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Computer Modeling in Engineering & Sciences 2022年第4期131卷 365-378页

作者： Yinhuan Yang Manfeng Gong xiaoqun Xia Linzhi wu School of Electromechanical Engineering Lingnan Normal UniversityZhanjiang524048China Key Laboratory of Advanced Ship Materials and Mechanics Harbin Engineering UniversityHarbin150001China Department of Engineering Mechanics College of Aerospace and Civil Engineering UniversityHarbin150001China

The mechanical properties of Z-pins reinforced composites adhesively bonded single-lap joints(SLJs)under un-directional tension loading are investigated by experimental and numerical *** kinds of joint configurations,including SLJs with three/two rows of Z-pins and“I”array of Z-pins,are investigated by tension *** failure modes and mechanism of reinforced joints with different Z-pins numbers and alignment are analyzed,and the comparison is performed for the failure strengths of no Z-pins and Z-pins reinforced *** to experimental results,failure modes of three kinds of joints are all mixed *** turns out that the Z-pins are pulled out *** strength of joints of more Z-pins at the end of the overlap area is relatively bigger for the joint of the same Z-pins *** strength of joints with Z-pins compared with non Z-pins joints is growing at 16%.Finally,the three-dimensional distribution of interfacial stress in the lap zone of three kinds of Z-pins reinforced joints is simulated,and the numerical results are in good agreement with the experimental *** is effective that the numerical calculation of stress analysis is verified.

关键词： Z-pins reinforced composite single-lap joint(SLJ) failure mode and strength un-directional tension test interfacial stress

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紫菜中微量铁的分光光度直接测定

商丘师范学院学报 2009年第12期25卷 54-57页

作者：潘仲巍陈美玲叶艺滨吴小群泉州师范学院化学与生命科学学院福建泉州362000 中国科学院青海盐湖研究所青海西宁810008

在表面活性剂存在下,pH5.00的HAC-NH4AC缓冲溶液中,铁与铁试剂(7 -碘-8 -羟基喹啉-5 -磺酸)产生灵敏的显色反应,络合物的最大吸收波长为610 nm且其他金属离子不干扰反应.据此建立了分光光度法直接测定紫菜中铁含量的方法,Fe3 +含量在0.... 详细信息

在表面活性剂存在下,pH5.00的HAC-NH4AC缓冲溶液中,铁与铁试剂(7 -碘-8 -羟基喹啉-5 -磺酸)产生灵敏的显色反应,络合物的最大吸收波长为610 nm且其他金属离子不干扰反应.据此建立了分光光度法直接测定紫菜中铁含量的方法,Fe3 +含量在0.02 ～3μg/mL范围内遵守Beer定律,测得福建晋江海域每克干紫菜中铁含量为641.13μg,相对标准偏差(RSD)1.41%,回收率97.5% ～104.5%.

关键词：紫菜铁铁试剂分光光度法

C_5全组分界构烯烃化的催化反应原理与催化剂──Ⅰ．正戊烷异构化制异戊烷

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石油炼制与化工 1995年第10期26卷 19-24页

作者：吴肖群周力慎炼吕德伟联合化学反应工程研究所浙江大学分所

ＴＡＭＥ（甲基叔戊基醚）市场需求量的不断增大，要求开拓生产原料──异戊烯（主要是２－甲基－１－丁烯和２－甲基－２－丁烯）的新来源。因此，通过对石油炼制中生成的Ｃ５馏分进行全组分的异构烯烃化处理来获取异戊烯，已成为近年... 详细信息

ＴＡＭＥ（甲基叔戊基醚）市场需求量的不断增大，要求开拓生产原料──异戊烯（主要是２－甲基－１－丁烯和２－甲基－２－丁烯）的新来源。因此，通过对石油炼制中生成的Ｃ５馏分进行全组分的异构烯烃化处理来获取异戊烯，已成为近年来众人关注的课题。该系列性综述针对Ｃ５馏分全组分异构烯烃化处理中必将遇到的正戊烷异构化制异戊烷、异成烷脱氢制异成烯和正戊烯异构化制异戊烯等几个主要过程的催化反应原理及其催化剂的研究状况，进行了较全面的探讨与述评。

关键词：异构化催化催化剂碳5 石油炼制

Induced pluripotency and direct reprogramming:a new window for treatment of neurodegenerative diseases

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Protein & Cell 2013年第6期4卷 415-424页

作者： Rui Li Ye Bai Tongtong Liu xiaoqun Wang Qian wu State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Human embryonic stem cells(hESCs)are pluripotent cells that have the ability of unlimited self-renewal and can be differentiated into different cell lineages,includ-ing neural stem(NS)*** regulatory signaling pathways of neural stem cells differentiation have been discovered,and this will be of great benefit to uncover the mechanisms of neuronal differentiation in vivo and in ***,the limitations of hESCs resource along with the religious and ethical concerns impede the pro-gress of ESCs ***,the induced pluri-potent stem cells(iPSCs)via somatic cell reprogramming have opened up another new territory for regenerative *** now can be derived from a number of lin-eages of cells,and are able to differentiate into certain cell types,including ***-specifi c iPSCs are being used in human neurodegenerative disease modeling and drug ***,with the development of somatic direct reprogramming or lineage reprogramming technique,a more effective approach for regenerative medicine could become a complement for iPSCs.

关键词： human embryonic stem cells(hESCs) neu-ronal differentiation induced pluripotent stem cells(iPSCs) somatic direct reprogramming lineage reprogramming regen-erative medicine

益生菌缓解高尿酸血症:研究现状、作用机制及面临的挑战

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食品工业科技 2024年第20期45卷 415-425页

作者：杨新如唐甲越曾小群吴振杜启伟涂茂林宁波大学食品科学与工程学院浙江宁波315800

高尿酸血症(Hyperuricemia,HUA)是一种由嘌呤代谢障碍所引起的,以血液中尿酸过量为特征的慢性代谢性疾病。研究表明,常规的临床治疗方法存在一定的局限性,而益生菌缓解高尿酸血症具有经济有效、毒副作用小、安全性相对较高的特点。本文... 详细信息

高尿酸血症(Hyperuricemia,HUA)是一种由嘌呤代谢障碍所引起的,以血液中尿酸过量为特征的慢性代谢性疾病。研究表明,常规的临床治疗方法存在一定的局限性,而益生菌缓解高尿酸血症具有经济有效、毒副作用小、安全性相对较高的特点。本文主要阐述了益生菌缓解高尿酸血症的作用机制:修复肠道屏障、调节肠道微生物群;抑制黄嘌呤氧化酶的活性;加快尿酸排泄;促进嘌呤降解或代谢。益生菌在改善高尿酸血症方面具有广阔的应用前景,是未来缓解和辅助治疗高尿酸血症的重要手段。本文对高尿酸血症、益生菌缓解高尿酸血症的研究现状、作用机制及面临的挑战进行了全面地综述,以期为开发可以缓解高尿酸血症的相关益生菌制剂和营养食品及高尿酸血症的临床治疗提供理论基础和新思路。

关键词：高尿酸血症益生菌尿酸肠道微生物群嘌呤

血栓弹力图和Caprini风险评估模型在骨折患者深静脉血栓形成中的临床价值研究

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标记免疫分析与临床 2024年第5期31卷 828-833页

作者：严平许毛宇吴莉青叶小群郑欣杭州市富阳中医骨伤医院浙江杭州311400 杭州市富阳区妇幼保健院浙江杭州311400

目的探讨血栓弹力图(TEG)和Caprini风险评估模型(Caprini RAM)在创伤性骨折患者发生深静脉血栓(DVT)中的临床预测价值。方法收集2022年6月至2023年4月收治的创伤性骨折患者400例,按照住院期间彩色多普勒超声检查结果分为DVT组(63例)和无... 详细信息

目的探讨血栓弹力图(TEG)和Caprini风险评估模型(Caprini RAM)在创伤性骨折患者发生深静脉血栓(DVT)中的临床预测价值。方法收集2022年6月至2023年4月收治的创伤性骨折患者400例,按照住院期间彩色多普勒超声检查结果分为DVT组(63例)和无DVT组(337例),比较两组常规凝血检验项目、TEG和Caprini RAM评分的差异,采用受试者工作特征(ROC)曲线分析单指标及多指标联合应用的诊断价值。结果除性别比、APTT、PLT外,其余指标在两组间的差异均有统计学意义(P<0.01),R和K值在DVT组中显著降低,而MA、Angle、CI、Caprini RAM评分等显著升高。多因素Logistic回归分析显示,在校正年龄、R值、Angle、CI、TT、Fib和DD等混杂因素后,K值、FDP和Caprini RAM评分为DVT发生的独立影响因素(P均<0.05);基于3者的联合应用模型诊断DVT的AUC为0.890(0.850~0.930),显著高于各单指标。随着K值的升高,DVT发生率逐渐降低(χ^(2)=17.872,P<0.001);FDP水平和Caprini RAM评分升高,DVT发生率显著升高(χ^(2)=58.950、64.827,P均<0.001)。结论低K值、高水平FDP和高Caprini RAM评分是创伤性骨折患者发生DVT的潜在危险因素,通过多指标的联合应用可显著提高其诊断效率。

关键词：血栓弹力图骨折深静脉血栓凝血指标风险评估

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like （ASPM related primary） microcephaly disease

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Protein & Cell 2017年第11期8卷 823-833页

作者： Rui Li Le Sun Ai Fang Peng Li Qian wu xiaoqun Wang State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence Technology (Shanghai) Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Beijing Institute for Brain Disorders Beijing 100069 China

The development of a cerebral organoid culture in vitro offers an opportunity to generate human brain-like organs to investigate mechanisms of human disease that are specific to the neurogenesis of radial glial （RG） and outer radial glial （oRG） cells in the ventrJcular zone （VZ） and subventricular zone （SVZ） of the developing neocortex. Modeling neuronal progenitors and the organization that produces mature subcortical neuron subtypes during early stages of development is essential for studying human brain developmental diseases. Several previous efforts have shown to grow neural organoid in culture dishes successfully, however we demonstrate a new paradigm that recapitulates neocortical development process with VZ, OSVZ formation and the lamination organization of cortical layer structure. In addition, using *** induced pluripotent stem cells （iPSCs） with dysfunction of the Aspm gene from a primary microcephaly patient, we demonstrate neurogenesis defects result in defective neuronal activity in patient organoids, suggesting a new strategy to study human developmental diseases in central nerve system.

关键词： neocortical development cerebralorganoid microcephaly ASPM

Assimilation of HY-2A scatterometer sea surface wind data in a 3DVAR data assimilation system-A case study of Typhoon Bolaven

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Frontiers of Earth Science 2015年第2期9卷 192-201页

作者： Yi YU Weimin ZHANG Zhongyuan wu Xiaofeng YANG xiaoqun CAO Mengbin ZHU National University of Defense Technology Changsha 410073 China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China

The scatterometer （SCAT） on-board China＇s HY-2A satellite has the capability to provide high resolution wind vector information over the global ocean surface. These wind vector data produced by the HY-2A scatterometer （HY-2A SCAT） are available to the data assimilation system with real-time information of high accuracy. In this paper, two experiments are designed to investigate the impact of HY-2A SCAT data in the three- dimensional variational assimilation system for the Weather Research and Forecast model （WRF 3DVAR）. The powerful Typhoon Bolaven, which struck South Korea in August 2012, is selected for this case study. The results clearly demonstrate that HY-2A SCAT data can effectively complement the scarce observations over the ocean surface and improve the prediction of the wind and pressure fields of a typhoon. The case study of Typhoon Bolaven exhibits the significant and positive impact of HY- 2A SCAT data on the numerical prediction of the tropical cyclone track.

关键词： HY-2A scatterometer data assimilation seasurface wind 3DVAR

The Management Pattern Carried Out in a Cataract Surgery Day Ward

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Eye Science 2013年第2期28卷 79-83页

作者： Jing Lin xiaoqun Fang Suhong wu Zhongshan Ophthalmic Center Sun Yat-sen University

Purpose: To evaluate the management practice and process of a cataract surgery day ward. Methods:From January to December in 2012,a portion of the cataract patients were evaluated for the pattern of day ward *** were as follows:1).Establish the cataract day ward. 2) Enroll the patients who met the following criteria: voluntary, local residents or outsiders who stayed in a hotel near the hospital, accompanied by family, and who had simple senile cataract without any systemic major diseases. 3) Establish the hospitalization process. 4) Analyze the nursing process. After cataract day surgery, the patients were followed for 2 hours and completed a questionnaire about their needs and sentiments. Results: A total of 3971 cases were observed in this study; 49 cases were switched to a normal pattern of hospitalization because of operative complications, 1 case had a strong desire to switch to a normal pattern of hospitalization because of ocular discomfort,8 cases went back to the hospital for treatment because of ocular pain,and 52 cases called on the phone to seek help. Overall, 3820 cases (96.2%) returned on time the next day to visit the *** patients showed severe postoperative complications and 98% expressed great satisfaction with the day ward *** 200 cases expressed great concern about not knowing how to deal with postoperative pain,the changes in condition outside the hospital, the therapeutic effects,and the problem of expense reimbursement. Conclusion: Day ward cataract surgery is an efficient and safe mode, and has the potential to relieve the demand for inpatient beds and to ensure timely treatment of the patients. In addition,it helps the patients enjoy health care at public expense,reserving reimbursement for those who need to be *** should pay more attention to systemic evaluation of the patients, health education, and psychological guidance,and keep in close communication with doctors, which is the key to ensure

关键词：白内障手术管理模式病房老年性白内障治疗效果住院病人医疗保健电子商务

Estimating the Ultimate Bound for the Generalized Quadratic Autonomous Chaotic Systems

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Estimating the Ultimate Bound for the Generalized Quadratic ...