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Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1

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Science China(life Sciences) 2011年第2期54卷 159-165页

作者： li xi NIE fen YIN Zhan HE JiangYan Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

Myostatin is a member of the transforming growth factor-β(TGF-β) super-family and functions as a negative regulator of muscle *** of the specific receptor,Activin receptor IIB(Act RIIB),with myostatin or other related TGF-β members,could be inhibited by the activin-binding protein follistatin(Fst) in *** Fst in mouse skeletal muscle leads to muscle hypertrophy and *** determine if Fst has similar roles in fish,we generated transgenic zebrafish expressing high levels of zebrafish Fst1 using the promoter of the zebrafish skeletal muscle-specific gene,myosin,light polypeptide 2,skeletal muscle(Mylz2).Independent transgenic zebrafish lines exhibited elevated expression levels of myogenic regulatory genes MyoD and Pax7 in muscle *** Fst1 overexpressing transgenic zebrafish exhibited a slight body weight *** high level of Fst1 expression dramatically increased myofiber numbers in skeletal muscle,without significantly changing the fiber *** findings suggest that Fst1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.

关键词： Follistatin1 myostatin muscle growth transgenic zebrafish

Study on the interactions of chlorpromazine hydrochloride and promethazine hydrochloride with nucleic acids by resonance Rayleigh scattering spectrum

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Science China Chemistry 2005年第6期48卷 591-599页

作者： liU Shaopu HU xiaoli liU Zhongfang li Ming WANG fen School of Chemistry and Chemical Engineering Southwest China Normal UniversityChongqing 400715China

The interactions of phenothiazine such as chlorpromazine hydrochloride(CPZ·HCl)and promethazine hydrochloride(PZ·HCl),with nucleic acids(NA)have been *** CPZ-NA system can produce very intense resonance Rayleigh scattering(RRS),but the RRS intensity of the PZ-NA system is very *** energy relationship of the two reaction systems has been calculated by the AM1 and B3LYP of density functional methods for quantum chemistry,the binding site and interacting model of CPZ-NA and PZ-NA are *** results show that CPZ has strong binding ability with nucleic acids,but PZ hardly react with nucleic *** can be expected that RRS method may be a useful means for molecular recognition of nucleic acids and the molecular design of gene medicine in the ***,the method is used for the quan-titative determination of nucleic acids by employing chlorpromazine hydrochloride as reagent,which has very high sensitivity and good ***,a sensitive,simple and rapid new method has been developed for the determination of nucleic acids.

关键词： resonance Rayleigh scattering nucleic acid promethazine chlorpromazine interaction.

Integrating Factors and Conservation Theorems for the Nonholonomic Singular Lagrange System

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Communications in Theoretical Physics 2007年第5X期48卷 791-794页

作者： ZHAO Shu-Hong liANG li-Fu QIAO Yong-fen School of Civil Engineering of Harbin Engineering University Harbin 150001 China Engineering College of Northeast Agricultural University Harbin 150030 China

We present a general approach to the construction of conservation laws for the nonholonomic singular Lagrange system. Firstly, the differential equations of motion of the system are written, the definition of integrating factors is given for the system. Next, the necessary conditions for the existence of the conserved quantity are studied in detail. Finally, the conservation theorem and its inverse are established for the system, an example is given to illustrate the application of the result.

关键词： analytical mechanics singular system integrating factor conserved quantity

Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer

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World Journal of Gastroenterology 2015年第33期21卷 9717-9726页

作者： Yu Yan li-feng Wang Rui-fen Wang Department of Pathology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Cancer-associated fibroblasts(CAFs) are important components of various types of tumors,including gastric cancer(GC).During tumorigenesis and progression,CAFs play critical roles in tumor invasion and metastasis via a series of functions including extracellular matrix deposition,angiogenesis,metabolism reprogramming and ***,the mechanism of the interaction between gastric cancer cells and CAFs remains largely *** RNAs(mi RNAs) are a class of non-coding small RNA molecules,and their expression in CAFs not only regulates the expression of a number of target genes but also plays an essential role in the communication between tumor cells and *** this review,we provide an overview of recent studies on CAF mi RNAs in GC and the relevant signaling pathways in gastrointestinal *** the attention on these signaling pathways may help us better understand their role in tumor invasion and metastasis and identify new molecular targets for therapeutic strategies.

关键词： Cancer-associated fibroblasts Micro RNA Signaling

Management of persistent pulmonary hypertension in newborns with ECMO support: a single center's experience

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World Journal of Pediatrics 2019年第1期15卷 100-103页

作者： li-fen Ye Yong Fan Qiang Shu Ru lin Heart Institute Children's HospitalZhejiang University School of MedicineHangzhou 310000China

Background To summarize the experience of management of persistent pulmonary hypertension of the newborn (PPHN) with extracorporeal membrane oxygenation (ECMO) *** We presented three neonates with PPHN supported by ECMO in our *** records and patient management notes were retrospectively *** For two neonates with congenital diaphragmatic hernia (CDH),diaphragm repair surgery was done under ECMO *** patient was weaned from ECMO after 73 hours,and recovered well at the last follow-up after 1 *** other patient was weaned from ECMO after 167 hours,and he died from septic shock 21 days after *** the neonate with idiopathic PPHN,ECMO was withdrawn *** ECMO is an effective rescue means for refractory *** intervention timing,accurate coagulation,and volume management are important.

关键词： Extracorporeal membrane oxygenation Persistent pulmonary hypertension of the newborn

Thermodynamic assessment of Mg-Ni-Y system focusing on long-period stacking ordered phases in the Mg-rich corner

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Journal of Magnesium and Alloys 2022年第11期10卷 3250-3266页

作者： Cheng liu Qun Luo Qin-fen Gu Qian li Kuo-Chih Chou State Key Laboratory of Advanced Special Steels&Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Australian Synchrotron Clayton 3168Australia

The long-period stacking ordered phases(LPSOs) in Mg-Ni-Y system have been attracting great interest as effective strengthening components because of their unique structural characteristics and deformation ***,the phase relationships in LPSOs are complicated and unclear,which restricts the design of advanced magnesium-based *** aim of the present work is to experimentally determine the phase equilibria relationships focusing on LPSOs and establish the thermodynamic description for Mg-Ni-Y *** types of LPSOs,that is,14H,12R,18R and 10H,are confirmed through equilibrated alloys and high-resolution transmission electron microscopy(HR-TEM).The formation enthalpies of LPSOs(14H,12R,18R and 10H) are calculated based on density functional theories(DFT) calculations.A new ternary compound,termed as τ phase,is observed for the first time which is likely to be the distorted structure of 12R as determined from the TEM image which shows a 12-layer closed packing plane distance of 3.252nm and a shear angle of 83.2°between(0002) and(10■0) *** on the determined phase equilibria relationship,the Mg-Ni-Y system is assessed and a selfconsistent description is obtained where the LPSOs are modeled as the stoichiometric *** comparison between the calculation result and experimental data suggests the accuracy of the present thermodynamic database in the Mg-rich corner.

关键词： LPSO phases Crystal structures Phase equilibria Thermodynamics

Wave Extraction and Attenuation Performance of An Edinburgh Duck Wave Energy Converter

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China Ocean Engineering 2021年第6期35卷 905-913页

作者： ZHOU Bin-zhen li Jia-hui ZHANG Heng-ming CHEN li-fen WANG Lei JIN Peng School of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510641China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Edinburgh Duck wave energy converter(ED WEC)has excellent energy extraction performance and shows a great potential to integrate with other marine *** paper aims to investigate its wave energy extraction performance as a WEC and wave attenuation performance as a protection method for shoreline or marine *** wave and ED WEC interactions in regular waves are modeled using the Star-CCM+software and verified by comparisons with published experimental *** motion response,energy conversion efficiency,and transmission coefficient of the ED WEC with different attack angles,rotation center,and incident wave heights are *** indicate that the ED WEC with an attack angle of 42°and a rotation center of 0.55 m below the mean water line can achieve both good wave energy extraction and wave attenuation *** wave energy extraction and wave attenuation performance of the ED WEC decrease significantly with the increase of wave nonlinearity characterized by the wave *** paper can guide the practical application of the ED WEC at the early stage of design.

关键词： Edinburgh Duck wave energy converter wave energy extraction wave attenuation wave nonlinearity

Quantum interferometry via a coherent state mixed with a squeezed number state

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Chinese Physics B 2019年第4期28卷 196-201页

作者： li-li Hou Yong-xing Sui Shuai Wang xue-fen xu School of Mathematics and Physics Jiangsu University of Technology Department of Fundamental Courses Wuxi Institute of Technology

We theoretically investigate the phase sensitivity with parity measurement on a Mach–Zehnder interferometer with a coherent state combined with a squeezed number state. Within a constraint on the total mean photon number, we find, via parity measurement, that the mixing of a coherent state and squeezed number state can give better phase sensitivity than mixing a coherent state and squeezed vacuum state when the phase shift deviates from the optimal phase φ= 0. In addition,we show that the classical Fisher information for parity measurement saturates the quantum Fisher information when the phase shift approaches to zero. Thus, the quantum Crame′r–Rao bound can be reached via the parity measurement in the case of φ= 0.

关键词： quantum optics phase sensitivity quantum metrology

Activating transcription factor 5 regulates lipid metabolism in adipocytes

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Science Bulletin 2016年第23期61卷 1802-1809页

作者： Jing-Hui Jiang Yue Zhao liu-ling xiao Cui-Song Zhu Shu-fen li xi li Key Laboratory of Metabolic Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology Fudan University Basic Medical SchoolShanghai 200032 China Jiangsu Key Laboratory of Molecular Medicine School of Medicine Nanjing University Nanjing 210093 China Chongqing Medical University Chongqing 400016 China

Activating transcription factor 5(ATF5) is a member of the activating transcription factor/cA MP response element binding protein(ATF/CREB) family, and is highly expressed in liver and adipose tissue. Previous reports have shown that ATF5 promoted 3T3-L1 preadipocytes differentiation. In this study, we found that ATF5 was highly expressed in mature adipocytes, suggesting a potential role of ATF5 in mature adipocytes, which has not been reported previously. To understand the function of ATF5 in mature adipocytes, we knocked down the expression of ATF5 in 3T3-L1 mature adipocytes and observed decreased lipid droplets. Consistent with the in vitro experiment, the knockdown of ATF5 in white adipose tissue led to less adipose tissue and smaller adipocytes size. Further research revealed that the inhibition of ATF5 diminished the adipocytes size via the inhibition of fatty acid synthetase, stearyl coenzyme A desaturation enzyme 1, and the induction of carnitine palmitoyl transferase 1, one key enzyme of lipid metabolism. In addition, ATF5 knockdown in inguinal white adipose tissue improved whole body insulin *** work provides a new understanding of ATF5 function in mature adipocytes and a potential therapeutic target of diabetes.

关键词： Activating tra scription factor 5 Adipocytes lipid metabolism.