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Intercalation,Cytotoxicity,and Molecular Modeling of Acenaphtho[1,2-b]pyrrole Chromophores as a New Family of Antitumor Agents

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Chemical Research in Chinese Universities 2008年第4期24卷 449-453页

作者： ZHANG Zhi-chao ZHANG Jing YUAN Chun-li wu gui-ye QIAN Xu-hong State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 P. R. China The First Clinic Hospital Jilin University Changchun 130021 P. R. China State Key Laboratory of Natural and Biomimetic Drugs Beijing 100083 P. R. China Shanghai Key Laboratory of Chemical Biology East China University of Science and Technology Shanghai 200237 P. R. China

To explore new platform for DNA intercalation and potent antitumor agent, a series of 8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters chromophores has been studied. Their intercalation geometries with DNA were rex;ealed through absorption titration, SYBR Green-DNA melt curve, circular dichroism（CD）, and docking studies. It was identified that some of the compounds could intercalate into DNA along their long axis parallel to the base-pair long axis, making right-handed B form DNA transform to A-like conformation. Their binding potency varied with the different steric hindrance. Their cytotoxicity（IC50） against MCF-7 cells was found to range between 1.3 to 40.9 umol/L by MTT assay. Interestingly, the IC50 values did not show any obvious correlation to their binding constants with DNA. The chromophore with a carboxyl group exhibited the most potency of intercalating DNA and could be the promising precursor for the future intercalator for DNA, while the bromide demonstrated the highest cytotoxic activity in this series of compounds.

关键词： Intercalation Cytotoxicity 8-Oxo-SH-acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-gui Peng Peng wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

一种氟碳铈矿捕收剂的设计筛选及浮选性能研究

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中国矿业 2014年第S2期23卷 273-275页

作者：吴桂叶张杰李松清张行荣谭鑫郑桂兵北京矿冶研究总院矿物加工科学与技术国家重点实验室北京102600

以氟碳铈矿为研究对象,研究了以羟肟酸、苯乙烯膦酸、邻苯二甲酸用作捕收剂时的浮选效果。研究结果表明:借助于CAMD技术研发的捕收剂羟肟酸类捕收剂BK415可以有效浮选氟碳铈矿,浮选效果优于H205、苯甲羟肟酸、水杨羟肟酸、邻苯二甲酸等... 详细信息

以氟碳铈矿为研究对象,研究了以羟肟酸、苯乙烯膦酸、邻苯二甲酸用作捕收剂时的浮选效果。研究结果表明:借助于CAMD技术研发的捕收剂羟肟酸类捕收剂BK415可以有效浮选氟碳铈矿,浮选效果优于H205、苯甲羟肟酸、水杨羟肟酸、邻苯二甲酸等,是一个很有前途的稀土捕收剂。

关键词：氟碳铈矿浮选羟肟酸 CAMD技术

新型铜抑制剂BK511用于某矿铜钼分离浮选的试验研究

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有色金属工程 2015年第1期5卷 46-48,57页

作者：王志平王金玲吴桂叶艾晶张杰中条山有色金属集团有限公司山西垣曲043700 北京矿冶研究总院北京100160 矿物加工科学与技术国家重点实验室北京100160

采用新型抑制剂BK511,对强捕收剂黄药浮选的铜钼混合精矿进行铜钼分离浮选试验。试验采用两次铜钼分离粗选、钼粗精矿一次精选后再磨、再经五次精选工艺流程,获得钼精矿含钼45.31%,含铜1.14%,钼回收率89.94%的浮选指标。结果表明,BK511... 详细信息

采用新型抑制剂BK511,对强捕收剂黄药浮选的铜钼混合精矿进行铜钼分离浮选试验。试验采用两次铜钼分离粗选、钼粗精矿一次精选后再磨、再经五次精选工艺流程,获得钼精矿含钼45.31%,含铜1.14%,钼回收率89.94%的浮选指标。结果表明,BK511对采用强捕收剂黄药浮选的铜钼混合精矿中的铜矿物,具有较好的抑制作用。

关键词：铜钼分离抑制剂浮选精选

Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue Christopher JScott HaiLun ye JianFei wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

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气相色谱法快速测定乙硫氨酯含量

现代化工 2020年第S01期40卷 306-308页

作者：纪爱亮吴桂叶刘崇峻刘惠南朱阳戈北京矿冶科技集团有限公司矿物加工科学与技术国家重点实验室北京100160

研究设计了用气相色谱仪快速检测多种不同工艺生产的乙硫氨酯含量的方法.对于选矿用乙硫氨酯,采用TP-WAX毛细管色谱柱(30 m×0.25 mm×0.25μL)、氢火焰离子化检测器,以程序升温面积归一法进行检测,各组分完全分离,范围内线性关系良好(R... 详细信息

研究设计了用气相色谱仪快速检测多种不同工艺生产的乙硫氨酯含量的方法.对于选矿用乙硫氨酯,采用TP-WAX毛细管色谱柱(30 m×0.25 mm×0.25μL)、氢火焰离子化检测器,以程序升温面积归一法进行检测,各组分完全分离,范围内线性关系良好(R^(2)=0.9979),相对标准偏差0.06%~0.18%,回收率97.4%~100.5%.实验表明,该方法精密度、稳定性及重复性均符合要求;通过与其他气相色谱方法比较发现,此方法解决了检测过程中不能使乙硫氨酯中全部组分出峰、部分杂质不能与目标物完全分离等缺陷,从而使检测误差降低.该方法已成功用于实际检测.

关键词：乙硫氨酯气相色谱法捕收剂

黔东南民族职业技术学院2009～2011年学生体质测试

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贵州师范大学学报（自然科学版） 2013年第1期31卷 117-120页

作者：王贵生董正清吴桂叶龙政和黔东南民族职业技术学院贵州凯里556000

采用文献资料、逻辑分析、数理统计等方法,对2009～2011年黔东南民族职业技术学院高职在校学生体质进行调查研究。结果发现:学生身体机能和身体素质与学生个体成长环境有关;部分学生心肺功能与国家体质健康标准有一定的差距;学生身体素... 详细信息

采用文献资料、逻辑分析、数理统计等方法,对2009～2011年黔东南民族职业技术学院高职在校学生体质进行调查研究。结果发现:学生身体机能和身体素质与学生个体成长环境有关;部分学生心肺功能与国家体质健康标准有一定的差距;学生身体素质发展不均衡等。针对研究结果,提出今后黔东南民族职业技术学院应从加强学生体质健康工作、让体育教师成为学生健身的引导者、广泛开展体育课外活动、改革体育考核内容和形式等方面来增强学生的体质。

关键词：标准体重测试生理指标测试体能测试

Design of a terahertz slotted waveguide array antenna based on photonic crystal

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Optoelectronics Letters 2025年

作者： PAN wu ye Kuan ZHANG Zhen LI Renpu QIU Sen HUANG Lei College of Photoelectronic Engineering， Chongqing University of Posts and Telecommunications Chongqing Municipal Key Laboratory of Photoelectric Information Sensing and Transmission Technology， Chongqing University of Posts and Telecommunications Laboratory of Quantum Information Technology， Chongqing University of Posts and Telecommunications

In this paper， a terahertz slotted waveguide array antenna is designed based on photonic crystal， which can realize efficient radiation of terahertz waves. The electromagnetic wave is fed from the rectangular waveguide at the bottom of the antenna， coupled to photonic crystal waveguide through photonic crystal cavity， and radiated outward through slots at the top layer of antenna. The simulation results show that the antenna achieves a peak gain of 13.45dBi at 360 GHz， a half-power beamwidth of 10.9o， and a side lobe level of -13.9dB. The antenna based on photonic crystal has the advantages of low profile， low loss， and high radiation efficiency， which can be applied to terahertz wireless communication systems.

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