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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali chunchu Deng Mingbo nie Hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye xie Runxue Zhou Jin Deng Weihong nie Shuwei Sun Haiping Wang chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian nie Wei HUANG Jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun nie Jing Zhang xue Fang Hongmei Luo chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina cAS center for Excellence in Molecular cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

InNi alloy-induced interface effect promoting the parallel electron transfer: improved photothermal catalytic cO2 hydrogenation

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Science china chemistry 2025年

作者： Haoyu Zhang Yuhang Li Yu nie xinyu Dou Haodong Ji xin Tan Jinhua Ye Tao Yu School of chemical Engineering and Technology Tianjin University Eco-environment and Resource Efficiency Research Laboratory School of Environment and Energy Peking University Shenzhen Graduate School School of Environmental Science and Engineering Tianjin University Advanced catalytic Materials Research center School of Materials Science and Engineering Tianjin University Research center for Solar Driven carbon Neutrality Hebei University

Photothermal catalytic cO2hydrogenation is an effective means of utilizing carbon ***,it is severely limited in terms of kinetics and ***,it is necessary to meticulously design catalysts to solve this ***,a sandwich structured NiO@InNi/In2O3is designed to intrinsically regulate the direction of photogenerated carriers transfer,resulting in a cO yield of 42.97 mmol g-1h-1(1290.3μmol h-1) with a selectivity near to 100%.InNi alloy favors the collection of photogenerated carriers by the parallel way and enhancement of the adsorption and activation of *** grown on the surface of InNi alloy not only improves the adsorption of H2and provides sufficient H+for the reaction,but also makes InNi alloy more stable during the reaction *** photothermal effect caused by In2O3accelerates the transfer of photogenerated carriers and increases the surface temperature of the catalyst,thereby synergistically promoting the reaction from a kinetic *** work ameliorates the kinetic and thermodynamic limitations of the photothermal catalytic cO2hydrogenation process through rationally designing the electron transfer direction of the sandwich structured catalysts to parallel way.

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Engineering N3c vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science china chemistry 2025年

作者： Yina nie Weijie Yang xin Wang xiang Li Lele Wei xiaolin Bai Lin Liu Feng Fu Jun Wan college of chemistry & chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research center of carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-c3N4（M1U3cN） photocatalyst with bridged N3cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3cvacancies and abundant micromeso-macroporous distribution in M1U3cN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Preparation and characterization of a new magnetic fluid with good low temperature resistance

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Nano Research 2025年第1期18卷 477-486页

作者： Shilin nie Decai Li ✉1 Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Tribology in advanced equipment Tsinghua UniversityBeijing 100084China

Magnetic fluids are a type of novel functionalmaterial that has emerged over the past two decades, whichhave found applications in various aspects of production anddaily life. However, the application of conventional magneticfluids in low-temperature environments is severely limited andoften unsatisfactory. To address this issue, we havedeveloped a new magnetic fluid with excellent low-temperatureresistance. Initially, bare Fe_(3)O_(4) magnetic nanoparticles(FMNPs) were synthesized via co-precipitation without aprotective gas. Subsequently, these particles were modified using polyethylene glycol (PEG)-4000 as a surfactant. Thebare and modified FMNPs (MFMNPs) were characterized using x-ray diffraction (xRD), vibrating sample magnetometer(VSM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetricanalysis-differential thermal gravimetric (TGA-DTG) analysis. The rheological properties, low-temperature resistance of themagnetic fluid were also evaluated. The characterization results indicate that the MFMNPs are spherical andmonodisperse, with a narrow size distribution and a mean particle size of approximately 12 nm. Furthermore, the FTIRspectra and TGA-DTA results suggest that PEG-4000 is linked to the bare Fe_(3)O_(4) particles via hydrogen bonding, indicatingsuccessful modification of the Fe_(3)O_(4) magnetic nanoparticles using PEG. VSM measurements demonstrate that surfacemodification does not alter the crystal morphology or superparamagnetic of Fe_(3)O_(4). However, it does reduce the saturationmagnetization from 68.17 to 54.75 emu/g. Additionally, the prepared magnetic fluid exhibits shear thinning and magneticviscosity effects. It also exhibits excellent low-temperature resistance, maintaining good fluidity without freezing even at -60 ℃. In summary, these results collectively indicate that the new low-temperature resistant magnetic fluid developed in thisstudy is stable and has broad application prospects.

关键词： magnetic fluid low-temperature resistance polyethylene glycol ethylene glycol aqueous solution superparamagnetic

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

DYNAMIc TENSILE BEHAVIOR OF 5crMnMo AT ELEVATED TEMPERATURES

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 521-527页

作者： W.Huang x.nie x.Zan Y.M.xia Department of Mechanical Engineering Key Laboratory of Mechanical Behavior and Design of Materials Hefei University of Science & Technology of China 230027 Hefei ChinaDepartment of Mechanical Engineering Key Laboratory of Mechanical Behavior and Design of Materials Hefei University of Science & Technology of China 230027 Hefei ChinaDepartment of Mechanical Engineering Key Laboratory of Mechanical Behavior and Design of Materials Hefei University of Science & Technology of China 230027 Hefei ChinaDepartment of Mechanical Engineering Key Laboratory of Mechanical Behavior and Design of Materials Hefei University of Science & Technology of China 230027 Hefei China

A new experimental technique has been developed for the performance of high temperature, high-strain rate tensile experiments in the self-designed tensile impact apparatus. This technique uses rapid contact heating method to heat the specimen to the desired temperature, thus avoids a significant temperature rise in incident and transmitted bars, and at the same time it is capable of retaining a nearly homogeneous temperature field within the specimen. As an illustration of its application, the high-temperature response of the forging die steel 5crMnMo at high strain rates has been examined. Stress-strain curves are obtained for this material at strain rates ranging from 230s-1 to 1200s-1 and at temperature ranging from 25 to 600℃, respectively. For comparison, quasi-static experiments are performed over a slightly smaller range of temperatures.

关键词： elevated temperature strain rate tensile 5crMnMo