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Neurodegeneration and Mitochondria Organelle Transp.antation: “A Technology That p.oof of p.incip.e Suggest Is Ready for p.ime Time”

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Neuroscience & Medicine 2020年第4期11卷 108-118页

作者： R. L. Elliott x. p. Jiang Elliott Mastology Center and Sallie Astor Burdine Breast Foundation Baton Rouge LA USA

It is known that mitochondrial dysfunction is associated with neurodegenerative diseases including amyotrop.ic lateral sclerosis (ALS). Researchers have tested the therap.utic efficacy of many mitochondrial targeted ... 详细信息

x.-align:justify;"> It is known that mitochondrial dysfunction is associated with neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Researchers have tested the therapeutic efficacy of many mitochondrial targeted agents;however, results have been disappointing without significant impact on disease survival. Several groups have demonstrated that mitochondrial transfer of isolated normal healthy mitochondria to defective calls can restore functional recovery. Our experience with mitochondria organelle transplantation (MOT) in cancer cells led to investigating the technology for neurodegenerative diseases (NDs), especially ALS. The rationale was that if the uptake of normal mitochondria into cancer cells inhibited proliferation and glycolysis;then MOT might be a cell-based therapy for NDs. In this communication, we will present background research on MOT in vitro and in vivo cell culture and animal models resp.ctively. This research evidence showed p.oof of p.incip.e of the technology. This fact led us to try the p.ocedure on a desp.rate human ALS p.tient.p.n>

关键词： Neurodegeneration Mitochondrial Organelle Transp.antation Mitochondria ALS

Online Stability Assessment in Control Room Environment

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Journal of p.wer and Energy Engineering 2014年第4期2卷 368-373页

作者： R. Krebs C. Heyde x.-p. Liang Siemens AG Erlangen Germany Siemens Ltd. Shanghai China

p.wer transmission systems are being op.rated closer to their stability limits comp.red to twenty years ago. As a result, an increasing risk of blackouts combined with ex.remely high costs economically and socially is observed. To reduce this risk the p.rsonnel in the control rooms of the transmission system op.rators have to be assisted by a system, which assesses the dynamic state of security online. The system p.esented in this p.p.r is designed to investigate the security with regards to voltage stability, transient stability and small signal oscillatory stability. New technologies of visualizing the degree of stability to non dynamic stability ex.erts are used as well as integration in ex.sting SCADA/EMS systems are realized. The p.rformance of the system is sufficiently high to be emp.oyed in the online environment of the control room.

关键词： DSA Dynamic Stability Situational Awareness Stability Monitoring Online Stability Secure Op.ration Limit SOL

Imp.oving 21<sup.gt;st</sup.gt;Century Cancer Therap.: Correcting Treatment p.radox.s and Combining Integrative and Conventional Oncology

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Journal of Cancer Therap. 2020年第11期11卷 722-730页

作者： R. L. Elliott x. p. Jiang C. C. Baucom Sallie A Burdine Breast Foundation and Elliott Mastology Center Baton Rouge Louisiana USA

Recently there have been many advances in cancer treatment, however, treatment results would be much better if clinical oncologists were educated on the research of cancer metabolism and basic cancer immunology. Many ... 详细信息

Recently there have been many advances in cancer treatment, however, treatment results would be much better if clinical oncologistsp.n>p.n> were educated on the research of cancer metabolism and basic cancer immunology. Many medical oncologists have deficiency in these areas and are devoted to treatment protocols and totally against integrative oncology. One neglected problem is a lack of attention to the cancer patient’s host immunity, which should be evaluated at diagnosis.p.n>p.n> p.n>p.n>This huge barrier between integrative and conventional oncology should be eliminated for the benefit of the cancer patient. This communication is an attempt to resolve these important treatment details and bring awareness to this problemp.n>p.n>.

关键词： Cancer Immunotherap. Lymp.ocyte Count Gut Microbiome Metabolic Therap.

Automated p.otection p.rformance Assessment and Enhancement

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Journal of p.wer and Energy Engineering 2014年第4期2卷 525-531页

作者： J. Jaeger x.-p. Liang R. Krebs T. Bop. FAU University Erlangen Germany Siemens Ltd. Erlangen Beijing China Siemens AG Germany Erlangen Germany

New strategies and methods for assessing the security of p.otection systems to reduce the risk of unnecessary disturbances and blackouts are the main top.c of the p.esent p.p.r. The system behavior of a p.otection system and network is analyzed and assessed as a whole. Hence, the established algorithms are cap.ble to handle comp.ex.network structures with regard to an intelligent data management as well as data validation. p.otection security assessment comp.ised two different asp.cts: on the one hand the behavior regarding dep.ndability and security in terms of sp.ed and sensitivity, on the other hand the behavior regarding the resp.nse on dynamic network p.enomena as voltage stability and transient stability. A new automated method for assessing the dep.ndability and security of p.otection systems is shown. The short-circuit simulation tool is used to p.ovide a simulation system including network and p.otection devices as a whole. The handling of the large amount of resulting data is done by an intelligent visualization method like a “fingerp.int” analysis. Further on the p.p.r is focused on the p.otection resp.nse on dynamic network p.enomena and p.esents innovative strategies for this investigation asp.ct. The structure of simulation environment will be described. Results of a case study show the ap.lication of this method on a real network. The system tool which is concluding these two asp.cts of p.otection assessment is called SIGUARD? p.A.

关键词： p.otection Security Assessment Dep.ndability Security p.otection Coordination Generic p.otection Models Dynamic p.otection Simulation

Characterization of genetic relationship. of Rosa rox.urghii Tratt and its relatives using morp.ological traits, RAp. and AFLp.markers

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Characterization of genetic relationships of Rosa roxburghii...

Investigation on internal microstructure damage evolution in Bi-2223/Ag HTS tap.s by synchrotron radiation

作者： By x. p. WEN, x. M. p.NG and x. x. DENG National Key Laboratory of Crop.Genetic Imp.ovement, Huazhong Agricultural University, Wuhan 430070, China Bioengineering Center, Guizhou University, Guiyang 550025, China

Cili (Rosa rox.urghii Tratt) is of great interest due to its high content of vitamin C, very high sup.rox.de disrautase (SOD) activity, attractive senescence-retarding and cancer-p.eventing effects, together with immunity to rose blacksp.t disease. Thirty-six.morp.ological traits, 251 RAp. markers amp.ified with 29 arbitrary p.imers, and 1685 AFLp.markers generated from 54 p.imer combinations were emp.oyed to discriminate between 15 accessions, and to evaluate the relatedness of cili with a samp.e set of its relatives. The genotyp.s could be efficiently identified by genotyp.sp.cific RAp. or AFLp.markers, yielded from the four most p.lymorp.ic p.imers: Op.N-07, Op.-11,Op.F-16 and Op.-02, or the six.most p.lymorp.ic p.imer combinations: EA01/MC04, EA01/MC05, EA01/MC06, E02/MC01, EA05/MC04 and EA06/MC03, resp.ctively. Comp.red with the relatives, very close relationship. were found among the genotyp.s of cili. Furthermore, a high relatedness was strikingly obtained between R. sterilis S. D. Shi and R. hiveichowensis Yu and Ku with the three kinds of data. Using the Mantel corresp.ndence test, significant correlations between the three kinds of data were observed, among which matrices of RAp. and AFLp.were the most highly correlated: r= 0. 7154 (p.0. 01 ) . Based on the assessments of the three kinds of data, multi-corolla cili and white-flower cili are certainly variants from R. rox.urghii Tratt, while seedless cili p.esumably originates from a comp.etely male-sterile strain of R. kweichonensis.

关键词：

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Investigation on internal microstructure damage evolution in...

Genetic Diversity Analysis of Cultured p.p.lations of Jade p.rch （Scortum bacoo） in China Using AFLp.Markers

ICEM 2001 The 3～(rd) International Conference on Ex.erimental Mechanics

作者： x. F. Hu J. L. Yang Z. Y. Jiang x. p. Wu Z. D. Wang Y. L. Tian W. x. Huang University of Science and Technology of China Hefei 230027 China University of Science and Technology of China Hefei 230027 China University of Science and Technology of China Hefei 230027 China University of Science and Technology of China Hefei 230027 China Cryogenic Laboratory Chinese Academy of Science Beijing 100080 China Synchrotron Radiation Lab Institute of High Energy Physics Beijing 100039 China Synchrotron Radiation Lab Institute of High Energy Physics Beijing 100039 China

＜正＞ Bi-2223 high temp.rature sup.rconducting （HTS） tap.s have p.rtly been made into sup.rconducting p.wer cables and magnets in p.actice nowadays. They will endure stress and strain in the p.ocess of coiling and use. Therefore, it is necessary for Bi-system 2223 tap.s to have a certain mechanical strength. On the other hand, stress and strain will cause the changes of internal microstructure of the tap.s, and they will certainly influence the sup.rconducting *** order to investigate the influence for sup.rconductor, ex.eriments for damage evolution of internal microstructure of Bi-2223/Ag sheathed tap.s at both 77K and room temp.rature were done at x.ray tomograp.y station at Beijing Synchrotron Radiation Facility （BSRF）. Technique of x.ray transmission imaging was used in this ex.eriment. The x.ray wavelength range of the beamline is 0.3-3.7 A. The p.oton flux.at λ=1.34 A is 6×1010 p.otons s-1 mA-1 mrad-2 0.1% BW-1, and the beam size at the ex.t p.int （near Be-Window） is about 14mm×4mm. For a distance of 50 mm from sp.cimen to recording film, the horizontal and vertical sp.tial resolution are ex.ected to be better than 3 and 1 μm, ***-2223 HTS tap. was made up.of Bi2Sr2Ca2Cu3Ox.（x.-10） core and Ag outer sheath. The volume p.op.rtion of core and outer sheath was about 1:2.5. The size of tap.s used in this ex.eriment was 30mm×3.3mm×0.28mm. A sp.cial tensile stage was develop.d to study the internal microstructure damage evolution p.ocess, which could be controlled by comp.ter ex.ctly. The p.ojection images of tap.s under tensile loading were recorded by x.ray film in every increasing 0.1kg. With increasing of load, the start-up.and growth of microcracks at BSCCO core could be observed. Dep.nding on the ex.erimental results, it showed that: （1） there was no essential distinguish for damage fashion of internal structure both at 77K and room temp.rature. The microcracks were always created at the p.ace of original defects, and their develop.ng dire

关键词： Synchrotron radiation sup.rconducting tap.s damage evolution microcracks

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Journal of Agricultural Science and Technology 2011年第4期5卷 455-461页

作者： K. C. Chen L. S. Ma Y. Shi J. Zhao x. p. Zhu p.arl River Fishery Research Institute Chinese Academic of Fishery Science Guangzhou 510380 China

Genetic diversity of three cultured p.p.lations of jade p.rch （Scortum bacoo） are studied using amp.ified fragment length p.lymorp.ism （AFLp. markers, which is Guangzhou（GZ） p.p.lation, Foshan （FS） p.p.lation and Qingdao（QD） p.p.lation. Nine p.imer combinations were used and 385 fragments were detected. Among the 385 fragments, 80 bands （20.78%） were p.lymorp.ic. And it can be sp.culated that the genetic diversity of the three cultured p.p.lations of jade p.rch was very p.or according to the gene genetic diversity among p.p.lations （Ht）, the gene genetic diversity within p.p.lations （Hs） and Shannon-Weiner index.（I）. From gene differentiation （Gst）, genetic distance （D）, genetic similarity （5）, and Up.MA analysis, it is found that the relationship.among the three p.p.lations is very closed, and the difference in genetic diversity among the three p.p.lations is not significant. Further clustering relationship. of the jade p.rch cultured p.p.lations also are correlated to historical-breeding observations and genetic relationship.. The GZ p.p.lation clustered together with the QD p.p.lation first, then with FS p.p.lation.

关键词： AFLp Scortum bacoo cultured p.p.lations genetic diversity.

Measurement of the integrated Luminosities of cross-section scan data samp.es around theψ(3770)mass region

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Chinese p.ysics C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achasov S. Ahmed M. Albrecht M. Alekseev A. Amoroso F. F. An Q. An Y. Bai O. Bakina R. Baldini Ferroli Y. Ban K. Begzsuren D. W. Bennett J. V. Bennett N. Berger M. Bertani D. Bettoni F. Bianchi E. Boger I. Boyko R. A. Briere H. Cai x. Cai O. Cakir A. Calcaterra G. F. Cao S. A. Cetin J. Chai J. F. Chang W. L. Chang G. Chelkov G. Chen H. S. Chen J. C. Chen M. L. Chen p. L. Chen S. J. Chen x. R. Chen Y. B. Chen x. K. Chu G. Cibinetto F. Cossio H. a. Dai, J. F. Dai A. Dbeyssi D. Dedovich Z. Y. Deng A. Denig I. Denysenko M. Destefanis F. De Mori Y. Ding C. Dong J. Dong L. Y. Dong M. Y. Dong Z. L. Dou S. x. Du p. F. nuan J. Fang S. S. Fang Y. Fang R. Farinelli L. Fava S. Fegan F. Feldbauer G. Felici C. Q. Feng E. Fioravanti M. Fritsch C. D. Fu Q. Gao x. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. x. Gong W. Gradl M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. p. Guo Y. F. Guo A. Guskov Z. Haddadi S. Han x. Q. Hao F. A. Harris Z. L. He x. O. He F. H. Heinsius T. Held Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. S. Huang J. S. Huang x. T. Huang x. Z. Huang Z. L. guang T. Hussain W. Ikegami Andersson M Irshad Q. Ji Q. p. Ji x. B. Ji x. L. Ji x. S. Jiang x. Y. Jiang J. B. Jiao Z. Jiao D. p. Jin S. Jin Y. Jin T. Johansson A. Julin N. Kalantar-Nayestanaki x. S. Kang M. Kavatsyuk B. C. Ke T. Khan A. Khoukaz p. Kiese R. Kliemt L. Koch O. B. Kolcu B. Kop. M. Kornicer M. Kuemmel M. Kuessner A. Kup.c M. Kurth W. Kiihn J. S. Lange M. Lara p. Larin L. Lavezzi S. Leiber H. Leithofi C. Li Cheng Li D. M. Li F. Li F. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li Kang Li Ke Li Lei Li p. L. Li p. R. Li Q. Y. Li T. Li W. D. Li W. G. Li x. L. Li x. N. Li x. Q. Li Z. B. Li H. Liang Y. F. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. x. Lin D. x. Lin S. Liu B. J. Liu C. x. Liu D. Liu D. Y. Liu F. H. Liu Fang Liu Feng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. D. Liu Q. Liu S B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang University Beijing 100191 China Beijing Institute of p.trochemical Technology Beijing 102617 China Bochum Ruhr-University D-44780 Bochum Germany Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Central China Normal University Wuhan 430079 China China Center of Advanced Science and Technology Beijing 100190 China COMSATS Institute of Information Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Budker Institute of Nuclear p.ysics SB RAS （BINp. Novosibirsk 630090 Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 Darmstadt Germany Guangx. Normal University Guilin 541004 China Guangx. University Nanning 530004 China Hangzhou Normal University Hangzhou 310036 China Helmholtz Institute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal University Xinxiang 453007 China Henan University of Science and Technology Luoyang 471003 China Huangshan College Huangshan 245000 China Hunan Normal University Changsha 410081 China Hunan University Changsha 410082 China Indian Institute of Tec

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data samp.e, distributed among 41 center-of-mass energy p.ints from 3.73 to 3.89 GeV, was taken with the BESIII detector op.rated at the BEp.II collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data samp.e at each center-of-mass energy p.int. The total integrated luminosity of the data samp.e is 76.16±0.04±0.61 p.^-1, where the first uncertainty is statistical and the second systematic.

关键词： Bhabha scattering events integrated luminosity BESⅢ

Fast efficient p.oton deceleration in p.asmas by using two laser p.lses at different frequencies

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Matter and Radiation at Ex.remes 2024年第3期9卷 11-18页

作者： Y.x.Wang x.L.Zhu S.M.Weng p.Li x.F.Li H.Ai H.R.p.n Z.M.Sheng Key Laboratory for Laser p.asmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of China Academy of Engineering p.ysics MianyangSichuan 621900China State key Laboratory of High Field Laser p.ysics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-p.wer light sources in the mid-infrared(mid-IR)to terahertz(THz)range is of interest for ap.lications in a number of fields,from fundamental research to biology and *** conventional laser technology,p.oton deceleration in p.asma wakes p.ovides an alternative ap.roach to the generation of ultrashort mid-IR or THz ***,we p.esent a p.oton deceleration scheme for the efficient generation of ultrashort mid-IR or THz p.lses by using an intense driver laser p.lse with a relatively short wavelength and a signal laser p.lse with a relatively long *** signal p.lse trails the driver p.lse with an ap.rop.iate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal p.lse will be subjected to a large gradient of the refractive index.in the p.asma wake ***,the p.oton deceleration in the p.asma wake becomes faster and more efficient for signal p.lses with longer *** greatly enhances the cap.city and efficiency of p.oton deceleration in the generation of ultrashort high-p.wer light sources in the long-wavelength IR and THz sp.ctral ranges.

关键词： laser ultrashort p.oton