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Theoretical & Applied Mechanics Letters 2024年第1期14卷 27-34页

作者： Zilan Zhang Yu ao Shaofan Li Grace x.Gu Department of Mechanical Engineering University of CaliforniaBerkeley 94720USA Department of Engineering Peking UniversityBeijing 100871China Department of Civil and Environmental Engineering University of CaliforniaBerkeley 94720USA

Conventional wing aerodynamic optimization processes can be time-consuming and imprecise due to the complexity of versatile flight *** of existing literature has considered two-dimensional infinite airfoil optimization,while three-dimensional finite wing optimizations are subject to limited study because of high computational *** we create an adaptive optimization methodology built upon digitized wing shape deformation and deep learning algorithms,which enable the rapid formulation of finite wing designs for specific aerodynamic performance demands under different cruise *** methodology unfolds in three stages:radial basis function interpolated wing generation,collection of inputs from computational fluid dynamics simulations,and deep neural network that constructs the surrogate model for the optimal wing *** has been demonstrated that the proposed methodology can significantly reduce the computational cost of numerical *** also has the potential to optimize various aerial vehicles undergoing different mission environments,loading conditions,and safety requirements.

关键词： Aerodynamic optimization Computational fluid dynamics Radial basis function Finite wing Deep learning neural network

Europium-bearing organic framework with excellent x-ray scintillating luminescence

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Journal of Rare Earths 2024年第2期42卷 251-255,I0001页

作者： Yugang Zhang Lanhua Chen xia wang Wei Liu Shu'ao wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China School of Environmental and Materials Engineering Yantai UniversityYantai264005China

Two europium-bearing organic frameworks,termed as EuTPO-1 and EuTPO-2(H_(3)TPO=tris(4-carboxylphenyI)-phosphineoxide),are reported in this work.A series of characterizations of EuTPO-1and EuTPO-2,such as x-ray crystallography and photoluminescence spectroscopy,was performed to expatiate their structure and physicochemical *** of them are constructed by dimers of the europium-oxygen subunit of [Eu_(2)O_(16)] and TPO *** from high x-ray stopping attenuation and excellent luminescence efficiency,they emit sufficient luminescence when irradiated with ***,they possess stable light outputs when exposed to high humidities and strong radiation dose,outperforming the commercial scintillator CsI:*** result paves the way for developing new scintillator and enriches the compound of europium-bearing organic framework with x-ray scintillating luminescence.

关键词： Metal-organic frameworks Scintillating material Luminescence efficiency Rare earths

Evolution mechanism and quantitative characterization of initial micro-cracks in marble under triaxial compression

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 586-595页

作者： Zhiliang wang Songyu LI Jianguo wang ao LI Weixiang wang Chenchen FENG Jingjing FU School of Civil Engineering Hefei University of TechnologyHefei230009China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou221116China

The initial micro-cracks affect the evolution characteristics of macroscopic deformation and failure of rock but are often ignored in theoretical calculation,numerical simulation,and mechanical *** this study,we propose a quantitative analysis model to investigate the effects of initial micro-cracks on the evolution of marble deformation and *** relationship between the micro-crack propagation and the marble failure characteristics was comprehensively studied by combining theoretical analysis with a micro-computed tomography(micro-CT)scanning *** found that with the increase of confining pressure,the matrix elastic modulus of the marble first increased and then tended to be stable,while the micro-cracks increased *** sensitivity ranges of the marble sample matrix elastic modulus and micro-cracks to confining pressure were 0–30 MPa and 30–50 MPa,*** porosity and Poisson’s ratio decreased *** increasing proportion of internal micro-cracks led to an increase in the sample *** samples presented mainly shear failure under triaxial compression,and the failure angle decreased linearly with the increase of confining *** convergence direction of cracks decreased *** quantitative analysis model could accurately portray the relationship between the overall macroscopic deformation and the deviatoric stress of the samples at the compaction and the linear elastic stages,thus deepening the understanding of the stress–strain behavior of rocks.

关键词： Marble Initial micro-cracks Triaxial compression Constitutive relationship Crack evolution

Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3295-3311页

作者： ao wang Yi Zhang xinting Lv Guang Liang Department of Pharmacy and Institute of Inflammation Zhejiang Provincial Affiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationYanbian UniversityYanji 133002China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’homeostasis and *** physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological *** of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic ***,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is ***,based on the current research status of targeted therapy,we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver *** an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical ***,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.

关键词： Tyrosine phosphorylation PTPs Signal transduction CLDs HCC Allosteric inhibitor PROTACs Drug development

Impact of the Complex Terrain in Beijing on Formation of Low-Level Jets

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Journal of Meteorological Research 2024年第1期38卷 138-150页

作者： Li’ao ZHOU Chenggang wang Shiguang MIao Ju LI School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089

This study investigated how the Taihang Mountains and the Yanshan Mountains affect low-level jets(LLJs)in the Beijing area,based on conventional radiosonde observations from Nanjiao Observatory(2016–2017)and high-resolution Weather Research and Forecasting–Advanced Research WRF(WRF-ARW)model *** of radiosonde observations indicated that LLJs in the study area are mainly from the southwest and northwest directions,with occurrence frequency of 44.6%and 33.0%,***(northwest)LLJs are aligned parallel(perpendicular)to the orientation of the Taihang Mountain *** sensitivity experiments using the WRF-ARW model were then conducted to examine the effects of terrain forcing on the northwest and southwest LLJs,with adopted terrain heights of 100%and 50%.The results showed that for northwest LLJs,reduction in the elevation of the Taihang Mountain Range led to weakening of jet intensity by approximately 20%and reduction in jet maximum height by approximately 250 m;lowering the Yanshan Mountain Range had minor influence on the northwest LLJs,with only a 5.2%reduction in intensity and no substantial change in jet maximum *** southwest LLJs,reduction in the elevation of both the Taihang and Yanshan Mountain ranges resulted in minor changes in the intensity and height of the *** analysis revealed that the topography in the Beijing area could modulate the height and intensity of the stable layer by altering the inversion structure within the boundary *** LLJs can develop rapidly within the stable layer,and both the location and the scale of the jet core exhibited reasonable agreement with the extent of the stable layer.

关键词： low-level jets(LLJs) mesoscale numerical simulation terrain forcing

Epigenetics:Mechanisms,potential roles,and therapeutic strategies in cancer progression

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Genes & Diseases 2024年第5期11卷 300-314页

作者： Dong wang Yan Zhang Qingbo Li Yu Li Wen Li ao Zhang Jingxuan xu Jingyan Meng lin Tang Shuhua Lyu Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pathology Tianjin Union Medical CenterTianjin 300121China

Mutations or abnormal expression of oncogenes and tumor suppressor genes are known to cause *** studies have shown that epigenetic modifications are key drivers of cancer development and ***,the mechanistic role of epigenetic dysregulation in the tumor microenvironment is not fully ***,we reviewed the role of epigenetic modifications of cancer cells and non-cancer cells in the tumor microenvironment and recent research advances in cancer epigenetic *** addition,we discussed the great potential of epigenetic combination therapies in the clinical treatment of ***,there are still some challenges in the field of cancer epigenetics,such as epigenetic tumor heterogeneity,epigenetic drug heterogeneity,and crosstalk between epigenetics,proteomics,metabolomics,and other omics,which may be the focus and difficulty of cancer treatment in the *** conclusion,epigenetic modifications in the tumor microenvironment are essential for future epigenetic drug development and the comprehensive treatment of *** combination therapy may be a novel strategy for the future clinical treatment of cancer.

关键词： Cancer Epigenetics Gene expression Heterogeneity Tumor microenvironment

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： x.aozhong Chen Wei wang Qingfeng Zou x.aodong Zhu Qin lin Yi Jiang Yan Sun Liangfang Shen lin wang Guorong Zou x.aoyan lin Shaojun lin Minying Li Ying wang Ruilian xu Rui ao Rensheng wang Haifeng lin Shuang Huang Tingting xu Wenting Li Mengying xia Yu xia Zhongmin wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

Automated identification of steel weld defects,a convolutional neural network improved machine learning approach

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 294-308页

作者： Zhan SHU ao WU Yuning SI Hanlin DONG Dejiang wang Yifan LI School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China School of Civil Engineering Shanghai Normal UniversityShanghai 201418China Shanghai PinlanData Technology Co. Ltd.Shanghai 200072China

This paper proposes a machine-learning-based methodology to automatically classify different types of steel weld defects,including lack of the fusion,porosity,slag inclusion,and the qualified(no defects)*** methodology solves the shortcomings of existing detection methods,such as expensive equipment,complicated operation and inability to detect internal *** study first collected percussed data from welded steel members with or without weld ***,three methods,the Mel frequency cepstral coefficients,short-time Fourier transform(STFT),and continuous wavelet transform were implemented and compared to explore the most appropriate features for classification of weld *** and convolutional neural network-enhanced algorithms were used to classify,the extracted ***,experiments were designed and performed to validate the proposed *** showed that STFT achieved higher accuracies(up to 96.63%on average)in the weld status *** convolutional neural network-enhanced support vector machine(SVM)outperformed six other algorithms with an average accuracy of 95.8%.In addition,random forest and SVM were efficient approaches with a balanced trade-off between the accuracies and the computational efforts.

关键词： steel weld machine learning convolutional neural network weld defect detection classification task percussion

QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： Yu Song xusheng Qian Nan Zhang Wei wang ao xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

Spray pyrolysis-derived W-doped MoSe_(2)/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei wang Jun-Yu Chen Jie Ouyang Hong Yin ao-Jie Li Liang Chen Jun-lin Huang Yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and TechnologyYueyang 414006China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang414006China Hunan Province Key Laboratory of Materials Surface&Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and TechnologyChangsha 410004China International Iberian Nanotechnology Laboratory(INL) AvMestre Jose Veiga4715-330 BragaPortuga

Two-dimensional MoSe_(2) is a promising candidate for lithium-ion battery ***,its conductivity and lithium storage volumetric effect still need to be *** this work,W-doped MoSe_(2)/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the ***,by utilizing the similar two-dimensional structure between MoSe_(2) and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the ***,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering ***,W-doping not only increases the interlayer spacing of MoSe_(2)(0.73 nm),thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the *** functional theory(DFT)calculations confirm that W-doped MoSe_(2)/rGO exhibits the narrowest bandgap(0.892 eV).Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g^(-1)after 300 cycles at a current density of 1 A·g^(-1).

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics