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NANOSIZE EFFECT IN GRAIN BOUNDARY MIGRATION OF COPPER

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Acta Metallurgica Sinica(English letters) 2004年第1期17卷 11-15页

作者： l.zhou x.q.wei N.G.zhou D.G.li School of Materials Science and Engineering Nanchang UniversityNanchang 330047ChinaSchool of Materials Science and EngineeringNanchang UniversityNanchang 330047ChinaSchool of Materials Science and EngineeringNanchang UniversityNanchang 330047ChinaCentral Iron and Steel Research InstituteBeijing 100083China

Molecular dynamics simulations of high temperature annealing of copper bicrystals have been carried out. The bicrystals have planar grain boundaries, and the gain size varies in nano range. An EAM (embedded atom method) potential of FS type is used for calculating the interatomic forces. The results show that in nanocrystalline copper, GB migration driven by inter-GB reaction can take place. A critical grain size is identified, below which the inter-GB reaction becomes strong enough to trigger GB motion, which accelerates rapidly and leads to annihilation of the grain boundaries. The critical size is found to be 16 atomic radii. A "through intermediate grain mechanism" is identified for the nano-grain boundary motion observed, which is never reported for GB migrations of conventional polycrystalline metals.

关键词： grain boundary migration nanocrystal copper

Eosinophilia and clonorchiasis presenting as fever of unknown origin in adult patients

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World Journal of Emergency Medicine 2025年第1期16卷 91-93页

作者： Jie Zhong xin zhou wei Gu Department of Emergency Medicine Chuiyangliu HospitalBeijing 100022China

Fever of unknown origin(FUO)is recognized as fever with uncertain diagnosis despite three days of hospital admission or three or more outpatient visits.[1]Acute liver fluke infection is characterized by fever,right upper quadrant pain,hepatomegaly,jaundice,and peripheral blood *** contrast,chronic liver fluke infection is asymptomatic in its early stage,but can easily progress to cirrhosis,cancer,or bile duct cancer *** diagnosis of clonorchiasis is particularly challenging in non-endemic *** herein report an unusual case of liver fluke infection in a patient who presented with FUO and eosinophilia.A 38-year-old male was admitted to our hospital with a history of intermittent and recurrent fever for over 10 d and a history of sudden abdominal pain for1 *** had no other medical *** than 10d ago,he visited our emergency department because of FUO,with his body temperature reaching 39.7℃,and he had no other symptoms at that *** and radiological examinations revealed:white blood cell(WBC)counts,10.9×10^(9)/l;neutrophil percentage,84.5%;eosinophil percentage,3.1%;C-reactive protein(CRP),141 mg/l;liver and kidney function,normal;influenza virus,negative;urine and stool tests,normal;and chest computed tomography(CT)findings,*** fever subsided after 1 week of anti-infective treatment with *** tests revealed the following results:WBC,15.0×10^(9)/l;neutrophil percentage,70.0%;eosinophil percentage,16.8%;and CRP,122 mg/*** antimicrobial treatment was then discontinued.

关键词： fever diagnosis admitted

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong wei Jin liu Tao Zhu Cheng zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3l1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Tandemly promoting the sulfur redox kinetics through low concentration mixed organodiselenide and organoditelluride in Ah-level high-energydensity li-S batteries

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Science China Materials 2025年第1期68卷 207-216页

作者： Jiangqi zhou Chengyong Shu qianyu Zhang wei Tang Yuping Wu School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China School of Energy and Environment Southeast UniversityNanjing 210096China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China

Homogeneous redox mediation is efficient in alleviating the shuttling effect and slow redox kinetics of lithium polysulfides in lithium-sulfur ***,their perfect performance is not fulfilled owning to the fact that the multi-step transformation of lithium polysulfides requests the multifunctional active positions for the tandem *** on the redox comediation principles,a promoter of mixing organodiselenide and organoditelluride(mixed-Se/Te)was raised to induce tandem catalysis and boost the effective electrochemical conversion of lithium *** specifically,diphenyl diselenide facilitated the liquid-liquid and solid-liquid transformation between lithium polysulfides and sulfur,while diphenyl ditelluride improved the solid-liquid transformation concerning lithium sulfide ***,even under high sulfur loading of 6.5 mg cm^(−2) and low electrolyte/sulfur ratio of 5.88μl mg^(−1),the 10 mM low concentration mixed-Se/Te promoter offered a high discharge capacity of 6.6 mAh cm^(−2) and high rate performance of 4.1 mAh cm^(−2) at 0.5 ***,the assembled 1.5 Ah-level lithium-sulfur pouch cells provide an energy density of 332 Wh kg^(−1) at 0.05 C and good cycling *** research demonstrates the applicability of propelling continuous sulfur conversion reactions with detached active positions and is anticipated to stimulate deep molecular design of kinetic promoter to targeted energy-associated redox reactions.

关键词： lithium-sulfur batteries redox kinetics tandem catalysis organodiselenide organoditelluride

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang zhou xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the x_(q^(3))/x_(q^(2))(x_(q^(i))is the molar fraction of q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.x-ray photoelectron spectroscopy(xPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng liu wei-Zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+Sl)compared to TACE with lenvatinib alone(TACE+l)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+Sl therapy in comparison to TACE+l therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+Sl group and 27 in the TACE+l *** TACE+Sl group demonstrated significantly improved median PFS and OS compared to the TACE+l group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+Sl group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+Sl demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Self-assembly of two pairs of homochiral M2l4 coordination capsules with varied confined space using Tr?ger's base ligands

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Chinese Chemical letters 2025年第2期36卷 360-365页

作者： Yi zhou wei Zhang Rong Fu Jiaxin Dong Yuxuan liu Zihang Song Han Han Kang Cai College of Chemistry Nankai University Department of Chemistry Northwestern University Department of Chemistry The University of Hong Kong

Chiral coordination molecular cages/capsules with discrete nanoconfined chiral cavities demonstrate significant potential applications across various fields. In this study, we utilized Tr?ger's base as the building block to design and synthesize two pairs of enantiopure ligands. These ligands were then self-assembled with Pd(II) ions through chiral self-sorting coordination, resulting in the formation of two pairs of homochiral M2l4-type coordination molecular capsules. Notably, due to differences in the substitution positions on the Tr?ger's base, these two pairs of enantiomeric coordination molecular capsules exhibited distinct levels of cavity closures, cavity sizes, and host-guest recognition properties. This research offers valuable insights into the construction of novel chiral molecular capsules and the regulation of confined cavities.

关键词： Chirality Host-guest recognition Metal-organic capsule Self-sorting Tröger's base

A new green approach to synthesizing MIP-202@porous silica microspheres for positional isomer/enantiomer/hydrophilic separation

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Chinese Chemical letters 2025年第1期36卷 501-505页

作者： Zhefei Hu Jingwen liao Jiawen zhou lulu Zhao Yanjuan liu Yuefei Zhang wei Chen Sheng Tang School of Chemistry and Environmental Engineering Hubei Key Laboratory of Novel Reactor and Green Chemical TechnologyWuhan Institute of TechnologyWuhan 430205China School of Pharmacy Linyi UniversityLinyi 276000China

Metal-organic frameworks(MOFs)with superior physicochemical properties have great potential for applications in chromatographic ***,currently popular methods for the synthesis of MOFbased silica composite materials usually require the use of harmful organic solvents and long-term hightemperature sealing *** order to respond to the needs of green chromatography,it is urgent to develop a new green organic-solvent-free strategy for the synthesis of MOF@SiO_(2)***-202 is a zirconium-MOF constructed from zirconium ion and l-aspartic acid,which features green synthesis as well as good hydrolytic stability and chemical *** this paper,SiO_(2)-NH_(2) was first prepared in a hydrophilic deep eutectic solvent,and then an amino acid-based MOF material(MIP-202)was modified on the surface of the SiO_(2)-NH_(2) in an aqueous solution to obtain a MIP-202@SiO_(2) composite *** multi-mode separation performance of MIP-202@SiO_(2) as a promising liquid chromatographic stationary phase was particularly evaluated and the separation mechanisms were *** MIP-202@SiO_(2) column exhibited excellent separation ability for aromatic positional *** addition,chiral enantiomers and hydrophilic analytes were also satisfactorily detected and *** work provides a new approach for the facile synthesis of MOF-based liquid chromatographic separation material by using green deep eutectic solvent and water as the reaction media.

关键词： Metal-organic framework Stationary phase Deep eutectic solvent Green chromatography High-performance liquid chromatography

Integration of perioperative features and intragraft TCF7l2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China(life Sciences) 2025年第1期68卷 297-299页

作者： Junbin zhou Rongli wei Guanghan Fan Zhengxing lian xuanyu Zhang linsong Tang Zhetuo qi Haiyang xie Shusen Zheng qiang wei xiao xu Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui UniversityLishui 323000China NHFPC Key laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Key laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People’s HospitalHangzhou 310006China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Urology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310011China Hangzhou Medical College Hangzhou 310059China Zhejiang University School of Medicine Hangzhou 310058China

Dear Editor,liver transplantation(lT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32.8%in 6 months after lT,is one of the major post-transplant complications(Toshima et al.,2020).With the prolongation of the recipient’s survival time,the incidence of PTHT is increasing,becoming an important factor that affects the recipient’s quality of life and survival *** with various metabolic complications,including PTHT,have a 1.78 times higher risk of atherosclerotic cardiovascular disease(ASCVD)development and death than recipients without these complications(Jiménez Pérez et al.,2016).Studies have shown that PTHT,accompanied by other posttransplant metabolic complications and immunosuppressants,are important risk factors for post-transplant ASCVD and mediate 19%–42% of nongraft-related deaths(Davis and Shadab Siddiqui,2017;Jiménez-Pérez et al.,2016).However,early prediction of PTHT remains a major challenge.

关键词： liver graft