检索结果-南通市图书馆

Comparison of the Absorption and Distribution of Cadmium via Cadmium Chloride and Cadmium-contaminated Rice in Rats

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第2期33卷 141-144页

作者： wu Qian WANG Lei CHEN Yu Wei ZHANG Hu FANG Min wu yong ning GONG Zhi yong Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education Wuhan Polytechnic UniversityWuhan 430023HubeiChina Key Laboratory of Food Safety Risk Assessment Ministry of HealthChina National Center for Food Safety Risk AssessmentBeijing 100021China

Cadmium(Cd)is considered a toxic element of which food is the major source of acquisition,which can lead to diseases such as renal dysfunction,cancer and osteoporosis[1].Cd is classified as a group I carcinogen by the International Agency for Research on Cancer[2].The results of dietary exposure to cadmium in Europe in 2012 showed that the contribution rate from the broad food categories of grain and grain products accounted for 26.9%.

关键词： Comparison Absorption Rats

Synergistic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine on Cell Malignant Transformation

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2013年第5期26卷 323-330页

作者： ZHANG Lei ZHAO Rui YE Shu Qing ZHOU Ling wu yong ning ZENG Yi Key Laboratory of Food Safety Risk Assessment Ministry of HealthChina National Center for Food Safety Risk Assessment College of Life Science and Bio-engineering Beijing University of Technology National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention

Objective The present paper aims to investigate the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin （TCDD） and N-nitrosodiethylamine （DEN） on tumorigenesis and its potential mechanism. Methods The potentials of TCDD and DEN in separation or in combination to induce malignant transformation were tested in Balb/c 3T3 cells by using a cell transformation assay method. The possible mechanism of observed effects was studied further by adding α-naphthoflavone （α-NF）, a competitive binding agent of TCDD, to the Aryl hydrocarbon receptor （AhR） pathway. The mRNA expressions of Cyp1a1 and Cyp2a5 gene in Balb/c 3T3 cells treated by DEN and TCDD in separation or in combination with or without presence of α-NF were measured with fluorescence quantification RT-PCR technique. Results The cell transformation frequency （TF） was significantly higher in case of induction with TCDD in combination with DEN, as compared to that with either TCDD or DEN alone. These effects were not inhibited via α-NF. The mRNA expression levels of both Cyp1a1 and Cyp2a5 were enhanced by TCDD treatment alone, but this inducible effect was blocked in cells treated by TCDD and DEN in combination. Conclusion TCDD and DEN had a significant synergistic effect on tumorigenesis when they were used in combination. AhR pathway may not be the key mechanism of this synergistic effect. Thus, it is necessary to further test the potential mechanism involved in cancer development.

关键词： Dioxin Nitrosodiethylamine Cell transformation Tumorigenesis

Dietary Exposure of the Chinese Population to Acrylamide

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2013年第6期26卷 421-429页

作者： ZHOU Ping Ping ZHAO Yun Feng LIU Hua Liang MA yong Jian LI Xiao Wei YANG Xin wu yong ning China National Center for Food Safety Risk Assessment Key Laboratory of Food Safety Risk Assessment Ministry of Health Jiangsu Province Center for Disease Control and Prevention

Objective To assess the current status of the acrylamide in the Chinese food supply, the dietary acrylamide exposure in the Chinese population and to estimate the public health risks of the current consumption. Methods The acrylamide content in the total diet study （TDS） food samples was analyzed using an LC-MS/MS method. Based on the analytical results, the dietary exposure calculations were performed using a deterministic method, combining mean acrylamide concentrations from the food group composite with their associated food consumptions. Results Acrylamide was detected in 43.7% of all samples collected and acrylamide concentration varied from ND to 526.6 I^g/kg. The estimated dietary intakes of acrylamide among Chinese general population given as the mean and the 95th percentile （P95） were 0.286 and 0.490 ***1 ***1, respectively. The margins of exposure （MOEs） for the population calculated using both benchmark dose lower confidence limit for a 10% extra risk of tumors in animals （BMDL10） 0.31 and 0.18 i^g.k8-1 bw-dayz, were 1069 and 621 for the mean dietary exposure, and 633 and 367 for the high dietary exposure respectively. Conclusion These MOE values might indicate a human health concern on acrylamide for Chinese population. Efforts should continue to reduce acrylamide levels in food in order to reduce the dietary risks to the human health.

关键词： Acrylamide Dietary exposure Assessment Health risk Total diet study

Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2014年第6期27卷 426-435页

作者： ZHU Pan FAN Sai ZOU Jian Hong MIAO Hong LI Jing Guang ZHANG Guo Wen wu yong ning State Key Laboratory of Food Science and Technology Nanchang University Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk Assessment Institute of Nutrition and Food Safety Beijing Centre of Disease Control and Prevention The Second Artillery General Hospital

Objective To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry （GC-MS）. Methods Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin （5 mg/kg bw）. Data were processed by 3P97 software. Results The serum deltamethrin level was significantly lower in tissues than in blood of miniature *** AUC0-72 h, Cmax, of deltamethrin were 555.330±316.987 ng h/mL and 17.861±11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004±3.131 h.Conclusion The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of I/C^2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.

关键词： Deltamethrin Miniature pig Pharmacokinetics Tissue distribution GC-MS

Development of An Enzyme-Linked Immunosorbent Assay for Determination of the Furaltadone Etabolite,3-Amino-5-Morpholinomethyl-2-Oxazolidinone(AMOZ) in Animal Tissues

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2012年第4期25卷 449-457页

作者： LUO Peng Jie JIANG Wen Xiao BEIER Ross C. SHEN Jian Zhong JIANG Hai Yang MIAO Hong ZHAO Yun Feng CHEN Xia wu yong ning Ministry of Health Key Laboratory China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Veterinary Pharmacology and Toxicology College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Southern Plains Agricultural Research Center Agricultural Research ServiceU.S.Department of AgricultureCollege StationTexas 77845-4988USA State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective To determine 3-amino-5-morpholinomethyl-2-oxazolidinone （AMOZ） residues released from protein bound AMOZ in animal tissues. Methods Polyclonal and monoclonal antibodies were produced in this study. A rapid, sensitive, and specific competitive direct enzyme-linked immunosorbent assay （cdELISA） was developed. Results Rabbit polyclonal antibodies were used in the optimized cdELISA method, and exhibited negligible cross-reactivity with other compounds structurally related to AMOZ. The IC50 of the polycional antibody was 0.16 ng/mL The method limit of detection in four different types of animal and fish tissues was less than 0.06 μg/kg. Recoveries ranged from 80% to 220% for fortified samples with the coefficient of variation values less than 15%. The results of the cdELISA method were in good agreement with the results from an established liquid chromatography-tandem mass spectrometry confirmatory method used for AMOZ residues. Conclusion The cdELISA method developed in the present study is a convenient practical tool for screening large numbers of animal and fish tissue samples for the the detection of released protein bound AMOZ residues.

关键词： AMOZ Animal tissue ELISA Fish tissue Furaltadone

The Benefit Risk Assessment of Consumption of Marine Species Based on Benefit-Risk Analysis for Foods(BRAFO)-tiered Approach

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2015年第4期28卷 243-252页

作者： GAO Yi Xiong ZHANG Hong Xia LI Jing Guang ZHANG Lei YU Xin Wei HE Jia Lu SHANG Xiao Hong ZHAO Yun Feng wu yong ning China National Center for Food Safety Risk Assessment Key Lab of Food Safety Risk Assessment Ministry of Health National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention Maternal and Child Care Service Centre of Shiquan County Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood Zhoushan Municipal Center of Disease Control and Prevention

Objective To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods （BRAFO）-tiered approach. Methods Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury （MeHg）, and dioxin-like compounds （DLCs） in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. Results Based on the BRAFO-tiered approach, reference scenario （no intake） and alternative scenario （intake of specific species of 200 g/week） were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. Conclusion The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.

关键词： N-3 long-chain polyunsaturated fatty acid Methyl mercury Dioxin-like compound Benefit-Risk Analysis for Foods (BRAFO) Benefit risk assessment

开展食品安全风险监测积极参与国际食品安全风险评估

在线全文

学校读者我要写书评

暂无评论

中华预防医学杂志 2010年第7期44卷 581-583页

作者：吴永宁中国疾病预防控制中心营养与食品安全所WHO食品污染监测合作中心(中国) 北京100050

《中华人民共和国食品安全法》（下简称《食品安全法》）规定国家实施食品安全风险监测制度和风险评估制度，为我国实行食品安全风险监测与评估制度提供了法律保障。食品安全保障已经成为控制食品污染、预防食物中毒和食源性疾病的重要... 详细信息

《中华人民共和国食品安全法》（下简称《食品安全法》）规定国家实施食品安全风险监测制度和风险评估制度，为我国实行食品安全风险监测与评估制度提供了法律保障。食品安全保障已经成为控制食品污染、预防食物中毒和食源性疾病的重要公共卫生手段，类似“三聚氰胺污染奶粉”事件在2009年再次发生，提示目前我国食品安全属于风险高发期，彰显出食品中有害因素的监测、评估和预警的重要性。食品安全风险监测针对食品污染、食源性疾病和食品中有害因素开展系统地主动监测，

关键词：食品安全安全管理风险评估监测方法

在线全文

学校读者我要写书评

暂无评论

清代册封琉球使齐鲲考述

福建师范大学学报（哲学社会科学版） 2012年第2期 137-141页

作者：吴永宁福建师范大学社会历史学院福建福州350108

嘉庆十三年(1808)时任翰林院编修的闽籍官员齐鲲受命前往琉球册封琉球国中山王尚灏。在琉球期间,齐鲲不仅恪尽职守完成使命,作为中华文化的传播者,其克己奉公、清正廉洁的作风亦在琉球国上下获得一致好评。作为清朝首位出任册封琉球使... 详细信息

嘉庆十三年(1808)时任翰林院编修的闽籍官员齐鲲受命前往琉球册封琉球国中山王尚灏。在琉球期间,齐鲲不仅恪尽职守完成使命,作为中华文化的传播者,其克己奉公、清正廉洁的作风亦在琉球国上下获得一致好评。作为清朝首位出任册封琉球使臣的闽籍官员,齐鲲册封琉球之著述《续琉球国志略》、诗文集《东瀛百咏》在中琉关系历史中留下了丰富且生动的记载。本文试图就齐鲲册封琉球之经历及其相关著述、诗文等方面,对册封琉球使齐鲲及其往封著述进行深入挖掘与探讨。

关键词：齐鲲《续琉球国志略》《东瀛百咏》册封使琉球

在线凝胶渗透色谱-气相色谱-串联质谱非衍生化法测定食品中氯丙醇

在线全文

学校读者我要写书评

暂无评论

分析化学 2016年第5期44卷 678-684页

作者：易青苗虹吴永宁武汉轻工大学食品科学与工程学院农产品加工湖北省协同创新中心国家食品安全风险评估中心卫生部食品安全风险评估重点实验室

建立了食品中氯丙醇类化合物的非衍生化在线凝胶渗透色谱-气相色谱-串联质谱（Online GPC-GCMS/MS）测定方法,目标化合物包括3-氯-1,2-丙二醇（3-MCPD）、2-氯-1,3-丙二醇（2-MCPD）、1,3-二氯-2-丙醇（1,3-DCP）和2,3-二氯-1-丙醇（2,3... 详细信息

建立了食品中氯丙醇类化合物的非衍生化在线凝胶渗透色谱-气相色谱-串联质谱（Online GPC-GCMS/MS）测定方法,目标化合物包括3-氯-1,2-丙二醇（3-MCPD）、2-氯-1,3-丙二醇（2-MCPD）、1,3-二氯-2-丙醇（1,3-DCP）和2,3-二氯-1-丙醇（2,3-DCP）。样品中加入氘代同位素内标后,采用ExtrelutTMNT硅藻土进行固相支持液液萃取净化,用正己烷淋洗去除非极性杂质,以乙酸乙酯萃取目标物,萃取液经浓缩后直接采用Online GPC-GC-MS/MS测定。4种氯丙醇在0.005;.000 mg/L范围内呈良好线性,相关系数均大于0.999,4种氯丙醇的检出限在0.002;.005 mg/kg之间,定量限在0.005;.01 mg/kg之间。以空白酱油样品为代表性基质的3个水平（0.02,0.1和0.5 mg/kg）的加标回收率和相对标准偏差（RSD,n=6）分别为94.8%;06.3%（2.2%;0.3%）,91.8%;08.8%（2.1%;0.6%）和83.1%;09.4%（1.3%;.4%）。采用本方法分别对酱油、水解植物蛋白液（粉）、料酒、鸡精、面包和糕点样品进行检测,均得到了满意的测定结果。

关键词：食品氯丙醇在线凝胶渗透色谱-气相色谱-串联质谱固相支持液液萃取净化非衍生化