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A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

Nano Research 2025年第1期18卷 341-350页

作者： Zili Zhang Ruolin Wang Hongfei Lu Di Zhang yu Zhao jing Xu Bin Sun Zhi-Min Dang Yang jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

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不同视野图形刺激的磁源成像研究

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中华放射学杂志 2006年第5期40卷 498-501页

作者：张淑倩叶玉芳孙吉林吴杰贾秀川李素敏吴晶赵华东刘连祥吴育锦河北省人民医院医学影像中心石家庄050051

目的分析全、半及四分视野图形刺激的视觉诱发磁场反应特点及其所对应等电流偶极源的确切位置。方法分别测试13名受试者对全、左半、右半、左上、左下、右上及右下四分视野的视觉诱发磁场反应，分析其潜伏期、偶极矩及偶极在x、y、z... 详细信息

目的分析全、半及四分视野图形刺激的视觉诱发磁场反应特点及其所对应等电流偶极源的确切位置。方法分别测试13名受试者对全、左半、右半、左上、左下、右上及右下四分视野的视觉诱发磁场反应，分析其潜伏期、偶极矩及偶极在x、y、z轴上的位置关系，并通过磁源成像精确定位不同视野图形刺激所引起视觉诱发磁场的位置。结果全视野可引起双侧枕叶的双偶极模式兴奋。双偶极模式的2个偶极潜伏期相同，偶极强度（偶极矩）不同。与MR图像叠加后，所有13个M100偶极出现在包括楔上回、楔下回、楔舌后回、舌上回、舌下回、楔前回及小脑蚓部在内的皮层区。半及四分视野刺激会在刺激野的对侧半球枕区引起单偶极模式的兴奋。半视野刺激所得26个M100偶极位于舌上回、楔下回、楔舌后回和舌下回。35个四分视野刺激M100偶极分布于舌上回、舌下回、楔下回和楔舌后回。对8例受试者的32个四分视野M100偶极在x、y、z轴上的位置x、y、z值进行了统计学处理，发现左上四分视野M100偶极z值中位数为49．6（35．1-72．8）mm，左下四分视野M100偶极z值中位数为53．5（44．8-76．3）mm，二者差值为3．9mm，差异有统计学意义（P〈0．05）；右上四分视野M100偶极z值中位数为40．0（34．8～44．6）mm，右下四分视野M100偶极z值中位数为53．8（40．6～61．3）mm，二者差值为13．8mm，差异有统计学意义（P〈0．05）。提示下四分视野刺激的M100偶极较上四分视野刺激时高。M100源位置与MR图像叠加后，主要位于包括舌上回、楔舌后回及楔下回在内的Brodmann17区。结论图形刺激视觉诱发磁场反应中的M100兴奋主要由纹状皮层的神经元产生，而且更偏向后方，即主要皮层反应位于刺激野对侧半球枕区的距状沟底部后方。

关键词：视野脑磁图描记术视皮质

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《我知道笼中鸟为何歌唱》中的不可靠叙述与黑人身份构建

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湖北开放职业学院学报 2022年第5期35卷 196-198页

作者：吴雨缙张建春红河学院云南蒙自661100

黑人(民族)身份构建和女性主体构建一直以来是非裔黑人女作家写作的主题之一。自传作为一种重要的文学形式,承载着美国黑人女作家们对民族和女性身份的渴望。玛雅·安吉洛在其自传《我知道笼中鸟为何歌唱》中通过描述医治牙齿事件,采用... 详细信息

黑人(民族)身份构建和女性主体构建一直以来是非裔黑人女作家写作的主题之一。自传作为一种重要的文学形式,承载着美国黑人女作家们对民族和女性身份的渴望。玛雅·安吉洛在其自传《我知道笼中鸟为何歌唱》中通过描述医治牙齿事件,采用不可靠叙述修辞达到反讽的目的,在想象中解构白人牙医和黑人女性的社会地位和两性地位,表达了对非裔美国人民族和女性身份构建的美好愿景。

关键词：玛雅·安吉洛《我知道笼中鸟为何歌唱》不可靠叙述反讽身份构建

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脂必泰对非酒精性脂肪肝病大鼠模型疗效评价

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中国医院药学杂志 2020年第22期40卷 2317-2321,2326页

作者：廖媛池晓玲吴宇金吕永慧詹原泉杨以琳广州中医药大学广东广州510006 广州医科大学附属中医医院脾胃科广东广州510130 广州中医药大学第二附属医院广东省中医院肝病科广东广州510000

目的:观察脂必泰胶囊对非酒精性脂肪性肝病(NAFLD)大鼠肝组织病理、纤维化指标及炎症的影响。方法:采用高脂饲料和10%果糖诱导NAFLD大鼠模型,并随机分为模型组,脂必泰低、高剂量组(100,200 mg·kg^-1),二甲双胍组(200 mg·kg^-1),水飞... 详细信息

目的:观察脂必泰胶囊对非酒精性脂肪性肝病(NAFLD)大鼠肝组织病理、纤维化指标及炎症的影响。方法:采用高脂饲料和10%果糖诱导NAFLD大鼠模型,并随机分为模型组,脂必泰低、高剂量组(100,200 mg·kg^-1),二甲双胍组(200 mg·kg^-1),水飞蓟宾组(100 mg·kg^-1),另设正常组,造模成功后连续给药9周。肝脏称重后并计算肝脏指数,对肝组织进行HE、油红和Masson染色;检测各组大鼠血清ALT、AST、CHOL、TG、HDL-C、LDL-C,肝纤维化指标透明质酸酶(HA),层粘连蛋白(LN),IV型胶原(IV-C)和Ⅲ型前胶原(PC-Ⅲ)水平;炎症指标(IL-2、IL-6、IL-8、IL-10、IL-18、TNF-α)。结果:与模型组比较,HE、油红和Masson染色示脂必泰组肝脏病变和肝纤维化显著减轻;ALT、AST、TG、CHOL、LDL-C、肝脏脏器系数及HA、LN、IV-C、PC-Ⅲ、IL-6、IL-8、IL-10、IL-18、TNF-α明显降低,HDL-C明显升高(P<0.05)。二甲双胍组和水飞蓟宾组对NAFLD大鼠血清肝功能指标、肝纤维化指标及炎性细胞因子的改善与脂必泰一致,脂必泰高剂量组对多项指标的作用效果优于水飞蓟宾组。结论:脂必泰胶囊可降低NAFLD大鼠血脂水平,减少炎性细胞因子释放,减轻炎性反应,改善大鼠的肝脏功能和肝纤维化,对NAFLD大鼠具有良好治疗作用。

关键词：脂必泰胶囊非酒精性脂肪性肝病肝纤维化炎症大鼠

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng wu Wen-Jia Chen Xin-Ning yu Hua-Tao wu jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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三种不同模式人工肝治疗肝衰竭患者的临床研究

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罕少疾病杂志 2023年第10期30卷 71-73页

作者：叶晓玲吴锦瑜吴刚九江市第一人民医院肝病科江西九江332000

目的比较三种不同模式人工肝治疗用于肝衰竭患者的效果。方法选取2021.01-2023.01本院收治的肝衰竭患者总共90例进行研究,结合随机数字表法分成A、B、C三组各有30例,A组予以双重血浆分子吸附加血浆置换(DPMAS+PE),B组予以血浆滤过透析(P... 详细信息

目的比较三种不同模式人工肝治疗用于肝衰竭患者的效果。方法选取2021.01-2023.01本院收治的肝衰竭患者总共90例进行研究,结合随机数字表法分成A、B、C三组各有30例,A组予以双重血浆分子吸附加血浆置换(DPMAS+PE),B组予以血浆滤过透析(PDF),C组予以血浆置换(PE),观察三组治疗前后的症状改善、疗效及化验指标改变情况,包含血清中总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(ALB)、血肌酐(CR)、尿素氮(BUN)、钠离子(Na+)、凝血酶原活动度(PTA)、白细胞(WBC)、血红蛋白(HGB)、血小板(PLT)变化,并统计不良反应和12周生存率。结果三组治疗后的临床症状存在程度不一改善,主要表现是食欲改进、腹胀缓解、乏力减轻、浮肿减退以及尿量增加等。三组有效率、不良反应和12周生存率相比无显著差异(P>0.05)。三组治疗前的ALT、AST、TBIL、CR、BUN、Na+、ALB、PTA、WBC、HGB、PLT相比无显著差异(P>0.05);治疗后,各组各项指标均较前改善(P0.05)。结论DPMAS+PE、PDF、PE三种模式人工肝用于肝衰竭患者的疗效、预后以及安全性相当,均能改善肝肾功能、凝血功能以及血常规指标,纠正钠离子紊乱,需要临床结合患者病情开展个体化指标,才能使患者获得最佳的治疗效果。

关键词：人工肝血浆置换双重血浆分子吸附血浆滤过透析肝衰竭

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao yuan Lingqi yu Xudong Zhuang Dongjing Wen jin He jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang wu Xueshun Xie Pengfei Xia jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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CT电离室校准条件的建立与模拟

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计量学报 2016年第6期37卷 663-666页

作者：廖振宇吴金杰屈国普王佳葛双霍彬彬杨扬南华大学核科学技术学院湖南衡阳421001 中国计量科学研究院北京100029

根据IAEA TRS 457报告提出的CT电离室校准方法，建立了RQT8辐射质，运用蒙特卡罗模拟程序EGSnrc得到RQT8辐射质下距源焦点95cm处，射野半径为5cm的平面上的注量谱及角分布，以此构造校准模型，并研究了附加光阑的长度、倒角对校准CT电... 详细信息

根据IAEA TRS 457报告提出的CT电离室校准方法，建立了RQT8辐射质，运用蒙特卡罗模拟程序EGSnrc得到RQT8辐射质下距源焦点95cm处，射野半径为5cm的平面上的注量谱及角分布，以此构造校准模型，并研究了附加光阑的长度、倒角对校准CT电离室的影响。建立的参考辐射质半值层偏差为1．4％，附加光阑在长度为50mm倒角为80°时散（透）射最小，总体达到了CT电离室校准、测试和国际比对的要求。

关键词：计量学 CT电离室校准条件参考辐射质附加光阑蒙特卡罗模拟

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Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang yunfei Du Zhichen wu Liang Xu Xinjie Wang Xiaoguang Liu Wanhua yu Wendong Xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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