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Virologica Sinica 2024年第4期39卷 525-536页

作者： Ding x. Liu J. Jiang T. wu A. State Key Laboratory of Common Mechanism Research for Major Diseases Suzhou Institute of Systems Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Suzhou 215123 China Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College) Ministry of Education Beijing 100730 China Guangzhou National Laboratory Guangzhou 510006 China State Key Laboratory of Respiratory Disease The Key Laboratory of Advanced Interdisciplinary Studies Center The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510030 China

Influenza A virus (IAV) shows an ex.ensive host range and rapid genomic variations, leading to continuous emergence of novel viruses with significant antigenic variations and the potential for cross-species transmission. This causes global pandemics and seasonal flu outbreaks, posing sustained threats worldwide. Thus, studying all IAVs' evolutionary patterns and underlying mechanisms is crucial for effective prevention and control. We developed FluTyping to identify IAV genotypes, to ex.lore overall genetic diversity patterns and their restriction factors. FluTyping groups isolates based on genetic distance and phylogenetic relationships using whole genomes, enabling identification of each isolate's genotype. Three distinct genetic diversity patterns were observed: one genotype domination pattern comprising only H1N1 and H3N2 seasonal influenza subtypes, multi-genotypes co-circulation pattern including majority avian influenza subtypes and swine influenza H1N2, and hybrid-circulation pattern involving H7N9 and three H5 subtypes of influenza viruses. Furthermore, the IAVs in multi-genotypes co-circulation pattern showed region-specific dominant genotypes, implying the restriction of virus transmission is a key factor contributing to distinct genetic diversity patterns, and the genomic evolution underlying different patterns was more influenced by host-specific factors. In summary, a comprehensive picture of the evolutionary patterns of overall IAVs is provided by the FluTyping's identified genotypes, offering important theoretical foundations for future prevention and control of these viruses. © 2024 The Authors

关键词： Genetic diversity Genetic pattern Genotype Influenza A virus Transmission

Electroacupuncture with different waveforms for primary dysmenorrhea: A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 357-362页

作者： wu x. Yuan J. Ni J. Ma x. Zhang Z. Hua Y. Dong J. Wang B.P. Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China These authors have contributed equally to this work. New Zealand College of Chinese Medicine Auckland 17467 New Zealand

Objective: To observe and compare the clinical effects of different electroacupuncture waveforms on primary dysmenorrhea. Methods: This was a prospective, randomized, three-group, parallel-controlled trial. Participants with primary dysmenorrhea were randomly divided into dense-sparse wave, continuous wave, and discontinuous wave groups in a 1:1:1 ratio. Two lateral Ciliao (BL 32) points were used. All three groups started treatment 3–5 days before menstruation, once a day for six.sessions per course of treatment, one course of treatment per menstrual cycle, and three menstrual cycles. The primary outcome measure was the proportion with an average visual analog scale (VAS) score reduction of ≥50% from baseline for dysmenorrhea in the third menstrual cycle during treatment. The secondary outcome measures included changes in dysmenorrhea VAS scores, Cox.Menstrual Symptom Scale scores and the proportion of patients taking analgesic drugs. Results: The proportion of cases where the average VAS score for dysmenorrhea decreased by ≥50% from baseline in the third menstrual cycle was not statistically significant (P > .05). Precisely 30 min after acupuncture and regarding immediate analgesia on the most severe day of dysmenorrhea, there was a statistically significant difference in the dense-sparse wave group compared with the other two groups during the third menstrual cycle (P ed symptoms in patients. The three groups showed similar results in terms of short- and long-term analgesic efficacy and a reduction in the number of patients taking analgesic drugs. Regarding achieving immediate analgesia, the dense-sparse wave group was slightly better than the other two groups. © 2024 Beijing University of Chinese Medicine

关键词： Ciliao (BL 32) Continuous waves Dense-sparse waves Discontinuous waves Electroacupuncture Primary dysmenorrhea Randomized controlled trial Waveforms

Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 316-329页

作者： Song x. Zhang Y. Tang Z. Dai J. wu Y. Huang G. Niu H. Wang Y. Jin x. Du L. School of Pharmacy Shandong University of Traditional Chinese Medicine Jinan 250355 China Department of Pharmaceutical Sciences Beijing Institute of Radiation Medicine Beijing 100850 China These authors have contributed equally to this work. Information Department General Hospital of Western War Zone Chengdu 610083 China Pharmaceutical College Henan University Kaifeng 475004 China Beijing Tiantan Hospital Capital Medical University Beijing 100070 China Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 China

Objective: To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder (PTSD), and to improve efficacy and patient compliance. Methods: In this study, we used ginger oil, a phytochemical with potential therapeutic properties, to prepare ginger oil patches. High-performance liquid chromatography (HPLC) was used to quantify the main active component of ginger oil, 6-gingerol. Transdermal absorption ex.eriments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers, including their type and concentration. Subsequently, the ginger oil patches were optimized and subjected to content determination and property evaluations. A PTSD mouse model was established using the foot-shock method. The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections, behavioral tests, and the evaluation of biomarkers such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF), and melatonin (MT). Results: The results demonstrated that ginger oil patches ex.rted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels. Pharmacokinetic ex.eriments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day, addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy. Conclusions: Ginger oil can be prepared as a transdermal drug patch that meets these requirements, and the bioavailability of the prepared patch is better than that of oral administration. It can improve PTSD with good patient compliance and ease of administration. Therefore, it is a promising therapeutic formulation for the treatment of PTSD. © 2024 Beijing University of Chinese Medicine

关键词： 6-Gingerol Post-traumatic stress disorder Pressure sensitive adhesive patch Transdermal delivery

AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase

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Virologica Sinica 2024年第4期39卷 632-644页

作者： Ren J. Yu L. Zhang Q. Ren P. Cai Y. Wang x. Lan K. wu S. State Key Laboratory of Virology College of Life Sciences Wuhan University Wuhan 430072 China Medical Research Institute Wuhan University Wuhan 430072 China Taikang Center for Life and Medical Sciences Wuhan University Wuhan 430072 China

Hand, foot and mouth disease (HFMD), mainly caused by enterovirus 71 (EV71), has frequently occurred in the Asia-Pacific region, posing a significant threat to the health of infants and young children. Therefore, research on the infection mechanism and pathogenicity of enteroviruses is increasingly becoming important. The 3D polymerase, as the most critical RNA-dependent RNA polymerase (RdRp) for EV71 replication, is widely targeted to inhibit EV71 infection. In this study, we identified a novel host protein, AIMP2, capable of binding to 3D polymerase and inhibiting EV71 infection. Subsequent investigations revealed that AIMP2 recruits the E3 ligase SMURF2, which mediates the polyubiquitination and degradation of 3D polymerase. Furthermore, the antiviral effect of AIMP2 ex.ended to the CVA16 and CVB1 serotypes. Our research has uncovered the dynamic regulatory function of AIMP2 during EV71 infection, revealing a novel antiviral mechanism and providing new insights for the development of antienteroviral therapeutic strategies. © 2024 The Authors

关键词： 3D polymerase AIMP2 E3 ligase SMURF2 Enterovirus 71 (EV71) Ubiquitination

Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao x.yang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower ex.ected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the ex.ected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery

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百年变局背景下国际直接投资趋势与政策展望

国际经济评论 2024年第2期170卷 71-94,5,6页

作者：詹晓宁齐凡吴琦琦联合国贸易和发展组织投资和企业司南开大学国际经济研究所

全球一体化生产网络正在广泛和深刻地分化重组。本文通过梳理全球国际直接投资的历史演变和现实状态,对未来国际直接投资的格局做出研判。本文基于全球治理变革、新技术革命、产业政策主导以及可持续发展浪潮四大关键推动因素,推断未来... 详细信息

全球一体化生产网络正在广泛和深刻地分化重组。本文通过梳理全球国际直接投资的历史演变和现实状态,对未来国际直接投资的格局做出研判。本文基于全球治理变革、新技术革命、产业政策主导以及可持续发展浪潮四大关键推动因素,推断未来国际投资生产格局将围绕着东亚、北美和西欧三大区域轴心,朝着十大方向转变。其中包括产业链的区域化、产业链缩短、投资的轻资产化、服务附加值份额增长、市场导向型外国直接投资(FDI)上升、中间品贸易下行、生产定制化转变、基础设施和公共服务领域FDI增长以及绿色经济、蓝色经济和循环经济投资成为投资促进的重点。最后,结合预测结论,本文对中国吸收外资、对外投资工作重点、促进投融资动态平衡、产业链重塑、可持续发展以及服务业提升六个方面提出了若干建议。

关键词：国际直接投资全球产业链国际投资政策环境、社会和公司治理最低所得税率改革

Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin wu Yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often ex.ibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R ex.ibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfox.de).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Dual-ion carrier storage through Mg^(2+) addition for high-energy and long-life zinc-ion hybrid capacitor

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 179-185页

作者： Junjie Zhang x.ang wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under ***,we modulate the electrolyte and achieve dual-ion storage by adding magnesium *** we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic *** zinc-ion capacitor with Mg^(2+)mix.0} solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 *** is superior to the other assembled zinc-ion devices in single-component *** finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.

关键词： zinc-ion hybrid capacitor MgSO_(4) electrolyte rate performance storage mechanism

Enhancing performance of low-temperature processed CsPbI2Br all-inorganic perovskite solar cells using polyethylene ox.de-modified TiO_(2)

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 786-794页

作者： x. Zhao Naitao Gao Shengcheng wu Shaozhen Li Sujuan wu School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute for Advanced Materials and Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China

CsPbx.(3)-based(x.I,Br,Cl)inorganic perovskite solar cells(PSCs)prepared by low-temperature process have attracted much attention because of their low cost and ex.ellent thermal ***,the high trap state density and serious charge recombination between low-temperature processed TiO_(2)film and inorganic perovskite layer interface seriously restrict the performance of all-inorganic *** a thin polyethylene ox.de(PEO)layer is employed to modify TiO_(2)film to passivate traps and promote carrier *** impacts of PEO layer on microstructure and photoelectric characteristics of TiO_(2)film and related devices are systematically *** results suggest that PEO modification can reduce the surface roughness of TiO_(2)film,decrease its average surface potential,and passivate trap *** optimal conditions,the champion efficiency of CsPbI_(2)Br PSCs with PEO-modified TiO_(2)(PEO-PSCs)has been improved to 11.24%from 9.03%of reference ***,the hysteresis behavior and charge recombination have been suppressed in PEO-PSCs.

关键词： polyethylene ox.de-modified TiO_(2) film low-temperature process CsPbI_(2)Br-based all-inorganic perovskite solar cells photo-voltaic performance