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Prevalence of abnormal glycometabolism in patients with chronic hepatitis C and related risk factors in china

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chinese Medical Journal 2011年第2期124卷 183-188页

作者： WANG Li-fen wu chi-hong SHAN Yuan FAN Xiao-hong HUO Na LU Hai-ying XU Xiao-yuan Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

Background An epidemiologic link between hepatitis C virus （HCV） and abnormal glycometabolism had been *** study was designed to investigate the prevalence of type 2 diabetes rnellitus and insulin resistance,and to explore the relation between insulin resistance and hepatitis C virus genotype,serum hepatitis C virus-RNA level in chronic hepatitis C（CHC） *** Three hundred and fifty-nine consecutive patients （CHC,n=296;chronic hepatitis B （CHB）,n=63） were *** genotyping was performed by restriction fragment method and serum hepatitis C virus-RNA quantified PCR for all CHC patients in the baseline *** levels of insulin and glucose were measured in all patients and the homeostatic assessment of insulin resistance was calculated in the baseline *** Type 2 diabetes mellitus was diagnosed in 15.5% of 296 CHC *** resistance was present in 23.8% of the 235 nondiabetic CHC patients,in 23.1% of the 182 nondiabetic and noncirrhotic CHC patients,and associated with high serum HCV RNA level （OR： 1.754;95% CI：1.207-2.548,P=0.003） and age 〉40 years （OR.3.542;95% CI：1.257-9.978,P=0.017）.Insulin resistance was less frequent in CHB than in matched CHC （7.9% vs.21.4%respectively,P 〈0.0001）.Conclusion The incidence of insulin resistance in CHC was significantly higher than that in CHB patients,associated with high serum HCV RNA level and age 〉40 years.

关键词： insulin resistance hepatitis C rapid virologic response

Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma

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chinese Medical Journal 2010年第6期123卷 730-733页

作者： WANG Jing-yu XU Xiao-yuan JIA Jing-hui wu chi-hong GE Ruo-wen Department of Infectious Disease Peking University First HospitalBeijing 100034China Department of Biological Science National University of SingaporeSingapore 117543Singapore

Background Hepatocellular carcinoma （HCC） is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC＇s development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells （TECs） of HCC and in the serum of rats. Methods We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry （IHC）. Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay （ELISA）. Results SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats （t=-2.8628, P=0.0086; t=4.4922, P 〈0.0001, respectively）. In contrast, SE-1 antigen in HCC rat serum was significantly decreased compared with normal rats （t=3.4983, P=-0.0011）.Conclusion SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum.

关键词： hepatocellular carcinoma tumor angiogenesis endothelial cell immunohistochemistry enzyme-linked immunosorbent assay

Assessment of prognosis and curative effect in patients with chronic severe hepatitis using the model for end-stage liver disease scores

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chinese Medical Journal 2006年第2期119卷 148-150页

作者： wu chi-hong TIAN Geng-shan XU Xiao-yuan YU Yan-yan LU Hai-ying Department of Infectious Disease Peking University First Hospital Beijing 100034 China

Severe hepatitis is the most severe liver disease, with poor prognosis and high mortality. We explored the practical use of the model for end-stage liver disease （MELD） on clinical and the molecular adsorbents recirculating system （MARS） on chronic severe hepatitis to predict the short-term prognosis of patients with chronic severe hepatitis using the MELD score and the curative effect of MARS treatment.

关键词： chronic severe hepatitis end-stage liver disease molecular adsorbents recirculating system

Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients

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chinese Medical Journal 2012年第22期125卷 4014-4017页

作者： FAN Xiao-hong wu chi-hong WANG Li-fen ZHENG Ying-ying YAO Ying LU Hai-ying XU Xiao-yuan WEI Lai Peking Univ Hosp 1 Dept Infect Dis Beijing 100034 Peoples R China Peking Univ Hosp 1 Dept Nephrol Beijing 100034 Peoples R China Peking Univ Peoples Hosp Inst Hepatol Beijing 100044 Peoples R China

Background Mixed cryoglobulinemia （MC） is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin. Methods This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus （HCV） RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response. Results Twenty-five patients were with MC （43.9%）. Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC~ patients was significantly lower than that in MC- patients （32.0% vs. 75.0%, P=-0.001）. Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC （odds ratio： 6.375; 95% Ch 1.998-20.343, P=0.002） was negatively associated with sustained virological response achievement. Conclusion MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.

关键词： hepatitis C cryoglobulinemia virological response

Clinical features of the overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis: retrospective study

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chinese Medical Journal 2006年第3期119卷 238-241页

作者： wu chi-hong WANG Qin-huan TIAN Geng-shan XU Xiao-yuan YU Yan-yan WANG Gui-qiang Department of Infectious Disease Peking University First HospitalBeijing 100034 China.

PBC-AIH overlap syndrome is an autoimmune liver disease between AIH （autoimmunehepatitis） and PBC （primary biliary cirrhosis）. To investigate the characteristic of the PBC-AIH ovedap syndrome, we have conducted a retrospective study of 12 diagnosed ovedap syndrome patients and compared them with typical PBC and AIH on the basis of clinical, biochemical, serological and histopathological findings.

关键词： primary biliary cirrhosi autoimmune hepatitis overlap syndrome clinical features

Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C

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chinese Medical Journal 2012年第11期125卷 1852-1856页

作者： ZHENG Ying-ying FAN Xiao-hong WANG Li-feng TIAN Di HUO Na LU Hai-ying wu chi-hong XU Xiao-yuan WEI Lai Department of Infectious Diseases Peking University First Hospital Beijing 100034 China Hepatology Institute Peking University People＇s Hospital Beijing 100044 China

Background In china, patients with hepatitis C virus （HCV）-associated liver disease are getting older, and thus the number of deaths due to such disease is increasing. The efficacy of combination therapy with ribavirin and interferon for chronic HCV infection in elderly patients has not been fully clarified. The aim of the present study was to evaluate the efficacy and tolerability of the combination therapy in the elderly patients. Methods Sixty-eight chronic hepatitis C patients, who received the combination therapy, were classified into two age groups： elderly group （〉60 years, n=25） and non-elderly group （〈60 years, n=43）. Rapid virological response, complete early virological response, sustained virological response, relapse, non-response rate, and safety were compared between the elderly group and non-elderly group. Results Overall sustained virological response was lower in the elderly group than non-elderly group （44% vs. 75%, P=0.012, OR=0.270, and 95% CI 0.095-0.768）. Among patients with HCV genotype 1, sustained virological response was lower in the elderly group than non-elderly group （45% vs. 77%, P=0.015, OR=0.247, 95% CI 0.078-0.781）. The proportions of dose reduction due to laboratory abnormalities were significantly higher in the elderly group than non-elderly group （60.0% vs. 32.6%, P=0.027）. Multiple binary Logistic regression analysis confirmed that patient age was an associated factor for sustained virological response. Conclusion Among patients with HCV genotype 1, the elderly patients had lower sustained virological response than non-elderly patients during pegylated interferon-alpha-2a plus ribavirin combination therapy.

关键词： interferon, therapeutics, hepatit& C aged

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science china(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo hong-Bo Jin Cong-Feng Qiao Yue-Liang wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

白细胞介素10基因启动子-1082A/G多态性与终末期肾病患者微炎症和动脉硬化的关系

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中华医学杂志 2005年第29期85卷 2076-2080页

作者：吴红赤凌红那士平解汝娟哈尔滨医科大学第一临床医学院肾内科 150001 哈尔滨医科大学免疫教研室

目的探讨抗炎白介素-10(IL-10)基因启动子-1082A/G多态性与终末期肾病(ESRD)患者微炎症状态及动脉粥样硬化(AS)的关系。方法采用PCR-RFLP方法,检测870例终末期肾病患者和正常对照组1000例IL-10基因-1082A/G多态位点各种基因型的分布及... 详细信息

目的探讨抗炎白介素-10(IL-10)基因启动子-1082A/G多态性与终末期肾病(ESRD)患者微炎症状态及动脉粥样硬化(AS)的关系。方法采用PCR-RFLP方法,检测870例终末期肾病患者和正常对照组1000例IL-10基因-1082A/G多态位点各种基因型的分布及与微炎症状态、动脉粥样硬化相关的指标,并分析该基因在保护终末期肾病患者免受微炎症及动脉粥样硬化侵害中的作用机制。结果终末期肾病组与对照组相比CRP、TNF-α、CH50、C3、IL-10、Alb水平在正常范围内,但仍显著高于对照组,而(IL-10、Alb水平均低,P均0.05);具有IL-10A/A基因型的终末期肾病患者CRP、TNF-α、CH50的水平均显著高于G/G、G/A型(P均<0.05),IL-10、Alb水平非常显著降低(P<0.01);IL-10A/A基因型患者血清IL-10水平显著低于A/G和G/G基因型患者(P<0.01);IL-10基因-1082A/A型患者动脉粥样硬化的发病率显著高于G/G、G/A型患者(P<0.01),动脉粥样硬化发病率的增高与血清IL-10水平的降低及血清CRP、Fib的升高一致。结论IL-10A/A基因为终末期肾病患者微炎症状态及动脉粥样硬化疾病高发的预测因子;终末期肾病患者是通过IL-10G/G基因调控血清IL-10"高产",下调炎症反应,来保护其免受微炎症及动脉粥样硬化的侵害。

关键词：白细胞介素10 单核苷酸多态性动脉硬化终末期肾病

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基于双赢合作机制的敏捷供应链管理系统

计算机工程 2009年第1期35卷 17-20页

作者：谢天保伍池宏西安理工大学工商管理学院信息管理系西安710048

敏捷供应链系统依据动态联盟运行的条件所设计,具有分布、可重构、支持异构等特点。该文在分析敏捷供应链动态性和可重构性的基础上,提出基于双赢合作机制的敏捷供应链管理系统模型,研究了信息不完备(效用计算公式私有)条件下的双赢谈... 详细信息

敏捷供应链系统依据动态联盟运行的条件所设计,具有分布、可重构、支持异构等特点。该文在分析敏捷供应链动态性和可重构性的基础上,提出基于双赢合作机制的敏捷供应链管理系统模型,研究了信息不完备(效用计算公式私有)条件下的双赢谈判模型及其实现算法,实验结果证明了该模型的对称性、公平性,谈判结果接近Parreto最优。

关键词：动态联盟敏捷供应链双赢谈判模型