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Analgesic action of suspended moxibustion in rats with chronic visceral hyperalgesia correlates with enkephalins in the spinal cord

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Neural Regeneration Research 2012年第3期7卷 219-222页

作者： Tao Yi Li Qi huangan wu Xiaopeng Ma Huirong Liu Xiaomei Wang Shanghai Institute of Acupuncture-Moxibustion and Meridians Shanghai University of Traditional Chinese Medicine Shanghai 200030China E-institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine Shanghai 200030 China

Rats that modeled chronic visceral hyperalgesia received suspended moxibustion at bilateral Tianshu （ST25） and Shangjuxu （ST37） once daily over a period of 7 days. Results show that suspended moxibustion significantly depressed abdominal withdrawal reflex scores and increased enkephalin concentration in the spinal cord. The experimental findings suggest that spinal enkephalins contributed to the analgesic effect of suspended moxibustion in rats with chronic visceral hyperalgesia.

关键词： suspended moxibustion chronic visceral hyperalgesia enkephalins irritable bowel syndrome

Journal of Acupuncture and Tuina Science Instructions for Authors

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Journal of Acupuncture and Tuina Science 2022年第5期20卷后插1-后插2页

作者： CHEN Hanping wu huangan No.650 South Wanping RoadShanghai 200030China

The Journal of Acupuncture and Tuina Science,a peerreview journal with an international scope(ISSN 1672-3597,CN 31-1908/R,Bimonthly),is indexed in Emerging Sources Citation Index(ESCI),The Western Pacific Region Index Medicus(WPRIM),Springer-Verlag GmbH Database,Index of Copernicus(IC),Chinese Science Citation Database(CSCD)and Chinese Scientific and Technical Papers and Citations Database.

关键词： Acupuncture journal SCI

Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2024年第5期44卷 981-990页

作者： ZHANG Fang YAN Cuina WENG Zhijun wu Luyi QI Li ZHAO Min XIN Yuhu wu huangan LIU Huirong Key Laboratory of Acupuncture and Immunological Effects Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Cancer Hospital Fudan UniversityShanghai 200032China

OBJECTIVE:To investigate the role of satellite glial cells in irritable bowel syndrome(IBS)and the effect of electroacupuncture(EA)at the Tianshu(ST25)and Shangjuxu(ST37)***:A model for visceral hypersensitivity in IBS was induced through colorectal distension(CRD)***-grade male Sprague-Dawley(SD)rats were randomly divided into four groups:a normal group(NG),a model group(MG),an electroacupuncture group(EA),and a glial cell inhibitor group(FCA).Bilateral EA(2/100 Hz,1 mA,30 min)was administered at the Tianshu(ST25)and Shangjuxu(ST37)in week *** withdrawal reflex(AWR)scores were used to assess the behavioral response associated with visceral hyperalgesia,while hematoxylin-eosin staining was employed to evaluate pathological changes in the *** protein and mRNA levels of glial fibrillary acidic protein(GFAP)in the colon and colon-related dorsal root ganglion(DRG)were analyzed using immun-ofluorescence,immunohistochemistry,Western blotting,real-time polymerase chain *** impact of EA on electrophysiological properties of colon-related DRG neurons was observed through whole-cell patch clamp ***:EA significantly reduced the visceral pain behavior scores in rats with IBS in response to graded(20,40,60,80 mm Hg)CRD ***,EA downregulated the protein and mRNA expression levels of GFAP in the colon and colon-related DRG of rats with *** also regulated the resting membrane potential,rheobase and action potential of colon-related DRG neurons in rats with ***:EA can regulate the excitatory properties of colon-related DRG neurons by downregulating the protein and mRNA expression of GFAP in the colon and colon-related DRG,indicating a potential neurobiological mechanism by which EA relieves visceral hypersensitivity in rats with IBS.

关键词： electroacupuncture satellite glial cell irritable bowel syndrome visceral hypersensitivity glial fibrillary acidic proteinSupporting information

Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis

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Journal of Traditional Chinese Medicine 2021年第3期41卷 478-484页

作者： QI Qin Hyoyoung Im LI Kunshan GU Muen wu huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong wu Luyi Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China

OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) ***: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and ***: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway.

关键词： colitis ulcerative moxibustion toll-like receptors 4 Mayo score Baron score

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BRAIN FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY OF DIARRHEA TYPE OF IRRITABLE BOWEL SYNDROME TREATED WITH MOXIBUSTION AND PLACEBO MOXIBUSTION

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Journal of Integrative Medicine 2014年第3期 246-247页

作者： huangan wu Shanghai Institute of Acupuncture-Moxibustion and Meridian

Objective: Moxibustion treatment for diarrhea type of irritable bowel syndrome(D-IBS) has exact clinical effects.D-IBS patients show intestinal *** efficacy mechanism of moxibustion treatment for D-IBS may be implicated during brain functional magnetic resonance imaging(fMRI).Methods: fMRI was performed in 6 female and 9 male patients with D-IBS in moxibustion treatment group and 6 female and 7 male patients in placebo moxibustion group during rectal balloondistension before and after the *** pain was scored before and after the ***: The first sensation threshold had no difference between 2 *** urge threshold increased significantly in moxibustion group after treatment(P<0.01) while no changes occurred in placebo moxibustion group after *** detection threshold increased significantly in moxibustion group after treatment(P<0.01) and increased in placebo moxibustion group but without statistical *** rectal pain score beneath 50 mL rectal balloon distention in both groups had no changes before and after the treatments.100 mL distention in moxibustion group decreased after treatment while no changes occurred in placebo moxibusition *** was no definite area activated beneath 50 mL rectal balloon in both groups before *** treatment, prefrontal cortex(PFC) was affected in moxibustion group, and prefrontal cortex and cingulated cortex(CC) were affected in placebo moxibustion *** 100 mL rectal balloon distention, activated area(PFC and CC) decreased in moxibustion group after treatment but didn’t decrease in placebo moxibusiton ***: The rectal sensitivity of D-IBS decreased after moxibustion *** mechanism of the effect of the moxibustion on D-IBS may relate with the decreased sensitivity of the rectum.

关键词： IBS fMRI BRAIN FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY OF DIARRHEA TYPE OF IRRITABLE BOWEL SYNDROME TREATED WITH MOXIBUSTION AND PLACEBO MOXIBUSTION PFC

Herb-partitioned moxibustion regulated the miRNA expression profile in the thyroid tissues of rats with experimental autoimmune thyroiditis

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Journal of Traditional Chinese Medicine 2021年第5期41卷 789-798页

作者： WANG Zhaoqin CUI Yunhua HUANG Yan wu huangan ZHAO Jimeng HE Jinsen LIU Huirong ZHENG Handan wu Luyi HU Zhihai LIU Yanan Department of Aeronautics and Astronautics Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint FunctionFudan UniversityShanghai 200433China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China Yueyang Hospital of Integrative Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai TCM-integrated Hospital Shanghai University of Traditional Chinese MedicineShanghai 200082China

OBJECTIVE:To observe the effect of herb-partitioned moxibustion(HPM)on the miRNA expression profile of thyroid tissue in experimental autoimmune thyroiditis(EAT)***:Rats were randomly divided into normal control(NC)group,EAT model(EAT)group,HPM group and western medicine(Med)*** model rats were prepared by a combined immunization with complete and incomplete Freund’s adjuvant emulsified with porcine thyroglobulin and *** in the HPM group were treated with HPM,while rats in the Med group were treated with levothyrocine(1μg/2 m L)by *** staining was used to observe the pathological morphological changes of thyroid tissue,ELISAs was uaed to detect the serum concentrations of TGAb,TPOAb,FT3,FT4,*** then performed high-throughput mi RNA sequencing to analyse the mi RNA expression profiles in the thyroid tissues,followed by a bioinformatics ***-q PCR was used to verify the identified differentially expressed mi ***:HPM improved the thyroid tissue morphology and reduced serum TPOAb,TGAb,TSH concentration in EAT rats(P<0.05),but with no obvious effect on FT3 and FT4 *** the TSH,FT3 and FT4 concentration was significantly changed in the Med group(P<0.01 or P<0.05)compared with that of EAT *** results showed that a total of 17 mi RNAs were upregulated,and 4 were downregulated in the EAT rats,in which the expression levels of mi R-346 and mi R-331-5 p were reversed by *** target genes of the mi RNAs that regulated by HPM wereassociated with a variety of immune factors and immune ***-q PCR verification showed that the expression of mi RNA-346 and mi RNA-331-5 p was consistent with the sequencing ***:HPM could regulate the the expression of mi RNA-346 and mi RNA-331-5 p,then act on their target genes to immune and inflammation-related pathways,which may be one of the mechanisms of HPM on EAT rats.

关键词： Experimental autoimmune thyroiditis Herb-partitioned moxibustion miRNA expression profile Immuneregulation

Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease

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Journal of Traditional Chinese Medicine 2019年第3期39卷 356-363页

作者： Lu Yuan Zheng Handan Lü Tingting Ma Zhe wu huangan Xu Manwen Weng Zhijun Feng Hui Zhang Fang Ding Guanghong wu Luyi Liu Huirong Department of Mechanics and Engineering Science Fudan University Shanghai 200433China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030 China Department of Acupuncture and Moxibustion Huashan Hospital Shanghai 200040 China Department of Acupuncture and Moxibustion and Tuina Guanghua Hospital Shanghai 200052 China

OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and ***:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) *** in the colons was scored and observed by hematoxylin and eosin *** and D1R protein expression in the colonic mucosa were detected by *** concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain ***:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa *** the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa ***:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion.

关键词： Crohn disease Dopamine Receptors,dopamine Neuropeptides Point ST25 (Tianshu) Point CV6 (Qihai) Herb-partitioned moxibustion

Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome： a patient-blinded pilot trial with orthogonal design

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Journal of Traditional Chinese Medicine 2017年第4期37卷 538-545页

作者： Yang Ling Lu Yuan Zhang Haifeng Ma Xiaopeng Bao Chunhui wu huangan Zhao Chen Ding Guanghong Qi Li Zhou Shuang Department of Mechanics and Engineering Science Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Fudan University Shanghai 200433 China Key Laboratory of Acupuncture-Moxibustion and Immunological Effects Shanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridians Shanghai 200030 China E-Institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Traditional Chinese Medicine Changhai Hospital Second Military Medical University Shanghai 200433 China

OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal ***: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were *** were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final ***: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and ***: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately.

关键词： Irritable bowel syndrome Diarrhea Warming moxibustion Point ST25 (Tianshu), Point CV6 (Qihai) Quality of life

Efficacy of herb-partitioned moxibustion at Qihai(CV 6) and bilateral Tianshu(ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn＇s disease

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Journal of Traditional Chinese Medicine 2018年第2期38卷 218-226页

作者： Zhang Dan Wei Kai Ma Xiaopeng wu huangan Hong Jue Zhang Cuihong wu Lingxiang Yan Huang Liu Jie Zhu Yi Yang Ling Key Laboratory for Acupuncture-Moxibustion and Immuno-logical Effects Shanghai Research Institute of Acupunctureand Meridian Shanghai 200030 China Shanghai Center for Systems Biomedicine Shang-hai Jiao Tong University Shanghai 200240 China Department of Acupuncture and Moxibustion Shanghai Huangpu Hospital of Integrated Traditional Chi- nese and Western Medicine Shanghai 200010 China

OBJECTIVE: To observe the effect of stimulating Qihai(CV 6) and bilateral Tianshu(ST 25) with herb-partitioned moxibustion(HPM) in rats with Crohn's disease(CD), and to investigate the possible anti-inflammatory mechanism of ***: Forty rats were randomly divided into four groups(n = 10 rats per group): normal control(NC), model control(MC), mesalamine(MES), and HPM. The CD rat model was established in the MC,MES, and HPM groups by administering a mixture of trinitrobenzenesulfonic acid and alcohol via enema. The HPM group received HPM on Qihai(CV 6)and bilateral Tianshu(ST 25), while the MES group received intragastric mesalamine. Colonic histomorphological scores, and serum concentrations of tumor necrosis factor α(TNF-α) and interleukin 1β(IL-1β) were assessed to evaluate the effects of HPM on colonic reparation and *** expressions of Toll-like receptor 4(TLR-4), nuclear factor κB inhibitor α(IκB-α), IκB kinase α/β(IKKα/β), and NF-κB p65 were further analyzed to investigate the regulatory effects of the interventions on the TLR4/NF-κB ***: CD rats showed inflammatory colonic damage and increased serum concentrations of TNF-α and IL-1β. The expressions of TLR4, IKKα/β,and NF-κB p65 in the colons of CD rats were significantly increased compared with the NC group,while the expression of IκBα(a key negative regulator of NF-κB p65) was decreased. HPM significantly mitigated colonic damage and reduced the serum concentrations of TNF-α and IL-1β. HPM downregulated the expressions of TLR4, IKKα/β, and NF-κB p65 in the colon, and upregulated the expression of IκBα. The effects of HPM in CD rats were similar to those of ***: HPM alleviates colonic inflammation in CD rats. This may be achieved through regulation of TLR4, which induces NF-κB signal transduction.

关键词： Moxibustion Anti-inflammation TLR4/NF-KB pathway Crohn's disease Rats