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Murtagh安全诊断策略联合思维导图构建临床思维在全科教学门诊中的应用

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中国全科医学 2025年第6期28卷 673-680页

作者：杨玲杜雪平北京市西城区首都医科大学附属复兴医院月坛社区卫生服务中心 100045

全科教学门诊是培养住院医师规范化培训(简称住培)全科医生临床思维、提升全科诊疗能力的重要培训方法。本文用1例以乏力为主要表现的患者为教学案例,介绍全科教学门诊中采用澳大利亚著名全科医学专家John Murtagh提出的Murtagh安全诊... 详细信息

全科教学门诊是培养住院医师规范化培训(简称住培)全科医生临床思维、提升全科诊疗能力的重要培训方法。本文用1例以乏力为主要表现的患者为教学案例,介绍全科教学门诊中采用澳大利亚著名全科医学专家John Murtagh提出的Murtagh安全诊断策略启发住培全科医生对乏力进行诊断与鉴别诊断:(1)引起乏力的常见疾病有哪些?(2)哪些重要疾病是不能忽视的?(3)乏力有什么容易被遗漏的疾病?(4)是否存在潜在的容易被掩盖的疾病?(5)患者是否有话没有说?结合病史、体格检查和实验室检查结果初步诊断为抗中性粒细胞胞浆抗体相关性血管炎引起急进性肾小球肾炎可能性大,及时转诊,肾病理检查确诊乏力的病因为抗中性粒细胞胞浆抗体相关性肾小球肾炎,取得满意疗效。带教老师基于Murtagh安全诊断策略帮助住培全科医生构建乏力鉴别、分析的系统知识框架,从而提升住培全科医生的临床逻辑思维能力和解决临床实际问题的能力;以思维导图为辅助工具,将Murtagh安全诊断策略诊断与鉴别诊断思路可视化、形象化,优化教学效果。

关键词：全科医学 Murtagh安全诊断策略思维导图全科临床思维乏力抗中性粒细胞胞浆抗体相关性肾小球肾炎

Correlations of the expression of Cx43,SCFFBxW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBxW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBxW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBxW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBxW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBxW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(Pxpressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBxW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBxW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Parametric down-conversion photon-pair source on a nanophotonic chip

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Light(Science & Applications) 2016年第1期5卷 96-103页

作者： xiang Guo Chang-ling Zou Carsten Schuck Hojoong Jung Risheng Cheng Hong x Tang Department of Electrical Engineering Yale UniversityNew HavenCT 06511USA

Quantum-photonic chips,which integrate quantum light sources alongside active and passive optical elements,as well as singlephoton detectors,show great potential for photonic quantum information processing and quantum *** semiconductor nanofabrication processes allow for scaling such photonic integrated circuits to on-chip networks of increasing ***-order nonlinear materials are the method of choice for generating photonic quantum states in the overwhelming majority of linear optic experiments using bulk components,but integration with waveguide circuitry on a nanophotonic chip proved to be ***,we demonstrate such an on-chip parametric down-conversion source of photon pairs based on second-order nonlinearity in an aluminum-nitride microring *** show the potential of our source for quantum information processing by measuring the high visibility anti-bunching of heralded single photons with nearly ideal state *** down-conversion source yields measured coincidence rates of 80 Hz,which implies MHz generation rates of correlated photon *** noise performance is demonstrated by measuring high coincidence-to-accidental *** generated photon pairs are spectrally far separated from the pump field,providing great potential for realizing sufficient on-chip filtering and monolithic integration of quantum light sources,waveguide circuits and single-photon detectors.

关键词： nanofabrication quantum photonic chip second-order nonlinear material single-photon source

Analysis of secretome of breast cancer cell line with an optimized semi-shotgun method

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Nuclear Science and Techniques 2009年第5期20卷 286-291页

作者： TANG xiaorong YAO ling CHEN Keying HU xiaofang xU Lisa x. FAN Chunhai Key Laboratory of Systems Biomedicine （Shanghai Jiao Tong University） China Ministry of Education Shanghai 200240 China Dept. of Biomedical Engineering School of Life Science and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China Med-x Research Institute Shanghai Jiao Tong University Shanghai. 200240 China Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

Secretome, the totality of secreted proteins, is viewed as a promising pool of candidate cancer biomarkers. Simple and reliable methods for identifying secreted proteins are highly desired. We used an optimized semi-shotgun liquid chromatography followed by tandem mass spectrometry (LC-MS/MS) method to analyze the secretome of breast cancer cell line MDA-MB-231. A total of 464 proteins were identified. About 63% of the proteins were classified as secreted proteins, including many promising breast cancer biomarkers, which were thought to be correlated with tumorigenesis, tumor development and metastasis. These results suggest that the optimized method may be a powerful strategy for cell line secretome profiling, and can be used to find potential cancer biomarkers with great clinical significance.

关键词：乳腺癌癌细胞放射性化疗

A discussion on“A selective review of statistical methods using calibration information from similar studies”

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Statistical Theory and Related Fields 2022年第3期6卷 196-198页

作者： ling Zhou Peter x.-K.Song Southwestern University of Finance and Economics FMCYNAMEChengduPeople’s Republic of China University of Michigan Ann ArborMIUSA

It is our pleasure to have an opportunity of making comments on this fine work in that the authors present a comprehensive review on empirical likelihood(EL)methods for integrative data *** paper focuses on a unified methodological framework based on EL and estimating equations(EE)to sequentially combine summary information from individual data batches to obtain desirable estimation and inference comparable to those obtained by the EL method utilizing all individual-level *** latter is sometimes referred to as an oracle estimation and inference in the setting of massively distributed data batches.

关键词： oracle batch estimation

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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基于进化规划的新型生物地理学优化算法研究

系统工程理论与实践 2010年第6期30卷 1106-1112页

作者：蔡之华龚文引 ling Charles-x 中国地质大学(武汉)计算机学院武汉430074 西安大略大学计算机系

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜... 详细信息

生物地理学优化算法是一种新的全局优化算法,但该算法存在搜索能力不强的缺点.针对此不足,提出一种基于进化规划算法的实数编码混合生物地理学优化算法,新算法将进化规划的搜索性与生物地理学优化算法的利用性进行有机结合,从而达到搜索性与利用性的平衡.通过13个高维标准测试函数对算法进行测试,验证了新算法的有效性.与基本生物地理学优化算法和两种经典的进化规划算法进行比较,结果表明新算法优于所比较的三种算法.此外,新算法在收敛速度上优于基本生物地理学优化算法.

关键词：生物地理学优化进化规划全局优化混合算法实数编码

生命周期视角下债务融资成本对制造业企业创新绩效的影响

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江苏商论 2025年第1期 87-90,96页

作者：余领昆明理工大学管理与经济学院云南昆明650504

制造业企业往往会存在“融资难、融资贵”的问题,这无疑会影响企业创新绩效。因此,文章以2011—2021年相关资料研究债务融资成本对制造业企业创新绩效的关系。同时,本文针对不同阶段的制造业企业,所实施的创新行为有所不同,债务融资成... 详细信息

制造业企业往往会存在“融资难、融资贵”的问题,这无疑会影响企业创新绩效。因此,文章以2011—2021年相关资料研究债务融资成本对制造业企业创新绩效的关系。同时,本文针对不同阶段的制造业企业,所实施的创新行为有所不同,债务融资成本对企业创新绩效的作用会有所差异。结果表明:债务融资成本对制造业企业创新绩效产生显著的负向影响,该影响在生命周期不同阶段的制造业企业中有所差异。在成长期和成熟期的制造业企业中更为显著,在衰退期的制造业企业中影响较弱。

关键词：债务融资成本制造业企业创新绩效生命周期

Computing infrastructure for big data processing

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Frontiers of Computer Science 2013年第2期7卷 165-170页

作者： ling LIU Distributed Data Intensive Systems Lab School of Computer Science Georgia Institute of TechnologyUSA Atlanta 30332

With computing systems undergone a fundamen- tal transformation from single-processor devices at the turn of the century to the ubiquitous and networked devices and the warehouse-scale computing via the cloud, the parallelism has become ubiquitous at many levels. At micro level, par- allelisms are being explored from the underlying circuits, to pipelining and instruction level parallelism on multi-cores or many cores on a chip as well as in a machine. From macro level, parallelisms are being promoted from multiple ma- chines on a rack, many racks in a data center, to the glob- ally shared infrastructure of the Internet. With the push of big data, we are entering a new era of parallel computing driven by novel and ground breaking research innovation on elas- tic parallelism and scalability. In this paper, we will give an overview of computing infrastructure for big data processing, focusing on architectural, storage and networking challenges of supporting big data paper. We will briefly discuss emerging computing infrastructure and technologies that are promising for improving data parallelism, task parallelism and encour- aging vertical and horizontal computation parallelism.

关键词： big data cloud computing data analytics elas-tic scalability heterogeneous computing GPU PCM bigdata processing