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阿片类药物诱导瘙痒的机制研究进展

中国药理学通报 2025年第1期41卷 29-34页

作者：马芳周培岚苏瑞斌军事医学研究院国家安全特需药品全国重点实验室北京100850 南京中医药大学药学院江苏南京210046

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后... 详细信息

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后,直接或间接影响瘙痒关键受体——胃泌素释放肽受体的功能,进而影响瘙痒信息传递。神经介素B、神经肽Y、B型利钠肽等神经肽,以及其他受体如瞬时受体电位香草素1受体、N-甲基-d-天冬氨酸受体、5-羟色胺受体等,在吗啡诱导的瘙痒中也具有重要作用。此外,阿片类药物所致瘙痒的预防和治疗也是围手术期吗啡镇痛的难点和热点之一。因此,明确瘙痒的具体发生机制,对寻找新的研究思路及预防和治疗阿片类药物诱导的瘙痒具有重要意义。

关键词：阿片类诱导的瘙痒瘙痒与镇痛瘙痒机制阿片受体胃泌素释放肽受体瘙痒治疗

Finite Element Prediction of the Thermal Conductivity of GNP/Al Composites

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 825-838页

作者： x.S.Yang L.Zhou K.Y.Liu Z.Y.Liu Q.Z.Wang B.L.xiao Z.Y.ma School of Electromechanical and Automotive Engineering Yantai UniversityYantai264005China Shi-Changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

A 3 d multi-scale finite element model was developed to predict the effective thermal conductivity of graphene nanoplatelet(GNP)/Al *** factors influencing the effective thermal conductivity of the GNP/Al composites were investigated,including the orientation,shape,aspect ratio,configuration and volume fraction of *** results show that GNPs shape has a little influence on the thermal conductivity of GNP/Al composites,and composites with elliptic GNPs have the highest thermal *** addition,with increasing the aspect ratio of GNPs,the thermal conductivity of GNP/Al composites increases and finally tends to be *** GNPs configuration strongly influences the thermal conductivity of GNP/Al composites,and the thermal conductivity of the composites with layered GNPs is the highest among the five *** effective thermal conductivity is sensitive to volume fraction of ***,when the volume fraction of layered GNPs reaches 1.54%,the thermal conductivity of GNP/Al composites is as high as 400 W/m *** findings of this study could provide a good theoretical basis for designing high thermal conductivity GNP/Al composites.

关键词： Multi-scale finite element model Thermal conductivity GNP/Al composites Shape Aspect ratio Configuration

Gravitational wave search by time-scale-recursive denoising and matched filtering

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Science China(Physics,Mechanics & Astronomy) 2024年第12期67卷 166-182页

作者： Cunliang ma Chenyang ma Zhoujian Cao Mingzhen Jia School of Information Engineering Jiangxi University of Science and TechnologyGanzhou341000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing102206China School of Fundamental Physics and mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou310024China Jiangxi Provincial Key Laboratory of Multidimensional Intelligent Perception and Control Ganzhou341000China

In our previous work [Physical Review d,2024,109(4):043009],we introduced MSNRnet,a framework integrating deep learning and matched filtering methods for gravitational wave(GW) *** with end-to-end classification methods,MSNRnet is physically *** denoising models and astrophysical discrimination models corresponding to different parameter space were operated independently for the template prediction and *** the MSNRnet has a lot of computational *** this study,we propose a new framework for template prediction,which significantly improves our previous *** new framework consists of the recursive application of denoising models and waveform classification models,which solve the problem of computational *** waveform classification network categorizes the denoised output based on the signal's time *** enhance the denoising performance for long-time-scale data,we upgrade the denoising model by incorporating Transformer and ResNet ***,we introduce a novel training approach that allows for the simultaneous training of the denoising network and waveform classification network,eliminating the need for manual annotation of the waveform dataset required in our previous ***-data analysis results demonstrate that our new method decreases the false alarm rate by approximately 25%,boosts the detection rate by roughly 5%,and slashes the computational cost by around 90%.The new method holds potential for future application in online GW data processing.

关键词： gravitational wave matched filtering deep learning

Spectral and Timing Analysis of the Black Hole Transient maxI J1631–479 during its 2019 Outburst Observed with Insight-HxMT

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Research in Astronomy and Astrophysics 2022年第11期22卷 21-33页

作者： Yu-Cong Fu L.M.Song G.Q.ding S.N.Zhang J.L.Qu S.Zhang L.Zhang Q.C.Bu Y.Huang x.ma Z.x.Yang Y.L.Tuo x.F.Lu d.K.Zhou B.Y.Wu T.M.Li Y.C.xu xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqiXinjiang 830011China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls UniversitatSand 1D-72076 TübingenGermany

We report spectral and timing analysis of the black hole transient maxI J1631–479 during the hard intermediate state of its 2019 outburst from the Insight-Hard x-ray Modulation Telescope(Insight-HxMT)*** find that the energy dependence of the type-C quasi-periodic oscillation(QPO)frequency evolves with time:during the initial rise of a small flare(~MJd 58526.0-58527.1),the QPO frequency increases with increasing energy from~1 to~100 ke V,and then the frequency remains constant after MJd *** discover a possible new phenomenon of Fe line’s QPO frequency jump that has never been observed for other black hole transients:during the small flare,the QPO frequency around the Fe line energy is higher than any other energy band,with the frequency difference Δf=0.25±0.08 Hz between 5.5–7.5 ke V and other energy *** spectral analysis shows that the evolution of QPOs is related to the equivalent width of the narrow Fe line,and its equivalent width increases during this small *** propose that the QPO frequency difference results from the differential precession of a vertically extended jet,and the higher QPO frequency of Fe line could be caused by the layered jet when the jet scale *** the same time,the evolution of QPOs is related to the accretion rate,while the energy dependence of QPOs supports the existence of deceleration in the vertically distributed jet.

关键词： accretion accretion disks stars:black holes x-rays:binaries

ASYMPTOTIC BEHAVIOR OF THE TE ANd TM APPROxImaTIONS TO SECONd HARMONIC GENERATION

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Journal of Computational mathematics 2007年第1期25卷 49-66页

作者： Na■ma A■ssa Faculté de mathématiques USTHBBP32El AliaBab Ezzouar16111Alger Centre de mathématiques Appliquées CNRS UMR 7641■Ecole PolytechniquePalaiseau 91128 CedexFrance

We consider a Second Harmonic Generation （SHG） problem of an optical signal wave with an optical pump in a medium represented by a smooth bounded domain Ω→∩ IR^d which is assumed to contain a heterogeneous material： a compactly imbedded subdomain B^r →∩∩ in the shape of a small ball contains a nonlinear material, while Ω／ B^r is filled with a linear material. We begin by proving existence and uniqueness of the solution to the TE approximation of SHG for arbitrary bounded susceptibilities, thus improving the result obtained by Bao and dobson （ Eur. J. Appl. math. 6 （1995）, 573-590） under small enough susceptibilities assuption. We then establish an existence and uniqueness result of a solution to the TM approximation problem. In both parts we study the asymptotic behavior of the system as the size of the nonlinear material vanishes： error estimates and asymptotic expansion of the solution are derived for both TE and TM approximations.

关键词： Second harmonic generation TE Approximation TM Approximation.

different diffusion Behavior of Cu and Ni Undergoing Liquidesolid Electromigration

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Journal of materials Science & Technology 2014年第12期30卷 1235-1242页

作者： M.L.Huang Z.J.Zhang H.T.ma L.d.Chen Electronic Packaging materials Laboratory School of Materials Science & Engineering Dalian University of Technology IC Packaging department Xi'an Institute of Microelectronic Technology

The diffusion behavior of Cu and Ni atoms undergoing liquidesolid electromigration（L-S EM） was investigated using Cu/Sn/Ni interconnects under a current density of 5.0 103A/cm2 at 250℃. The flowing direction of electrons significantly influences the cross-solder interaction of Cu and Ni atoms, i.e., under downwind diffusion, both Cu and Ni atoms can diffuse to the opposite interfaces; while under upwind diffusion,Cu atoms but not Ni atoms can diffuse to the opposite interface. When electrons flow from the Cu to the Ni, only Cu atoms diffuse to the opposite anode Ni interface, resulting in the transformation of interfacial intermetallic compound（IMC） from Ni3Sn4into（Cu,Ni）6Sn5and further into [（Cu,Ni）6Sn5t Cu6Sn5], while no Ni atoms diffuse to the opposite cathode Cu interface and thus the interfacial Cu6Sn5 *** electrons flow from the Ni to the Cu, both Cu and Ni atoms diffuse to the opposite interfaces,resulting in the interfacial IMC transformation from initial Cu6Sn5into（Cu,Ni）6Sn5and further into[（Cu,Ni）6Sn5t（Ni,Cu）3Sn4] at the anode Cu interface while that from initial Ni3Sn4into（Cu,Ni）6Sn5and further into（Ni,Cu）3Sn4at the cathode Ni interface. It is more damaging with electrons flowing from the Cu to the Ni than the other way.

关键词： Cu/Sn/Ni Electromigration Cross-solder interaction Interfacial reaction diffusion

EFFECTS OF HddR PROCESS ON STRUCTURE ANd maGNETIC PROPERTIES OF Nd(Fe,Ti)_(12)N_δ PREPAREd BY MECHANICAL ALLOYING

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Acta Metallurgica Sinica(English Letters) 1998年第1期11卷 68-78页

作者： B.ZCui x.K.Sun x.G.Zhao W.Liu Q.F.xiao T.Zhao Z.d.Zhang Y.C.Sui Chinese Acad of Sciences Shenyang China

The effects of the hydrogenation-disproportionation-desorption-recombination (HddR) process on the structure and the magnetic properties of the mechanical alloying (ma) prepared Nd8Fe84 Ti8 alloy and its nitride counterpart have been studied in detail. It has been found that Nd(Fe, Ti)12Hδ is formed in the temperature range from 300 to 550°℃. The disproportionation is ready to start at 550°℃ and is complete at 960°℃.The desorption and the recombination are almost synchronized. The phase of Nd(Fe,Ti)7 is formed at 750°℃ during the HddR treatment. With increasing temperature of HddR process, the metastable structure of TbCu7 type is gradually transformed into the structure of ThMn12 type. The intrinsic coercivity and the maximum magnetic energy product increase with increasing temperature of HddR process.

关键词： Nd(Fe Ti)_(12)N_δ compound,magnetic property hydrogenation

Joint 2d-dOA and polarization estimation for sparse nonuniform rectangular array composed of spatially spread electromagnetic vector sensor

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1116-1127页

作者： ma Huihui TAO Haihong National Laboratory of Radar Signal Processing Xidian UniversityXi'an 710071China

In this paper,a sparse nonuniform rectangular array based on spatially spread electromagnetic vector sensor(SNRASSEMVS)is introduced,and a method for estimating 2d-direction of arrival(dOA)and polarization is ***,according to the special structure of the sparse nonuniform rectangular array(SNRA),a set of accurate but ambiguous direction-cosine estimates can be *** the steering vector of spatially spread electromagnetic vector sensor(SSEMVS)can be extracted from the array manifold to obtain the coarse but unambiguous direction-cosine ***,the disambiguation approach can be used to get the final accurate estimates of 2ddOA and *** with some existing methods,the SNRA configuration extends the spatial aperture and refines the parameters estimation accuracy without adding any redundant antennas,as well as reduces the mutual coupling ***,the proposed algorithm resolves multiple sources without the priori knowledge of signal information,suffers no ambiguity in the estimation of the Poynting vector,and pairs the x-axis direction cosine with the y-axis direction cosine *** results are given to verify the effectiveness and superiority of the proposed algorithm.

关键词： sparse nonuniform rectangular array(SNRA) spatially spread electromagnetic vector sensor(SSEMVS) directioncosine polarization mutual coupling

demonstration of a distributed feedback laser diode working as a graded-potential-signaling photonic neuron and its application to neuromorphic information processing

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Science China(Information Sciences) 2020年第6期63卷 176-183页

作者： Bowen ma Weiwen ZOU State Key Laboratory of Advanced Optical Communication Systems and Networks Intelligent Microwave Lightwave Integration Innovation Center (iMLic) Department of Electronic Engineering Shanghai Jiao Tong University

We find that a commonly-used distributed feedback laser diode(dFB-Ld) can work as a gradedpotential-signaling photonic neuron. Through theoretical and experimental demonstration, dFB-Lds are proved useful for three graded-potential-signaling-based neuromorphic processing applications of the pattern recognition, the single-wavelength implementation of spike timing dependent plasticity(STdP), and the sound azimuth measurement. The pattern recognition with a full-width-at-half-maximum(FWHM) of 1 μs is realized in the experiment.

关键词： neuromorphic photonics graded-potential-signaling photonic neuron pattern recognition optical spike timing dependent plasticity sound azimuth measurement