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Journal of Magnesium and Alloys 2021年第2期9卷 560-568页

作者： B.J.wang D.K.xu x.Cai Y.x.Qiao L.Y.Sheng School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiangChina Peking University Shenzhen InstituteShenzhen Key Lab Human Tissue Regenerate&RepairShenzhen 518057China

In this work,the influence of rolling ratios on microstructural changes and corrosion behavior of an as-rolled Mg-8 wt.%Li alloy in0.1 mol/L Na Cl solution has been *** revealed that with the rolling ratio being increased from 3 to 10,theα-Mg phases were elongated and fragmented,whilst the area fraction of exposedβ-Li phases ***,the corrosion performance of the alloy decreased with the increased rolling *** all the samples,their corrosion processes were quite similar and can have two *** the initial stage with the samples being immersed for less than 6 h,the corrosion mainly occurred inβ-Li *** the samples were immersed for longer than 6 h,the corrosion attack transferred toα-Mg phases and the hydrogen evolution rate was accelerated.

关键词： Mg-li alloys Wrought Microstructure Corrosion performance

It takes a team: a gairvof-function story of p53-R249S

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Journal of Molecular Cell Biology 2019年第4期11卷 277-283页

作者： Huai wang Peng Liao Shelya x. Zeng Hua Lu Department of Biochemistry and Molecular Biology Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA School of Public Health Nanchang University Nanchang 330006 China Jiangxi Provincial Key Laboratory of Preventive Medicine Nanchang University Nanchang 330006 China

Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and R273 with distinct molecular mechanisms. Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole hotspot mutation in hepatocellular carcinoma (HCC) that is highly associated with chronic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin B1 (AFB1). Its GOF is suggested by the facts that this mutant is associated with earlier onset of HCC and poorer prognosis of cancer patients and that its overexpression drives HCC proliferation and tumorigenesis. By contrast, simply knocking in this mutant in normal mice did not show apparent GOF activity. Hence, the GOF activity for p53-R249S and its underlying mechanisms have been elusive until recent findings offered some new insights. This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC.

关键词： p53-R249S Liver cancer HCC CDK4/cyclin D1 PIN1 c-Myc FBW7a

The unfolded protein response signaling and retinal Müller cell metabolism

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Neural Regeneration Research 2018年第11期13卷 1861-1870页

作者： Kristen Kelly Joshua J.wang Sarah x.Zhang Department of Ophthalmology and Neuroscience Program Ross Eye InstituteUniversity at BuffaloState University of New York SUNY Eye Institute State University of New YorkBuffaloNYUSA

The retina is one of the most energy demanding tissues in the body. Like most neurons in the central nervous system, retinal neurons consume high amounts of adenosine-5′-triphosphate（ATP） to generate visual signal and transmit the information to the brain. Disruptions in retinal metabolism can cause neuronal dysfunction and degeneration resulting in severe visual impairment and even blindness. The homeostasis of retinal metabolism is tightly controlled by multiple signaling pathways, such as the unfolded protein response（UPR）, and the close interactions between retinal neurons and other retinal cell types including vascular cells and Müller glia. The UPR is a highly conserved adaptive cellular response and can be triggered by many physiological stressors and pathophysiological conditions. Activation of the UPR leads to changes in glycolytic rate, ATP production, de novo serine synthesis, and the hexosamine biosynthetic pathway, which are considered critical components of Müller glia metabolism and provide metabolic support to surrounding neurons. When these pathways are disrupted, neurodegeneration occurs rapidly. In this review, we summarize recent advance in studies of the UPR in Müller glia and highlight the potential role of the UPR in retinal degeneration through regulation of Müller glia metabolism.

关键词： unfolded protein response retina Müller glia metabolism neurodegeneration x-box binding protein 1 glycolysis glucose transporter

Relationship of Corrosion Behavior Between Single-Phase Equiatomic CoCrNi,CoCrNiFe,CoCrNiFeMn Alloys and Their Constituents in NaCl Solution

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1574-1584页

作者： D.P.wang J.W.Shen Z.Chen F.G.Chen P.Y.Guo Y.x.Geng Y.x.wang School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The composition is a significant issue for corrosion resistance of metallic *** reveal the correlation of corrosion behavior between multiprinciple alloys and their constituents,a series of single-phase equiatomic alloys of CoCrNi,CoCrNiFe and CoCrNiFeMn was *** electrochemical and scanning electron microscope results demonstrated that corrosion resistance of the equiatomic alloys in 0.1 M NaCl solution is located in the range but not the average value of their constituents.x-ray photoelectron spectroscopy analysis indicated that the protective performance of passive film is mainly determined by the constituent with the highest corrosion resistance and the breakdown of passive film is mainly dominated by the elements with the highest corrosion *** findings can guide the materials design of multiprinciple alloys with expected corrosion performance.

关键词： High-entropy alloy Corrosion Constituent x-ray photoelectron spectroscopy(xPS) Passive films

Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei xiu Jiafeng wang Tianle Cheng Dong He Qiang Sun xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu xiaoling Liu Biao Meng Tao Chen Yu Han Jun wang Shibo xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge x-ray absorption near-edge structure （xANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

Effect of grain size on fatigue cracking at twin boundaries in a CoCrFeMnNi high-entropy alloy

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Journal of Materials Science & Technology 2020年第4期39卷 1-6页

作者： A.G.wang x.H.An J.Gu x.G.wang L.L.Li W.L.Li M.Song Q.Q.Duan Z.F.Zhang x.Z.Liao School of Aerospace Mechanical&Mechatronic EngineeringThe University of Sydne0ySydneyAustralia State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Materials Fatigue and Fracture Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Max-Planck-Institut für Eisenforschung Max-Planck-Stra?e 140237 DüsseldorfGermany

The fatigue cracking behavior at twin boundaries(TBs)in a Co Cr Fe Mn Ni high-entropy alloy with three different grain sizes was systematically investigated under low-cycle *** of grain size,the change from slip band cracking to TB cracking occurred with increasing the difference in the Schmid factors(DSF)between matrix and ***,the required critical DSF for the transition of the dominant cracking mode decreases with decreasing grain size due to the reduced slip band spacing that increases the impingement sites on the TBs and facilitates the coalescence of defects and voids to initiate TB cracks.

关键词： High-entropy alloy Fatigue cracking Twin boundary Slip band Grain size

Construction of Ni single-atom coordinated with doped N and S elements for mild hydrogenation of methyl acrylate to methyl propionate

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Nano Research 2025年第1期18卷 217-224页

作者： Taolue Sun Chen Jian Gang wang Hui Zhao Guoliang Zhang Zengxi Li Chunshan Li State Key Laboratory of Mesoscience and Engineering CAS Key Laboratory of Green Process and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Huizhou Institute of Green Energy and Advanced Materials Huizhou 516081China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516081China

Although the nickel-based catalyst is able toexhibit comparative catalytic activity to noble metal formethyl acrylate hydrogenation,it requires strict reactioncondition,which can be improved by regulation ofcoordination *** this study,we constructed akind of Ni single-atom coordinated with N and S(Ni-NSC)through the pyrolysis of organic Ni-based precursors at600℃.The existence and fine structure of Ni single-atom were confirmed by the spherical electron microscopicobservation in combination with the x-ray absorption spectroscopy(xAS)*** addition,the catalytichydrogenation assessment suggested that the as-prepared Ni-NSC catalyst exhibited higher activity and stability than theNi/NSC supported catalyst prepared by incipient wetness impregnation *** remarkable catalytic activity was dueto the high dispersion and density of Ni single-atom and weak adsorption energy of intermediates on these Ni sites.

关键词： methyl acrylate mild hydrogenation Ni single-atom coordination environment adsorption energy

Laser facilitates vaccination

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Journal of Innovative Optical Health Sciences 2016年第1期9卷 12-20页

作者： Ji wang Peiyu Li xinyuan Chen Mei x.Wu Wellman Center for Photomedicine Massachusetts General Hospital and Department of Dermotology Harvard Medical SchoolBostonMA 02114USA Biomedical and Pharmaceutical Science College of Pharmacy University of Rhode IslandKingstonRI 02881USA

Development of novel vaccine deliveries and vaccine adjuvants is of great importance to address the dilemma that the vaccine field faces:to improve vaccine efficacy without compromising *** the specific effects of laser on biological systems,a number of novel concepts have been proposed and proved in recent years to facilitate vaccination in a safer and more efficient *** key advantage of using laser technology in vaccine delivery and adjuvantation is that all processes are initiated by physical e®ects with no foreign chemicals administered into the ***,we review the recent advances in using laser technology to facilitate vaccine delivery and augment vaccine efficacy as well as the underlying mechanisms.

关键词： Laser vaccine delivery adjuvant

HExAHEDRAL ELEMENT REFINEMENT FOR THE PREDICTION- CORRECTION ALE FEM SIMULATION OF 3D BULKINGFORMING PROCESS

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Acta Metallurgica Sinica(English Letters) 2004年第6期17卷 923-927页

作者： J.Chen Y.x.wang W.P.Dong x.Y.Ruan DepartmentofPlasticityEngineering ShanghaiJiaotongUniversityShanghai200030China

Based on the characteristics of 3D bulk forming process, the arbitrary Lagrangian-Eulerian (ALE) formulation-based FEM is studied, and a prediction-correction ALE-based FEM is proposed which integrates the advantages of precisely predicting the boundary configuration of the deformed material, and of efficiently avoiding hexahedron remeshing processes. The key idea of the prediction-correction ALE FEM is elaborated in detail. Accordingly, the strategy of mesh quality control, one of the key enabling techniques for the 3D bulk forming process numerical simulation by the prediction-correction ALE FEM is carefully investigated, and the algorithm for hexahedral element refinement is formulated based on the mesh distortion energy.

关键词： prediction-correction ALE FEM 3D bulk forming numerical simulation hexahedron mesh refinement