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homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： Chun-xin Jiang Guang Yang Lian-Ping Shi Peng-Yu su Department of Cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** suMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia

DEVELOPMENT OF NEW ThERMO-MEChANICAL SIMULATOR

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Acta Metallurgica Sinica(English Letters) 2004年第1期17卷 33-37页

作者： Z.G.Luo h.L.su D.h.Zhang G.D.Wang x.h.Liu The State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 ChinaThe State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 ChinaThe State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 ChinaThe State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 ChinaThe State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 China

A new multifunction thermo-mechanical simulator was successfully developed. The accuracy of measurement and control is very high through all digital control. More than twenty tests may be fulfilled including tension, compression, torsion, combination large deformation that meets the study of supersteel, etc. Its performance is introduced in the paper, such as designed ideas, machine structure, man-machine interface, control system, etc.

关键词： thermo-mechanical simulator multifunction control system combination large deformation

Effects of longwall-induced stress and deformation on the stability and mechanical integrity of shale gas wells drilled through a longwall abutment pillar

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International Journal of Mining Science and Technology 2017年第1期27卷 115-120页

作者： Daniel W.h.su National Institute for Occupational Safety and health Bruceton 15236PAUSA

This paper presents the results of a comprehensive study conducted by CONSOL Energy, Marcellus Shale Coalition, and Pennsylvania Coal Association to evaluate the effects of longwall-induced subsurface deformations on the mechanical integrity of shale gas wells drilled over a longwall abutment *** primary objective is to demonstrate that a properly constructed gas well in a standard longwall abutment pillar can maintain mechanical integrity during and after mining operations. A study site was selected over a southwestern Pennsylvania coal mine, which extracts 457-m-wide longwall faces under about 183 m of cover. Four test wells and four monitoring wells were drilled and installed over a 38-m by84-m centers abutment pillar. In addition to the test wells and monitoring wells, surface subsidence measurements and underground coal pillar pressure measurements were conducted as the 457-m-wide longwall panels on the south and north sides of the abutment pillar were mined by. To evaluate the resulting coal protection casing profile and lateral displacement, three separate 60-arm caliper surveys were conducted. This research represents a very important step and initiative to utilize the knowledge and science obtained from mining research to improve miner and public safety as well as the safety and health of the oil and gas industries.

关键词： Gas well Casing Abutment pillar Stability Safety and health Instrumentation Numerical simulation

EFFECT OF COLD WORKING ON ThE AGING PROPERTIES OF Cu-Cr-Zr-Mg ALLOY BY ARTIFICIAL NEURAL NETWORK

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Acta Metallurgica Sinica(English Letters) 2004年第5期17卷 741-746页

作者： J.h.su h.J.Li Q.M.Dong P.Liu B.x.Kang B.h.Tian CollegeofMaterialsScienceandEngineering NorthwesternPolytechnicalUniversityXi＇an710072China GollegeofMaterialsScienceandEngineering HenanUniversityofScienceandTechnologyLuoyang471003China

A developmental research has been carried out to deal with the high performance of Cu-Cr-Zr-Mg lead frame alloy by artificial neural network (ANN). Using the cold working to assist in the aging hardening can improve the the hardness and electrical conductivity properties of Cu-Cr-Zr-Mg lead frame alloy. This paper studies the effect of different extent of cold working on the aging properties by a supervised ANN to model the non-linear relationship between processing parameters and the properties. The back-propagation (BP) training algorithm is improved by Levenberg-Marquardt algorithm. A basic repository on the domain knowledge of cold worked aging processes is established via sufficient data mining by the network. The predicted values of the ANN coincide well with the tested data. So an important foundation has been laid for prediction and optimum controlling the rolling and aging properties of Cu-Cr-Zr-Mg alloy.

关键词： Cu-Cr-Zr-Mg alloy cold working aging artificial neural network (ANN)

Oxidation behavior and microstructural evolution of FeCoNiTiCu five-element high-entropy alloy nanoparticles

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Journal of Materials Science & Technology 2024年第10期177卷 133-141页

作者： h.Bai R.su R.Z.Zhao C.L.hu L.Z.Ji Y.J.Liao Y.N.Zhang Y.x.Li x.F.Zhang Key Laboratory for Anisotropy and Texture of Materials(MOE) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China Institute of Advanced Magnetic Materials College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou310012China

high-entropy alloys(hEAs)have attracted extensive attention ascribed to their unique physical and chemical properties induced by the cocktail ***,their oxidation behaviors,in particular at nanoscale,are still lack because of multi-element complexity,which could also be completely differ-ent from the bulk *** this work,we synthesized FeCoNiTiCu five-element hEA nanopar-ticles(NPs)with uniform elemental distribution by arc-discharging approach,and further investigated their oxidation behaviors at 250 ℃,and 350 ℃.The morphology,structure and element distribution of NPs were analyzed by transmission electron microscopy(TEM),energy dispersive spectroscopy(EDS)and electron energy loss spectroscopy(EELS).The surface oxidation in FeCoNiTiCu NPs during the high-temperature process can induce nanoscale pores at core/shell interfaces by Kirkendall effect,and even the eventual coalescence into a single ***,the oxidation states of NPs with diameters(d)varying from 60 to 350 nm were analyzed in detail,revealing two typical configurations:hollow(dhell structures(d>150 nm).The experimental results were complemented by first-principles calculations to investigate the diffusion behaviors of five elements,evidencing that the surface oxidation strongly alters the surface segregation preferences:(1)in the initial stage,Cu and Ni appear to prefer segregating on the surface,while Co,Ti and Fe tend to stay in the bulk;(2)in the oxidation process,Cu prefers to stay in the center,while Ti segregates to the surface ascribed to the reduced po-tential *** study gives new insights into oxidation of nanoscale hEA,and also provides a way for fabrication of high-entropy oxides with controllable architectures.

关键词： high-entropy alloy Nanoparticles Oxidation Kirkendall effect Exchange bias effect

Enhancing strength and ductility in the nugget zone of friction stir welded 7Mn steel via tailoring austenitic stability

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Journal of Materials Science & Technology 2024年第18期185卷 174-185页

作者： Y.Q.Wang F.Y.Li J.x.su R.h.Duan Z.A.Luo G.M.xie State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The martensite often appears in the nugget zone(NZ)of friction stir welding(FSW)7 wt.%Mn steel due to low austenite stability,deteriorating ductility and *** this work,a 7 wt.%Mn steel was sub-jected to FSW,and preheating was used to tailor the austenitic stability to greatly improve the strength-ductility combination of the *** austenitic deformation behavior and strain hardening mechanism in the NZ were systematically *** microstructure of the as-welded NZ was composed of ultrafine blocky ferrite,austenite,and small amounts of martensite,whereas the as-preheated NZ con-tained ultrafine blocky ferrite and austenite,and the concentration of Mn in austenite was increased from 8.4 wt.%to 10.7 wt.%.This enhanced the austenitic stability,resulting in a significant increase in the volume fraction of austenite in the as-preheated NZ from 37.3%to 66.4%.The product of strength and elongation(PSE)in the as-preheated NZ increased dramatically from 42.6 GPa%to 67.1 GPa%,depending on a persistent high strain hardening rate(ShR).Multiple strain-hardening mechanisms were *** austenite with enhanced stability can provoke sustained transformation-induced plasticity(TRIP)and twinning-induced plasticity(TWIP)effects,and massive dislocation multiplication occurs during tension,resulting in strong strain hardening.

关键词： Friction stir welding Medium Mn steel Preheating Transformation-induced plasticity Twinning-induced plasticity

ExTENDED WARRANTY STRATEGIES FOR ONLINE ShOPPING suPPLY ChAIN WITh COMPETING suPPLIERS CONSIDERING COMPONENT RELIABILITY

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Journal of Systems Science and Systems Engineering 2017年第6期26卷 753-773页

作者： xinghong Qin Qiang su Samuel h. huang 1.School of Economics and Management Tongji University Shanghai 200092 China 2.School of Business Planning Chongqing Technology and Business University Chongqing 400067 China 3.Department of Mechanical and Materials Engineering University of Cincinnati Cincinnati OH 45221 USA

This article presents the issue of extended warranty and management strategies in a three-echelon competing online shopping supply chain with price- and base warranty period-dependent demand. We employ game theory to develop decision models to explore the interactions between component suppliers and the manufacturer, as well as competition between two component suppliers. Products and extended warranty are sold by an online store, which is the leader in the Stackelberg game. Two scenarios are considered： either the manufacturer offers a prepaid extended warranty to customers or doses not. In each scenario, base warranties are assumed to be bundled with products. Our results show that when the manufacturer＇s repair costs change in a proper range, providing extended warranty can benefit both the manufacturer and the online store; otherwise, the manufacturer has no incentive to offer the extended warranty. Reducing repair costs, improving component reliability, or shortening the base warranty period allows the manufacturer to realize significantly better value of the extended warranty. high component reliability benefits both the manufacturer and the online store, with the manufacturer reaping more benefit. Extending the length of the base warranty adversely affects profit of the manufacturer and the value of the extended warranty.

关键词： Extended warranty online shopping supply chain game theory online shopping

ThE EFFECT OF BORON TREATMENT ON ThE hYDROGEN ATTACK BEhAVIOR 0F 1.25Cr-0.5Mo STEELS

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Acta Metallurgica Sinica(English Letters) 1997年第3期10卷 233-238页

作者： x.h Luo T.J. su C.G Fan Y Y Liand Cx Shi(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China)x Chen and A.M Guo (Iron & Steel Research Institute, Wuhan Iron & Steel (Group) Company, Wuhan 430083, China) Inst of Metal Research Chinese Acad of Sciences Shenyang China

1.25Cr-0.5Mo steels with different Ti-B or Al-B treatment were exposed in 18 MPa hydrogen atmosphere at 480℃ fo f 100, 500 and 1000 h respectively. Tensile and bend properties of steels before and after hydrogen changing were tested. The results show that the different mechanical properties of the steels with different B content have different responses to high temperature high pressure hydrogen charging *** hydrogen changing, more loss of ductility can be found in the steel not treated with B than those in the steels treated with B. Metallographic analyses indicated that decarburization occurred in all the steels. Furthermore, many methane bubbles were found by SEM analysis in the surface decarburization layer in the steel without B,while only a few bubbles, the number and size of which decreased with increasing B content, were found in steels with B treatment. In addition, hydrogen determination results manifested that after being exposed in hydrogen atmosphere the steel containing no B had higher hydrogen content than that of steels containing B. All this suggests that B treatment improved the hA resistance of 1.25Cgr-0.5Mo steel, and the more B the steel contained the more perceptible the effect.

关键词： boron hydrogen attack Cr-Mo steel low alloy steel

Evaluation of seismic potential in a longwall mine with massive sandstone roof under deep overburden

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International Journal of Mining Science and Technology 2018年第1期28卷 115-119页

作者： Mark A.Van Dyke Wen h.su Joe Wickline Ground Control Branch NIOSHPittsburgh15236 PAUSA Coronado Coal LLC BeckleyWVUSA

A recent seismic event was recorded by a deep longwall mine in Virginia at 3.7 ML on the local magnitude scale and 3.4 MMS by the United States Geological survey(USGS) in *** investigations by the National Institute for Occupational Safety and health(NIOSh) and Coronado Coal researchers have shown that this event was associated with geological features that have also been associated with other, similar seismic events in *** mapping and geological exploration in the mining area has made it possible to forecast possible locations for future seismic *** order to use the geology as a forecaster of mining-induced seismic events and their energy potential, two primary components are *** first component is a long history of recorded seismic events with accurately plotted *** second component is a high density of geologic data within the mining *** this case, 181 events of 1.0 MLor greater were recorded by the mine's seismic network between January, 2009, and October, *** the mining area, 897 geophysical logs, 224 core holes, and 1031 fiberscope holes were examined by mine *** this information, it was found that overburden thickness, sandstone thickness, and sandstone quality contributed greatly to seismic *** the data was analyzed, a pattern became apparent indicating that the majority of seismic events occurred under specific *** forecast maps were created based on geology of previous seismic *** forecast maps have shown an accuracy of within 74%–89% when compared to the recorded 181 events that were1.0 MLor greater when considering three major geological criteria of overburden thickness of 579.12 m or greater, 6.096–12.192 m of sandstone within 15.24 m of the Pocahontas number 3 seam, and a longwall caving height of 4.572 m or less.

关键词： Seismic Mapping Deep overburden Massive sandstone