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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

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Signal Transduction and Targeted Therapy 2024年第1期9卷 279-294页

作者： Liping Chen Shihao Zhu Tianyuan Liu x.an Zhao Tao xiang x.ao Hu Chen Wu dongx.n Lin department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Cancer Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Ox.ord Institute Chinese Academy of Medical SciencesBeijing 100006China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Epithelial-mesenchymal transition(EMT)and proliferation play important roles in epithelial cancer formation and progression,but what molecules and how they trigger EMT is largely *** we performed spatial transcriptomic and functional analyses on samples of multistage esophageal squamous-cell carcinoma(ESCC)from mice and humans to decipher these critical *** investigating spatiotemporal gene ex.ression patterns and cell–cell interactions,we demonstrated that the aberrant epithelial cell interaction via EFNB1-EPHB4 triggers EMT and cell cycle mediated by downstream SRC/ERK/AKT *** aberrant epithelial cell interaction occurs within the basal layer at early precancerous lesions,which ex.ands to the whole epithelial layer and strengthens along the cancer development and *** analysis revealed that the aberrant EFNB1-EPHB4 interaction is caused by overex.ressedΔNP63 due to TP53 mutation,the culprit in human ESCC *** results shed new light on the role of TP53-TP63/ΔNP63-EFNB1-EPHB4 ax.s in EMT and cell proliferation in epithelial cancer formation.

关键词： esophageal TP53 squamous

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the ex.ression and nucleocytoplasmic localization of Lipin1

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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： Fang Wang Yux.ng Liu Yi dong Meifang Zhao Hao Huang Jieyuan Jin Liangliang Fan Rong xiang department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid ***,little is known about the function of Lipin3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.d612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-ex.me sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lipin3 ***,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to ex.lore the pathophysiological roles of Lipin3 in TG *** found that Lipin3-heKO mice ex.ibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overex.ression and abnormal distribution of Lipin1 in cytosol and *** increased ex.ression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lipin3 was a novel disease-causing gene inducing obesity and *** also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

Brillouin Klein space and half-turn space in three-dimensional acoustic crystals

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Science Bulletin 2024年第13期69卷 2050-2058页

作者： Zhenx.ao Zhu Linyun Yang Jien Wu Yan Meng xiang x. Bei Yan Jingming Chen Jiuyang Lu x.eqin Huang Weiyin deng Ce Shang Perry Ping Shum Yihao Yang Hongsheng Chen Kex.n xiang Gui-Geng Liu Zhengyou Liu Zhen Gao State Key Laboratory of Optical Fiber and Cable Manufacture Technology Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China King Abdullah University of Science and Technology(KAUST) Physical Science and Engineering Division(PSE)Thuwal 23955-6900Saudi Arabia Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Science and Technology Innovation CenterCollege of Information Science and Electronic EngineeringZJU-UIUC InstituteZhejiang UniversityHangzhou 310027China division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The Bloch band theory and Brillouin zone(BZ)that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics,ranging from condensed matter to topological *** theoretical breakthrough revealed that,under the projective symmetry algebra enforced by artificial gauge fields,the usual two-dimensional(2d)BZ(orientable Brillouin two-torus)can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold ***,the physical consequence of artificial gauge fields on the more general three-dimensional(3d)BZ(orientable Brillouin three-torus)was so far ***,we theoretically discovered and ex.erimentally observed that the fundamental domain and topology of the usual 3d BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3d acoustic crystal with artificial gauge *** ex.erimentally identify peculiar 3d momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band ***,we ex.erimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist,radically distinct from all previous 3d topological *** discovery not only fundamentally modifies the fundamental domain and topology of 3d BZ,but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gaugesymmetry-enriched topological physics and robust acoustic wave manipulations beyond the ex.sting paradigms.

关键词： Momentum-space non-symmorphic symmetry Brillouin Klein space and half-turn space Acoustic Klein bottle insulator Self-collimated topological surface states

Achieving Ultra-Broad Microwave Absorption Bandwidth Around Millimeter-Wave Atmospheric Window Through an Intentional Manipulation on Multi-Magnetic Resonance Behavior

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Nano-Micro Letters 2024年第9期16卷 291-307页

作者： Chuyang Liu Lu x. x.eyu xiang Yujing Zhang Li Zhou Bo Ouyang Fan Wu dong‑Hyun Kim Guangbin Ji School of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016JiangsuPeople’s Republic of China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Physics Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuPeople’s Republic of China School of Physics Chungbuk National UniversityCheongju 28644South Korea department of Chemistry School of ScienceTianjin UniversityTianjin 300072People’s Republic of China

The utilization of electromagnetic waves is rapidly advancing into the millimeter-wave frequency range,posing increasingly severe challenges in terms of electromagnetic pollution prevention and radar ***,ex.sting millimeter-wave absorbers are still inadequate in addressing these issues due to their monotonous magnetic resonance *** this work,rare-earth La^(3+)and non-magnetic Zr^(4+)ions are simultaneously incorporated into M-type barium ferrite(BaM)to intentionally manipulate the multi-magnetic resonance *** leveraging the contrary impact of La^(3+)and Zr^(4+)ions on magnetocrystalline anisotropy field,the restrictive relationship between intensity and frequency of the multi-magnetic resonance is successfully *** magnetic resonance peak-differentiating and imitating results confirm that significant multi-magnetic resonance phenomenon emerges around 35 GHz due to the reinforced ex.hange coupling effect between Fe^(3+)and Fe^(2+)***,Mosbauer spectra analysis,first-principle calculations,and least square fitting collectively identify that additional La^(3+)doping leads to a profound rearrangement of Zr^(4+)occupation and thus makes the portion of polarization/conduction loss increase *** a consequence,the La^(3+)-Zr^(4+)co-doped BaM achieves an ultra-broad bandwidth of 12.5+GHz covering from 27.5 to 40+GHz,which holds remarkable potential for millimeter-wave absorbers around the atmospheric window of 35 GHz.

关键词： Microwave absorption Ultra-broad bandwidth M-type barium ferrite Magnetocrystalline anisotropy field Multimagnetic resonance

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MACS-W:A modified optical clearing agent for imaging 3d cell cultures

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 24-34页

作者： xiang Zhong Chao Gao Hui Li Yuening He Peng Fei Zaozao Chen Zhongze Gu dan Zhu Tingting Yu Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China School of Optical and Electronic Infrmation Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University NanjingJiangsu 210096P.R.China Institute of Biomaterials and Medical devices Southeast University Suzhou Jiangsu 215163P.R.China

Three-dimensional(3d)cell cultures have contributed to a variety of biological research fields by filling the gap between monolayers and animal *** modern optical sectioning microscopic methods make it possible to probe the complex.ty of 3d cell cultures but are limited by the inherent *** tissue optical clearing methods have emerged as powerful tools for investigating whole-mount tissues in 3d,they often have limitations,such as being too harsh for fragile 3d cell cultures,requiring complex.handling protocols,or inducing tissue deformation with shrinkage or *** address this issue,we proposed a modified optical clearing method for 3d cell cultures,called MACS-W,which is simple,highly efficient,and *** our evaluation of MACS-W,we found that it ex.ibits ex.ellent clearing capability in just 10 min,with minimal deformation,and helps drug evaluation on tumor *** summary,MACS-W is a fast,minimally-deformative and fluorescence compatible clearing method that has the potential to be widely used in the studies of 3d cell cultures.

关键词： Tissue optical clearing 3d cell cultures imaging

Optimizing 3d spin polarization of CoOOH by in situ Mo doping for efficient ox.gen evolution reaction

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Carbon Energy 2024年第1期6卷 236-244页

作者： Zhichao Jia Yang Yuan Yanx.ng Zhang xiang Lyu Chenhong Liu x.aoli Yang Zhengyu Bai Haijiang Wang Lin Yang Key Laboratory of Green Chemical Media and Reactions School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsMinistry of EducationHenan Normal UniversityXinxiangHenanChina School of Physics Henan Normal UniversityXinxiangHenanChina Oak Ridge National Laboratory Electrification and Energy Infrastructures DivisionOak RidgeTennesseeUSA department of Mechanical and Energy Engineering Key Laboratory of Energy Conversion and Storage TechnologiesSouthern University of Science and TechnologyShenzhenGuangdongChina

Transition-metal ox.hydrox.des are attractive catalysts for ox.gen evolution reactions(OERs).Further studies for developing transition-metal ox.hydrox.de catalysts and understanding their catalytic mechanisms will benefit their quick transition to the nex. ***,Mo-doped CoOOH was designed as a high-performance model electrocatalyst with durability for 20 h at 10 mAcm−***,it had an overpotential of 260 mV(glassy carbon)or 215 mV(nickel foam),which was 78 mV lower than that of IrO_(2)(338 mV).In situ,Raman spectroscopy revealed the transformation process of *** using the density functional theory showed that during OER,doped Mo increased the spin-up density of states and shrank the spin-down bandgap of the 3d orbits in the reconstructed CoOOH under the electrochemical activation process,which simultaneously optimized the adsorption and electron conduction of ox.gen-related intermediates on Co sites and lowered the OER *** research provides new insights into the methodical planning of the creation of transition-metal ox.hydrox.de OER catalysts.

关键词： electrocatalyst in situ Raman Mo-doped CoOOH ox.gen evolution reaction

Ultra-high-temperature application of Mx.ne: Stabilization of 2d Ti_(3)C_(2)T_(x. for cross-scale strengthening and toughening of 3d TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： Lu Liu Guobing Ying Quanguo Jiang dong Wen Peng Wang Meng Wu Ziying Ji Yongting Zheng xiang Wang department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within Mx.nes make them considerably useful for ultra-high-temperature ***,ex.ensive research on Ti_(3)C_(2)T_(x. Mx.ne has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x. and TiC is performed to prevent the Ti_(3)C_(2)T_(x. phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and ex.mining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x. and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x. *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x. can effectively improve the cross-scale strengthening and toughening of the TiC matrix.providing a new path for designing and developing two-dimensional(2d)carbides cross-scale-enhanced three-dimensional(3d)carbides with the same elements relying on a wide variety of Mx.nes.

关键词： Mx.ne ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

GCGR:novel potential therapeutic target for chronic kidney disease

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Science China(Life Sciences) 2024年第7期67卷 1542-1544页

作者： Yan Hu Hao Huang Rong xiang Key Laboratory of Birth defects and Related diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu 610041China department of Nephrology Xiangya Hospital Central South UniversityChangsha 410008China department of Cell Biology School of Life SciencesCentral South UniversityChangsha 410013China National Clinical Research Center for Geriatric disorders Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Organ Fibrosis Central South UniversityChangsha 410013China

The kidney,a central regulator of systemic homeostasis essential for human health,plays a vital role in various metabolic pathways,including fatty acid metabolism,gluconeogenesis,glycolysis,and mitochondrial *** kidney disease(CKd)manifests as a progressive decline in renal function,marked by reduced glomerular filtration rate(GFR)or persistent kidney damage persisting for more than three months.

关键词： kidney metabolism homeostasis

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Heterointerface engineering of rhombic Rh nanosheets confined on Mx.ne for efficient methanol ox.dation

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Journal of Energy Chemistry 2024年第6期93卷 419-428,I0011页

作者： Qi Zhang Quanguo Jiang xiang Yang Chi Zhang Jian Zhang Lu Yang Haiyan He Guobing Ying Huajie Huang College of Materials Science and Engineering Hohai UniversityNanjing 210098JiangsuChina New Energy Technology Engineering Lab of Jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023JiangsuChina School of Materials Science and Engineering Southeast UniversityNanjing 211100JiangsuChina

Although metallic rhodium(Rh)is regarded as a promising platinum-alternative anode catalyst of direct methanol fuel cell(dMFC),the conventional"particle-to-face"contact model between Rh and matrix.largely limits the overall electrocatalytic performance due to their insufficient cooperative ***,we report a controllable and robust heterointerface engineering strategy for the bottom-up fabrication of rhombic Rh nanosheets in situ confined on Ti_3C_(2)T_x.Mx.ne nanolamellas(Rh NS/Mx.ne)via a convenient stereoassembly *** unique design concept gives the resulting 2d/2d Rh NS/Mx.ne heterostructure intriguing tex.ural features,including large accessible surface areas,strong"face-toface"interfacial interactions,homogeneous Rh nanosheet distribution,ameliorative electronic structure,and high electronic *** a consequence,the as-prepared Rh NS/Mx.ne nanoarchitectures ex.ibit ex.eptional electrocatalytic methanol ox.dation properties in terms of a large electrochemically active surface area of 126.2 m~2 g_(Rh)~(-1),a high mass activity of 1056.9 mA mg_(Rh)-~1,and a long service life,which significantly outperform those of conventional particle-shaped Rh catalysts supported by carbon black,carbon nanotubes,reduced graphene ox.de,and Mx.ne matrix.s as well as the commercial Pt nanoparticle/carbon black and Pd nanoparticle/carbon black catalysts with the same noble metal loading *** functional theory calculations further demonstrate that the direct electronic interaction at the well-contacted 2d/2d heterointerfaces effectively enhances the adsorption energy of Rh nanosheets and induces a left shift of the d-band center,thereby making the Rh NS/Mx.ne configuration suffer less from CO *** work highlights the importance of rational heterointerface design in the construction of advanced noble metal/Mx.ne electrocatalysts,which may provide new avenues for developing the nex.-generation dMFC devices.

关键词： Rhodium nanosheet Ti_(3)C_(2)T_(x.Mx.ne Heterointerface Electrocatalyst Fuel cell

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