Retrotransposon expansion has profoundly reshaped genomes[1],[2].As crucial defense mechanisms that counteract retrotransposons in humans,members of the Krüppel-associated box(KRAB)zinc finger(ZF)protein(KZFP)family ...
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Retrotransposon expansion has profoundly reshaped genomes[1],[2].As crucial defense mechanisms that counteract retrotransposons in humans,members of the Krüppel-associated box(KRAB)zinc finger(ZF)protein(KZFP)family have undergone significant changes in both their numbers and binding capabilities[3].
To monitor nuclear and radiation emergencies,it is crucial to obtain accurate in situ measurements of the environmentalγ radiation dose rate from key radionuclides,particularly for large radioactive surface *** meth...
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To monitor nuclear and radiation emergencies,it is crucial to obtain accurate in situ measurements of the environmentalγ radiation dose rate from key radionuclides,particularly for large radioactive surface *** methods currently used for measuring dose rates are inadequate for obtaining the dose rates of key radionuclides and have large angular response errors when monitoring surface *** address this practical problem,this study proposes three methods for measuring the dose rate:the weighted peak total ratio,mean value regression,and numerical integration *** methods are based on energy-spectrum measurement data,and they were theoretically derived and numerically ***,a 1-m-long hexagonal radioactive surface source was integrated into a larger surface *** situ measurement experiments were conducted on a large radioactive surface source using a dose-rate meter and a portable HPGespectrometer to analyze the errors of the three aforementioned methods and verify their validity.
This letter to the editor involves the article published in the World Journal of Gastrointestinal *** metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy *** significantly impairs quality of...
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This letter to the editor involves the article published in the World Journal of Gastrointestinal *** metastasis(BM)in gastric cancer(GC)is uncommon but can be prevalent in autopsy *** significantly impairs quality of life and is frequently underdiagnosed,as sensitive diagnostic tests are only performed after symptoms *** is crucial for the diagnosis of BM but is not routinely used for screening and is *** laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.
Epstein-Barr virus(EBV), the first identified human tumor virus, is implicated in various human malignancies, infectious mononucleosis,and more recently, multiple sclerosis. Prophylactic vaccines have the potential to...
Epstein-Barr virus(EBV), the first identified human tumor virus, is implicated in various human malignancies, infectious mononucleosis,and more recently, multiple sclerosis. Prophylactic vaccines have the potential to effectively prevent EBV infection. Glycoprotein B(gB)serves as the fusogen and plays a pivotal role in the virus entry process, making it a critical target for EBV vaccine development. Surface membrane proteins of enveloped viruses serve as native conformational antigens, making them susceptible to immune recognition. Utilizing lipid membrane-bound viral antigens is a promising strategy for effective vaccine presentation in this context. In this study, we employed a truncated design for gB proteins, observing that these truncated gB proteins prompted a substantial release of extracellular vesicles(EVs) in insect cells. We verified that EVs exhibited abundant gB proteins, displaying the typical virus particle morphology and extracellular vesicle characteristics. gB EVs demonstrated a more efficient humoral and cellular immune response compared with the gB ectodomain trimer vaccine in mice. Moreover, the antisera induced by the gB EVs vaccine exhibited robust antibody-dependent cytotoxicity. Consequently, gB EVs-based vaccines hold significant potential for preventing EBV infection and offer valuable insights for vaccine design.
This research optimized the structure of lithium extraction solar ponds to enhance the crystallization rate and yield of Li_(2)CO_(3).Using the response surface methodology in Design-Expert 10.0.3,the authors conducte...
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This research optimized the structure of lithium extraction solar ponds to enhance the crystallization rate and yield of Li_(2)CO_(3).Using the response surface methodology in Design-Expert 10.0.3,the authors conducted experiments to investigate the influence of four factors related to solar pond structure on the crystallization of Li_(2)CO_(3) and their pairwise *** Fluid Dynamics(CFD)simulations of the flow field within the solar pond were performed using COMSOL Multiphysics software to compare temperature distributions before and after *** results indicate that the optimal structure for lithium extraction from the Zabuye Salt Lake solar ponds includes UCZ(Upper Convective Zone)thickness of 53.63 cm,an LCZ(Lower Convective Zone)direct heating temperature of 57.39℃,a CO32−concentration of 32.21 g/L,and an added soda ash concentration of 6.52 g/*** this optimized pathway,the Li_(2)CO_(3) precipitation increased by 7.34% compared to the initial solar pond process,with a 33.33% improvement in lithium carbonate crystallization *** study demonstrates the feasibility of optimizing lithium extraction solar pond structures,offering a new approach for constructing such ponds in salt *** provides valuable guidance for the efficient extraction of lithium resources from carbonate-type salt lake brines.
Scientific knowledge on the chemical compositions of fine particulate matter(PM_(2.5)) is essential for properly assessing its health and climate effects,and for decisionmakers to develop efficient mitigation strategi...
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Scientific knowledge on the chemical compositions of fine particulate matter(PM_(2.5)) is essential for properly assessing its health and climate effects,and for decisionmakers to develop efficient mitigation strategies.A high-resolution PM_(2.5) chemical composition dataset(CAQRA-aerosol)is developed in this study,which provides hourly maps of organic carbon,black carbon,ammonium,nitrate,and sulfate in China from 2013 to 2020 with a horizontal resolution of 15 *** paper describes the method,access,and validation results of this *** shows that CAQRA-aerosol has good consistency with observations and achieves higher or comparable accuracy with previous PM_(2.5) composition *** on CAQRA-aerosol,spatiotemporal changes of different PM_(2.5) compositions were investigated from a national viewpoint,which emphasizes different changes of nitrate from other *** estimated annual rate of population-weighted concentrations of nitrate is 0.23μg m^(−3)yr^(−1) from 2015 to 2020,compared with−0.19 to−1.1μg m^(−3)yr^(−1) for other *** whole dataset is freely available from the China Air Pollution Data Center(https://***/10.12423/capdb_***).
The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to i...
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The original intention of the algorithmic recommender system is to grapple with the negative impacts caused by information overload,but the system also can be used as"hypernudge",a new form of online manipulation,to inten⁃tionally exploit people's cognitive and decision-making gaps to influence their decisions in practice,which is particu⁃larly detrimental to the sustainable development of the digital *** harmful algorithmic online manipula⁃tion in digital markets has become a challenging ***,both the EU and China have responded to this issue,and the differences between them are so evident that their governance measures can serve as the typical *** EU focuses on improving citizens'digital literacy and their ability to integrate into digital social life to independently ad⁃dress this issue,and expects to address harmful manipulation behavior through binding and applicable hard law,which is part of the digital *** comparison,although there exist certain legal norms that have made relevant stipula⁃tions on manipulation issues,China continues to issue specific departmental regulations to regulate algorithmic recom⁃mender services,and pays more attention to addressing collective harm caused by algorithmic online manipulation through a multiple co-governance approach led by the government or industry associations to implement supervision.
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