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基于光谱的橘小实蝇侵染柑橘检测系统设计

中国农机化学报 2024年第7期45卷 209-214页

作者：龙江文韬代兴勇韩龙波龚中良中南林业科技大学机械与智能制造学院长沙市410004

为实现可见/近红外光谱对橘小实蝇侵染柑橘的准确检测。针对侵染位置的未知问题,设计一套橘小实蝇侵染柑橘多光路无损检测分级系统。采集四个检测光路的半透射光谱信息,利用偏最小二乘判别法建立并比较单一检测光路和混合四个检测光路... 详细信息

为实现可见/近红外光谱对橘小实蝇侵染柑橘的准确检测。针对侵染位置的未知问题,设计一套橘小实蝇侵染柑橘多光路无损检测分级系统。采集四个检测光路的半透射光谱信息,利用偏最小二乘判别法建立并比较单一检测光路和混合四个检测光路的分类模型。结果显示,混合所有检测光路的模型取得较优的分类结果。利用竞争性自适应重加权采样法筛选的47个特征波长变量建模,四个检测光路中分类效果最佳地预测集的准确率和特异性分别达到93.5%和95.2%。利用四个检测光路的柑橘样本建立的PLS-DA混合分类模型,结合CARS算法进行有效特征波长变量筛选,可提高橘小实蝇侵染柑橘分类模型的精度,实现橘小实蝇侵染柑橘的准确分类。研究结果可为在线检测橘小实蝇侵染柑橘提供参考。

关键词：柑橘无损检测橘小实蝇可见/近红外光谱偏最小二乘判别

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高职教育服务战略性新兴产业的多方协同路径研究

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岳阳职业技术学院学报 2024年第4期39卷 1-5页

作者：戴文静湖南理工学院教育科学学院湖南岳阳414000

战略性新兴产业已成为推动我国经济高质量发展的“新引擎”。政府部门需要促使产教融合发展的政策文件和法律法规落地,加大对服务战略性新兴产业院校的经费投入;高职院校应优化内部管理机制,培育柔性的适应产业变化决策能力,培育教师适... 详细信息

战略性新兴产业已成为推动我国经济高质量发展的“新引擎”。政府部门需要促使产教融合发展的政策文件和法律法规落地,加大对服务战略性新兴产业院校的经费投入;高职院校应优化内部管理机制,培育柔性的适应产业变化决策能力,培育教师适应产业变化教研能力,开展对接新兴产业的科技研发,创新产学研协同创新的管理机制;新兴产业企业应树立“产教融合、校企合作是行业企业的社会责任”的理念,建设以战略性新兴产业协会为主导的产教融合中介机构,协同推进战略性新兴产业发展。

关键词：高职教育战略性新兴产业协同路径

呼吸调控下的细胞膜完整性对仔姜贮藏失水的影响

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食品与发酵工业 2024年第3期50卷 232-240页

作者：廖雯代慧舒丽洁骆佳周俞含张敏西南大学食品科学学院重庆400715 西南大学食品贮藏与物流研究中心重庆400715 农业部农产品贮藏保鲜质量安全风险评估实验室(重庆) 重庆400715

通过比较包装与否对高水分仔姜贮藏失水的影响,探究裸露仔姜即使在高湿冷库贮藏依然失水严重的原因及包装控制呼吸从而抑制失水的机制。设置未包装相对湿度(relative humidity,RH)60%组、未包装RH95%组、包装[30μm双向拉伸聚丙烯薄膜(b... 详细信息

通过比较包装与否对高水分仔姜贮藏失水的影响,探究裸露仔姜即使在高湿冷库贮藏依然失水严重的原因及包装控制呼吸从而抑制失水的机制。设置未包装相对湿度(relative humidity,RH)60%组、未包装RH95%组、包装[30μm双向拉伸聚丙烯薄膜(biaxially oriented polypropylene,BOPP)]RH60%组12℃下贮藏仔姜12 d,每2 d测定其感官、气体成分、呼吸强度、硬脆度、失重率、相对电导率、丙二醛含量、活性氧及相关酶活性等指标。结果表明,12 d后未包装RH60%组、未包装RH95%组、包装(30μm BOPP)RH60%组的失重率分别为47.8%、21.0%、2.5%,即包装处理能显著减少失重率的上升,并保持较高硬脆度且有良好的感官得分。同时包装能营造低O_(2)高CO_(2)环境,降低呼吸速率,从而抑制了·O_(2)^(-)及H_(2)O_(2)等活性氧的上升,且其低呼吸速率也增强了抗氧化酶(过氧化氢酶、过氧化物酶、超氧化物歧化酶)的活性,更好地清除了活性氧;而活性氧的减少使得相对电导率及丙二醛的上升速率得以抑制,细胞膜的完整性得以维持,从而降低了胞内水分向胞外的扩散速度,抑制了仔姜失水及品质劣变。高湿度裸露贮藏并不能很好地抑制仔姜的失水皱缩等品质下降,而包装处理通过呼吸调控维持了细胞膜的完整性,减少了失水,更好地维持了仔姜的品质。

关键词：仔姜贮藏呼吸调控细胞膜失水

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基于低频外差干涉的光纤环形器重合度检测

物理学报 2024年第8期73卷 138-147页

作者：戴玉张文喜孔新新沈杨翊徐豪张晓强中国科学院空天信息创新研究院北京100094 中国科学院大学光电学院北京101400

光纤点衍射环形器是激光相干多普勒测振系统中光纤光路和空间光光路耦合的关键器件,其耦合效率等性能参数对测振系统测量准确度和测量距离的提升具有重要意义.常规环形器重合度检测采用能量监测法和远场重合度监测法,不能对光纤失配因... 详细信息

光纤点衍射环形器是激光相干多普勒测振系统中光纤光路和空间光光路耦合的关键器件,其耦合效率等性能参数对测振系统测量准确度和测量距离的提升具有重要意义.常规环形器重合度检测采用能量监测法和远场重合度监测法,不能对光纤失配因素进行定量分析,环形器耦合效率的一致性无法保障.针对上述问题,提出了一种基于低频外差干涉的相位检测技术,利用干涉相位信息进行光纤相对姿态解算,可有效解决光纤环形器重合度定量检测的问题.对不同光纤相对姿态形成的干涉波前进行了仿真分析和实验验证,给出了光纤相对横向位移、纵向位移和光轴偏离角度与干涉相位PV(peak-to-valley)值、Zernike系数和环形器耦合效率间的规律,实现了干涉相位到光纤失配因素的分离解算,解算结果可指导光纤相对姿态的调整.最后通过实验验证了该技术的可行性,结果表明该技术对于光纤横向位移的检测精度优于1μm,为提升光纤环形器重合度提供了新的检测途径.

关键词：光纤失配对准误差外差干涉测量耦合效率

光照区域对近红外光谱在线检测柚子糖度的影响

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食品与机械 2024年第6期40卷 124-129页

作者：唐子叶文韬代兴勇胡峰中南林业科技大学机电工程学院湖南长沙410004

[目的]提高近红外光谱技术在线检测柚子糖度的精度。[方法]采用自主研发的柚子在线无损检测设备采集3种光照区域的柚子的漫透射光谱数据,在650~950 nm的波长范围内采用标准正交变量变换(SNV)、多元散射校正(MSC)、归一化(normalize)、S... 详细信息

[目的]提高近红外光谱技术在线检测柚子糖度的精度。[方法]采用自主研发的柚子在线无损检测设备采集3种光照区域的柚子的漫透射光谱数据,在650~950 nm的波长范围内采用标准正交变量变换(SNV)、多元散射校正(MSC)、归一化(normalize)、SG一阶求导(savitzky-golay first order derivative,SG-1st)对原始数据进行预处理,使用自适应性加权算法(CARS)筛选反映柚子糖度的光谱特征,建立了偏最小二乘回归(PLSR)模型。使用未参与到建模的30个柚子样本进行在线验证。[结果]光照区域C结合SNV-CARS-PLSR方法的建模效果最优。其预测集的决定系数为0.95,均方根误差为0.30°Brix。在线验证时决定系数为0.90,均方根误差为0.58°Brix。模型对于柚子糖度具有较强的在线检测能力。[结论]在光斑直径为70 mm且位于柚子赤道上方20 mm的光照区域C的条件下采集的柚子光谱数据所建立的预测模型能更有效地实现柚子糖度的在线预测。

关键词：近红外光谱光照区域在线检测糖度柚子

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特应性皮炎伴双眼视网膜脱离及视网膜血管炎1例

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Chinese Medical Sciences Journal 2024年第1期39卷 74-78,I0008页

作者：程世瑜王造文戴荣平中国医学科学院北京协和医学院北京协和医院眼科北京100730 中国医学科学院北京协和医学院眼底病重点实验室北京100730

特应性皮炎可伴有多种眼部并发症,如结膜炎、角膜炎、白内障和视网膜脱离等。我们报道了1例因双眼视网膜脱离及白内障就诊于眼科的21岁中国男性患者。该患者8年前诊断为特应性皮炎,并接受氯雷他定和吡美莫司治疗。我们为该患者进行了双... 详细信息

特应性皮炎可伴有多种眼部并发症,如结膜炎、角膜炎、白内障和视网膜脱离等。我们报道了1例因双眼视网膜脱离及白内障就诊于眼科的21岁中国男性患者。该患者8年前诊断为特应性皮炎,并接受氯雷他定和吡美莫司治疗。我们为该患者进行了双眼白内障摘除术、右眼巩膜外加压术,以及左眼玻璃体切除及硅油填充术。术后随访期间,患者的特应性皮炎加重,眼底荧光素血管造影结果显示双眼视网膜血管广泛渗漏和左眼黄斑水肿。随后患者至皮肤科接受4个月规律的度普利尤单抗治疗,左眼黄斑水肿好转,术后3年眼部情况一直保持稳定。

关键词：特应性皮炎视网膜脱离视网膜血管炎

串联囊式压力脉动衰减器气压主动控制方法研究

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振动与冲击 2024年第19期43卷 266-275页

作者：习毅戴巨川刘文王菊维潘玉明湖南科技大学机电工程学院湖南湘潭411201 浙江万里学院信息与智能工程学院浙江宁波315100 宁波双林汽车部件股份有限公司浙江宁波315100

针对现有串联囊式衰减器(囊式衰减器)压力适应范围窄的问题,提出了通过气压控制系统实现囊式衰减器气囊内部气压主动跟随液压系统工作压力变化的方法,使囊式衰减器在不同工作压力时均具有良好压力脉动抑制性能。在建立气动伺服控制系统... 详细信息

针对现有串联囊式衰减器(囊式衰减器)压力适应范围窄的问题,提出了通过气压控制系统实现囊式衰减器气囊内部气压主动跟随液压系统工作压力变化的方法,使囊式衰减器在不同工作压力时均具有良好压力脉动抑制性能。在建立气动伺服控制系统数学模型的基础上,分别采用比例积分微分(proportional integral derivative,PID)及模糊PID控制方法实现了囊式衰减器气囊内部气压主动跟随系统工作压力的变化,分析了系统工作压力的变化频率、振幅、气瓶充气压力等因素对气囊内压力控制性能的影响,在理论上证明了所提出方法的可行性;分别通过声学仿真软件和试验研究了采用与不采用气压主动控制时囊式衰减器对压力脉动的抑制性能,研究结果均表明采用气压主动控制方法时囊式衰减器对液压管道系统压力脉动的衰减幅值更大、压力适应范围更广,进而验证了所提出气压主动控制方法的有效性与可行性。

关键词：囊式衰减器充放气模型主动控制

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu wen-Qiang Li Yong-Feng Yang xiao xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-xing Wang Zhuo Huang dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China:A nationwide,multi-center,population-based cross-sectional study

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Chinese Medical Journal 2024年第11期137卷 1324-1331页

作者： Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng wen Pengcheng xu Weimin Yu Hui Chen Liang Wang Zhitao Lin Tao dai Yunzhi Lin Tao xu Department of Urology Peking University People’s HospitalBeijing 100044China Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China Department of Urology Beijing HospitalNational Center of GerontologyBeijing 100005China Institute of Geriatric Medicine Chinese Academy of Medical SciencesBeijing 100005China Department of Urology Wuhan Union HospitalHuazhong University of Science&TechnologyWuhanHubei 430022China Department of Urology The Third People’s Hospital of ChengduChengduSichuan 610014China Department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Urologic Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Urology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021China Department of Urology Liaoning Cancer HospitalShenyangLiaoning 110801China Department of Urology The Second Hospital of Tianjin Medical UniversityTianjin 300141China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300141China Department of Urology Lu’an Affiliated Hospital of Anhui Medical UniversityLu’anAnhui 237322China Department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Urology Harbin Medical University Affiliated Cancer HospitalHarbinHeilongjiang 150081China Department of Urology The Second Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology Surgery Fujian Cancer HospitalFuzhouFujian 350014China Department of Urology Surgery Hunan Cancer HospitalChangshaHunan 410031China Department of Urology Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China

Background:Cardiovascular disease(CVD)has emerged as the leading cause of death from prostate cancer(PCa)in recent decades,bringing a great disease burden *** with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy(ADT).The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in ***:Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience *** was defined as myocardial infarction,arrhythmia,heart failure,stroke,ischemic heart disease,and *** risk was estimated by calculating Framingham risk scores(FRS).Patients were accordingly divided into low-,medium-,and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical ***:A total of 4253 patients were enrolled in the present study.A total of 27.0%(1147/4253)of patients had comorbid PCa and CVD,and 7.2%(307/4253)had two or more *** enrolled population was distributed in six regions of China,and approximately 71.0%(3019/4253)of patients lived in urban *** imaging and pathological evaluation,most PCa patients were diagnosed at an advanced stage,with 20.5%(871/4253)locally progressing and 20.5%(871/4253)showing *** of them initiated prostatectomy(46.6%,1983/4253)or regimens involving ADT therapy(45.7%,1944/4253)for prostate *** the present PCa cohort,43.1%(1832/4253)of patients had hypertension,and half of them had poorly controlled blood *** FRS stratification,as expected,a higher risk of CVD was related to aging and metabolic ***,we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without *** was in accordance with clinical practice,i.e.,aged patients or patients at advanced oncological stages were inclined to accept sys

关键词： Prostate cancer Castration Cardiovascular disease Prevalence Cardiovascular risk