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Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

International Journal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun J. Zhang x. Ding x.-Y. Bai J. Liang x.-Q. Wei x.-J. Liu x.-L. Yang T. Liang x.-L. Li C.-x. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms behind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may ex.cerbate psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We then performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the ex.ression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Nex., we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The ex.ression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathway

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A time-space network-based model for transportation service optimization of China Railway Ex.ress

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High-speed Railway 2024年第3期2卷 153-163页

作者： Yin W. Hu W. Yan x. Peng B. Yang x. College of Urban Rail Transit and Logistics Beijing Union University Beijing 100101 China School of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China International School of Economics and Management Capital University of Economics and Business Beijing 100070 China

This paper describes the development and optimization plans for the China Railway Ex.ress (CR Ex.ress). As a new type of international land transport organization, CR Ex.ress has emerged with the continuous ex.ansion of China toward European investment and trade, and in particular, has ex.anded with the continuous progress of the One Belt and One Road (OBOR) initiative. In addition to improving the service quality of CR Ex.ress, the operating costs must be reduced for developing “smart railways” that serve “smart cities”. We propose a dual-objective-based function mathematical optimization model; the satisfaction of the cargo owner is considered, and the timeliness, transportation capacity, and goods category constraints of CR Ex.ress transportation are designed. Moreover, we present the normalized equivalent method of the two-objective function of the model. Finally, a case study is conducted against the background of certain trains in the western corridor of CR Ex.ress to validate the effectiveness of the model and research methods proposed in this study. © 2024 Beijing Jiaotong University

关键词： China Railway Ex.ress Mathematical optimization One Belt and One Road Time-space network Transportation service

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Food poisoning due to money tree seeds: A case report of tox.c encephalopathy

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Emergency and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Zhao Y. Quan x. Wang T. Department of Emergency Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China The Center of Heat Stroke Prevention and Treatment of Peoples' Liberation Army Sanya Hainan China

Background The money tree is a favored indoor potted plant in China. Its seeds resemble chestnuts in both shape and flavor when cooked, which are generally considered non-Tox.c and safe for consumption. Case presentation This report presents the first published case of food poisoning due to the ingestion of large amounts of money tree seeds. A 67-year-old man ex.ibited tox.c encephalopathy symptoms and dyspnea after consuming the seeds for approx.mately 6 months. After empirical mechanical ventilation, therapeutic plasma ex.hange, and other medical interventions, the patient's clinical status improved significantly. He was subsequently discharged from the hospital. Conclusion Consuming a substantial quantity of money tree seeds within a limited timeframe can lead to poisoning, resulting in adverse outcomes, particularly tox.c encephalopathy. Moreover, plasma ex.hange may have some therapeutic effect. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Case report Money tree Pachira macrocarpa Respiratory failure Tox.c encephalopathy

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DeepRice: A deep learning and deep feature based classification of Rice leaf disease subtypes

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ARTIFICIAL INTELLIGENCE IN AGRICULTURE 2024年第1期11卷 34-49页

作者： Ritharson, P. Isaac Raimond, Kumudha Mary, x. Anitha Robert, Jennifer Eunice Andrew, J. Karunya Inst Technol & Sci Dept CSE Coimbatore Tamilnadu India Karunya Inst Technol & Sci Dept Robot Engn Coimbatore India Manipal Acad Higher Educ Manipal Inst Technol Dept Mechatron Engn Manipal 576104 Karnataka India Manipal Acad Higher Educ Manipal Inst Technol Dept Comp Sci & Engn Manipal 576104 Karnataka India

Rice stands as a crucial staple food globally, with its enduring sustainability hinging on the prompt detection of rice leaf diseases. Hence, efficiently detecting diseases when they have already occurred holds paramount importance for solving the cost of manual visual identification and chemical testing. In the recent past, the identification of leaf pathologies in crops predominantly relies on manual methods using specialized equipment, which proves to be time-consuming and inefficient. This study offers a remedy by harnessing Deep Learning (DL) and transfer learning techniques to accurately identify and classify rice leaf diseases. A comprehensive dataset comprising 5932 self-generated images of rice leaves was assembled along with the benchmark datasets, categorized into 9 classes irrespective of the ex.ent of disease spread across the leaves. These classes encompass diverse states including healthy leaves, mild and severe blight, mild and severe tungro, mild and severe blast, as well as mild and severe brown spot. Following meticulous manual labelling and dataset segmentation, which was validated by horticulture ex.erts, data augmentation strategies were implemented to amplify the number of images. The datasets were subjected to evaluation using the proposed tailored Convolutional Neural Networks models. Their performance are scrutinized in conjunction with alternative transfer learning approaches like VGG16, x.eption, ResNet50, DenseNet121, Inception ResnetV2, and Inception V3. The effectiveness of the proposed custom VGG16 model was gauged by its capacity to generalize to unseen images, yielding an ex.eptional accuracy of 99.94%, surpassing the benchmarks set by ex.sting state-of-the-art models. Further, the layer wise feature ex.raction is also visualized as the interpretable AI. (c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativeco

关键词： Rice leaf disease Deep learning CNN Crop yield Agriculture Food security IDENTIFICATION

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Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： x.Y.Yue S.Y.Peng x.Zhang C.N.He Y.Z.Tian Key Laboratory for Anisotropy and Tex.ure of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained ex.ellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

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Virtually coupled train set control subject to space-time separation: A distributed economic MPC approach with emergency braking configuration

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High-speed Railway 2024年第3期2卷 143-152页

作者： Luo x. Tang T. Wang L. Liu H. State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong University Beijing 100044 China Department of Electrical and Computer Engineering University of California Riverside 92521 CA United States Beijing Zongheng Electro-Mechanical Technology Development Co. Ltd. Beijing 100081 China School of Automation and Intelligence Beijing Jiaotong University Beijing 100044 China National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University Beijing 100044 China

The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set (VCTS) at a minimal but safe distance. To guarantee collision avoidance, the safety distance should be calculated using the state-of-the-art space-time separation principle that separates the Emergency Braking (EB) trajectories of two successive units during the whole EB process. In this case, the minimal safety distance is usually numerically calculated without an analytic formulation. Thus, the constrained VCTS control problem is hard to address with space-time separation, which is still a gap in the ex.sting literature. To solve this problem, we propose a Distributed Economic Model Predictive Control (DEMPC) approach with computation efficiency and theoretical guarantee. Specifically, to alleviate the computation burden, we transform implicit safety constraints into ex.licitly linear ones, such that the optimal control problem in DEMPC is a quadratic programming problem that can be solved efficiently. For theoretical analysis, sufficient conditions are derived to guarantee the recursive feasibility and stability of DEMPC, employing compatibility constraints, tube techniques and terminal ingredient tuning. Moreover, we ex.end our approach with globally optimal and distributed online EB configuration methods to shorten the minimal distance among VCTS. Finally, ex.erimental results demonstrate the performance and advantages of the proposed approaches. © 2024 Beijing Jiaotong University

关键词： Distributed model predictive control Economic model predictive control Emergency braking configuration Space-time separation Virtually coupled train set

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Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang J. Fatima K. Zhou x. He C. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defects requires superior mechanical strength, a feat that a single hydrogel scaffold cannot achieve. The objective is to seamlessly integrate optimal microarchitecture, mechanical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PCL)-based integrated scaffold. Within the voids of 3D printed PCL scaffold, a methacrylate gelatin (GelMA)/methacrylated silk fibroin (SFMA) composite hydrogel incorporated with parathyroid hormone (PTH) peptide-loaded mesoporous silica nanoparticles (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/PCL (PM@GS/PCL) scaffold. The feasibility of fabricating this functional scaffold with a customised hierarchical structure was confirmed through meticulous chemical and physical characterisation. Compression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the composite scaffold. Additionally, in vitro angiogenesis potential of PM@GS/ PCL scaffold was evaluated through Transwell and tube formation assays using human umbilical vein endothelium, revealing the superior cell migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenchymal stem cells clearly illustrated robust osteogenic differentiation properties within this scaffold. Furthermore, the bone repair potential of the scaffold was investigated on a rat femoral defect model using micro-computed tomography and histological ex.mination, demonstrating enhanced osteogenic and angiogenic performance. This study presents a promising strategy for fabricating a microenvironment-matched composite scaffold for bone tissue engineering, providing a potential solution for effective bone defect repair. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserve

关键词： angiogenesis bone regeneration methacrylated gelatin methacrylated silk fibroin osteogenesis PTH

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Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Ex.remes 2024年第3期9卷 11-18页

作者： Y.x.Wang x.L.Zhu S.M.Weng P.Li x.F.Li H.Ai H.R.Pan Z.M.Sheng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of China Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(THz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or THz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or THz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index.in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and THz spectral ranges.

关键词： laser ultrashort photon

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Large non-pedunculated colorectal polyp management: The elephant in the room

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World Journal of Gastroenterology 2024年第25期30卷 3126-3131页

作者： Shirley x.Jiang Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z 2K5BCCanada

Minimally invasive innovations have transformed *** to colorectal cancer(CRC),there has been a shift towards less invasive surgical techniques and use of endoscopic resection as an alternative for low risk T1 *** role of endoscopic resection is however much more ex.ensive:It is now considered the first line management strategy for most large(≥20 mm)non-pedunculated colorectal polyps,the majority of which are *** is due to the well-established efficacy,safety,and cost-effectiveness of endoscopic techniques compared to *** endoscopic modalities now ex.st with distinct risk-benefit profiles and their outcomes are further improved by site-specific technical modifications,aux.liary techniques,and adverse event miti-gation *** capacity continues to evolve with emerging endoscopic techniques and ex.anding applications,particularly in the confines of a multi-disciplinary setting.

关键词： Cancer Colonoscopy Endoscopy Polyp Endoscopic mucosal resection Endoscopic submucosal dissection

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Chinese Ex.ert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-J. Cui Y. Deng D.-Q. Gao x.-H. He Y.-L. Kang x.-J. Jin H.-Z. Li C.-x. Li F. Li H.-J. Liao W.-J. Liu x.-M. Lu Q.-J. Lu Y. Pan M. Pan W.-H. Shu x.-M. Sun Q. Tang K.-Y. Tao J. Wang Y. x.ao T. Zhang F.-R. Zhang H.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, prox.mal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, ex.erts from the Dermatology Branch of the China International Ex.hange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and ex.ert advice. © 2024 Wolters Kluwer Health. All rights reserved.

关键词： adult clinical protocols dermatomyositis diagnosis ex.ert consensus treatment

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