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Male contraception:prospects for the new millennium

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Asian Journal of Andrology 2000年第1期2卷 3-12页

作者： w.M.Hair F.C.w.wu Department of Medicine University of Manchester Manchester MI3 9WL UKDepartment of Medicine University of Manchester Manchester MI3 9WL UK

Effective regulation of human fertility has global consequences in terms of resource depletion, pollution and pover-ty. Current family planning services predominantly target a female clientele with few significant developments in malefertility regulation for over a century. The last two decades have witnessed a gathering interest, initially from the scien-tific community, and laterally from industry, in the development of safe, reliable, reversible methods of contraceptionfor men. This review summarises the methods of male fertility regulation which are currently available and critically ex-amines the published data on novel developments in male hormonal contraception which offer the potential of improvedcontraceptive choice for all in new millennium. (Asian J Androl 2000; 2: 3 - 12)

关键词： contraception male contraceptive agents male contraceptive devices gonadotropins testosterone androgen

VOLUMETRIC MASS TRANSFER COEFFICIENT BETwEEN SLAG AND METAL IN COMBINED BLOwING CONVERTER

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Acta Metallurgica Sinica(English Letters) 2005年第2期18卷 91-95页

作者： Z.H.wu Z.S.Zou w.wu SchoolofMaterialsandMetallurgy NortheasternUniversityShenyang110004China CentralIron＆SteelResearchInstitute Beijing100081China

The effects of operation parameters of combined blowing converter on the volumetric mass transfer coefficient between slag and steel are studied with a cold model with water simulating steel, oil simulating slag and benzoic acid as the transferred substance between water and oil. The results show that, with lance level of 2.1m and the top blowing rate of 25000Nm3/h, the volumetric mass transfer coefficient changes most significantly when the bottom blowing rate ranges from 384 to 540Nm3/h. The volumetric mass transfer coefficient reaches its maximum when the lance level is 2.1m, the top blowing rates is 30000Nm3/h, and the bottom blowing rate is 384Nm3/h with tuyeres located symmetrically at 0.66D of the converter bottom.

关键词： combined blowing converter cold modeling volumetric mass transfer coefficient operational parameter

Effect of extracts from Stachys sieboldii Miq. on cellular reactive oxygen species and glutathione production and genomic DNA oxidation

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Asian Pacific Journal of Tropical Biomedicine 2018年第10期8卷 485-489页

作者： Jw Lee w wu SY Lim Division of Marine Bioscience Korea Maritime and Ocean University Department of Marine Bio-Pharmacology Shanghai Ocean University

Objective: To evaluate the antioxidant activity of extracts and fractions from Stachys sieboldii Miq., and to examine its effect on the cellular reactive oxygen species(ROS) and glutathione(GSH) production and genomic DNA oxidation in HT-1080 cells. Methods: The ROS generation induced by H2 O2 was measured by the dichlorofluorescein-diacetate assay. GSH levels were measured using a fluorescent method with mBBr. Genomic DNA oxidative damage was measured with levels of oxidative DNA induced by the reaction of ferritin with H2 O2. Results: The n-hexane, 85% aqueous methanol and n-butanol fractions(0.05 mg/mL concentrations) inhibited H2 O2-induced ROS generation by 63%, 35% and 45%, respectively. GSH levels were significantly increased in both acetone+methylene chloride and methanol extracts(Pwith n-hexane significantly increased GSH levels at concentrations of 0.05 mg/mL(Pwell as all fractions significantly inhibited oxidative DNA damage(Pwas inhibited by the n-hexane fraction and this fraction may contain valuable active compounds.

关键词： Stachys sieboldii Miq. Reactive oxygen species Glutathione DNA oxidation Antioxidant

The Novel Mechanical Property of Tongue of a woodpecker

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Journal of Bionic Engineering 2009年第3期6卷 214-218页

作者： P Zhou X Q Kong C w wu Z Chen National Key Laboratory for Structural Analysis of Industrial Equipment Dalian University of Technology Department of Civil and Environmental Engineering University of Missouri

Biomaterials such as bone,teeth,nacre and silk are known to have superior mechanical properties due to their specific nanocomposite *** we report that the woodpecker's tongue exhibits a novel strength and flexibility due to its special composite micro/*** tongue consists of a flexible cartilage-and-bone skeleton covered with a thin layer tissue of high strength and *** the interface between the cartilage-and-bone skeleton and the tissue layer,there is a hierarchical fiber-typed *** is this special design of the tongue that makes the woodpeckers efficient in catching the insects inside *** special micro/nanostructures of the woodpecker's tongue show us a potential method to enhance the interfacial connection between soft and hard material layers for bio-inspired composite system designs.

关键词： woodpeckcr hyoid cartllage multilevel structure tensile strength

Influence of wall slip on the hydrodynamic behavior of a two-dimensional slider bearing

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Acta Mechanica Sinica 2007年第6期23卷 655-661页

作者： G. J. Ma C. w. wu P. Zhou State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Dalian 116024 China

In the present paper, a multi-linearity method is used to address the nonlinear slip control equation for the hydrodynamic analysis of a two-dimensional （2-D） slip gap flow. Numerical analysis of a finite length slider bearing with wall slip shows that the surface limiting shear stress exerts complicated influences on the hydrodynamic behavior of the gap flow. If the slip occurs at either the stationary surface or the moving surface （especially at the stationary surface）, there is a transition point in the initial limiting shear stress for the proportional coefficient to affect the hydrodynamic load support in two opposite ways： it increases the hydrodynamic load support at higher initial limiting shear stresses, but decreases the hydrodynamic load support at lower initial limiting shear stresses. If the slip occurs at the moving surface only, no fluid pressure is generated in the case of null initial limiting shear stress. If the slip occurs at both the surfaces with the same slip property, the hydrodynamic load support goes off after a critical sliding speed is reached. A small initial limiting shear stress and a small proportionality coefficient always give rise to a low friction drag.

关键词： wall slip Slider beating Multi-linearity method Quadratic programming

Diagnosis of bile duct hepatocellular carcinoma thrombus without obvious intrahepatic mass

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world Journal of Gastroenterology 2010年第39期16卷 4998-5004页

作者： Long XY Li YX wu w Li L Cao J. Department of General Surgery Xiangya Hospital Central South University Changsha 410008 Hunan Province China. liyixiong6@***

AIM:To study the diagnosis of hepatocellular carcinoma(HCC)presenting as bile duct tumor thrombus with no detectable intrahepatic ***:Six patients with pathologically proven bile duct HCC thrombi but no intrahepatic mass demonstrated on the preoperative imaging or palpated intrahepatic mass during operative exploration,were *** clinical and imaging data were retrospectively *** major findings or signs on comprehensive imaging were correlated with the surgical and pathologic ***:Jaundice was the major clinical symptom of the *** elevated serum total bilirubin,direct bilirubin and alanine aminotransferase levels were in concordance with obstructive jaundice and the underlying liver *** the 6 patients showing evidence of viral hepatitis,5 were positive for serum alpha fetoprotein and carbohydrate antigen 19-9,and 1 was positive for serum carcinoembryonic *** patient was correctly diagnosed by *** main features of patients on comprehensive imaging were filling defects with cup-shaped ends of the bile duct,with large filling defects presenting as casting moulds in the expanded bile duct,hypervascular intraluminal nodules,debris or blood clots in the bile *** obvious circular thickening of the bile duct walls was ***:Even with no detectable intrahepatic tumor,bile duct HCC thrombus should be considered in patients predisposed to HCC,and some imaging signs are indicative of its diagnosis.

关键词： Hepatocellular carcinoma Obstructive jaundice Bile duct tumor thrombus Diagnosis Diagnostic imaging

Effective data sampling strategies and boundary condition constraints of physics-informed neural networks for identifying material properties in solid mechanics

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Applied Mathematics and Mechanics(English Edition) 2023年第7期44卷 1039-1068页

作者： w.wu M.DANEKER M.A.JOLLEY K.T.TURNER L.LU Department of Anesthesiology and Critical Care Medicine Children's Hospital of PhiladelphiaPhiladelphiaPA 19104U.S.A. Division of Pediatric Cardiology Children's Hospital of PhiladelphiaPhiladelphiaPA 19104U.S.A. Department of Chemical and Biomolecular Engineering University of PennsylvaniaPhiladelphiaPA 19104U.S.A. Department of Mechanical Engineering and Applied Mechanics University of PennsylvaniaPhiladelphiaPA 19104U.S.A.

Material identification is critical for understanding the relationship between mechanical properties and the associated mechanical ***,material identification is a challenging task,especially when the characteristic of the material is highly nonlinear in nature,as is common in biological *** this work,we identify unknown material properties in continuum solid mechanics via physics-informed neural networks(PINNs).To improve the accuracy and efficiency of PINNs,we develop efficient strategies to nonuniformly sample observational *** also investigate different approaches to enforce Dirichlet-type boundary conditions(BCs)as soft or hard ***,we apply the proposed methods to a diverse set of time-dependent and time-independent solid mechanic examples that span linear elastic and hyperelastic material *** estimated material parameters achieve relative errors of less than 1%.As such,this work is relevant to diverse applications,including optimizing structural integrity and developing novel materials.

关键词： solid mechanics material identification physics-informed neural network(PINN) data sampling boundary condition(BC)constraint

消声器传递损失预测的边界元模态展开混合方法

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声学学报 2015年第6期40卷 836-844页

作者：杨亮季振林 wu T w 哈尔滨工程大学动力与能源工程学院哈尔滨150001 肯塔基大学机械工程学院美国列克星敦40506

将边界元法和解析方法结合形成一种混合方法用于计算消声器的传递损失,消声器被划分成若干个子结构,解析方法和边界元方法被分别用于计算规则结构和不规则结构的阻抗矩阵,不同子结构之间通过阻抗矩阵连接起来。为减少计算时间,采用一种... 详细信息

将边界元法和解析方法结合形成一种混合方法用于计算消声器的传递损失,消声器被划分成若干个子结构,解析方法和边界元方法被分别用于计算规则结构和不规则结构的阻抗矩阵,不同子结构之间通过阻抗矩阵连接起来。为减少计算时间,采用一种基于模态配点法的简化方法。对单级膨胀腔、双级膨胀腔和穿孔管阻性消声器的传递损失进行了计算,混合方法计算结果与解析方法和三维数值方法计算结果吻合良好。分析了混合方法的计算效率并与传统子结构方法进行了比较,混合方法能明显节省计算时间。

关键词：阻性消声器混合方法传递损失模态展开边界元法损失预测子结构方法解析方法

消声器传递损失预测的边界元数值配点混合方法

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振动与冲击 2016年第2期35卷 153-157,206页

作者：杨亮季振林 wu T w 哈尔滨工程大学动力与能源工程学院哈尔滨150001 肯塔基大学机械工程学院列克星敦40506

将边界元法与数值配点法结合形成混合方法用于计算任意截面形状消声器的传递损失。消声器划分为若干子结构,用边界元法计算具有非规则形状的子结构阻抗矩阵,用二维有限元法提取等截面子结构特征值及特征向量,用配点法获得阻抗矩阵;将每... 详细信息

将边界元法与数值配点法结合形成混合方法用于计算任意截面形状消声器的传递损失。消声器划分为若干子结构,用边界元法计算具有非规则形状的子结构阻抗矩阵,用二维有限元法提取等截面子结构特征值及特征向量,用配点法获得阻抗矩阵;将每个子结构阻抗矩阵连接用于传递损失计算。为减少计算时间提出简化方法计算消声器传递损失。结果表明,混合法在保证计算精度前提下可节省计算时间。

关键词：消声器传递损失边界元方法数值配点方法