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Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott f.d.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick don C.Rockey department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA digestive disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between february 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage Liver disease-Sodium,and fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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dynamic Behavior of Bubble Interface during Boiling

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Journal of Thermal Science 2002年第4期11卷 308-319页

作者： x.f.Peng Z.wang d.J.Lee department of Thermal Engineering Tsinghua UniversityDepartment of Thermal Engineering Tsinghua UniversityDepartment of Chemical Engineering Taiwan University Beijing 100084 China Beijing 100084 China Taipei 106 China

A brief review with discussions is conducted for some pertinent works, done and ongoing in the Laboratory of Phase-Change and Interfacial Phenomena at Tsinghua University, on interfacial behavior of vapor bubbles and interfacial transport phenomena during liquid nucleation boiling. from a sequence of experimental investigations, some new phenomena, particularly, the visually observed interfacial transport phenomena or processes including jet-like flows, bubble interaction and spatial scale effect, were described in this article. The interfacial effects and transport phenomena associated with surface tension gradients caused by temperature and concentration variations were theoretically analyzed to reveal the marked influence on bubble interfacial shape and dynamic behavior, the bubble dynamics including nucleation, bubble motion and coalescence. Several theoretical models and methods were proposed to describe the dynamic characteristics and explain the physics of interfacial phenomena/processes. The

关键词： boiling interfacial phenomena transport process phase change bubble.

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Polyhydroxyurethanes from Biobased Monomers and CO_(2):A Bridge between Sustainable Chemistry and CO_(2) Utilization

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Chinese Journal of Chemistry 2024年第6期42卷 652-685页

作者： Tharinee Theerathanagorn Tanika Kessaratikoon Hafeez Ur Rehman Valerio d'Elia daniel Crespy VISTEC Advanced Laboratory for Environment-Related Inorganic and Organic Syntheses Department of Materials Science and EngineeringVidyasirimedhi Institute of Science and Technology21210Wang ChanRayongThailand department of Materials Science and Engineering Vidyasirimedhi Institute of Science and Technology21210Wang ChanRayongThailand

Polyhydroxyurethanes(PHUs)have received considerable attention in the last decade as potential alternatives to traditional phosgene-based polyurethanes(PUs).The development of suitable 5CC(five membered-ring cyclic carbonate)precursors bearing multiple carbonate moieties(multi-5CCs)is a key requisite for preparing PHUs by polyaddition reaction with bis-or *** sustainable PHUs from CO_(2)-based five-membered cyclic carbonates(5CCs)obtained from biobased epoxides is a valuable strategy to bridge CO_(2) utilization and the upcycling of renewable *** this context,while many multi-5CC monomers reported in the literature are oil-based,recent efforts have led to the development of a large variety of multifunctional 5CCs that are produced by the combination of CO_(2) and renewable resources such as fatty acids and vegetable oils,lignin,terpenes,and *** this work,recent crucial advances(2019—2023)on PHUs prepared from bis-and multi-5CCs produced from CO_(2) and(partially/potentially)biobased substrates are reviewed with respect to their synthesis,thermal and mechanical properties,and their recent,emerging applications.

关键词： CO_(2) conversion Polyhydroxyurethanes Cyclic carbonates Biobased compounds fatty acids functional polymers Monomers Renewable resources

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RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation

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world Journal of Stem Cells 2024年第6期16卷 656-669页

作者： daniel B ferreira Leticia M Gasparoni Cristiane f Bronzeri Katiucia B S Paiva Laboratory of Extracellular Matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUNd Validation of the reference gene(RG)stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction(RT-qPCR)data ***,in an unreliable way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPdH),18S rRNA,andβ-actin]without paying attention to whether they are suitable for such experimental conditions or the reason for choosing such ***,such studies use only one gene when Minimum Information for Publication of Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credibility of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the best experimental or therapeutical *** cultivated dPSCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,both for 35 *** evaluated the gene expression of 10 candidates for RGs[ribosomal protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPdH,actin beta(ACTB),tubulin(TUB),aminolevulinic acid synthase 1(ALAS1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YwHAZ),eukaryotic translational elongation factor 1 alpha(Ef1a),succinate dehydrogenase complex,subunit A,flavoprotein(SdHA),and beta-2-micro-globulin(B2M)]every 7 d(1,7,14,21,28,and 35 d)by *** data were analysed by the four main algorithms,ΔCt method,geNorm,Normfinder,and BestKeeper and ranked by the Reffinder *** subdivided the samples into eight *** All of the data sets from clonogenic and osteogenic samples were analysed using the Reffinder *** final ranking showed RPLP0/TBP as the two most stable RGs and TUB/B2M as the two least stable *** theΔCt method or Normfinder analysis showed TBP/RPLP0 as the two most stable ***,geNorm analysis showed RPLP0/Ef1αin the first *** algorithms’two least stab

关键词： dental pulp stem cells Reference gene Housekeeping gene Endogenous gene Osteogenic differentiation Reffinder

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-d614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita way Yin Ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon wendy C.S.Ho Maggie Haitian wang Renee wan Yi Chan Albert Martin Li david shu Cheong Hui Paul Kay Sheung Chan department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-d614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCd614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORf7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-d614G RNA-seq Subgenomic RNA(sgRNA)

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Preparation of Ga_2O_3 thin film solar-blind photodetectors based on mixed-phase structure by pulsed laser deposition

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Chinese Physics B 2019年第1期28卷 171-177页

作者： Y M Lu C Li x H Chen S Han P J Cao f Jia Y x Zeng x K Liu w Y xu w J Liu d L Zhu College of Materials Science and Engineering Shenzhen Key Laboratory of Special Functional MaterialsShenzhen Engineering Laboratory for Advanced Technology of CeramicsGuangdong Research Center for Interfacial Engineering of Functional MaterialsShenzhen UniversityShenzhen 518060China

Gallium oxide(Ga_2O_3) thin films were deposited on a-Al2O3(1120) substrates by pulsed laser deposition(PLd) with different oxygen pressures at 650?C. By reducing the oxygen pressure, mixed-phase Ga_2O_3 films with α and β phases can be obtained, and on the basis of this, mixed-phase Ga_2O_3 thin film solar-blind photodetectors(SBPds) were *** the responsivities of the mixed-phase Ga_2O_3 SBPds and the single β-Ga_2O_3 SBPds at a bias voltage of 25 V,it is found that the former has a maximum responsivity of approximately 12 A/w, which is approximately two orders of magnitude larger than that of the latter. This result shows that the mixed-phase structure of Ga_2O_3 thin films can be used to prepare high-responsivity SBPds. Moreover, the cause of this phenomenon was investigated, which will provide a feasible way to improve the responsivity of Ga_2O_3 thin film SBPds.

关键词： Ga2O3 mixed-phase solar-blind photodetector pulsed laser deposition

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Strengthening mechanisms in magnesium alloys containing ternary Ⅰ,w and LPSO phases

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Journal of Materials Science & Technology 2018年第7期34卷 1110-1118页

作者： N.Tahreen d.f. Zhang f.S. Pan x.Q. Jiang d.Y. Li d.L. Chen department of Mechanical and Industrial Engineering Ryerson University Toronto Ontario MSB 2K3 Canada College of Materials Science and Engineering Chongqing University Chongqing 400045 China National Engineering Research Center for Magnesium Alloys Chongqing University Chongqing 400044 China Advanced Materials Research Center ChongqingAcademy of Science and Technology Chongqing 401123 China faculty of Materials and Energy Southwest University Chongqing 400715 China department of Chemical and Materials Engineering University of Alberta Alberta T6G 11-19 Canada

This study was aimed at identifying underlying strengthening mechanisms and predicting the yield strength of as-extruded Mg-Zn-Y alloys with varying amounts of yttrium （Y） element. The addition of Y resulted in the formation of ternary 1 （Mg3YZn6）, w （Mg3Y2Zn3） and LPSO （Mg12YZn） phases which subse- quently reinforced alloys ZM31 ＋ 0.3Y, ZM31 ＋ 3.2Y and ZM31 ＋ 6Y, where the value denoted the amount of Y element （in wt%）. Yield strength of the alloys was determined via uniaxial compression testing, and grain size and second-phase particles were characterized using OM and SEM. In-situ high-temperature xRd was performed to determine the coefficient of thermal expansion （CTE）, which was derived to be 1.38 x 10^-5 K^-1 and 2.35 x 10^-5 K^-1 for w and LPSO phases, respectively. The individual strengthening effects in each material were quantified for the first time, including grain refinement, Orowan looping, thermal mismatch, dislocation density, load-bearing, and particle shearing contributions. Grain refinement was one of the major strengthening mechanisms and it was present in all the alloys studied, irrespective of the second-phase particles. Orowan looping and crE mismatch were the predominant strengthening mechanisms in the ZM31＋0.3Y and ZM31 ＋ 3.2Y alloys containing I and w phases, respectively, while load-bearing and second-phase shearing were the salient mechanisms contributing largely to the superior yield strength of the LPSO-reinforced ZM31 ＋ 6Y alloy.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.

关键词： Magnesium alloy I-phase w-phase LPSO phase Strengthening mechanism

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Hot deformation and work Hardening Behavior of an Extruded Mg–Zn–Mn–Y Alloy

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Journal of Materials Science & Technology 2015年第12期31卷 1161-1170页

作者： N.Tahreen d.f.Zhang f.S.Pan x.Q.Jiang d.Y.Li d.L.Chen department of Mechanical and Industrial Engineering Ryerson University College of Materials Science and Engineering Chongqing University National Engineering Research Center for Magnesium Alloys Chongqing University Advanced Materials Research Center Chongqing Academy of Science and Technology faculty of Materials and Energy Southwest University department of Chemical and Materials Engineering University of Alberta

The aim of this study was to evaluate the strain hardening and hot deformation behavior of asextruded Mg-Zn-Mn （ZM31） magnesium alloy with varying Y contents （0.3, 3.2, and 6 wt%） via compression testing along the extrusion direction at room temperature, 200℃ and 300 ℃. Texture and phases were identified by x-ray diffraction. Alloy ZM31 ＋ 0.3Y consisted of a mixture of fine equiaxed grains and elon- gated grains with 1-phase （Mg3YZno）; alloy ZM31 ＋ 3.2Y contained 1-phase and w-phase （Mg3Y2Zn3）; alloy ZM31 ＋ 6Y had long-period stacking-ordered （LPSO） x-phase （Mg12YZn） and Mg24Y5 particles. with increasing Y content the basal texture became weakened significantly. while alloys ZM31 ＋ 0.3Y and ZM31 ＋ 3.2Y exhibited a skewed true stress-true stain curve with a three-stage strain hardening feature caused by the occurrence of {1072} extension twinning, the true stress-true stain curve of alloy ZM31 ＋ 6Y was normal due to the dislocation slip during compression. with increasing temperature the extent of skewness decreased. while the compressive yield stress, ultimate compressive stress, strain hardening exponent, and hardening capacity all decreased as the temperature increased, the retention of the high- temperature deformation resistance increased with increasing Y content mainly due to the presence of thermally-stable LPSO x-ohase.

关键词： Magnesium alloy Yttrium effect Temperature effect Strain hardening I and w-phase LPSO x-phase

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Effect of drug therapies on self-reported chemosensory outcomes after COVId-19

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world Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides fernandes Neto deusdedit Brandão Neto Richard L.Voegels fábio d.R.Pinna department of Surgery Londrina State UniversityLondrinaBrazil department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil department of Otorhinolaryngology University of São PauloSao PauloBrazil department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVId-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVId-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVId-19 drug therapy SARS-CoV-2 smell loss taste loss

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Microstructural characteristics and mechanical properties of the hot extruded Mg-Zn-Y-Nd alloys

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Journal of Materials Science & Technology 2021年第1期60卷 44-55页

作者： B.N.du Z.Y.Hu L.Y.sheng d.K.xu Y.x.Qiao B.J.wang J.wang Y.f.Zheng T.f.xi Shenzhen Institute Peking UniversityShenzhen 518057China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Jiangsu University of Science and Technology Zhenjiang 212003China Shenzhen Yezhan Electronics Co. LtdShenzhen 518110China

A new type of Mg-Zn-Y-Nd alloy for degradable orthopedic implants was *** the present study,the Zn and Y content was adjusted and their influences on the microstructures and mechanical behaviors were discussed in *** results showed that the as-extruded Mg-Zn-Y-Nd alloys are mainly composed of fine dynamic recrystallized grains(dRxed grains),la rge undRxed grains and linearly distributed secondary *** cha nge of Zn content exerts little influence on the grain structure of the extruded Mg-Zn-Y-Nd alloy,while the increase of Y content would hinder the dynamic recrystallization process and the growth of the dRxed grains,thus the size and volume fraction of the equiaxed dRxed grains *** tensile and compressive properties are very little affected by Zn content because of the similar grain *** Y content increases,the tensile yield strength(TYS) and ultimate strength(TUS) increase while the elongation decreases,this is caused by a combined strengthening effect of grain refinement,texture,precipitation and *** compressive yield strength(CYS) and ultimate strength(CUS) of Mg-Zn-Y-Nd alloy with diffe rent Y content exhibit a similar tendency as the tensile test.

关键词： Mg-Zn-Y-Nd alloy Microstructure Tensile properties Compressive properties Basal texture Twin

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