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创意显微摄影在组织学及病理学教学中的应用

中国组织化学与细胞化学杂志 2019年第6期28卷 569-572页

作者：董娟娟吴怡娴陈邬锦倪萍李琴赵雨欣许彭李秀梅新疆医科大学基础医学院乌鲁木齐830011

"组织学、病理学创意显微摄影大赛"为当代大学生在组织学与胚胎学、病理学课程学习中的发散思维和新颖解读提供了展示平台。本次研究对大赛实施过程及结果进行了描述和反思,旨在激发学生创新观察潜能,提高学生自主学习和教学效果的同时... 详细信息

"组织学、病理学创意显微摄影大赛"为当代大学生在组织学与胚胎学、病理学课程学习中的发散思维和新颖解读提供了展示平台。本次研究对大赛实施过程及结果进行了描述和反思,旨在激发学生创新观察潜能,提高学生自主学习和教学效果的同时,为今后开展顺应时代发展的多元化教学活动提供一定的参考。

关键词：组织学病理学显微摄影大赛

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丽江市家犬中致病性耶尔森菌流行病学调查

中国热带医学 2018年第12期18卷 1199-1201页

作者：张海鹏吴鹤松陈邬锦段存娟钟佑宏郭英段然梁俊容王鹏大理大学公共卫生学院云南大理671000 云南省地方病防治所云南省自然疫源性疾病防控技术重点实验室云南大理671000 中国疾病预防控制中心传染病预防控制所北京102206

目的了解丽江市鼠疫疫源地内家犬中携带致病性耶尔森菌的流行情况及其病原学特征。方法选择丽江市古城区和玉龙县各2个乡镇,逐户采集犬肛拭子及血液标本。肛拭子经4℃冷增菌后,采用耶尔森选择培养基对小肠结肠炎耶尔森菌、鼠疫耶尔森... 详细信息

目的了解丽江市鼠疫疫源地内家犬中携带致病性耶尔森菌的流行情况及其病原学特征。方法选择丽江市古城区和玉龙县各2个乡镇,逐户采集犬肛拭子及血液标本。肛拭子经4℃冷增菌后,采用耶尔森选择培养基对小肠结肠炎耶尔森菌、鼠疫耶尔森菌和假结核耶尔森菌三种致病性耶尔森菌进行分离;对所分菌株再进行生化鉴定、生物分型、血清分型和毒力基因型检测;对血液标本进行鼠疫F1抗体的检测。结果共采集467份肛拭子,分离到4株小肠结肠炎耶尔森菌,未分离到鼠疫耶尔森菌及假结核耶尔森菌;4株小肠结肠炎耶尔森菌中,2株为O∶3血清型和非1A生物型,毒力基因齐全为致病株;另2株为1A生物型血清型未定,毒力基因阴性为非致病株;467份血液标本中26份为F1抗体阳性,其中1份阳性标本与1份分离到小肠结肠炎耶尔森菌的肛拭子来自同一只家犬。结论丽江市家犬中携带小肠结肠炎耶尔森菌,且有致病性菌株;此外,在一只家犬中,发现存在着鼠疫耶尔森菌与小肠结肠炎耶尔森菌共感染的现象。

关键词：小肠结肠炎耶尔森菌家犬毒力

Analysis of Hospital Budget Management Control Based on Smart Hospital

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Journal of Clinical and Nursing Research 2024年第5期8卷 169-173页

作者： Yuqi chen Changzhou wujin People’s Hospital Changzhou Eighth People’s HospitalChangzhou 213000China

Hospitals are crucial healthcare facilities where patients seek treatment,and effective budget management within hospitals significantly impacts their operational efficiency and financial *** the age of information technology and advanced healthcare solutions,the emergence of smart hospitals represents a new trend in the medical industry’s *** modern information technology can enhance the development of hospital IT systems and drive budget management toward greater *** paper begins by analyzing the influence of smart hospitals on hospital budget *** then examines the current state of budget management control within smart ***,it proposes several strategies for budget management control in smart hospitals,aiming to provide guidance for relevant stakeholders.

关键词： Smart hospital Hospital management Budget management Financial control Control strategies

SLC2A9基因rs7349721位点多态性及基因—环境交互与痛风易感性的关系

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山东医药 2022年第14期62卷 1-4页

作者：陈邬锦李瑞田婷婷梁美婷玛依娜·卡哈尔贺怡崔月娜孙玉萍新疆医科大学基础医学院乌鲁木齐830011 新疆第二医学院

目的探讨SLC2A9基因rs7349721位点多态性及基因—环境交互与痛风易感性的关系。方法选取314例痛风男性患者(痛风组)和507例健康体检男性(对照组),采集受试者外周静脉血,采用PCR法检测SLC2A9基因rs7349721位点多态性。采用Logistic回归... 详细信息

目的探讨SLC2A9基因rs7349721位点多态性及基因—环境交互与痛风易感性的关系。方法选取314例痛风男性患者(痛风组)和507例健康体检男性(对照组),采集受试者外周静脉血,采用PCR法检测SLC2A9基因rs7349721位点多态性。采用Logistic回归分析法及叉生分析法分析不同临床病理特征对痛风发病的影响,不同遗传模型痛风易感性及基因—环境的相乘、相加交互作用。结果痛风组SLC2A9基因rs7349721位点AA、AT基因型及等位基因型A分布低于对照组,TT基因型及等位基因型T分布高于对照组(P均1.00),规律运动为痛风发病的保护因素(P<0.05,OR<1.00)。加性遗传模型中TT为痛风发病的危险因素OR=1.73,95%CI为1.14~2.63,隐性遗传模型中AA+AT为痛风发病的保护因素OR=0.66,95%CI为0.49~0.89。SLC2A9基因rs7349721位点AT+TT基因型与规律运动在相加和相乘交互模型中均为痛风发病的保护因素(P<0.05,OR<1.00)。结论SLC2A9基因rs7349721位点多态性与痛风易感性存在关联,且不同遗传模型与规律运动对痛风易感性存在交互作用。

关键词：痛风 SLC2A9基因基因多态性基因—环境交互作用新疆

基于“云板书”的微信公众号辅助教学在组织学与胚胎学教学中的应用

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中国组织化学与细胞化学杂志 2018年第6期27卷 592-595,591页

作者：木萨.艾麦尔赵雨欣陈邬锦秦纹孟晓彤张馨怡白生宾新疆医科大学形态中心新疆医科大学组胚教研室乌鲁木齐830011

通过手机进行碎片化记忆已经成为一种学习方式,在微信公众号中获取学习资源已经成为医学生的日常行为。将"云板书"与微信公众号融合作为一种辅助教学和学习方法,应用在组织学与胚胎学教学中,通过推送每个章节微信公众号(基于云板书),便... 详细信息

通过手机进行碎片化记忆已经成为一种学习方式,在微信公众号中获取学习资源已经成为医学生的日常行为。将"云板书"与微信公众号融合作为一种辅助教学和学习方法,应用在组织学与胚胎学教学中,通过推送每个章节微信公众号(基于云板书),便于学生在课前预习与课后归纳总结。教师通过一对一微信在线答疑的方式解决学生在课堂中存在的疑惑,解决了学生课堂提问和讨论时间不足的问题,提高了学生学习成绩,促进学生学习组织学与胚胎学的兴趣,养成了学生自主学习的能力。

关键词：云板书微信公众号组织学与胚胎学教学改革

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 458-474页

作者： Wei Ding Wei-Wei chen Yi-Qin Wang Xue-Zhong Xu Yi-Bo Wang Yong-Min Yan Yu-Lin Tan Department of General Surgery Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213003Jiangsu ProvinceChina Changzhou Medical Center Nanjing Medical UniversityChangzhou 213017Jiangsu ProvinceChina Department of General Surgery The Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal ***710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC *** To assess the correlation between ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC *** We obtained data from The Cancer Genome Atlas and wujin *** assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cytometry *** real-time polymerase chain reaction(qRT-PCR)was used to identify the potential downstream targets of *** In GC tissues with low ZNF710-AS1-201 expression,immunoassays detected significant infiltration of various antitumor immune cells,such as memory CD8 T cells and activated CD4 T *** the low-expression group,the half-maximal inhibitory concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitabine,and trametinib were lower,whereas the IC_(50)s of dasatinib and vorinostat were *** malignant degree of GC was higher and the stage was later in the high-expression ***,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival *** vitro,the overexpression of ZNF710-AS1-201 greatly enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 *** contrast,the reduced expression of ZNF710-AS1-201 greatly hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 *** expression changes in ZNF710 were significant,but the corresponding changes in isocitrate dehydrogenase-2,Semaphorin 4B,ARHGAP10,RGMB,hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201,as determined by ***

关键词： Gastric cancer ZNF710-AS1-201 Proliferation Metastasis Invasion Apoptosis

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1株温和性噬菌体的发现及其流行病学意义

医学动物防制 2017年第10期33卷 1073-1075页

作者：李存香李伟王鹏李振军申小娜陈邬锦丁奕博和映天和琼光青海省地方病预防控制所西宁811602 中国疾病预防控制中心传染病预防控制所云南省地方病研究所玉龙县疾病预防控制所

目的对云南省野鼠鼠疫疫源地齐氏姬鼠盲肠内容物中分离的1株鼠疫噬菌体(L128m)进行鉴定,探讨鼠疫自然疫源地微生态因素保存鼠疫自然疫源性发挥的作用。方法以鼠疫疫苗株EV 76为宿主菌,采用双层琼脂平皿法从云南省鼠疫疫源地齐氏姬鼠盲... 详细信息

目的对云南省野鼠鼠疫疫源地齐氏姬鼠盲肠内容物中分离的1株鼠疫噬菌体(L128m)进行鉴定,探讨鼠疫自然疫源地微生态因素保存鼠疫自然疫源性发挥的作用。方法以鼠疫疫苗株EV 76为宿主菌,采用双层琼脂平皿法从云南省鼠疫疫源地齐氏姬鼠盲肠中分离1株温和噬菌体;描述其形态特征;测定裂解能力、宿主谱。结果鼠疫噬菌体L128m形成的噬菌斑中心和边缘均模糊,直径为0.9~1.0 mm,其为溶原性噬菌体;通过液体增殖培养后其效价达到106~P FU/ml;电镜观察其形态呈蝌蚪形,头部为正多面体结构,头部直径约为61 nm,尾部长约155 nm,带有一伸缩的尾鞘,归类为肌尾噬菌体。宿主谱评价发现仅裂解鼠疫疫苗株。结论从1只齐氏姬鼠盲肠内容物中分离的鼠疫噬菌体属溶原性噬菌体,它的发现对我国鼠疫疫源地宿主动物肠道微生态学和流行病学研究具有重要意义。

关键词：鼠疫噬菌体鼠疫菌生物学特性流行病学

《正常人体形态学》混合式教学+形成性评价的实施效果分析

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中华医学教育探索杂志 2018年第3期17卷 244-247页

作者：陈邬锦赵雨欣秦纹杨文清木萨·艾麦尔孟晓彤董娟娟白生宾新疆医科大学形态中心乌鲁木齐830011 新疆医科大学组胚教研室乌鲁木齐830011 新疆医科大学解剖教研室乌鲁木齐830011

为对比传统教学及评价体系与混合教学+形成性评价在《正常人体形态学》这门课程中的应用效果.选择2009至2016级护理专业学生《正常人体形态学》期中、技能、平时、期末及综合成绩,并结合课程融合不同阶段对其进行单因素的方差分析.经SPS... 详细信息

为对比传统教学及评价体系与混合教学+形成性评价在《正常人体形态学》这门课程中的应用效果.选择2009至2016级护理专业学生《正常人体形态学》期中、技能、平时、期末及综合成绩,并结合课程融合不同阶段对其进行单因素的方差分析.经SPSS 17.0统计分析可得:该课程形成阶段(传统教学)学生平均成绩为(67.55±12.72)分,融合阶段(混合或教学)平均成绩为(72.79±10.93)分,发展阶段(混合式教学+形成性评价)学生成绩为(83.94±9.58)分,做两两比较后得出各阶段《正常人体形态学》成绩差异均有统计学意义(P＜0.001).分析可见,课程的整体发展日趋成熟,而新型教学模式可对平时不爱复习的学生有一定督促作用.

关键词：正常人体形态学混合式教学形成性评价

Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation