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Interleukin-10 genotype protects end stage renal disease patients from microinflammation and arteriosclerosis

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chinese Medical Journal 2005年第18期118卷 1549-1551页

作者： wu hong-chi LING hong NA Shi-ping XIE Ru-juan Department of Nephrology First Affiliated Hospital Harbin MedicalUniversity Harbin 150001 China Department of Immunity Harbin Medical University Harbin 150001 China

End stage renal disease （ ESRD ） and cardiovascular disease are induced by arteriosclerosis （AS）. The latest investigation shows that AS is a special inflammatory state. The constant inflammation,which has been defined as a micro inflammatory state is related to the decline of renal function and blood purification, but not the result of infections caused by external pathogenic microorganisms or internal opportunistic pathogenic microorganisms. We investigated the mechanism of interleukin-10 （IL-10） gene-1082 A/G protection effect to keep ESRD patients away from micro inflammation and AS.

关键词： end stage renal disease·interleukin-10·micro-inflammatory state·arteriosclerosis

Optical Microsphere Nano-Imaging:Progress and Challenges

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Engineering 2024年第5期36卷 102-123页

作者： Guangxing wu Minghui hong Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale *** the past decade,the optical microsphere nanoimaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about k6k8 in a real-time and label-free manner,making it highly competitive among numerous super-resolution imaging *** this review,we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement:first,to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level;second,to compose the microsphere compound lens;and third,to engineer the geometry or ingredients of *** also analyze challenges yet to be overcome in optical microsphere nano-imaging,followed by an outlook of this technique.

关键词： Microsphere Nano-imaging Virtual imaging Microsphere compound lens Engineered microsphere

Mixed H_(∞)/Passive Exponential Synchronization for Delayed Memristive Neural Networks with Switching Event-Triggered Control

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Journal of Systems Science & Complexity 2024年第1期37卷 294-317页

作者： wu Wenhuang GUO Lulu CHEN hong Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with H∞and passivity *** aim is to guarantee the exponential synchronization and mixed H∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed H_(∞)and passivity ***,an event-triggered controller design scheme is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.

Method for determining the position of landslide slip-surface with a typical inclinometric curves

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Journal of Mountain Science 2024年第2期21卷 413-432页

作者： CHEN Hao wu hong-gang Ocean College Zhejiang UniversityZhoushan 316000China china Northwest Research Institute Co.Ltd.of CREC Lanzhou 730070China

In the actual monitoring of deep hole displacement,the identification of slip surfaces is primarily based on abrupt changes observed in the inclinometric *** conventional identification methods,inclinometric curves exhibiting indications of sliding can be categorized into three types:B-type,D-type,and *** position of the slip surface is typically determined by identifying the depth corresponding to the point of maximum displacement ***,this method is sensitive to the interval of measurement points and the observation scale of the coordinate axes and suffers from unclear sliding surfaces and uncertain *** on the variation characteristics of these diagonal curves,we classified the landslide into three components:the sliding body,the sliding interval,and the immobile ***,three different generalization models were established to analyze the relationships between the curve form and the slip surface location based on different physical indicators such as displacement rate,relative displacement,and *** results show that the displacement rate curves of an r-type slope exhibit a clustering feature in the sliding interval,and by solving for the depth of discrete points within the step phase,it is possible to determine the location of the slip *** the other hand,D-type slopes have inflection points in the relative displacement curve located at the slip *** acceleration curves of B-type slopes exhibit clustering characteristics during the sliding interval,while the scattered acceleration data demonstrate wandering ***,the slip surface location can be revealed by solving the depth corresponding to the maximum acceleration with cubic spline *** approach proposed in this paper was applied to the monitoring data of a landslide in Yunnan Province,*** results indicate that our approach can accurately identify the slip surface location and enable computability of its po

关键词： Inclinometric curve Slip-surface position Displacement rate Relative displacement Acceleration

Prevalence of abnormal glycometabolism in patients with chronic hepatitis C and related risk factors in china

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chinese Medical Journal 2011年第2期124卷 183-188页

作者： WANG Li-fen wu chi-hong SHAN Yuan FAN Xiao-hong HUO Na LU Hai-ying XU Xiao-yuan Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

Background An epidemiologic link between hepatitis C virus （HCV） and abnormal glycometabolism had been *** study was designed to investigate the prevalence of type 2 diabetes rnellitus and insulin resistance,and to explore the relation between insulin resistance and hepatitis C virus genotype,serum hepatitis C virus-RNA level in chronic hepatitis C（CHC） *** Three hundred and fifty-nine consecutive patients （CHC,n=296;chronic hepatitis B （CHB）,n=63） were *** genotyping was performed by restriction fragment method and serum hepatitis C virus-RNA quantified PCR for all CHC patients in the baseline *** levels of insulin and glucose were measured in all patients and the homeostatic assessment of insulin resistance was calculated in the baseline *** Type 2 diabetes mellitus was diagnosed in 15.5% of 296 CHC *** resistance was present in 23.8% of the 235 nondiabetic CHC patients,in 23.1% of the 182 nondiabetic and noncirrhotic CHC patients,and associated with high serum HCV RNA level （OR： 1.754;95% CI：1.207-2.548,P=0.003） and age 〉40 years （OR.3.542;95% CI：1.257-9.978,P=0.017）.Insulin resistance was less frequent in CHB than in matched CHC （7.9% vs.21.4%respectively,P 〈0.0001）.Conclusion The incidence of insulin resistance in CHC was significantly higher than that in CHB patients,associated with high serum HCV RNA level and age 〉40 years.

关键词： insulin resistance hepatitis C rapid virologic response

Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang Xiang wu Sa Cai Guosong hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

Regulating the crystal phase of bismuth-based semiconductors for promoted photocatalytic performance

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Science china Chemistry 2024年第6期67卷 1839-1864页

作者： Zhaohui wu Mei-chi Chong Shiying Zhang Junshan Li Yongfa Zhu Hunan Key Laboratory of Applied Environmental Photocatalysis Changsha UniversityChangsha410022China Department of Chemistry Tsinghua UniversityBeijing100084China Institute for Advanced Study Chengdu UniversityChengdu610106China

Numerous bismuth-based semiconductors(BBSs)with sophisticated and desirable structures used as photocatalysts for efficient photocatalytic degradation of water organic contaminants have attracted considerable ***,regulating the crystal phases and phase transition of BBSs for promoted photocatalytic performance is ***,the unique crystal structure and band structure features of each typical BBSs,and the vital roles on phase controlling of each phase were systematically presented based on the classification of ***,the critical factors for the phase transition of BBSs and intrinsic driving forces endowed by phases of BBSs for enhanced photocatalytic performance of organic contaminants removal were also *** review will provide systematical guidelines and horizons for regulating the crystal phase and phase transition of BBSs,promoting photocatalytic degradation and mineralization of organic contaminants.

关键词： bismuth-based semiconductors phase regulation photocatalytic performances organic contaminants

Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma

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chinese Medical Journal 2010年第6期123卷 730-733页

作者： WANG Jing-yu XU Xiao-yuan JIA Jing-hui wu chi-hong GE Ruo-wen Department of Infectious Disease Peking University First HospitalBeijing 100034China Department of Biological Science National University of SingaporeSingapore 117543Singapore

Background Hepatocellular carcinoma （HCC） is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC＇s development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells （TECs） of HCC and in the serum of rats. Methods We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry （IHC）. Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay （ELISA）. Results SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats （t=-2.8628, P=0.0086; t=4.4922, P 〈0.0001, respectively）. In contrast, SE-1 antigen in HCC rat serum was significantly decreased compared with normal rats （t=3.4983, P=-0.0011）.Conclusion SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum.

关键词： hepatocellular carcinoma tumor angiogenesis endothelial cell immunohistochemistry enzyme-linked immunosorbent assay

Assessment of prognosis and curative effect in patients with chronic severe hepatitis using the model for end-stage liver disease scores

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chinese Medical Journal 2006年第2期119卷 148-150页

作者： wu chi-hong TIAN Geng-shan XU Xiao-yuan YU Yan-yan LU Hai-ying Department of Infectious Disease Peking University First Hospital Beijing 100034 China

Severe hepatitis is the most severe liver disease, with poor prognosis and high mortality. We explored the practical use of the model for end-stage liver disease （MELD） on clinical and the molecular adsorbents recirculating system （MARS） on chronic severe hepatitis to predict the short-term prognosis of patients with chronic severe hepatitis using the MELD score and the curative effect of MARS treatment.

关键词： chronic severe hepatitis end-stage liver disease molecular adsorbents recirculating system