goula Teresa Susagna Instituto Superior Técnico Universidade de Lisboa Institut Cartogràfic i Geològic de Catalunya

During the NERIES Project, an accelerometric database containing European digital information was developed. Besides event and station metadata, ground motion parameters, computed in a homogeneous manner, were assembled： PGA, PGV, AI, TD, CAV, H1 and PSV（f,5%）（19,961 components, 2629 events, 547 stations）. Merging small and moderate magnitude events produced a unique database capable of providing important information such as：（i） Correlations between several ground motion parameters follow analogous trends as in previous worldwide datasets, with slight corrections. （ii） Although PGA attenuations with distance show great uncertainties, four recent GMPEs recommended for Europe fit quite well the central 50% data interval for the distance range 10 〈 R 〈 200 kin; outside these distances, they do not fit. （iii） Soil amplification ratios indicate that weak motion （low magnitudes and larger distances） shows larger amplification than strong motion （short distances and large magnitudes） as represented in UBC97 for the USA, but not in EC8 for Europe. （iv） Average spectral shapes are smaller than in the EC8. （v） Differences in amplification factors for PGA, PGV and HI for EC8 soil classes B and C, and differences in spectral shapes for these soil classes, indicate that EC8, Type 2 S-coefficient should be frequency dependent, as in UBC97.

关键词： NERIES project parametric accelerometric database European region PGA EC8 soil amplification

Phosphine functionalised multiwalled carbon nanotubes:A new adsorbent for the removal of nickel from aqueous solution

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Journal of Environmental Sciences 2012年第6期24卷 1133-1141页

作者： Muleja Anga Adolph Yangkou Mbianda xavier Pillay Kriveshini Krause Rui Department of Chemical Technology University of JohannesburgDoornfontein Campus P.O Box 17011JohannesburgSouth Africa

Synthesised triphenylphosphine-linked multiwalled carbon nanotubes （Tpp-MWCNTs） were used to study the adsorption of nickel in aqueous solutions and their adsorption capabilities were compared with purified *** adsorption capacity increased with an increase in pH for all *** adsorption equilibrium was reached in 40 and 30 min for purified MWCNTs and Tpp-MWCNTs,*** Freundlich and Langmuir isotherms used to investigate the adsorption process fitted the experimental data well with the correlation coefficient R 2 close to 1 for all *** the other hand,the experimental data fitted well with a pseudo secondorder *** speciation of nickel also influenced the adsorption on the purified and *** adsorbents used in this study showed superior adsorption capacity when compared to other adsorbents reported in the literature.

关键词： phosphine functionalised multiwalled carbon nanotubes adsorbent XPS remediation nickel

Raised into Ruins： Transforming Debris in Contemporary Photography from China

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第2期11卷 263-297页

作者： xavier Ortells-Nicolau Department of Modern Languages and Literatures and English Studies Universitat deBarcelona Facultat de Filologia Gran Via de les Corts Catalanes 585 Barcelona 08007Spain

At the turn of the twenty-first century, contemporary art from China has displayed a recurrent engagement with urban ruins. Painting, performance, film, and photography have turned the rubble of demolition and construction works, an outcome of the vast urban development programs of the past few decades, into a powerful symbol of China＇s contemporary milieu. Critical and academic approaches to contemporary Chinese art have rightly inquired about the meaning of these ruins, in a process that has also reevaluated the place of these images in the representational traditions of China. Starting with these academic perspectives, this paper situates images of ruination in contemporary Chinese art in dialogue with transnational debates on the meaning and epistemology of the ruin, to argue for an essential element of constructedness in the representations of ruins. Photographic series by Wang Qingsong, Jiang Pengyi, and Yang Yongliang are analyzed as examples of an active appropriation of the process of ruin creation from a critical stance. Recycling urban wasteful rubble into an aesthetic object, these photo artists generate alternative visions of urban development and its consequent demolition and contribute to the negotiation of the meaning of the ruin.

关键词： contemporary photography constructedness ruins JiangPengyi Wang Qingsong Yang Yongliang

Measurement of electrical charges carried by airborne bacteria laboratory-generated using a single-pass bubbling aerosolizer

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Particuology 2015年第1期13卷 179-185页

作者： xavier Simon Sébastien Bau Denis Bémer Philippe Duquenne Institut National de Recherche et de Securite(INRS)

Widely used bioaerosol generators like Collison nebulizer probably produce electrostatically charged par- ticles, but the electrical charges carried by laboratory-generated airborne microorganisms using bubbling aerosolizers are poorly understood. In this study, we measured the fraction of neutral particles and num- ber of elementary charges per particle as a function of the aerodynamic diameter of airborne bacteria （Escherichia coli and Enterococcus hirae）. Bioaerosols were produced by a liquid sparging aerosolizer-type bubbling generator, with particle sizes ranging from roughly 0.6 to 2 p^m. The experimental setup included an electrostatic precipitator and real-time devices including an electrometer, aerodynamic particle sizer, and electrical low-pressure impactor. Experimental results obtained for various operating conditions showed that aerosols produced with a higher bubbling airflow contained a larger proportion of neutral particles （from around 30% to 50%） and that bacteria carried a greater average absolute number of elementary charges （from around -10 to -60 elementary units） than those under lower airflow. Under the investigated conditions, a neutralization step is unnecessary because it may have a negative effect on the viability of sensitive microorganisms. Our results suggest that the neutral fraction can be used down- stream of an electrostatic precipitator, and that this setup may have advantages over bipolar neutralizers.

关键词： Bubbling generator Bioaerosol Electrical charge Electrostatic precipitator Escherichia coil Enterococcus hirae

Experimental Study of Corner Stall in a Linear Compressor Cascade

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Chinese Journal of Aeronautics 2011年第3期24卷 235-242页

作者： MA Wei OTTAVY xavier LU Lipeng LEBOEUF Francis GAO Feng Laboratoire de Mecanique des Fluides et d'Acoustique Ecole Centrale de Lyon Ecully 69134 France School of Jet Propulsion Beihang University Beijing 100191 China

In order to gain a better knowledge of the mechanisms and to calibrate computational fluid dynamics （CFD） tools including both Reynolds-averaged Navier-Stokes （RANS） and large eddy simulation （LES）, a detailed and accurate experimental study of comer stall in a linear compressor cascade has been carried out. Data are taken at a Reynolds number of 382 000 based on blade chord and inlet velocity. At first, inlet flow boundary layer is surveyed using hot-wire anemometry. Then in order to investigate the effects of incidence, measurements are acquired at five incidences, including static pressures on both blade and endwall sur- faces measured by pressure taps and the total pressure losses of outlet flow measured by a five-hole pressure probe. The maxi- mum losses as well as the extent of losses of the comer stall are presented as a function of the investigated incidences.

关键词： comer separation compressor cascades incidence hot-wire anemometry computational fluid dynamics

Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

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Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： María Gracia Luigi-Sierra Almudena Fernández Amparo Martínez Dailu Guan Juan Vicente Delgado Javier FernándezÁlvarez Vincenzo Landi Francesc xavier Such Jordi Jordana María Saura Marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,CCL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score