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Chinese Physics C 2022年第7期46卷 74-84页

作者： M.Ablikim M.N.Achasov P.Adlarson s.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An x.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang W.L.Chang G.Chelkov G.Chen H.s.Chen M.L.Chen s.J.Chen x.R.Chen Y.B.Chen Z.J.Chen W.s.Cheng G.Cibinetto F.Cossio J.J.Cui x.F.Cu H.L.Dai J.P.Dai x.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong x.Dong s.x.Du P.Egorov Y.L.Fan J.Fang s.s.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao Y.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.x.Gong W.Gradl M.Greco L.M.Gu M.H.Gu C..Y.Guan A.Q.Guo A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold M.Himmelreich T.Holtmann G.Y.Hou Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.s.Huang L.Q.Huang x.T.Huang Y.P.Huang Z.Huang T.Hussain N Husken W.Ikegami Andersson W.Imoehl M.Irshad s.Jaeger s.Janchiv Q.Ji Q.P.Ji x.B.Ji x.L.Ji Y.Y.Ji H.B.Jiang x.s.Jiang J.B.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing T.Johansson N.Kalantar-Nayestanaki x.s.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.G.Kurth W.Kuhn J.J.Lane J.s.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li H.N.Li J.L.Li J.Q.Li J.s.Li Ke Li L.K.Li Lei Li P.R.Li s.Y.Li W.D.Li W.G.Li x.H.Li x.L.Li xiaoyu Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao J.Libby A.Limphirat C.x.Lin D.x.Lin T.Lin B.J.Liu C.x.Liu D.Liu F.H.Liu Fang Liu Feng Liu G.M.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.Liu Ke Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu s.B.Liu T.Liu T.Liu W.M.Liu x.Liu Y.Liu Y.B.Liu Z.A.Liu Z.Q.Liu x.C.Lou F.x.Lu H.J.Lu J.D. Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Camnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced science and Technology Beijing 100190China COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physies sBRAs(BINP) Novosibirsk 630090Russia GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN sezione di Perugia I-06100PerugiaItaly University of Perugia I-06100PerugiaItaly University of Ferrara I-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physies and Technology Peace Ave 54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen Ⅱ.Physikaliches InstitutHeinricH-Buff-Ring 16D-35392 GiessenGermany Lanzhou University Lnzhou 730000China Liaoning Normal University Dalian 116029China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing Univ

Using inclusive decays of J/ψ aprecise determination of the number of J/ψ events collected with the BEsIII detector was *** the two data sets taken in 2009 and 2012,the numbers of J/ψ events were recalculated to be(224.0±1.3)×10^(6) and(1088.5±4.4)×10^(6),respectively;these numbers are in good agreement with the previous measurements. For the J/ψ sample taken in 2017-2019,the number of events was determined to be(8774.0±39.4)×10^(6).The total number of J/ψ events collected with the BEsIII detector was determined to be(10087±44)×10^(6),where the uncertainty is dominated by systematic effects,and the statistical uncertainty is negligible.

关键词： number of J/ψevents BEsIII detector inclusive J/ψdecays

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Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

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Chinese Physics C 2019年第3期43卷 5-16页

作者： M.Ablikim M.N.Achasov s.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren D.W.Bennett J.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi I.Boyko R.A.Briere H.Cai x.Cai A.Calcaterra G.F.Cao s.A.Cetin J.Chai J.F.Chang W.L.Chang G.Chelkov G.Chen H.s.Chen J.C.Chen M.L.Chen s.J.Chen Y.B.Chen W.s.Cheng G.Cibinetto F.Cossio H.L.Dai J.P.Dai A.Dbeyssi D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong Z.L.Dou s.x.Du J.Z.Fan J.Fang s.s.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao x.L.Gao Y.N.Gao Y.G.Gao Z.Gao B.Garillon I.Garzia A.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl M.Greco L.M.Gu M.H.Gu s.Gu Y.T.Gu A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov Z.Haddadi s.Han x.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.s.Huang J.s.Huang x.T.Huang x.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji x.B.Ji x.L.Ji H.L.Jiang x.s.Jiang x.Y.Jiang J.B.Jiao Z.Jiao D.P.Jin s.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki x.s.Kang M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth W.Kühn J.s.Lange P.Larin L.Lavezzi H.Leithoff C.Li Cheng Li D.M.Li F.Li F.Y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.Y.Li W.D.Li W.G.Li x.L.Li x.N.Li x.Q.Li Z.B.Li H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao J.Libby C.x.Lin D.x.Lin B.Liu B.J.Liu C.x.Liu D.Liu D.Y.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.L Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.Y.Liu K.Y.Liu Kai Liu Ke Liu Q.Liu s.B.Liu x.Liu Y.B.Liu Z.A.Liu Zhiqing Liu Y.F.Long x.C.Lou H.J.Lu J.D.Lu J.G.Lu Y.Lu Y.P.Lu C.L.Luo M.x.Luo P.W.Luo T.Luo x.L.Luo s.Lusso x.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma x.N.Ma x.x.Ma x.Y.Ma Y.M.Ma F.E.Maas M.Maggiora s.Maldaner Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao s.Marcello Z.x.Meng J.G.Messchendorp G.Mezzadri J.Min T.J.Min R.E.Mitchell x.H.Mo Y Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced science and Technology Beijing 100190China COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN sezione di Ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China shandong University Jinan 250100China shanghai

studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BEsIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. For the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be J^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.

关键词： cross section P-wave D_s mesons resonance parameters spin-parity BEsIII

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Determination of the number ofψ(3686)events taken at BEsⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen H.Y.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen x.R.Chen x.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen s.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding x.x.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du s.x.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang s.s.Fang W.x.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao x.B.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl s.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu s.L.Hu T.Hu Y.Hu G.s.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson s.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji x.B.Ji x.L.Ji Y.Y.Ji x.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang x.s.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing x.M.Jing T.Johansson s.Kabana N.Kalantar-Nayestanaki x.L.Kang x.s.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.x.Li R.Li s.x.Li T.Li W.D.Li W.G.Li x.Li x.H.Li x.L.Li x.Z.Li xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BEsⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BEsⅢdetector

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu siying Kang song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina state Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin suyu Wang Yujia Yao qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth school of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

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Measurement of the integrated Luminosities of cross-section scan data samples around theψ(3770)mass region

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Chinese Physics C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achasov s. Ahmed M. Albrecht M. Alekseev A. Amoroso F. F. An Q. An Y. Bai O. Bakina R. Baldini Ferroli Y. Ban K. Begzsuren D. W. Bennett J. V. Bennett N. Berger M. Bertani D. Bettoni F. Bianchi E. Boger I. Boyko R. A. Briere H. Cai x. Cai O. Cakir A. Calcaterra G. F. Cao s. A. Cetin J. Chai J. F. Chang W. L. Chang G. Chelkov G. Chen H. s. Chen J. C. Chen M. L. Chen P. L. Chen s. J. Chen x. R. Chen Y. B. Chen x. K. Chu G. Cibinetto F. Cossio H. a. Dai, J. F. Dai A. Dbeyssi D. Dedovich Z. Y. Deng A. Denig I. Denysenko M. Destefanis F. De Mori Y. Ding C. Dong J. Dong L. Y. Dong M. Y. Dong Z. L. Dou s. x. Du P. F. nuan J. Fang s. s. Fang Y. Fang R. Farinelli L. Fava s. Fegan F. Feldbauer G. Felici C. Q. Feng E. Fioravanti M. Fritsch C. D. Fu Q. Gao x. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. x. Gong W. Gradl M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. P. Guo Y. F. Guo A. Guskov Z. Haddadi s. Han x. Q. Hao F. A. Harris Z. L. He x. O. He F. H. Heinsius T. Held Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. s. Huang J. s. Huang x. T. Huang x. Z. Huang Z. L. guang T. Hussain W. Ikegami Andersson M Irshad Q. Ji Q. P. Ji x. B. Ji x. L. Ji x. s. Jiang x. Y. Jiang J. B. Jiao Z. Jiao D. P. Jin s. Jin Y. Jin T. Johansson A. Julin N. Kalantar-Nayestanaki x. s. Kang M. Kavatsyuk B. C. Ke T. Khan A. Khoukaz P. Kiese R. Kliemt L. Koch O. B. Kolcu B. Kopf M. Kornicer M. Kuemmel M. Kuessner A. Kupsc M. Kurth W. Kiihn J. s. Lange M. Lara P. Larin L. Lavezzi s. Leiber H. Leithofi C. Li Cheng Li D. M. Li F. Li F. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li Kang Li Ke Li Lei Li P. L. Li P. R. Li Q. Y. Li T. Li W. D. Li W. G. Li x. L. Li x. N. Li x. Q. Li Z. B. Li H. Liang Y. F. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. x. Lin D. x. Lin s. Liu B. J. Liu C. x. Liu D. Liu D. Y. Liu F. H. Liu Fang Liu Feng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. D. Liu Q. Liu s B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang University Beijing 100191 China Beijing Institute of Petrochemical Technology Beijing 102617 China Bochum Ruhr-University D-44780 Bochum Germany Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Central China Normal University Wuhan 430079 China China Center of Advanced science and Technology Beijing 100190 China COMsATs Institute of Information Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Budker Institute of Nuclear Physics sB RAs （BINP） Novosibirsk 630090 Russia GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 Darmstadt Germany Guangxi Normal University Guilin 541004 China Guangxi University Nanning 530004 China Hangzhou Normal University Hangzhou 310036 China Helmholtz Institute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal University Xinxiang 453007 China Henan University of science and Technology Luoyang 471003 China Huangshan College Huangshan 245000 China Hunan Normal University Changsha 410081 China Hunan University Changsha 410082 China Indian Institute of Tec

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BEsIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb^-1, where the first uncertainty is statistical and the second systematic.

关键词： Bhabha scattering events integrated luminosity BEsⅢ

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An efficient quantum proactive incremental learning algorithm

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi song sujuan qin Qiaoyan Wen Fei Gao state Key Laboratory of Networking and switching Technology Beijing University of Posts and Telecommunications school of Cyberspace security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen qin xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets signaling pathway

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CxCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CxCL12/CxCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CxCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CxCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CxCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CxCL12 secreted by activated microglia),CxCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CxCL12/CxCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CxCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CxCR4 induced neural stem cell microglia neuroinflammation

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： xiaorong Zhang Zhiying Chen Yinyi xiong qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive science and Transdisciplinary studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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