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Advances in functional MRI research in bipolar disorder:from the perspective of mood states

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General Psychiatry 2024年第1期37卷 33-43页

作者： Yankun wu Yun-Ai Su Linlin Zhu Jitao Li Tianmei Si Department of Clinical Psychopharmacology Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratoryof Mental Health(Peking University)National Clinical Research Centerfor Mental Disorders(Peking University Sixth Hospital)BeijingChina

Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and *** breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar ***,the pathophysiology underlying mood instability,mood switching and the development of extreme mood states is less well *** reviewpresents a comprehensive overviewof current evidence from functional MRI studies from the perspective of mood *** first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder,irrespective of the mood *** next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related ***,we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research.A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.

关键词： anatomy bipolar functional

LEPTON MIXING-RIGHT SYMMETRY ELECTROWEAK GAUGE THEORY AND v_3 NEUTRINO DECAY

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Science China Mathematics 1983年第5期30卷 499-511页

作者：吴詠时曹南薇 Instiute of theoretical physics Academia Sinica Beijing institute of High Energy physics Academia Sinica Beijing

In this paper, we introduce four models for the discrete horizontal symmetry in the gauge theory of electroweak interactions with left-right symmetry （i. e., the SU（2.L × SU（2.R × U（1） model） to obtain four sets of the mixing angles among the different generations of leptons separately. In light of the corresponding mass relations obtained and the preliminary result for mv1 and mv2. we estimate the possible value of mv3 and discuss the various physical effects arising from the lepton mixing and non-vanishing mass of neutrinos in these four models, such as their influences on the determination of quark mixing angle and the representation of the μ-e universality, the neutrino oscillations and their applications in astrophysics and so on, with special emphasis on the life-time and various possible decay modes of v3 （its mass is about 2.102.Mev in Model B） so as to give a clue to experimental detection of v3.

关键词： LEPTON MIXING-RIGHT SYMMETRY ELECTROWEAK GAUGE THEORY AND v3 NEUTRINO DECAY

Hierarchical Voronoi Structure Inspired by Cat Paw Pads Substantially Enhances Landing Impact Energy Dissipation

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Journal of Bionic Engineering 2024年第4期21卷 1847-1861页

作者： Da Lu Baoqing Pei Yangyang Xu Mengyuan Hu Shijia Zhang Le Zhang Xin Huang Yangwei Wang Xueqing wu beijing Key Laboratory for Design and Evaluation Technology of Advanced Implantable&Interventional Medical Devices Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang University100083BeijingChina National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing Institute of Technology100081BeijingChina Shenzhen institute of Beihang University 518000ShenzhenChina

When a human lands from a high drop,there is a high risk of serious injury to the lower *** the other hand,cats can withstand jumps and falls from heights without being fatally wounded,largely due to their impact-resistant paw *** aim of the present study was to investigate the biomechanism of impact resistance in cat paw pads,propose an optimal hierarchical Voronoi structure inspired by the paw pads,and apply the structure to bionic cushioning shoes to reduce the impact force of landing for *** microstructure of cat paw pads was observed via tissue section staining,and a simulation model was reconstructed based on CT to verify and optimize the structural cushioning *** distribution pattern,wall thickness of compartments,thickness ratio of epidermis and dermis,and number of compartments in the model were changed and simulated to achieve an optimal composed structure.A bionic sole was 3D-printed,and its performance was evaluated via compression test and a jumping-landing *** results show that cat paw pads are a spherical cap structure,divided from the outside to the inside into the epidermis,dermis,and compartments,each with different cushioning capacities.A finite element simulation of different cushioning structures was conducted in a cylinder with a diameter of 2. mm and a height of 10 mm,featuring a three-layer *** optimal configuration of the three layers should have a uniform distribution with 0.3–0.5 mm wall thickness,a 1:1–2.thickness ratio of epidermis and dermis,and 100–150 compartments.A bionic sole with an optimized structure can reduce the peak impact force and delay the peak arrival *** energy absorption rate is about 4 times that of standard *** jumping 80,100,and 12. cm,the normalized ground reaction force is also reduced by 8.7%,12.6%and 15.1%compared with standard *** study provides theoretical and technical support for effective protection against human lower limb landing injuries.

关键词： Cat paw pads Hierarchical Voronoi structure Landing impact Energy dissipation Bionic sole

Effects of projectile parameters on the momentum transfer and projectile melting during hypervelocity impact

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Defence Technology（防务技术） 2024年第2期32卷 89-103页

作者： Wenjin Liu Qingming Zhang Renrong Long Zizheng Gong Ren Jiankang Xin Hu Siyuan Ren Qiang wu Guangming Song State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China beijing institute of Spacecraft Environment Engineering China Academy of Space TechnologyBeijing100094China

The effects of projectile/target impedance matching and projectile shape on energy,momentum transfer and projectile melting during collisions are investigated by numerical *** comparing the computation results with the experimental results,the correctness of the calculation and the statistical method of momentum transfer coefficient is *** shapes of aluminum,copper and heavy tungsten alloy projectiles striking aluminum,basalt,and pumice target for impacts up to 10 km/s are *** influence mechanism of the shape of the projectile and projectile/target density on the momentum transfer was *** an increase in projectile density and length-diameter ratio,the energy transfer time between the projectile and targets is *** projectile decelerates slowly,resulting in a larger cratering *** energy consumed by the projectile in the excavation stage increased,resulting in lower mass-velocity of ejecta and momentum transfer *** numerical simulation results demonstrated that for different projectile/target combinations,the higher the wave impedance of the projectile,the higher the initial phase transition velocity and the smaller the mass of phase *** results can provide theoretical guidance for kinetic impactor design and material selection.

关键词： Hypervelocity impact Energy partitioning Impact melting Momentum transfer

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双浮体自由垂向振荡响应特性

水动力学研究与进展（A辑） 2006年第4期21卷 458-464页

作者：吴必军胡城郑永红游亚戈中国科学院广州能源研究所广东广州510640

双圆柱体系统在波能装置和防波构件中得到应用,该系统是一个多自由度受迫阻尼振荡系统,阻力和激励力都来自于波浪力。本文采用线性波理论和特征函数展开皮配法,在平面入射波条件下,求解了双圆柱体垂荡运动辐射速度势和圆柱体固定不动时... 详细信息

双圆柱体系统在波能装置和防波构件中得到应用,该系统是一个多自由度受迫阻尼振荡系统,阻力和激励力都来自于波浪力。本文采用线性波理论和特征函数展开皮配法,在平面入射波条件下,求解了双圆柱体垂荡运动辐射速度势和圆柱体固定不动时的绕射速度势,推导了附加质量、阻尼系数、波浪激励力表达式,列出了浮体垂荡运动微分方程。最后讨论了下浮体尺度及位置对系统响应特性的影响。数值计算表明无论下浮体尺度及位置如何变化,它只影响到浮体垂荡响应在低频端的值,下浮体的振幅值总是小于入射波的振幅值,而且它在一个较窄的频率范围内从较大的值很快变化接近于零。下浮体半径与上浮体半径之比的变化不仅影响到两个浮体的响应幅值,而且也影响到曲线的变化趋势;两浮体距离的变化对曲线的变化趋势影响不大,但对曲线的幅值有影响;下浮体厚度的变化只少许改变了响应曲线的幅值。

关键词：受迫阻尼振荡系统速度势响应

Post-Newtonian binary dynamics in the effective field theory of Horndeskigravity

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chinese physics C 2024年第3期48卷 180-190页

作者：武文浩汤勇 School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China School of Fundamental physics and Mathematical sciences Hangzhou Institute for Advanced StudyChinese Academy of SciencesHangzhou 310024China International Center for theoretical physics Asia-Pacific Beijing 100049China

General relativity has been very successful since its proposal more than a century ***,various cosmological observations and theoretical consistency still motivate us to explore extended gravity *** gravity stands out as one attractive theory by introducing only one scalar *** we formulate the post-Newtonian effective field theory of Horndeski gravity and investigate the conservative dynamics of inspiral compact binary *** calculate the leading effective Lagrangian for a compact binary and obtain the periastron advance per *** particular,we apply our analytical calculation to two binary systems,PSR B 1534+12.and PSR J0737-3039,and constrain the relevant model *** theoretical framework can also be systematically extended to higherorders.

关键词： effective field theory modified gravity pulsar

Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

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Protein & Cell 2024年第1期15卷 6-20页

作者： Ning wu Ling Wei Zhipeng Zhu Qiang Liu Kailong Li Fengbiao Mao Jie Qiao Xiaolu Zhao State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyCenter for Reproductive MedicinePeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China institute of Medical Innovation and Research Peking University Third HospitalBeijing 100191China Cancer Center Peking University Third HospitalBeijing 100191China Department of Biochemistry and Biophysics Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China beijing Advanced Innovation Center for Genomics Beijing 100191China Peking-Tsinghua Center for Life sciences Peking UniversityBeijing 100191China

Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular *** biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are *** advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research *** mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification *** tumors and disorders of embryonic and fetal development are major threats to human reproductive *** roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer *** present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and *** also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic *** review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

关键词： extrachromosomal circular DNAs gynecologic tumors reproduction liquid biopsy non-invasive prena-tal testing

Simulation of the Motion of a Bead in Shallow Water via SPH Method

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Simulation of the Motion of a Bead in Shallow Water via SPH ...

Effect of valence and spin state on ethane dehydrogenation in Fe-S-1 catalyst

第六届国际流体力学会议

作者： Q.wu Y.An Q.Q.Liu Lab.of Environmental Mechanics institute of Mechanics {2. {2. of sciences beijing 100190 China

This paper numerically investigated the two-dimensional motion of a bead in shallow water down a steep rough bed via smoothed particle hydrodynamics（SPH）.The motivation of this work is to study the mechanism of particle transport in shallow *** simulated results show agreement with the experimental data which also verifies the validity of ***,a series of numerical experiments are carried out to discuss the influences of bead material,slope gradient on the characteristics of bead motion and the state of shallow flow.

关键词： particle transport shallow water steep rough bed smoothed particle hydrodynamics(SPH)

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Journal of Energy Chemistry 2024年第10期97卷 677-686,I0014页

作者： Liusai Huang Yumeng Fo Peng Zhang Shaojia Song Xinxin Zhang Xueqiu wu Saeed Soltanali Jian Liu Weiyu Song State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China China Petrochemical Research institute Petro China Company LimitedBejing 102206China Catalysis Technologies Development Division Research Institute of Petroleum Industry(RIPI)Tehran 14665-1998Iran

Light alkanes non-oxidative dehydrogenation is an attractive non-oil route for olefins *** alkane dehydrogenation reaction is limited by thermodynamic equilibrium,and the C-H bond cleavage is commonly considered as the rate-determined *** valence state of metal sites in catalysts will influence the stabilization of the vital intermediate(i.e.,C_(x)H_(y)...M^(δ+)...H)during the C-H bond cleavage process,which in turn affects the catalytic ***,we explicitly investigated the effect of different valence states of framework-Fe in silicate-1 zeolite on ethane dehydrogenation reaction through the combination of experimental and theoretical ***(Ⅱ)-S-1 and Fe(Ⅲ)-S-1 catalysts are successfully synthesized by ligand-assisted in situ crystallization method,In-situ C_(2.H_6-FTIR shows the higher coverage of hydrocarbon intermediates on Fe(Ⅱ)-S-1,Under the same evaluation co nditio n,Fe(Ⅱ)-S-1 exhibits a higher space time yield of *** functional theory(DFT)results reveal that the more coordinate-unsaturated and electron-enriched Fe(Ⅱ)sites boost the first C-H bond activation by slight deformation and efficient electron donation with C_(2.H_(5)^(*)***,the second C-H bond cleavage on Fe(Ⅱ)-S-1 undergoes a spin-crossing process from quintet state to triplet state,which involves a two-electro n-two-orbital interaction,further promoting the formation of *** analysis is consistent with the experimental and DFT *** work could provide methodology for elucidating the effect of metal valence states on catalytic performance as well as offer guidance for designing more efficient Fe-zeolite catalysts.

关键词： Iron Ethane dehydrogenation Electron-enriched Spin crossover DFT