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Ganoderma Lucidum Spore Oil enhances the effect of cyclophosphamide via inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 652-659页

作者： JIANG Zhaojian CAI Hongfei YUAN Cheng CAO Lin xu wendong HAN Yaming ZHANG Qin LI Jing WANG Qin LIU Juyan Guangzhou HanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Zhongshan Medical College Sun Yat-sen UniversityGuangzhou 510080China Guangzhou Pharmaceutical Holdings Limited Guangzhou 510130China National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation Guangzhou 510240China

OBJECTIVE:To investigate the effect of Ganoderma Lucidum Spore Oil(GLSO)on the tumor growth and survival of H22 tumor-bearing mice treated with cyclophosphamide(CTX),and explore the underlying ***:Allograft H22 hepatocellular carcinoma mouse model was applied to investigate the effect of GLSO on the tumor growth and survival of animals,and Kaplan-Meier survival analysis was used to analyze the life *** biochemical examination was used to determine the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),urea(UREA)and creatinine(CRE).Western blot analysis was performed to detect Programmed Death-1(PD-1),Programmed Death Ligand 1(PD-L1),Janus Kinase 2(JAK2),phosphorylated Signal Transducer and Activator of Transcription 3(p-STAT3),and Signal Transducer and Activator of Transcription 3(STAT3)***:GLSO increased the anti-tumor effect of CTX and prolonged the survival of H22 tumor-bearing mice treated with ***,GLSO increased the thymus index and showed no obvious toxicity to liver functions of *** also decreased the level of UREA in H22 tumor-bearing mice treated with ***,GLSO could inhibit the expression of PD-1 in spleen,which was independent of JAK2 expression and STAT3 ***,GLSO did not affect the expression of PD-L1,JAK2,and p-STAT3 in tumor ***:GLSO could strengthen the anti-tumor effect of CTX and prolong the life span of H22 tumorbearing mice,while the underlying mechanism might be relevant to the amelioration effect of thymus function and inhibition of PD-1 expression in ***,these findings implied the promising role of GLSO in combination with CTX to extend the survival of patients in clinical chemotherapy of hepatocellular carcinoma.

关键词： carcinoma,hepatocellular cyclophosphamide survival programmed cell death 1 receptor Ganoderma Lucidum SporeOil

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Process Study and Exergy Analysis of a Novel Air Separation Process Cooled by LNG Cold Energy

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Journal of Thermal Science 2014年第1期23卷 77-84页

作者： xu wendong DUAN Jiao MAO Wenjun Key Laboratory of Enhanced Heat Transfer & Energy Conservation of the Ministry of Education School of Chemistry and Chemical EngineeringSouth China University of Technology Zhongshan ling niao Gas Co.Ltd.

In order to resolve the problems of the current air separation process such as the complex process, cumbersome operation and high operating costs, a novel air separation process cooled by LNG cold energy is proposed in this paper, which is based on high-efficiency heat exchanger network and chemical packing separation technology. The operating temperature range of LNG cold energy is widened from 133K-203K to l13K-283K by high- efficiency heat exchanger network and air separation pressure is declined from 0.5MPa to about 0.35MPa due to packing separation technology, thereby greatly improve the energy efficiency. Both the traditional and novel air separation processes are simulated with air handling capacity of 20t＇h-1. Comparing with the traditional process, the LNG consumption is reduced by 44.2%, power consumption decrease is 211.5 kWh per hour, which means the annual benefit will be up to 1.218 million CNY. And the exergy efficiency is also improved by 42.5%.

关键词： LNGs air separation cold energy exergy analysis heat exchanger.

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Preliminary Study on PAHs Distribution in High-grade Oil Shale and Its Spontaneous Combustion Product in Fushun,Liaoning Province

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Acta Geologica Sinica(English Edition) 2007年第1期81卷 158-164页

作者： ZHANG Liping ZENG Rongshu xu wendong Institute of Geology and Geop-hysics ChineseAcademy of Sciences.Beijing 100029

Spontaneous combustion of oil shale is very common as a result of long-time exposure to the air in the Fushun West Open-Pit Mine and West Dump. The PAHs in the high-grade off shale and its spontaneous combustion product were analyzed semiquantitatively by GC-MS in order to investigate their distribution in different states and their potential negative effects on the environment. Totally 57 and 60 PAHs and their alkyl homologues were identified in the two analyzed samples, among which the alkyl derivatives were predominant, taking up to about 65% in the total PAHs. Those low-molecular mass PAHs （3- or 4-ring） were the main compounds in the two samples. Ten of sixteen USEPA priority pollutant PAHs were detected in two samples, of which phenanthrene was the richest whose contents were 6.93% and 15.03%. Based on comparison of analysis results, the amount and contents of PAHs, except for triaromatic steroid group, were higher in the burning oil shale. So it can be determined that the effects caused by spontaneous combustion of oil shale would be more serious and that the effects of the Fushun oil shale and its spontaneous combustion on the environment should not be ignored in the future work.

关键词： High-grade oil shale spontaneous combustion polycyclic aromatic hydrocarbons (PAHs),GC-MS Fushun

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一种植物工厂内可移动装配式大黄育苗装置设计

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现代制造技术与装备 2024年第3期60卷 132-134页

作者：徐文栋张开礼刘生武威职业学院武威733000 天祝高原净土农业发展有限公司武威733200

设计的可移动装配式大黄育苗装置由发光二极管(Lighting Emitting Diode,LED)补光系统、水肥一体化系统、栽培系统和自动控制系统等组成,可以随时拆卸、重组,方便搬运、调整,便于回收和再利用,适应性强,具有集约化和标准化的特点,是大... 详细信息

设计的可移动装配式大黄育苗装置由发光二极管(Lighting Emitting Diode,LED)补光系统、水肥一体化系统、栽培系统和自动控制系统等组成,可以随时拆卸、重组,方便搬运、调整,便于回收和再利用,适应性强,具有集约化和标准化的特点,是大黄工厂化育苗的一种省力型生产装置。

关键词：植物工厂大黄育苗装置控制系统

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需求导向的养老服务设施专项规划编制——以浙江“家门口幸福养老”模式为例

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城乡规划 2024年第3期 62-70页

作者：梁薇陈建义徐文东上海复旦规划建筑设计研究院浙江省民政厅养老服务处

文章以浙江省为例,基于当前我国养老服务设施规划布局中存在的问题,探讨养老服务设施规划布局的配置标准和规划策略创新。文章从配建标准创新、因地制宜布局、增量存量结合、功能菜单配置等方面着手,介绍浙江省养老服务设施专项规划的... 详细信息

文章以浙江省为例,基于当前我国养老服务设施规划布局中存在的问题,探讨养老服务设施规划布局的配置标准和规划策略创新。文章从配建标准创新、因地制宜布局、增量存量结合、功能菜单配置等方面着手,介绍浙江省养老服务设施专项规划的编制经验。在此基础上,以供需匹配、事业产业协同为重点,提出我国养老服务设施规划布局和体系建设的建议,期望为养老服务设施规划提供参考,推动养老服务进一步发展和完善。

关键词：养老服务设施专项规划供需匹配空间配置编制方法

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LNG冷能利用技术研究进展

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天然气与石油 2024年第3期42卷 75-85页

作者：徐文东彭曦严万波华南理工大学化学与化工学院广东广州510640 佛山市寰晟通新能源科技有限公司广东佛山528000 中国石油工程建设有限公司北京100032

液化天然气(Liquefied Natural Gas,LNG)冷能利用有利于中国冷产业低碳转型和健康发展。总结了LNG冷能用于发电、空气分离、液态CO_(2)与干冰制备、冷藏与制冰及冷冻海水淡化、食品冷加工、梯级利用等技术的典型研究成果和产业化实施情... 详细信息

液化天然气(Liquefied Natural Gas,LNG)冷能利用有利于中国冷产业低碳转型和健康发展。总结了LNG冷能用于发电、空气分离、液态CO_(2)与干冰制备、冷藏与制冰及冷冻海水淡化、食品冷加工、梯级利用等技术的典型研究成果和产业化实施情况。在此基础上,分析得出目前LNG冷能利用存在利用率低、投产项目单一等局限性。展望了以LNG冷能为核心,耦合闪蒸气(Boil-off Gas,BOG)燃烧发电、电压缩制冷、蓄冷及光伏发电和综合供能站等多种能源供给技术,以实现多能互补、储能调峰、智能调控、综合供能,形成特色区域冷产业集群,推动分布式产业协同发展的格局。

关键词： LNG 冷能利用梯级利用冷产业研究进展

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The planimetric unfold method of fullerene cage structure

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Chinese Science Bulletin 2000年第20期45卷 1893-1896页

作者： YE Danian Al Desheng HE Wei xu wendong Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Beijing Fine Ceramic Laboratory Institute of Nuclear Energy TechnologyTsinghua UniversityBeijing 102201China

Two kinds of planimetric diagrams, which consist of the boat form F6 and F5, the storm petrel form F6and F5, respectively, were proposed to express the geometric structure of fullerene cage in this study. There are two chief advantages using the diagrams: ( i) the spatial symmetrical characteristic of fullerene cage is not destroyed; (ii) the coordination forms of F5 and F6 in the structure can be clearly expressed. This work has laid the foundation for studying the structural geometry of fullerene cage and its quantum chemistry and property.

关键词： fullerene cage structural geometry boat form storm petrel form symmetry.

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Triaxial test on glass beads simulating coarse-grained soil

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Research in Cold and Arid Regions 2022年第4期14卷 274-280页

作者： wendong xu xueFeng Li WenWei Yang HongJin Jia School of Civil and Hydraulic Engineering Ningxia UniversityYinchuanNingxia 750021China Solid Mechanics Institute Ningxia UniversityYinchuanNingxia 750021China Ningxia Center for Research on Earthquake Protection and Disaster Mitigation in Civil Engineering YinchuanNingxia 750021China School of Physics and Electronic-Electrical Engineering Ningxia UniversityYinchuanNingxia 750021China

It is feasible to study the mechanical characteristics of coarse-grained soil by simulated granular materials such as glass *** this paper,3 mm diameter glass beads are used to conduct drained and undrained triaxial tests under different confining pressures to explore their strength,deformation and critical state ***,the influence of drainage and confining pressure on the stick-slip phenomenon of glass beads is *** experimental findings from triaxial tests show that the stress-strain relationship of glass beads softens when the confining pressure is *** the undrained condition,the initial modulus increases with the increase in the confining *** contrast,it is not significantly affected by the confining pressure in the drained *** is quite evident that the glass beads hardly contract during the shearing process,and their stress path is approximately a segmented straight *** slope of the critical state line under the undrained condition is greater than that under the drained condition,and the friction angle of the glass beads under the undrained and drained conditions is calculated to be 28.1and 29.5,*** phenomenon of stick-slip has been depicted for the different test conditions,and the stick-slip amplitude linearly increases with the confining pressure,especially in the undrained *** is also found that the maximum energy released from the phenomenon of stick-slip increases linearly with the confining pressure.

关键词： Triaxial test Glass beads Strength Critical state Stick-slip

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Neuroinflammation Mediates Faster Brachial Plexus Regeneration in Subjects with Cerebral Injury

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Neuroscience Bulletin 2021年第11期37卷 1542-1554页

作者： Fan Su Guobao Wang Tie Li Su Jiang Aiping Yu Xiaomin Wang wendong xu Department of Hand Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai200040China Department of Hand and Upper Extremity Surgery Jing’an District Central HospitalFudan UniversityShanghai200040China The National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai200040China Institute of Brain Science State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai200040China Co-innovation Center of Neuroregeneration Nantong University226000NantongChina

Our previous investigation suggested that faster seventh cervical nerve(C7)regeneration occurs in patients with cerebral injury undergoing contralateral C7 *** finding needed further verification,and the mechanism remained largely ***,Tinel’s test revealed faster C7 regeneration in patients with cerebral injury,which was further confirmed in mice by electrophysiological recordings and histological ***,we identified an altered systemic inflammatory response that led to the transformation of macrophage polarization as a mechanism underlying the increased nerve regeneration in patients with cerebral *** mice,we showed that,as a contributing factor,serum amyloid protein A1(SAA1)promoted C7 regeneration and interfered with macrophage polarization in *** results indicate that altered inflammation promotes the regenerative capacity of the C7 nerve by altering macrophage ***1 may be a therapeutic target to improve the recovery of injured peripheral nerves.

关键词： Nerve regeneration Cerebral injury Neuroinflammation Macrophage polarization Brachial plexus injury Nerve transfer Contralateral seventh cervical nerve transfer

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Restoring After Central Nervous System Injuries:Neural Mechanisms and Translational Applications of Motor Recovery

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Neuroscience Bulletin 2022年第12期38卷 1569-1587页

作者： Zhengrun Gao Zhen Pang Yiming Chen Gaowei Lei Shuai Zhu Guotao Li Yundong Shen wendong xu Department of Hand Surgery Huashan HospitalFudan UniversityShanghai 200040China The National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China Department of Hand and Upper Extremity Surgery Jing’an District Central HospitalFudan UniversityShanghai 200040China Institutes of Brain Science Fudan UniversityShanghai 200040China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200040China Institute of Automation State Key Laboratory of Management and Control for Complex SystemsChinese Academy of SciencesBeijing 100190China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China Research Unit of Synergistic Reconstruction of Upper and Lower Limbs after Brain Injury Chinese Academy of Medical SciencesShanghai 200400China

Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are leading causes of long-term *** is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated *** studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote ***,the ability to increase plasticity in the injured brain is restricted and difficult to ***,over several decades,researchers have been prompted to enhance the compensation by the unaffected *** experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor *** addition,several clinical treatments have been designed to restore ipsilateral motor control,including brain stimulation,nerve transfer surgery,and brain–computer interface ***,we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.

关键词： Stroke Traumatic brain injury Spinal cord injury Brain-computer interface system Neuroplasticity Ipsilateral motor control Axon regrowth

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