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Food Science and Human Wellness 2024年第2期13卷 748-764页

作者： Ruonan Yan chi-Tang Ho Yanan Liu Shengnan Zhan Zufang wu Xin Zhang Department of Food Science and Engineering Ningbo UniversityNingbo 315211China Department of Food Science Rutgers UniversityNew BrunswickNew Jersey 08901USA

The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host *** present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state *** fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,Dbp and Rorb in hypothalamic *** results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health.

关键词： Gut microbiota Circadian rhythm Oolong tea polyphenols Single-cell sequencing Metabolism

54例孕妇超前分娩镇痛的有效性和安全性观察

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广东医科大学学报 2024年第1期42卷 86-88页

作者：颜振艺陈晓凤莫坚陈昊王永燕吴驰广东医科大学附属医院广东湛江524000 广东医科大学附属第二医院广东湛江524001

目的观察超前镇痛用于孕妇超前分娩镇痛的有效性和安全性。方法 108例孕妇随机分为对照组和超前镇痛组,每组54例。对照组:采用硬膜外注入罗哌卡因+舒芬太尼混合液进行自控麻醉镇痛(PCEA)。超前镇痛组:孕妇即将进入临产、未规律宫缩前泵... 详细信息

目的观察超前镇痛用于孕妇超前分娩镇痛的有效性和安全性。方法 108例孕妇随机分为对照组和超前镇痛组,每组54例。对照组:采用硬膜外注入罗哌卡因+舒芬太尼混合液进行自控麻醉镇痛(PCEA)。超前镇痛组:孕妇即将进入临产、未规律宫缩前泵入1 mL/h镇痛药(包括1.2 g/L罗哌卡因、0.4 mg/L舒芬太尼),进入规律宫缩后进行PCEA。比较两组镇痛效果、麻醉药物用量、分娩方式、孕妇满意度以及不良反应。结果超前镇痛组的镇痛有效率、孕妇满意度均明显高于对照组,剖宫产率低于对照组(P0.05)。结论超前镇痛用于分娩镇痛可以有效提高镇痛效果和孕妇满意度,降低剖宫产率。

关键词：超前镇痛分娩镇痛罗哌卡因舒芬太尼

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氟吡菌酰胺对非靶标生物的急性毒性效应

现代农药 2024年第1期23卷 65-69页

作者：吴迟李敏刘新刚崔少青孙田何明远中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100193 广西思浦林科技有限公司南宁530001

探究了氟吡菌酰胺对8种非靶标生物的急性毒性,以明确氟吡菌酰胺对环境生物的毒性风险。结果表明,氟吡菌酰胺对鸟、蜜蜂、家蚕、蚯蚓和鱼的毒性等级均为低毒,对赤眼蜂属于低风险,对水生生物大型溞和藻类的毒性等级均为中等毒。因此,在田... 详细信息

探究了氟吡菌酰胺对8种非靶标生物的急性毒性,以明确氟吡菌酰胺对环境生物的毒性风险。结果表明,氟吡菌酰胺对鸟、蜜蜂、家蚕、蚯蚓和鱼的毒性等级均为低毒,对赤眼蜂属于低风险,对水生生物大型溞和藻类的毒性等级均为中等毒。因此,在田间施用氟吡菌酰胺时,应注意对水生生物的保护,使用时远离水产养殖区,避免在水体中清洗施药用具。

关键词：氟吡菌酰胺非靶标生物急性毒性

Leaching kinetics and permeability of polyethyleneimine added ammonium sulfate on weathered crust elution-deposited rare earth ores

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Journal of Rare Earths 2024年第8期42卷 1610-1619,I0008页

作者： Huifang Yang Aoyang Sha Zhengyan He Chenjie wu Yuanlai Xu Jingjing Hu Zhigao Xu Ru'an chi Key Laboratory for Green Chemical Process of Ministry of Education School of Resources&Safety EngineeringWuhan Institute of TechnologyWuhan 430073China Key Laboratory of Resources Conversion and Pollution Control of the State Ethnic Affairs Commission College of Resources and Environmental ScienceSouth-Central MinzuUniversityWuhan430074China

At present,in-situ leaching of weathered crust elution-deposited rare earth ores(WCE-DREOs) encounter with problems such as long leaching cycles,slow infiltration rate and low product *** order to solve the above problems,the conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4)) was compounded with polymeric surfactant polyethyleneimine(PEI) to form a composite leaching *** effects of leaching temperature,PEI *** rate and pH on leaching kinetics and permeability of rare earths(RE) and aluminum(AI) in orebody were *** is found that with temperature increasing,the time required to reach leaching equilibrium for both RE and Al is shortened,the apparent activation energies of RE and AI are 14.79 and 13.45 kJ/mol,respectively,and the leaching processes are in accordance with the outer diffusion control,When the concentrations of(NH_(4))_(2)SO_(4) and PEI in the composite leaching agent are 2.0 wt% and 0.4 wt%;the time required to reach leaching equilibrium for RE and AI is about 50% shorter than that using(NH_(4))_(2)SO_(4) alone,and the leaching efficiencies of RE are slightly higher than that of *** increasing the temperature and flow rate of the composite leaching agent can improve the leaching efficiencies of RE and Al,but pH has neglected effects on the leaching efficiencies of *** PEI concentrations below 0,4 wt%, the addition of PEI promotes the leaching of RE and *** column leaching studies of the WCE-DREO,the addition of 0.4 wt% PEI to the traditional leaching agent(NH_(4))_(2)SO_(4) has no impact on the leaching efficiencies of ***,it can significantly increase the infiltration rate of WCE-DREO,shortening the leaching time per 10 mL effluent from about 30 min for(NH_(4))_(2)SO_(4) leaching system to 20 min for the composite leaching *** leaching time is shortened by one-third,and the leaching cost is reduced,which can provide theoretical guidance for the development and commercial implementa

关键词： Polyethyleneimine Kinetics Rare earths Permeability Activation energy

Carbene-catalyzed enantioselective seleno-Michael addition as access to antimicrobial active Se-containing heterocycles

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Science china Chemistry 2024年第7期67卷 2199-2205页

作者： Hongyan Long Sha Zhao Chunyan Jian Xiuli wu Fengfei Lu Minghong Liao Fengrui Che Xingxing wu Yonggui Robin chi State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Organoseleniums exhibit a diverse set of biological activities that are pivotal for drug discovery and are widely explored in synthetic chemistry and material *** many transformations have been developed for non-enantioselective C–Se bond formations,the catalyst-controlled stereoselective preparation of chiral organoseleniums continues to be of considerable *** particular,there are limited studies on the enantioselective seleno-Michael addition reactions to access chiral selenium functional ***,we disclose a carbene-catalyzed highly enantioselective nucleophilic C–Se bond construction through formal[3+3]annulations between selenocarboxamides and bromoenals,affording seleno-thiazinone products with good yields and excellent *** choice of a weak inorganic base was pivotal to suppressing the unproductive racemization and decomposition of the selenium ***,the catalytically generated chiral selenium-containing heterocyclic products feature remarkable antimicrobial activities that could serve as promising lead scaffolds for further agrochemical development.

关键词： seleno-Michael addition organocatalysis N-heterocyclic carbene seleno-heterocycles antimicrobial activity

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High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： chi-Hao wu Yin-Hsuan Chang chin-Lin Hsu Sheng-Yi Chen Gow-chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

Hydrazone derivatives in agrochemical discovery and development

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chinese Chemical Letters 2024年第3期35卷 104-113页

作者： Ya Wang Shengxin Guo Lijiao Yu Wei Zhang Zhenchao Wang Yonggui Robin chi Jian wu National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

As a common active substructure,hydrazone has attracted increasing attention and is considered essential for pesticide *** has been widely regarded as a potential insecticidal,antibacterial,antifungal,antiviral,and herbicidal *** this review,we highlight the pesticide versatility of hydrazone fragments and provide a comprehensive summary of the biological activity,structure-activity relationship analysis(SARs),and primary mechanism of their *** profile is expected to give valuable information for discovering new pesticides.

关键词： Hydrazone Agrochemicals Biological activity Structure-activity relationship Preliminary mechanism

Addressable structured light system using metasurface optics and an individually addressable VCSEL array

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Photonics Research 2024年第6期12卷 1129-1137页

作者： CHENYANG wu XUANLUN HUANG YIPENG JI TINGYU CHENG JIAXING WANG NAN chi SHAOHUA YU CONNIE J.CHANG-HASNAIN School of Information Science and Technology Fudan UniversityShanghai 200433China Berxel Photonics Co. Ltd.Shenzhen 518071China Peng Cheng Laboratory Shenzhen 518055China chinese University of Hong Kong Shenzhen 518172China

Structured-light(SL)based 3D sensors have been widely used in many *** SL is the most widely deployed among all SL sensors due to its light weight,compact size,fast video rate,and low *** transmitter(known as the dot projector)consists of a randomly patterned vertical-cavity surface-emitting laser(VCSEL)array multiplicated by a diffractive optical element(DOE)with a fixed repeated *** that the separation of any two speckles is only one known and fixed number(albeit random),there are no other known scales to cal-ibrate or ***,typical SL sensors require extensive in-factory calibrations,and the depth resolution is limited to 1 mm at-60 cm *** this paper,to the best of our knowledge,we propose a novel dot projector and a new addressable SL(ASL)3D sensor by using a regularly spaced,individually addressable VCSEL array,multiplicated by a metasurface-DOE(MDOE)into a random pattern of the *** turning on or off the VCSELs in the array provides multiple known distances between neighboring speckles,which is used as a“built-in caliper”to achieve higher accuracy of *** as a precise“vernier caliper,”the addressable VCSEL array enables fine control over speckle positions and high detection *** experimentally dem-onstrated that the proposed method can result in sub-hundred-micron level *** new concept opens new possibilities for applications such as 3D computation,facial recognition,and wearable devices.

关键词： speckle light surface

Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study

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Science china Chemistry 2012年第1期55卷 118-124页

作者： DIAO Shu ZHAO Hong WANG WeiMao wu chi Department of Chemistry The Chinese University of Hong Kong Hong Kong China The Hefei National Laboratory of Physical Science at Microscale Department of Chemical physics The University of Science and Technology of China Hefei 230022 China

Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and ***,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain *** resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are *** addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution.

关键词：聚合动力学淀粉样蛋白多肽单体关联动力学动态激光光散射正解制备

Federated Dynamic Client Selection for Fairness Guarantee in Heterogeneous Edge Computing

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Journal of Computer Science & Technology 2024年第1期39卷 139-158页

作者：毛莺池沈莉娟吴俊平萍吴杰 Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing 211100China College of Computer and Information Hohai UniversityNanjing 211100China Center of Networked Computing Temple UniversityPhiladelphiaPA 19122-6096U.S.A

Federated learning has emerged as a distributed learning paradigm by training at each client and aggregat-ing at a parameter *** heterogeneity hinders stragglers from responding to the server in time with huge com-munication *** client grouping in federated learning can solve the straggler problem,the stochastic selection strategy in client grouping neglects the impact of data distribution within each ***,current client grouping ap-proaches make clients suffer unfair participation,leading to biased performances for different *** order to guaran-tee the fairness of client participation and mitigate biased local performances,we propose a federated dynamic client selec-tion method based on data representativity(FedSDR).FedSDR clusters clients into groups correlated with their own lo-cal computational *** estimate the significance of client datasets,we design a novel data representativity evalua-tion scheme based on local data ***,the two most representative clients in each group are selected to optimize the global ***,the DYNAMIC-SELECT algorithm updates local computational efficiency and data representativity states to regroup clients after periodic average *** on real datasets show that FedS-DR improves client participation by 27.4%,37.9%,and 23.3%compared with FedAvg,TiFL,and FedSS,respectively,tak-ing fairness into account in federated *** addition,FedSDR surpasses FedAvg,FedGS,and FedMS by 21.32%,20.4%,and 6.90%,respectively,in local test accuracy variance,balancing the performance bias of the global model across clients.

关键词： federated learning fairness computational efficiency data distribution client selection client grouping