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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu Tao Li Ze‑bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang han‑Tao Jing bo Mei Qi An Hao‑Fan Bai Jiang‑bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai han Zi‑Jie han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu han‑Xiong huang Wei‑hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Guang‑Yuan Luan bin‑bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑Guang wu Xuan wu Li‑Kun Xie Yi‑Wei Yang han Yi Yong‑Ji Yu Guo‑hui Zhang Lin‑Hao Zhang Mo‑han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai han Zi-Jie han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei hu han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-bin Liu Guang-Yuan Luan Chang-Jun Ning bin-bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-hui Wang Zhong-Wei Wen Xiao-Guang wu Xuan wu Li-Kun Xie Yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang Mo-han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai han Zi‑Jie han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei hu han‑Xiong huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑Guang wu Xuan wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang hang‑Chang Zhang Lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Influence of deep brain stimulation of the subthalamic nucleus on cognitive function in patients with Parkinson's disease

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Neuroscience Bulletin 2014年第1期30卷 153-161页

作者： bin wu Lu han bo-Min Sun Xiao-wu hu Xiao-Ping Wang Department of Neurology Shanghai First People’s Hospital School of Medicine Shanghai Jiao Tong University Department of Functional Neurosurgery Ruijin Hospital Affiliated to the School of Medicine Shanghai Jiao Tong University Department of Neurosurgery Changhai Hospital Second Military University

Deep brain stimulation （DBS） is an effective technique for treating Parkinson＇s disease （PD） in the middle and advanced stages. The subthalamic nucleus （STN） is the most common target for clinical treatment using DBS. While STN-DBS can significantly improve motor symptoms in PD patients, adverse cognitive effects have also been reported. The specific effects of STN-DBS on cognitive function and the related mechanisms remain unclear. Thus, it is imperative to identify the influence of STN-DBS on cognition and investigate the potential mechanisms to provide a clearer view of the various cognitive sequelae in PD patients. For this review, a literature search was performed using the following inclusion criteria：（1） at least 10 patients followed for a mean of at least 6 months after surgery since the year 2006; （2） pre- and postoperative cognitive data using at least one standardized neuropsychological scale; and （3） adequate reporting of study results using means and standard deviations. Of -170 clinical studies identified, 25 cohort studies （including 15 self-controlled studies, nine intergroup controlled studies, and one multi-center, randomized control experiment） and one meta- analysis were eligible for inclusion. The results suggest that the precise mechanism of the changes in cognitive function after STN-DBS remains obscure, but STN-DBS certainly has effects on cognition. In particular, a progressive decrease in verbal fluency after STN-DBS is consistently reported and although executive function is unchanged in the intermediate stage postoperatively, it tends to decline in the early and later stages. However, these changes do not affect the improvements in quality of life. STN-DBS seems to be safe with respect to cognitive effects in carefully-selected patients during a follow-up period from 6 months to 9 years.

关键词： Parkinson's disease subthalamic nucleus deep brain stimulation cognitive function mechanism

Laser irradiation of graphite foils as robust current collectors for high-mass loaded electrodes of supercapacitors

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Rare Metals 2022年第12期41卷 4094-4103页

作者： Xi-Tong Sun Yi Wan bin Wang Qian Xu Xiao-Ling Teng Hai-Yan Liu Yu-Juan Wang Shi-Wei Guo Cheng-Hao wu han hu Ming-bo wu State Key Laboratory of Heavy Oil Processing Institute of New EnergyCollege of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China School of Chemistry Lancaster University New Energy Division Shandong Energy Group Co.LtdZoucheng 273500China

Conductive substrates with low cost,lightweight,and chemical stability have been highly recognized as alternative current collectors for energy storage *** foil is promising to fulfill these requests,whereas the inert surface chemistry denies its possibility as the carrier with high-mass loading active ***,we report a facile yet efficient laser-mediated strategy to fast regulate graphite foils for robustly loading active *** smooth and hydrophobic graphite foil surface turned to be a rough,super-hydrophilic one containing oxygen-rich clusters after *** reconstructed surface affords anchors for active species,such as nanostruetured MnO_(2),FeOOH,and Fe_(2)O_(3),with the highest loading mass of 20 mg·cm^(-2).The high-mass loading MnO_(2)electrode offers an areal capacitance of 3933 mF·cm^(-2)at 1 mA·cm^(-2).Then,the asymmetric supercapacitor,fabricated by MnO_(2)and Fe_(2)O_(3)deposited laser-irradiated graphite foils,exhibits improved performance with high energy density,large power capability,and long-term *** strategy suggests a reliable way to produce alternative current collectors for robust energy storage devices.

关键词： Laser irradiation Graphite foils High-mass loading Current collectors Supercapacitors

Photometric Calibration of the Lunar-based Ultraviolet Telescope for Its First Six Months of Operation on the Lunar Surface

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Research in Astronomy and Astrophysics 2015年第7期15卷 1068-1076页

作者： Jing Wang Li Cao Xian-Min Meng Hong-bo Cai Jing-Song Deng Xu-hui han Yu-Lei Qiu Fang Wang Shen Wang Wei-bin Wen Chao wu Jian-Yan Wei Jing-Yao hu National Astronomical Observatories Chinese Academy of Sciences Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of Sciences Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of Sciences

We describe the photometric calibration of the Lunar-based Ultraviolet Telescope（LUT）, the first robotic astronomical telescope working on the lunar surface, for its first six months of operation on the lunar surface. Two spectral datasets（set A and B） from near-ultraviolet（NUV） to the optical band were constructed with 44 International Ultraviolet Explorer（IUE） standards, because of the LUT＇s relatively wide wavelength coverage. Set A was obtained by extrapolating the IUE NUV spectra（λ 〈 3200 ） to the optical band based upon the theoretical spectra of stellar atmosphere models. Set B was composed of theoretical spectra from 2000  to 8000 extracted from the same model grid. In total, seven standards have been observed in15 observational runs until May 2014. The calibration results show that the photometric performance of LUT is highly stable in its first six months of operation. The magnitude zero points obtained from the two spectral datasets are also consistent with each other, i.e., zp = 17.54 ± 0.09 mag（set A） and zp = 17.52 ± 0.07 mag（set B）.

关键词： space vehicles: instruments -- telescopes -- techniques: photometric --ultraviolet: general

2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

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Cancer Biology & Medicine 2023年第2期20卷 129-146页

作者： Ping Li Yang Liu Yun Liang Jian bo sujun Gao Yongxian hu Yu hu He huang Xiaojun huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi bin Zhang huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang huang Jun Zhu Wenbin Qian Weidong han Aibin Liang Department of Hematology Shanghai Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Bio-therapeutic Chinese PLA General HospitalBeijing 100853China Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009China Department of Hematology Chinese PLA General HospitalBeijing 100853China Department of Hematology The First Hospital of Jilin UniversityChangchun 130012China Center for bone Marrow Transplantation The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China Institute of Hematology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peking University People’s Hospital&Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijing 100191China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Hematology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Lu Daopei Institute of Hematology Beijing 101102China Department of Hematology West China HospitalSichuan UniversityChengdu 610041China The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008China Department of Lymphoma Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Hematology Shanxi Cancer HospitalTaiyuan 030013China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesDivision of Pediatric Blood Disease CenterInstitute of Hematology&Blood Disease HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianj

Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of ***,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this *** and studying the clinical management of these toxicities are *** contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for ***,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese *** consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.

关键词： CAR T-cell therapy B-cell non-Hodgkin lymphoma toxicity cytokine-release syndrome clinical management

Can aspirin use reduce the risk of pancreatic cancer:an updated systematic review and meta-analysis

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Journal of Pancreatology 2020年第4期3卷 201-210页

作者： Dong wu bin Zhou Jian Yang Fa-bo Qiu San-yuan hu han-xiang Zhan Department of General Surgery Qilu HospitalShandong UniversityJinan Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao University Department of Retroperitoneal Tumor Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina

Background:Chemoprevention effect of aspirin for pancreatic cancer(PC)remains *** we performed an updated systematic review and meta-analysis to investigate the real association between aspirin consumption and risk of ***:PubMed,Web of Science,EMBASE and the Cochrane Database were systematic searched to identify the potential *** ratio(ORs)with 95%confidence intervals(CIs)were applied to assess the strength of ***:Thirteen studies and approximately 28,440 participants were *** significantly reduced the incidence of PC(OR,0.82;95%CI,0.73-0.93)in case-control ***,the overall results did not reveal an obvious association(OR,0.92;95%CI,0.74-1.16).both low-dose(OR=0.86)and high-dose(OR=0.80)aspirin intake showed prevention *** addition,low frequency(OR,0.87;95%CI,0.73-1.05)and high frequency(OR,0.84;95%CI,0.69-1.03)seemed to be equally associated with decreased risk for *** consumption longer than 10 years use seems to have better effect(OR,0.73;95%CI,0.51-1.04)than shorter aspirin use(OR,0.94;95%CI,0.77-1.15).Conclusions:Our study indicated that aspirin use might be associated with decreased risk of PC,especially at high *** we still need to be cautious when interpreting the results.

关键词： Aspirin Cancer chemoprevention Meta-analysis Pancreatic cancer

Elevated Plasma Tissue-type Plasminogen Activator (t-PA) and Soluble Throm-bomodulin in Patients Suffering From Severe Acute Respiratory Syndrome (SARS) as a Possible Index for Prognosis and Treatment Strategy

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Biomedical and Environmental Sciences 2005年第4期18卷 260-264页

作者： ZHONG-huA LIU RAN WEI YA-PING wu TON LISMAN ZENG-XIAN WANG JI-JU han DAO-LING REN bin CHEN ZUO-LI XIA BIAO CHEN ZHEN Zhu YAN ZhanG XING CUI HAI-TAO hu PHILIP G. DE GROOT WEN-bo XU School of Medicine Xi＇an Jiaotong University （SMXJU） Xi＇an 710061 Shaanxi China Basic Medical Science Institute Taishan Medical College （TMC） Tai＇ an China Haematology University Medical Center Utrecht （UMCU） the Netherlands Xuanwu Hospital of Capital University of Medical Sciences BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China College of Medicine Shandong University Jinan China

To detect the presence of endothelial injury in patients with severe acute respiratory syndrome （SARS） via enhanced levels of tissue-type plasminogen activator （t-PA） and soluble thrombomodulin （sTM）. Methods Case patients were from Xuanwu Hospital （Capital University of Medical Sciences, Beijing, China）, and all of them met clinical criteria for SARS. Healthy controls were some of the hospital employees. Endothelial injury bio-markers tPA and sTM were detected by commercial ELISA-methods. Results Classic plasma markers of endothelial injury, tPA and sTM significantly elevated in SARS patients in comparison to controls [t-PA： 1.48±0.16 nmol/L versus 0.25±0.03 nmol/L （P〈0.0001）, and sTM： 0.26±0.06 nmol/L versus 0.14±0.02 nmol/L （P〈0.05）]. The only patient who died had extremely high levels of these endothelial injury markers （t-PA： 2.77 nmol/L and sTM： 1.01 nmol/L）. The likelihood ratio analysis indicated the excellent discriminating power for SARS at the optimal cut-point of 0.49 nmol/L for tPA and 0.20 nmol/L for sTM, respectively. Significant numerical correlations were found among these endothelial injury markers in SARS patients. The numerical coefficient of correlation Pearson r between t-PA and sTM was 0.5867 （P〈0.05）. Conclusion Increased plasma concentrations of tPA and sTM in patients with SARS suggest the possibility of endothelial injury. SARS patients might need anticoagulant therapy or fibrinolytic therapy in order to reverse intraalveolar coagulation, microthrombi formation, alveolar and interstitial fibrin deposition. It may not only provide a useful treatment and prognostic index but also allow a further understanding of the pathological condition of the disease.

关键词： Severe acute respiratory syndrome (SARS) Tissue-type plasminogen activator (t-PA) Soluble thrombomodulin(sTM) SARS-coronavirus Bio-markers Endothelial injury