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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue liN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei li Qing-bo li Shan-shan WANG Shi-dong DAI Fang liU Zhen-jie ZHAO ling WEN Jian-xuan wu li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen liANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai li Chun-ji OUyanG Wen-wei li Geng wu Ming-hui li An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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自然公园游客投喂野生动物的意愿、态度与行为研究——以峨眉山风景名胜区为例

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西华师范大学学报（自然科学版） 2024年第2期45卷 126-133页

作者：吴艳丽刘影张晋东西华师范大学西南野生动植物资源保护教育部重点实验室四川南充637009 西华师范大学生命科学学院四川南充637009

随着自然保护地旅游业的快速发展,投喂野生非人灵长类动物的行为在各景区屡见不鲜,然而此举会带来诸多危害。本研究采用问卷调查法于峨眉山风景名胜区对游客投喂藏酋猴(Macaca thibetana)的意愿、态度与行为进行调查。结果显示:(1)景区... 详细信息

随着自然保护地旅游业的快速发展,投喂野生非人灵长类动物的行为在各景区屡见不鲜,然而此举会带来诸多危害。本研究采用问卷调查法于峨眉山风景名胜区对游客投喂藏酋猴(Macaca thibetana)的意愿、态度与行为进行调查。结果显示:(1)景区投喂现象常见,多发生在生态猴区和雷洞坪,游客投喂的食物种类繁多;(2)有投喂意愿的游客较多(55.81%),其年龄和受教育年限低于无投喂意愿的游客;(3)支持投喂的游客较多(66.11%),其受教育年限低于不支持投喂的游客,游客投喂态度与意愿之间具有明显地一致性;(4)男性、年龄小、受教育年限低、为了看藏酋猴、有投喂意愿或支持投喂的游客更容易向藏酋猴投喂食物;(5)向受访者科普给藏酋猴投喂食物的危害和风险后,其投喂态度及劝阻他人投喂的意愿发生了明显转变,支持投喂者比例从66.11%下降至19.93%,愿意劝阻他人投喂者比例从6.31%上升到35.22%。本研究旨在为自然生态类景区生态旅游管理提供参考建议,以促进人与野生动物自然和谐相处。

关键词：峨眉山风景名胜区游客投喂野生动物意愿与态度

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浅析专业认证背景下“制药设备与车间设计”课程改革

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教育教学论坛 2024年第26期 53-56页

作者：吴丽艳孟凡欣高波珠海科技学院药学与食品科学学院广东珠海519041 吉林大学生命科学学院吉林长春130012

“制药设备与车间设计”属于高等教育制药工程专业的关键课程,在工程专业认证环境下,“制药设备与车间设计”课程需转变育人思想,深化课程改革。基于此,简单阐述分析了“制药设备与车间设计”课程的工程教育专业认证背景,提出了确定课... 详细信息

“制药设备与车间设计”属于高等教育制药工程专业的关键课程,在工程专业认证环境下,“制药设备与车间设计”课程需转变育人思想,深化课程改革。基于此,简单阐述分析了“制药设备与车间设计”课程的工程教育专业认证背景,提出了确定课程目标,突出课程定位;拓展课程内容,优化教学方法;引入虚拟仿真,加强实践教学;深化多方互动,注重能力培养;融入模块教学,实现以生为本;改革考核模式,课程有效评价等六项改革策略,以供参考借鉴。

关键词：专业认证制药设备与车间设计课程改革

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Hydrothermal hydrogenation/deoxygenation of palmitic acid to alkanes over Ni/activated carbon catalyst

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Chinese Journal of Chemical Engineering 2024年第2期66卷 8-18页

作者： Min lin Yuhao yan Xiaoxian li Rui li Yulong wu MOE Engineering Center of Forestry Biomass Materials and Bioenergy Beijing Forestry UniversityBeijing 100083China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua UniversityBeijing 100084China

To produce paraffin from hydrogenation/deoxygenation of palmitic acid,model compound of bio-oil obtained by hydrothermal liquefaction(HTL)of microalgae has been an attractive focus in recent *** order to avoid energy-intensive separation process of water and bio-oil,it is of importance that deoxygenation upgrading of fatty acids under hydrothermal conditions similar to HTL ***,it is the first time to explore the application of activated carbon(AC)-supported non-noble-metal catalysts,such as Ni,Co,and Mo,and so on,in the hydrothermal hydrogenation/deoxygenation of long-chain fatty acids,and the obtained Ni/AC-H(the Ni/AC was further H_(2)pre-reduced)is one of the best *** addition,it is found that the catalytic activity can be further improved by H_(2)pre-reduction of *** results that are more low valences of nickel and oxygen vacancy can be obtained after H_(2)pre-reduction,thus significant promoting the deoxygenation especially the decarbonylation pathway of fatty *** total alkanes yield can reaches 95.9%at optimal conditions(280℃,360 min).This work confirmed that the low-priced AC-supported non-noble-metal catalysts have great potential compared with the noble-metal catalyst,in hydrothermal upgrading of bio-oil.

关键词： Bio-oil Fatty acids Deoxygenation Hydrothermal upgrading

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Flight Time Minimization of UAV for Cooperative Data Collection in Probabilistic LoS Channel

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China Communications 2024年第2期21卷 210-226页

作者： yan li Shaoyi Xu Yunpu wu Dongji li School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Electrical Engineering and Electronic Information Xihua UniversityChengdu 610039China

This paper investigates the data collection in an unmanned aerial vehicle(UAV)-aided Internet of Things(IoT) network, where a UAV is dispatched to collect data from ground sensors in a practical and accurate probabilistic line-of-sight(LoS) channel. Especially, access points(APs) are introduced to collect data from some sensors in the unlicensed band to improve data collection efficiency. We formulate a mixed-integer non-convex optimization problem to minimize the UAV flight time by jointly designing the UAV 3D trajectory and sensors’ scheduling, while ensuring the required amount of data can be collected under the limited UAV energy. To solve this nonconvex problem, we recast the objective problem into a tractable form. Then, the problem is further divided into several sub-problems to solve iteratively, and the successive convex approximation(SCA) scheme is applied to solve each non-convex subproblem. Finally,the bisection search is adopted to speed up the searching for the minimum UAV flight time. Simulation results verify that the UAV flight time can be shortened by the proposed method effectively.

关键词： data collection flight time probabilistic line-of-sight channel unlicensed band unmanned aerial vehicle

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Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang li limeng wu Aiqin Zhang Shaohua wu yan lin Chunping yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain ***,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/*** Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet ***,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet *** excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent *** to undoped N/C,Co doping could significantly enhance the catalytic *** 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported *** addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation *** study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

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Attributes of Specialized Households'Resilience and Its Impact on Rural Industrial Advancement:A Case Study of National Musical Instrument Production Specialized Households in Lankao County,Henan,China

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Chinese Geographical Science 2024年第3期34卷 383-400页

作者： wu Nalin WEI Yike FAN Sizhe li li SUN Yufan ZHANG yan SHU yan Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of Educa-tion/The College of Geography and Environmental ScienceHenan UniversityKaifeng 475001China College of Urban and Envir-onmental Science Central China Normal UniversityWuhan 430079China Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural *** this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in *** musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience *** influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future ***,heightened exposure to the external macroeconomic environment can lead to a higher rate of export *** enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology

关键词： resilience specialized households rural industry Lankao County,China

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丁苯酞联合依达拉奉右莰醇治疗缺血性脑卒中的疗效及成本

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中国药物经济学 2024年第3期19卷 56-59页

作者：黄俊荣王彬曲政耿毅楠顾彦铭李龙吴艳丽魏威牡丹江医学院药学院黑龙江牡丹江157011 牡丹江医学院附属第二医院药剂科黑龙江牡丹江157010

目的探讨丁苯酞联合依达拉奉右莰醇治疗缺血性脑卒中的疗效及成本。方法通过查阅牡丹江医学院附属第二医院的医院信息系统(HIS),收集2021年1—12月所有使用丁苯酞氯化钠注射液联合依达拉奉右莰醇注射用浓溶液、依达拉奉右莰醇注射用浓... 详细信息

目的探讨丁苯酞联合依达拉奉右莰醇治疗缺血性脑卒中的疗效及成本。方法通过查阅牡丹江医学院附属第二医院的医院信息系统(HIS),收集2021年1—12月所有使用丁苯酞氯化钠注射液联合依达拉奉右莰醇注射用浓溶液、依达拉奉右莰醇注射用浓溶液的缺血性脑卒中患者住院规范治疗信息,共获取945例患者。为了避免错误分类,对两组患者基线特征进行混杂控制,采用倾向评分匹配法(1∶1)匹配联合组和对照组,945例缺血性脑卒中患者最终确定丁苯酞联合依达拉奉右莰醇+常规治疗为联合组270例,依达拉奉右莰醇+常规治疗为对照组270例。比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、超敏C反应蛋白(hs-CRP)及临床疗效、成本、安全性。结果治疗后,两组NIHSS评分、hs-CRP水平降低,且联合组下降幅度更大,差异有统计学意义(P0.05);两组总药费、检查费、化验费、治疗费、直接医疗成本比较差异无统计学意义(P>0.05);两组均无明显不良反应发生。结论与单用依达拉奉右莰醇比较,丁苯酞联合依达拉奉右莰醇治疗缺血性脑卒中,显效率更高,可有效改善患者神经功能,但经济性相当。

关键词：丁苯酞依达拉奉右莰醇缺血性脑卒中成本-效果

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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu yan li yan Feng Shaowei wu yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

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Theoretical and experimental investigation of the resonance responses and chaotic dynamics of a bistable laminated composite shell in the dynamic snap-through mode

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 581-602页

作者： Meiqi wu Pengyu LV Hongyuan li Jiale yan Huiling DUAN Wei ZHANG State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China Nanchang Innovation Institute of Peking University Nanchang 330096China Department of Mechanics Guangxi UniversityNanning 530004China

The dynamic model of a bistable laminated composite shell simply supported by four corners is further developed to investigate the resonance responses and chaotic *** existence of the 1:1 resonance relationship between two order vibration modes of the system is *** resonance response of this class of bistable structures in the dynamic snap-through mode is investigated,and the four-dimensional(4D)nonlinear modulation equations are derived based on the 1:1 internal resonance relationship by means of the multiple scales *** Hopf bifurcation and instability interval of the amplitude frequency and force amplitude curves are *** discussion focuses on investigating the effects of key parameters,e.g.,excitation amplitude,damping coefficient,and detuning parameters,on the resonance *** numerical simulations show that the foundation excitation and the degree of coupling between the vibration modes exert a substantial effect on the chaotic dynamics of the ***,the significant motions under particular excitation conditions are visualized by bifurcation diagrams,time histories,phase portraits,three-dimensional(3D)phase portraits,and Poincare ***,the vibration experiment is carried out to study the amplitude frequency responses and bifurcation characteristics for the bistable laminated composite shell,yielding results that are qualitatively consistent with the theoretical results.

关键词： bistable laminated composite shell dynamic snap-through mode Hopf bifurcation chaotic dynamics vibration experiment

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