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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei Yun-Xia wu Yun Lu Zi-shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

Improvement of the nutritional support management system for patients in intensive care units

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World Journal of Psychiatry 2024年第1期14卷 44-52页

作者： Yuan-Yuan Zhang Chun-Yi Wang Dong-Xian Guo Hai-Nu Gao Xian-shan Jin Yan-Li wu Lu-Han Chen Zhi-Xian Feng Department of Critical Care Medicine Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Information Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Pharmacy Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Nutrition Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Administrative Office Shulan(Hangzhou)HospitalZhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina

BACKGROUND Nutritional support for patients hospitalized in the intensive care unit(ICU)is an important part of clinical treatment and care,but there are significant implementation *** To introduce a modified nutritional support management system for ICU patients based on closed-loop information management and psychological *** The division of functions,personnel training,system construction,development of an intelligent decision-making software system,quality control,and improvement of the whole process were carried out to systematically manage nutritional support for ICU *** Following the implementation of the whole process management system,the scores of ICU medical staff’s knowledge,attitudes/beliefs,and practices regarding nutritional support were comprehensively *** proportion of hospital bed-days of total enteral nutrition(EN)in ICU patients increased from 5.58%to 11.46%,and the proportion of EN plus parenteral nutrition increased from 42.71%to 47.07%.The rate of EN initiation within 48 h of ICU admission increased from 37.50%to 48.28%,and the EN compliance rate within 72 h elevated from 20.59%to 31.72%.After the implementation of the project,the Self-rating Anxiety Scale score decreased from 61.07±9.91 points to 52.03±9.02 points,the Self-rating Depression Scale score reduced from 62.47±10.50 points to 56.34±9.83 points,and the ICU stay decreased from 5.76±2.77 d to 5.10±2.12 *** The nutritional support management system based on closed-loop information management and psychological counseling achieved remarkable results in clinical applications in ICU patients.

关键词： Closed-loop information Psychological counseling Intensive care unit patients Nutritional support Management system

Analysis of amino acid enantiomers in ambient aerosols:Effects and removal of coexistent aerosol matrix

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Journal of Environmental Sciences 2024年第3期137卷 732-740页

作者： Ying Li Xiaoying Li Libin wu Luhan Shi shanWang Pingqing Fu Yingyi Zhang Senchao Lai The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China now at Hong Kong University of Science and Technology Hong Kong 00852China

Amino acids(AAs)including D-and L-enantiomers are a group of organic nitrogen species in ambient *** to the low abundances of AAs(level of ng/m^(3))and the matrix effects by coexistent components,it is challenging to quantify AA enantiomers in ambient aerosols especially under pollution *** this study,we present an optimized method for analyzing AA enantiomers in atmospheric aerosol samples including a pretreatment process and the detection by high performance liquid chromatography coupled to a fuorescence detector(HPLC-FLD).Matrix effects caused by coexistent chemicals on AA enantiomers analysis in ambient aerosol samples were investigated especially for those collected in pollution *** results revealed that the determination of AA enantiomers is significantly affected by the coexistent organic carbon(as a proxy of organic matter)and water-soluble ion of NH_(4)^(+).To remove the matrix effects,we applied a pretreatment using the solid phase extraction column coupled with alkaline adjustment to sample *** pretreatment,18 AAs including 6 pairs of D-and L-enantiomers(i.e.,leucine,isoleucine,valine,alanine,serine,and aspartic acid)can be successfully separated and quantified in aerosol samples by *** recoveries are in the range of 67%-106%.This method was successfully applied to the urban aerosol samples from pollution and non-pollution periods for AA enantiomers *** suggest that the concentrations of D-AAs and the ratio of D-AA/L-AA are indicative of the contribution of bacterial sources and the infuence of biomass burning.

关键词： Amino acid enantiomers Atmospheric aerosol Organic carbon Ammonia Chiral ratio

Genomic characterization of peritoneal lavage cytology-positive gastric cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 66-77页

作者： Zhouqiao wu Tingfei Gu Changxian Xiong Jinyao Shi Jingpu Wang Ting Guo Xiaofang Xing Fei Pang Ning He Rulin Miao Fei shan Yuan Zhou Ziyu Li Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Department of Biomedical Informatics Department of Physiology and PathophysiologyCenter for Noncoding RNA MedicineMOE Key Lab of Cardiovascular SciencesSchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Positive peritoneal lavege cytology(CY1) gastric cancer is featured by dismal prognosis, with high risks of peritoneal metastasis. However, there is a lack of evidence on pathogenic mechanism and signature of CY1and there is a continuous debate on CY1 therapy. Therefore, exploring the mechanism of CY1 is crucial for treatment strategies and targets for CY1 gastric ***: In order to figure out specific driver genes and marker genes of CY1 gastric cancer, and ultimately offer clues for potential marker and risk assessment of CY1, 17 cytology-positive gastric cancer patients and 31matched cytology-negative gastric cancer patients were enrolled in this study. The enrollment criteria were based on the results of diagnostic laparoscopy staging and cytology inspection of exfoliated cells. Whole exome sequencing was then performed on tumor samples to evaluate genomic characterization of cytology-positive gastric ***: Least absolute shrinkage and selection operator(LASSO) algorithm identified 43 cytology-positive marker genes, while Mut Sig CV identified 42 cytology-positive specific driver genes. CD3G and CDKL2 were both driver and marker genes of CY1. Regarding mutational signatures, driver gene mutation and tumor subclone architecture, no significant differences were observed between CY1 and negative peritoneal lavege cytology(CY0).Conclusions: There might not be distinct differences between CY1 and CY0, and CY1 might represent the progression of CY0 gastric cancer rather than constituting an independent subtype. This genomic analysis will thus provide key molecular insights into CY1, which may have a direct effect on treatment recommendations for CY1and CY0 patients, and provides opportunities for genome-guided clinical trials and drug development.

关键词： Cytology gastric carcinoma peritoneal metastasis whole exome sequencing

Revenue management method and critical techniques of railway passenger transport

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Railway Sciences 2024年第5期3卷 636-649页

作者： Xinghua shan Xiaoyan Lv Jinfei wu Shuo Zhao Junfeng Zhang Institute of Computing Technologies China Academy of Railway Sciences Corporation LimitedBeijingChina

Purpose–Revenue management(RM)is a significant technique to improve revenue with limited *** the macro environment of dramatically increasing transit capacity and rapid railway transport development in China,it is necessary to involve the theory of RM into the operation and decision of railway passenger ***/methodology/approach–This paper proposes the theory and framework of generalized RM of railway passenger transport(RMRPT),and the thoughts and methods of the main techniques in RMRPT,involving demand forecasting,line planning,inventory control,pricing strategies and information systems,are all studied and *** involved methods and techniques provide a sequential process to help with the decision-making for each stage of *** corresponding techniques are integrated into the information system to support practical businesses in railway passenger ***–The combination of the whole techniques devotes to railway benefit improvement and transit resource utilization and has been applied into the practical operation and organization of railway passenger ***/value–The development of RMRPT would provide theoretical and technical support for the improvement of service quality as well as railway benefits and efficiency.

关键词： Revenue management Railway passenger transport Demand forecasting Line planning Inventory control Pricing strategy

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一种数据流上截止期敏感的滑动窗口处理策略

计算机科学 2007年第7期34卷 99-102页

作者：武珊珊谷峪吕雁飞于戈东北大学信息科学与工程学院沈阳110004

在数据流上定义了截止期作为连续查询的实时约束,并建立了基于截止期的滑动窗口处理模型;提出了一种基于预测的截止期敏感的滑动窗口处理策略;在多滑动窗口查询处理环境中,提出了一种(k,m)截止期约束机制,在提高查询实时性的前提下,尽... 详细信息

在数据流上定义了截止期作为连续查询的实时约束,并建立了基于截止期的滑动窗口处理模型;提出了一种基于预测的截止期敏感的滑动窗口处理策略;在多滑动窗口查询处理环境中,提出了一种(k,m)截止期约束机制,在提高查询实时性的前提下,尽可能的满足不同查询对结果丢失率的不同约束。实验结果表明该处理策略能够有效提高数据流上滑动窗口查询的截止期满足率。

关键词：数据流滑动窗口截止期查询处理

Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan shan Tang Changlin Tian Ping Wang Bian wu Chuanliu wu Junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae

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Science China(Life Sciences) 2024年第4期67卷 803-816页

作者： Kun-Li Xiang Sheng-Dan wu Lian Lian Wen-Chuang He Dan Peng Huan-Wen Peng Xiao-Ni Zhang Hong-Lei Li Jia-Yu Xue Hong-Yan shan Gui-Xia Xu Yang Liu Zhi-Qiang wu Wei Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyLaboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China China National Botanical Garden Beijing 100093China State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Landscape Architecture and Life Science/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160China College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Fairylake Botanical Garden Shenzhen&Chinese Academy of SciencesShenzhen 518004China

Living fossils are evidence of long-term sustained ecological ***,whether living fossils have little molecular changes remains poorly known,particularly in ***,we have introduced a novel method that integrates phylogenomic,comparative genomic,and ecological niche modeling analyses to investigate the rate of molecular evolution of Eupteleaceae,a Cretaceous relict angiosperm family endemic to East *** assembled a high-quality chromosome-level nuclear genome,and the chloroplast and mitochondrial genomes of a member of Eupteleaceae(Euptelea pleiosperma).Our results show that Eupteleaceae is most basal in Ranunculales,the earliest-diverging order in eudicots,and shares an ancient whole-genome duplication event with the other *** document that Eupteleaceae has the slowest rate of molecular changes in the observed *** unusually low rate of molecular evolution of Eupteleaceae across all three independent inherited genomes and genes within each of the three genomes is in association with its conserved genome architecture,ancestral woody habit,and conserved niche *** findings reveal the evolution and adaptation of living fossil plants through large-scale environmental change and also provide new insights into early eudicot diversification.

关键词： conservation genomics eudicots evolutionary rates niche conservatism phylogenomics

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腹针“补肾填髓”法静息状态脑功能成像研究

中国针灸 2011年第2期31卷 139-143页

作者：钟治平吴珊珊陈志光刘波广东省中医院影像科广州510120

目的:利用静息状态脑功能磁共振成像研究腹针的中枢神经作用机制。方法:对12例老年健康志愿者进行标准化腹针"补肾填髓"法操作,穴取中脘、下脘、气海、关元、气穴、商曲、滑肉门,于针刺前和针刺起针后行磁共振静息状态脑功能成像扫描,... 详细信息

目的:利用静息状态脑功能磁共振成像研究腹针的中枢神经作用机制。方法:对12例老年健康志愿者进行标准化腹针"补肾填髓"法操作,穴取中脘、下脘、气海、关元、气穴、商曲、滑肉门,于针刺前和针刺起针后行磁共振静息状态脑功能成像扫描,采用双侧海马为种子点对全脑皮层进行功能连接分析。结果:①针刺前,双侧额中回、双侧颞上回、双侧颞中回、双侧丘脑、双侧海马旁回、双侧岛叶、右侧小脑顶、右侧小脑坡、左侧额上回、左侧尾状核头、左侧后扣带回、左侧顶下小叶与双侧海马存在功能连接(均P<0.05)。②针刺后,双侧额上回、双侧颞上回、双侧颞中回、双侧丘脑、双侧岛叶、双侧海马旁回、双侧顶下小叶、双侧中央后回、双侧扣带回、右侧尾状核头、右侧枕中回、右侧后扣带回与双侧海马存在功能连接(均P<0.05)。③针刺后与针刺前比较,双侧额上回、双侧额中回、双侧颞上回、双侧顶上小叶、右侧额下回、右侧前扣带回、右侧梭状回、右侧楔前叶、右中央后回与双侧海马的功能连接增强;左侧颞中回、右侧舌回、左侧楔叶、左侧楔前叶、左侧顶下小叶与双侧海马的功能连接减弱。结论:老年健康志愿者腹针"补肾填髓法"针刺后与认知、记忆及情感、感觉有关的皮层结构与双侧海马的功能连接增强,提示腹针可改善中枢神经系统认知网络的整体功能状态。

关键词：针刺疗法脑磁共振光谱法腹针